Browsing by Author "Hasirci, Ismail"

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Outcome of Surgical Treatment of Intestinal Perforation in Typhoid Fever
(Baishideng Publishing Group inc, 2010) Sumer, Aziz; Kemik, Ozgur; Dulger, Ahmet Cumhur; Olmez, Aydemir; Hasirci, Ismail; Kisli, Erol; Kotan, Cetin
AIM: To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever. METHODS: The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively. RESULTS: There were 18 males and 4 females, mean age 37 years (range, 8-64 years). Presenting symptoms were fever, abdominal pain, diarrhea or constipation. Sixteen cases were subjected to segmental resection and end-to-end anastomosis, while 3 cases received 2-layered primary repair following debridement, one case with multiple perforations received 2-layered primary repair and end ileostomy, one case received segmental resection and end-to-end anastomosis followed by an end ileostomy, and one case received segmental resection and end ileostomy with mucous fistula operation. Postoperative morbidity was seen in 5 cases and mortality was found in one case. CONCLUSION: Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey. In management of this illness, early and appropriate surgical intervention is vital. (C) 2010 Baishideng. All rights reserved.
The Relationship Among Acute-Phase Response Proteins, Cytokines and Hormones in Cachectic Patients With Colon Cancer
(Bmc, 2010) Kemik, Ozgur; Sumer, Aziz; Kemik, Ahu Sarbay; Hasirci, Ismail; Purisa, Sevim; Dulger, Ahmet Cumhur; Tuzun, Sefa
Backgraund: Acute-phase response proteins (APRP), cytokines and hormones have been claimed to be an independent prognostic factor of malignancies, however the basis for their association with prognosis remains unexplained. We suggest that in colon malignancies, as similar to pancreatic and lung cancers, changes in APRP are associated with angiogenesis. Methods: C-reactive protein (CRP), albumin, IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, TNF-alpha, midkine, VEGF-A, VEGF-C, leptin, adiponectin, and ghrelin serum levels are studied in 126 colon cancer patients and 36 healthy subjects. Results: We found statistically significant difference and correlations between two groups. We found significantly higher serum CRP, IL-1 alpha, IL-1 beta,IL-6, IL-8, IL-10, TNF-alpha, VEGF-A, VEGF-C and leptin concentrations in patients relative to controls (p < 0.001). We found lower levels of the serum albumin, midkine, adiponectin and ghrelin in patients compared to control subjects (p < 0.001). Conclusions: Cachexia in patients with colon cancers is associated with changes in APRP, cytokines and hormone concentrations. These biomarkers and cachexia together have a direct relationship with accelerated angiogenesis. This may lead to a connection between the outcomes in malignancies and the biomarkers.
Small Bowel Obstruction Due To Mesodiverticular Band of Meckel's Diverticulum: a Case Report
(Hindawi Ltd, 2010) Sumer, Aziz; Kemik, Ozgur; Olmez, Aydemir; Dulger, A. Cumhur; Hasirci, Ismail; Iliklerden, Umit; Kotan, Cetin
Meckel's diverticulum is the most common congenital anomaly of the small intestine. Common complications related to a Meckel's diverticulum include haemorrhage, intestinal obstruction, and inflammation. Small bowel obstruction due to mesodiverticular band of Meckel's diverticulum is a rare complication. Herein, we report the diagnosis and management of a small bowel obstruction occurring due to mesodiverticular band of a Meckel's diverticulum.