Browsing by Author "Hatipoglu, Fatih"

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Surgical Removal of Coenurus Cerebralis Cysts Located in the Brain of Sheep
(Taylor & Francis Ltd, 2024) Tas, Abuzer; Sen, Ismail; Hatipoglu, Fatih; Ari, Hasan Huseyin; Risvanli, Ali; Salykov, Ruslan; Kyzy, Aiperi Aitmyrza
Coenurosis caused by Coenurus cerebralis poses a significant economic threat to sheep. To date, no effective treatment has been identified for this parasitic infection once it has settled in the brain. This study aimed to investigate the surgical removal of C. cerebralis cysts from the brains of infected sheep. Twenty sheep were utilized in the experiment, and the animals underwent a 24-hour fasting period before the surgical procedure. Various biochemical parameters, including TP, ALP, BUN, AST, CK, LDH, RBC, WBC, Hb, and Hct, were measured in the animals both before and one month after the operation. Anesthesia was induced by administering 2.2 mg/kg IV ketamine hydrochloride, five minutes after the administration of 0.1 mg/kg IV xylazine hydrochloride. Following anesthesia, the trepanation site was determined through percussion. Subsequently, an incision was made in the skin, exposing the skull bone. The skull was opened using a scalpel through trepanation, and the cysts were carefully removed. The results demonstrated that the presented surgical technique effectively treated C. cerebralis cysts in the sheep's brains, restoring normal motor and metabolic functions. Given these outcomes, it is concluded that the proposed surgical technique holds promise for practical application in the field.
Undifferentiated Embryonal Rhabdomyosarcoma in a German Shepherd Dog: Macroscopic, Histopathologic and Immunohistochemical Features
(Univ Ljubljana, 2025) Hatipoglu, Fatih; Tas, Abuzer; Bozkurt, Mehmet Fatih; Kyzy, Ayperi Aitmyrza; Kadiralieva, Nariste
This case report describes an 8-year-old female German Shepherd dog with undifferentiated embryonal rhabdomyosarcoma. The mass measured 13 x 12 x 9 cm, weighed 900 grams, and had an elastic consistency. Histopathologic examination revealed a large necrosis area in the center of the mass. We determined cells with spindle-oval and rounded morphology, hyperchromatic nuclei, unclear cytoplasmic borders, tightly arranged atypia, and mitosis around the necrosis. We noted long cells with nuclei arranged in a row and wreath-like multinucleated giant cells among these cells. In the immunohistochemical examination, neoplastic cells were stained with vimentin, desmin, skeletal muscle myosin, sarcomeric actin, and SMA positively, while Iba1, HLADR, pancytokeratin, S100B, SOX10, and GFAP were stained negatively. Myogenin was intranuclearly positive in approximately half of the cells. The case was diagnosed as RMS and was classified as undifferanted varyant of embryonal type on the basis of histopathologic and immunohistochemical findings. The original morphological and immunophenotyping structure of the tumor, along with the intriguing structure of the giant cells, led us to believe that sharing the case would be beneficial. This case will contribute to the pathomorphological knowledge of canine striated muscle tumors for studies in the field of veterinary oncology.