Browsing by Author "Hayiroglu, Mert Ilker"

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The Association of Serum Uric Acid/Albumin Ratio With No-Reflow in Patients With St Elevation Myocardial Infarction
(Sage Publications inc, 2023) Cinar, Tufan; Saylik, Faysal; Hayiroglu, Mert Ilker; Asal, Suha; Selcuk, Murat; Cicek, Vedat; Tanboga, Ibrahim Halil
The goal of this investigation was to explore the relationship between serum uric acid/albumin ratio (UAR) and no-reflow (NR) in ST elevation myocardial infarction (STEMI) patients (n = 838) who underwent primary percutaneous coronary intervention (pPCI). Angiographic NR was defined as thrombolysis in myocardial infarction (TIMI) flows 0, 1, and 2 in the absence of coronary spasm or dissection. NR developed in 91 (10.9%) STEMI patients. Patients with NR had higher UAR and according to multivariable logistic regression models, a high UAR was an independent risk factor for NR. The area under the curve (AUC) value of the UAR was .760 (95%CI: .720-.801) in a receiver-operating characteristics curve (ROC) assessment. Notably, the UAR AUC value was greater than that of its components: albumin (AUC: .642) and serum uric acid (AUC: .637) (P < .05 for both comparisons). The optimum UAR value in detecting NR in STEMI patients was >1.21 with a sensitivity of 82% and a specificity of 67%. This was the first study to report that the UAR was independently associated with NR in STEMI patients who underwent pPCI.
Comparison of Long-Term Outcomes Between Intravascular Ultrasound-, Optical Coherence Tomography- and Angiography-Guided Stent Implantation: a Meta-Analysis
(Sage Publications inc, 2024) Saylik, Faysal; Hayiroglu, Mert Ilker; Akbulut, Tayyar; Cinar, Tufan
Intravascular ultrasonography (IVUS) and optical coherence tomography (OCT) guided percutaneous coronary interventions (PCI) are alternative techniques to angiography-guided (ANG-g) PCI in patients with coronary artery disease (CAD), especially for optimal stent deployment in coronary arteries. We conducted a network meta-analysis including studies comparing those three techniques. We searched databases for studies that compared IVUS, OCT, and ANG-g PCI in patients with CAD. Overall, 52 studies with 231,137 patients were included in this meta-analysis. ANG-g PCI had higher major adverse cardiovascular events (MACEs), all-cause death, cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stent thrombosis (ST) than IVUS-guided PCI. Of note, both OCT-guided and IVUS-guided PCI had similar outcomes. The frequency of MACEs, cardiac death, and MI were higher in ANG-g PCI than in OCT-guided PCI. The highest benefit was established with OCT for MACEs (P-score=.973), MI (P-score=.823), and cardiac death (P-score=.921) and with IVUS for all-cause death (P-score=.792), TLR (P -score=.865), and ST (P-score=.930). This network meta-analysis indicated that using OCT or IVUS for optimal stent implantation provides better outcomes in comparison with ANG-g in patients with CAD undergoing PCI.
Comparison of Outcomes Between Single Long Stent and Overlapping Stents: a Meta-Analysis of the Literature
(Urban & Vogel, 2023) Saylik, Faysal; Cinar, Tufan; Selcuk, Murat; Cicek, Vedat; Hayiroglu, Mert Ilker; Orhan, Ahmet Lutfullah
ObjectivesThere is no consensus on whether to treat diffuse coronary artery lesions with a single long stent (SLS) or by overlapping two or more stents (OLS). The goal of this review was to compare the outcomes of these two approaches through a meta-analysis of the literature.MethodsWe searched for relevant studies in MEDLINE, Scopus, EMBASE, Google Scholar, and the Cochrane Library. Our meta-analysis included 12 studies (n = 6414) that reported outcomes during the follow-up period.ResultsIndividuals who received OLS had a greater risk of cardiac mortality and target lesion revascularization (TLR) than those who received SLS (RR: 1.51, CI: 1.03-2.21, p = 0.03, I-2 = 0% and RR: 1.64, CI: 1.02-2.65, p = 0.04, I-2 = 38%, respectively). The fluoroscopy period in the OLS group was longer than in the SLS group (SMD: 0.35, CI: 0.25-0.46, p < 0.01, I-2 = 0%). more contrast volume was sued for the OLS group; however, there was substantial variability in the pooled analysis (I-2 = 95%). In terms of all outcomes, there were no differences between stent generation types.ConclusionIn the first meta-analysis of mainly observational data comparing OLS vs. SLS for long coronary lesions, OLS had higher rates of cardiac mortality and TLR as well as longer fluoroscopy times compared to SLS.
Digital Health Interventions in Patient Management Following Acute Coronary Syndrome: a Meta-Analysis of the Literature
(Kare Publ, 2023) Saylik, Faysal; Cinar, Tufan; Hayiroglu, Mert Ilker; Tekkesin, Ahmet Ilker
Objective: Acute coronary syndrome patients should be closely followed-up to maintain optimal adherence to medical treatments and to reduce adverse events. Digital health interventions might provide improved outcomes for patient care by providing closer follow-up, compared to standard care. Thus, in this meta-analysis, we aimed to evaluate the effect of digital health interventions on follow-up in acute coronary syndrome patients. Methods: We searched medical databases to obtain all relevant studies comparing digital health interventions with standard care in acute coronary syndrome patients. After reviewing all eligible studies, a meta-analysis was conducted with the remaining 11 randomized controlled studies and 2 non-randomized controlled studies. A modified Jadad scale and Newcastle-Ottawa scale were used to assess the quality of the publications for randomized controlled studies and non-randomized controlled studies, respectively. Results: This meta-analysis consisted of 7657 patients. The all-cause mortality rate was 49% lower in the digital health intervention cases, compared to those who received standard care [relative risk (RR) = 0.51 (0.37; 0.70), P <.01]. There was a significant decrease in systolic blood pressure in the digital health interventions group, compared to the standard care group [mean difference = -5.28 (-9.47; -1.08), P =.01]. The rate of nonadherence to anti-aggregant drugs was 69% lower in the digital health interventions than in the standard care group [RR = 0.31 (0.20; 0.46), P <.01]. Also, nonadherence rates for statin and beta-blockers were lower in the digital health interventions group. The risk of rehospitalization was observed to be 55% less in the digital health interventions patients, compared to the standard care group [RR = 0.45 (0.30; 0.67), P <.01]. Conclusion: Digital health interventions can be effective in follow-up for secondary prevention in acute coronary syndrome patients.
The Effect of Number of Pregnancies on Aortic Stiffness Index, Aortic Velocity Propagation, and Epicardial Fat Thickness
(Federal Reserve Bank St Louis, 2024) Saylik, Faysal; Cinar, Tufan; Akbulut, Tayyar; Hayiroglu, Mert Ilker; Selcuk, Murat; Uzuner, Zeynep Sevde Serdaroglu; Tanboga, Ibrahim Halil
Objective: Pregnancy causes physiological, hormonal, and hemodynamic changes that affect the aortic wall dimensions and elastic properties. Multiple pregnancies increase the risk of aortic enlargement and reduce aortic elasticity. The aortic stiffness index (ASI) and aortic velocity propagation (AVP) are markers of elasticity. Additionally, epicardial fat thickness (EFT) is associated with cardiovascular risk factors. The impact of multiparity on ASI, AVP, and EFT has not been previously reported in the literature. Therefore, we aimed to investigate the association of these parameters with the number of live pregnancies in this study. Methods: A total of 410 patients were enrolled in this prospective study. Patients were divided into three groups based on the number of live births: Group 1 (n = 0, 128 patients), Group 2 (4 >= n > 0, 157 patients), and Group 3 (n >= 5, 125 patients). A linear regression analysis was conducted to investigate trend associations of ASI, AVP, and EFT between the study groups. Multiple linear regression analysis was used to evaluate the independent predictors of continuous parameters. Results: There were increasing trends in multiparity with variables such as aortic systolic (ASD) and diastolic diameters, pulmonary artery diameters, ASI, and EFT, and a decreasing trend in AVP. The number of pregnancies was strongly and positively correlated with ASI, moderately and positively correlated with EFT and ASD, and moderately and negatively correlated with AVP. Conclusion: Multiparity was independently associated with ASI, EFT, ASD, and AVP, reflecting decreased elasticity and elevated cardiovascular risk in multiparous women.
Evaluation of Intermountain Risk Score for Short- and Long-Term Mortality in St Elevation Myocardial Infarction Patients
(Sage Publications inc, 2023) Cinar, Tufan; Saylik, Faysal; Akbulut, Tayyar; Korkmaz, Yetkin; Cicek, Vedat; Asal, Suha; Hayiroglu, Mert Ilker
The aim of this study was to examine the Intermountain Risk Score (IMRS) for short- and long-term mortality in ST elevation myocardial infarction (STEMI) patients and compare it with the well-known risk scores, such as the Thrombolysis in Myocardial Infarction (TIMI) and the Global Registry of Acute Coronary Events (GRACE). In this retrospective and cross-sectional study, 1057 consecutive patients with STEMI were evaluated. The end-points of the study were short- and long-term mortality. The overall mortality rate was 16% (n = 170 patients). The IMRS was significantly higher in STEMI patients who did not survive compared with those who survived. According to multivariable COX proportional regression analysis, the IMRS was independently related to both short- (HR: 1.482, 95% CI: 1.325-1.675, p < .001) and long-term mortality (HR: 1.915, 95% CI: 1.711-2.180, p < .001). The comparison of receiver operating characteristic curves revealed that the IMRS had non-inferior predictive capability for short- and long-term mortality than the TIMI and GRACE risk scores. To the best of our knowledge, this is the first study to show that the IMRS can predict short- and long-term prognosis of patients with STEMI. Further, the IMRS' predictive value for overall mortality was non-inferior compared with TIMI and GRACE scores.
Evaluation of Naples Score for Long-Term Mortality in Patients With St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
(Sage Publications inc, 2024) Saylik, Faysal; cinar, Tufan; Selcuk, Murat; Akbulut, Tayyar; Hayiroglu, Mert Ilker; Tanboga, Ibrahim Halil
The Naples score (NS), which is a composite of cardiovascular adverse event predictors including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, albumin, and total cholesterol, has emerged as a prognostic risk score in cancer patients. We aimed to investigate the predictive value of NS for long-term mortality in ST-segment elevation myocardial infarction patients (STEMI). A total of 1889 STEMI patients were enrolled in this study. The median duration of the study was 43 months (IQR: 32-78). Patients were divided into 2 groups according to NS as group 1 and group 2. We created 3 models as a baseline model, model 1 (baseline + NS in continuous), and model 2 (baseline + NS as categorical). Group 2 patients had higher long-term mortality rates than group 1 patients. The NS was independently associated with long-term mortality and adding NS to a baseline model improved the model performance for prediction and discrimination of long-term mortality. Decision curve analysis demonstrated that model 1 had a better net benefit probability for detecting mortality compared with the baseline model. NS had the highest contributive significant effect in the prediction model. An easily accessible and calculable NS might be used for risk stratification of long-term mortality in STEMI patients undergoing primary percutaneous coronary intervention.
Evaluation of Risk Factors for Long-Term Atrial Fibrillation Development in Patients Undergoing Typical Atrial Flutter Ablation: a Multicenter Pilot Study
(Urban & Vogel, 2025) Yumurtas, Ahmet cagdas; Pay, Levent; Tezen, Ozan; Cetin, Tugba; Yucedag, Furkan Fatih; Arter, Ertan; Hayiroglu, Mert Ilker
BackgroundAtrial flutter (AFL) and atrial fibrillation (AF) are the most commonly detected supraventricular arrhythmias and share similar pathophysiological mechanisms. After the successful ablation of AFL, AF frequently occurs in the long-term follow-up. As emphasized in some studies, certain mechanisms seem to predispose to the development of AF in AFL patients, and approximately 20% of these patients have accompanying AFL.PurposeWe aimed to analyze independent risk factors that predict the development of AF in patients who underwent typical AFL ablation.MethodsThis was a multicenter, cross-sectional, and retrospective study. A total of 442 patients who underwent typical AFL ablation at three different centers between January 1, 2018 and January 1, 2022 were included retrospectively. After the ablation procedure the patients were divided into those who developed AF and those who did not. The patients were followed up for an average of 12 (4-20) months. In the post-procedural period, atrial arrhythmias were investigated with 24-h Holter and ECG at 1 month, 6 months, and 12 months and then at 6-month intervals thereafter.ResultsOverall, AF developed in 206 (46.6%) patients in the long-term follow-up. Age, hypertension (HT), obstructive sleep apnea syndrome (OSAS), previous cerebrovascular accident (CVA), left atrium anteroposterior diameter, severe mitral regurgitation, hemoglobin, blood glucose, and HbA1c values were found to be significant in univariable analysis. According to multivariable analysis, HT (p = 0.014; HR: 1.483 [1.084-2.030]), OSAS (p = 0.008; HR: 1.520 [1.117-2.068]) and previous CVA (p = 0.038; HR: 1.749 [1.031-2.968]) were independently associated with the development of AF in AFL patients who underwent ablation procedure.ConclusionIn the present study, we found that HT, OSAS, and previous CVA were independently correlated with the development of AF in the long-term follow-up of patients who underwent typical AFL ablation. We consider that AFL patients with such risk factors should be followed up closely following cavotricuspid isthmus ablation for the development of AF. HintergrundVorhofflattern (VFL) und Vorhofflimmern (VF) sind die am h & auml;ufigsten diagnostizierten supraventrikul & auml;ren Arrhythmien und haben & auml;hnliche pathophysiologische Mechanismen. Nach erfolgreicher Ablation des VFL tritt w & auml;hrend des Langzeit-Follow-up oftmals VF auf. Wie in einigen Studien herausgestellt wurde, scheinen bestimmte Mechanismen f & uuml;r die Entstehung von VF bei VFL-Patienten zu pr & auml;disponieren, und bei ann & auml;hernd 20% dieser Patienten besteht ein begleitendes VFL.ZielZiel der vorliegenden Arbeit war die Untersuchung unabh & auml;ngiger Risikofaktoren, die Pr & auml;diktoren f & uuml;r die Entstehung von VF bei Patienten mit Ablation wegen typischem VFL sind.MethodenEs handelte sich um eine retrospektive multizentrische Querschnittstudie. Darin wurden retrospektiv 442 Patienten eingeschlossen, bei denen in 3 verschiedenen Zentren zwischen 1. Januar 2018 und 1. Januar 2022 eine Ablation wegen typischem VFL durchgef & uuml;hrt wurde. Nach der Ablation wurden die Patienten unterteilt in diejenigen, welche VF entwickelten, und diejenigen ohne VF. Im Durchschnitt wurden die Patienten 12 (4-20) Monate lang nachbeobachtet. In der Phase nach dem Eingriff wurden atriale Arrhythmien mittels 24-h-Langzeit-EKG und EKG nach einem Monat, 6 und 12 Monaten und danach in 6-monatigen Abst & auml;nden untersucht.ErgebnisseW & auml;hrend des Langzeit-Follow-up trat ein VF bei 206 (46,6%) Patienten auf. Alter, Hypertonie (HT), obstruktives Schlafapnoesyndrom (OSAS), fr & uuml;here zerebrovaskul & auml;re Ereignisse (CVA), linksatrialer anteroposteriorer Durchmesser, schwere Mitralregurgitation, H & auml;moglobin-, Blutzucker- und HbA1c-Wert wurden in der univariablen Analyse als signifikant eingestuft. Gem & auml;ss der multivariablen Analyse waren HT (p = 0,014; Hazard Ratio, HR: 1,483 [1,084-2,030]), OSAS (p = 0,008; HR: 1,520 [1,117-2,068]) und fr & uuml;here CVA (p = 0,038; HR: 1,749 [1,031-2,968]) unabh & auml;ngig mit der Entstehung von VF bei VFL-Patienten mit Zustand nach Ablation assoziiert.SchlussfolgerungIn der vorliegenden Studie stellte sich heraus, dass HT, OSAS und fr & uuml;here CVA unabh & auml;ngig mit der Entstehung von VF im Langzeit-Follow-up bei Patienten korreliert waren, bei denen eine Ablation wegen typischem VFL erfolgte. Den Autoren zufolge sollten VFL-Patienten mit solchen Risikofaktoren nach einer kavotrikuspidalen Isthmusablation engmaschig in Bezug auf die Entstehung von VF nachuntersucht werden.
Investigation of Predictive Parameters for Recurrence in Patients Undergoing Electrical Cardioversion for Atrial Fibrillation
(Wiley, 2025) Pay, Levent; Tezen, Ozan; Cetin, Tugba; Yumurtas, Ahmet Cagdas; Keskin, Kivanc; Dereli, Seyda; Hayiroglu, Mert Ilker
Background Electrical cardioversion (ECV) is a technique used to restore sinus rhythm in atrial fibrillation (AF), aiming to reduce AF-related symptoms. Various recurrence predictors, such as non-paroxysmal pattern, prolonged duration, chronic obstructive pulmonary disease, advanced age, or left atrial dilation, have been identified. Hence, the aim of our study was to determine the parameters that could predict AF recurrence in the long term in patients who underwent ECV. Methods One hundred seventy-two patients who underwent electrical cardioversion due to AF at our tertiary center were included in the study. Patients with recurrent AF after cardioversion were defined as the AF recurrence (+) group, and those with normal sinus rhythm were defined as the AF recurrence (-) group. Parameters that would predict AF recurrence were investigated between these two groups. Results AF recurrence was observed in 91 patients, while 81 patients did not experience any recurrence. The prediction model, constructed using multivariate Cox regression analysis, included six variables: non- high-density lipoprotein (HDL) cholesterol, free T3, mean corpuscular volume (MCV), left atrium anterior-posterior diameter, number of cardioversions, and oral anticoagulant use. ROC curve analysis demonstrated that our prediction model effectively distinguished between patients with arrhythmia relapse and those without, with an AUC value of 0.719 (p < .05). Conclusions This study revealed that AF recurrence after ECV can be predicted by our prediction model consisting of patient characteristics, disease factors, and various biochemical parameters. The current study demonstrated a statistically significant association between the number of cardioversions and non-HDL cholesterol levels in patients with recurrent AF.
Meta-Analysis of the Current Research on the Relationship Between Blood Lipid Levels and the Occurrence of Atrial Fibrillation
(Elsevier Science inc, 2023) Hayiroglu, Mert Ilker; Saylik, Faysal; Cinar, Tufan; Tokgozoglu, Lale
Background There is still debate in the literature about the relationship between lipid profile and the occurrence of atrial fibrillation (AF). In order to assess the association between blood lipid profiles and incidence of AF, this review was conducted to perform a meta-analysis of all available studies.Methods This review analysed all studies up to 28 February 2023 in PubMed, Google Scholar, and the Cochrane Library that included data regarding blood lipid levels and incidence of AF. For the purpose of calculating pooled estimates, the hazard ratios were extracted from all studies.Results Fourteen studies including 19 cohorts with 3,990,484 patients were included in this meta-analysis. An elevation of one standard deviation in total cholesterol (TC) level was associated with an 8% reduction (HR=0.92, 0.88-0.96; p<0.01) in the risk of developing AF. Although increased low-density lipoprotein cholesterol levels were associated with a 7% reduction in the development of AF (HR=0.93, 0.87-1.00; p=0.04), there was high heterogeneity in the random effects model (I-2=92%). Changes in high-density lipoprotein cholesterol and triglyceride levels were not found to be associated with AF risk in the pooled analysis. Dose-response meta-analysis showed that TC was inversely linearly associated with the risk of AF (p<0.001).Conclusions Higher TC levels were shown to be independently attributed to an increased risk of AF in individuals without cardiovascular disease. There was no association between the incidence of AF and triglyceride, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol blood levels.
Prognostic Value of Pulmonary Artery Diameter/Aorta Diameter Ratio in Patients With Acute Pulmonary Embolism
(Urban & Vogel, 2024) Pay, Levent; Cetin, Tugba; Keskin, Kivanc; Dereli, Seyda; Tezen, Ozan; Yumurtas, Ahmet Cagdas; Hayiroglu, Mert Ilker
BackgroundThe ratio of pulmonary artery diameter (PAD) to ascending aortic diameter (AoD) has been reported to be a prognostic marker in several lung diseases; however, the usefulness of this tool in patients with acute pulmonary embolism (APE) is unknown. Here, we aimed to determine the long-term prognostic value of the PAD/AoD ratio in patients with APE.MethodsA total of 275 patients diagnosed with APE at our tertiary care center between November 2016 and February 2022 were included in the study. The patients were divided into two groups according to the presence of long-term mortality and their PAD/AoD ratios were compared.ResultsLong-term mortality was observed in 48 patients during the median follow-up of 59 (39-73) months. The patients were divided into two groups for analysis: group 1, consisting of 227 patients without recorded mortality, and group 2, consisting of 48 patients with documented mortality. A multivariate Cox regression model indicated that the PAD/AoD ratio has the potential to predict long-term mortality (HR: 2.9116, 95% CI: 1.1544-7.3436, p = 0.023). Analysis of the receiver operating characteristic curve revealed that there was no discernible difference in discriminative ability between the simplified pulmonary embolism severity index (sPESI) and PAD/AoD ratio (area under the curve [AUC] = 0.679 vs. 0.684, respectively, p = 0.937). The long-term predictive ability of the PAD/AoD ratio was not inferior to the sPESI score.ConclusionsThe PAD/AoD ratio, which can be easily calculated from pulmonary computed tomography, may be a useful parameter for determining the prognosis of APE patients. HintergrundDas Verh & auml;ltnis zwischen dem Pulmonalarteriendurchmesser (PAD) und dem Durchmesser der Aorta ascendens (AoD) wurde als prognostischer Marker f & uuml;r verschiedene Lungenerkrankungen beschrieben; sein Nutzen bei Patienten mit akuter Lungenembolie (LE) ist jedoch nicht bekannt. Ziel der vorliegenden Arbeit war es, den prognostischen Langzeitwert des PAD-AoD-Quotienten bei Patienten mit LE zu ermitteln.MethodenZwischen November 2016 und Februar 2022 wurden 275 Patienten mit der Diagnose einer LE im Terti & auml;rversorgungszentrum der Autoren in die Studie eingeschlossen. Dabei wurden die Patienten entsprechend dem Vorliegen von Langzeitmortalit & auml;t in 2 Gruppen eingeteilt und ihre PAD-AoD-Quotienten verglichen.ErgebnisseLangzeitmortalit & auml;t wurde bei 48 Patienten w & auml;hrend des mittleren Follow-up von 59 (39-73) Monaten festgestellt. Zur Auswertung wurden die Patienten in 2 Gruppen unterteilt: Gruppe 1, bestehend aus 227 Patienten ohne dokumentierte Mortalit & auml;t, und Gruppe 2, bestehend aus 48 Patienten mit dokumentierter Mortalit & auml;t. Ein multivariates Cox-Regressions-Modell ergab, dass der PAD-AoD-Quotient das Potenzial aufweist, die Langzeitmortalit & auml;t vorherzusagen (Hazard Ratio, HR: 2,9116; 95%-Konfidenzintervall, 95%-KI: 1,1544-7,3436; p = 0,023). Die Analyse der Receiver-Operating-Characteristic-Kurve zeigte, dass es keinen erkennbaren Unterschied in der Unterscheidungsf & auml;higkeit zwischen dem Simplified Pulmonary Embolism Severity Index (sPESI) und dem PAD-AoD-Quotienten gab (,,area under the curve" [AUC] = 0,679 vs. 0,684; p = 0,937). Die langfristige Vorhersagekraft des PAD-AoD-Quotienten war dem sPESI-Score nicht unterlegen.SchlussfolgerungDer PAD-AoD-Quotient, der einfach anhand der Computertomographie der Lunge errechnet werden kann, ist m & ouml;glicherweise ein n & uuml;tzlicher Parameter zur Ermittlung der Prognose von Patienten mit LE.
The Role of Smart Devices and Mobile Application on the Change in Peak Vo2 in Patients With High Cardiovascular Risk: a Sub-Study of the Light Randomised Clinical Trial
(Taylor & Francis Ltd, 2023) Hayiroglu, Mert Ilker; Cinar, Tufan; Hayiroglu, Selin Cilli; Saylik, Faysal; Uzun, Mehmet; Tekkesin, Ahmet Ilker
BackgroundThis investigation aims to assess the influence of a mobile application and smart devices on cardiopulmonary exercise testing (CPET) over a one-year period in individuals who have high risk for cardiovascular disease. Methods: This is a post-hoc subgroup analysis of Lifestyle Intervention Using Mobile Technology in Patients with High Cardiovascular Risk: A Pragmatic Randomised Clinical Trial (LIGHT). In the intervention plus standard care standard standard care arms, 138 and 103 patients were recruited, respectively. The 1-year VO2 measurements were adjusted to the baseline VO2 measurements as the study's endpoint. VO2 measurements were taken for each subject during the randomisation and final CPET examinations. Results The intervention plus standard care improved VO2 measurements by 1.1 (adjusted treatment effect 1.1, 95% confidence interval (CI): 0.8, 1.4, p < 0.001) compared to standard care following 1-year follow-up. Conclusion At a 1-year follow-up, the smart device and mobile application technologies increased VO2 measurements in individuals with high cardiovascular risk compared to conventional treatment alone.