Browsing by Author "Huyut, Mehmet Tahir"
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Article Can Zaprinast and Avanafil Induce the Levels of Angiogenesis, Bone Morphogenic Protein 2, 4 and 7 in Kidney of Ovariectomised Rats(Taylor & Francis Ltd, 2022) Huyut, Zubeyir; Bakan, Nuri; Yildirim, Serkan; Akbay, Halil Ibrahim; Huyut, Mehmet Tahir; Ahlatci, Adem; Ucar, BunyaminObjective: This study investigated effects of zaprinast and avanafil on angiogenesis, vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 2, 4 and 7. Methods: Female rats were randomly divided into four groups (n = 6). Sham; abdomen was approximately 2 cm opened and closed. Ovariectomised (OVX); abdomen was opened 2 cm and the ovaries were cut. OVX + zaprinast and OVX + avanafil groups; after the same procedure with OVX, 10 mg/kg zaprinast and avanafil were orally administered for 2 month, respectively. Angiogenesis and the levels of VEGF, BMP2, 4 and 7 were determined. Results: VEGF, BMP2, 4 and 7 levels in OVX + zaprinast and especially OVX + avanafil groups were higher than the sham and OVX (p < .05). However, only VEGF and BMP2 levels in OVX + zaprinast group were significant according to sham (p < .05). Also, angiogenesis in OVX + zaprinast and OVX + avanafil groups was dominant according to sham and OVX (p < .05). Conclusions: Zaprinast and avanafil induced BMP2, 4 and 7 levels synergistically with increased VEGF and angiogenesis in renal tissue.Article Characteristics of Resveratrol and Serotonin on Antioxidant Capacity and Susceptibility To Oxidation of Red Blood Cells in Stored Human Blood in a Time-Dependent Manner(Sage Publications Ltd, 2018) Huyut, Zubeyir; Sekeroglu, Mehmet Ramazan; Balahoroglu, Ragip; Huyut, Mehmet TahirObjective In stored red blood cells (RBCs), which are used in diseases (e.g., acute blood loss and leukaemia), storage lesions arise by oxidative stress and other factors over time. This study investigated the protective effects of resveratrol and serotonin on stored RBCs. Methods Blood from each donor (n=10) was placed in different bags containing 70mL of citrate phosphate dextrose (total volume: 500mL) and divided into three groups (n=30): control, 60 mu g/mL resveratrol, and 60 mu g/mL serotonin. Malondialdehyde (MDA) and glutathione (GSH) levels, activity of glutathione peroxidase (GSH-Px), catalase, and carbonic anhydrase (CA), and susceptibility to oxidation in RBCs, and pH in whole blood were measured at baseline and on days 7, 14, 21, and 28. Results MDA levels and susceptibility to oxidation were increased in all three groups time-dependently, but this increase was greater in the serotonin group than in the other groups. Activity of GSH-Px, CAT, and CA, as well as GSH levels, were decreased in the control and serotonin groups time-dependently, but were significantly preserved in the resveratrol group. The pH was decreased in all groups time-dependently. Conclusion Our study shows that resveratrol attenuates susceptibility to oxidation of RBCs and protects their antioxidant capacity, and partially preserves CA activity time-dependently.Doctoral Thesis Comparison of Canonical Correspondence Analysis and Redundant Analysis Based on Constrained Ordination Methods: an Application on a Cardiological Data Set(2019) Huyut, Mehmet Tahir; Keskin, SıddıkDoğadaki olaylar, birbirleri ile ilişkili olan çok sayıdaki değişkenin veya faktörün ayrı ayrı ya da birlikte etkisi ile ortaya çıkmaktadır. Gereksizilik Analizi (Redundacy Analysis, RDA) ve Kanonik Uyum Analizi (Canonical Correspondence Analysis, KUA) bu ilişkileri belirlemede kullanılan analiz yöntemlerindendir. Doğrudan Gradient Analizleri (DGA) olarak da bilinen kısıtlı kanonik analiz yöntemleri ile ilgili yapılan çalışmaların, genellikle çevrebilimciler tarafından yapıldığı ve sağlık alanında sınırlı sayıda çalışmanın olduğu görülmüştür. Bu nedenle tez çalışmasında, KUA ve RDA'nın incelenmesi amaçlanmıştır. Ayrıca, farklı ölçek seviyelerindeki değişkenlere ait verileri içeren Kardiyoloji alanındaki bir veri seti ile yöntemlerin uygulaması yapılarak performansları karşılaştırılmıştır. Performans ölçütleri olarak Belirleme Katsayısı (R2) ve MAPE (Mean Absolute Percentage Error) değeri hesaplanmıştır. Elde edilen sonuçlara göre farklı ölçek türlerinde olan değişkenler arasındaki ilişki yapılarını analiz eden kısıtlı ordinasyon yöntemleri olan KUA ve RDA'nın varyasyonu yeterli düzeyde açıkladığı görülmüştür. Ayrıca, her iki yöntemin düşük MAPE değeri ile (% 10'dan düşük) iyi sınıflama yaptığı ve ordinasyon diyagramı gerçekleştirdiği böylece sağlık alanında da kullanılabileceği vurgulanmıştır. Anahtar Sözcükler: Kanonik form, ölçekleme, biplot, boyut indirgeme, MAPE, anginaMaster Thesis Determination of Effective Factors for Success of Math Score Using Multiple Correspondence Analysis(2014) Huyut, Mehmet Tahir; Keskin, SıddıkMatematik sosyal yaşamın bir parçası olan, yaşamın ve dünyanın anlaşılması ve bunlar hakkında fikirler üretilebilmesi için yardımcı bir eleman olarak görülmektedir. Bu nedenle, günümüzde eğitimle ilgili yapılan reform çalışmalarının en önemli amacı, öğrencilerin matematiği anlayarak öğrenmelerini kolaylaştırabilecek bir sistemin oluşturulmasını sağlamaktır. Öğrencilerin matematik başarısını etkileyen birçok faktör vardır. Ayrıca, bu faktörler birbirleriyle sürekli olarak etkileşim içerisindedir. Bu çalışmada, Van genelinde orta öğretim dokuzuncu sınıflarda Matematik dersi başarısını etkileyen faktörler (değişkenler) arası ilişkiyi incelemek amacıyla Çoklu Uyum Analizi yöntemi kullanılmıştır. Çok değişkenli istatistik analiz yöntemlerden birisi olan çoklu uyum analizi, üç ya da daha çok kategorik değişken arasındaki ilişkiyi, tekil değer ayrışımı ile inceler. Analiz sonrası, değişkenler arası ilişkiler, daha düşük boyutlu (genellikle iki boyut) bir uzayda grafiksel olarak sunulur. Çalışma öncesi, anket sorularının ve kapsamının belirlenmesi için bir ön çalışma yapılmıştır. Bu çalışma sonucunda öğrenciler için hazırlanan anketlerde yer alabilecek sorular belirlenmiş ve 35 soru içeren bir anket oluşturulmuştur. Çalışmada, Van merkezde 40 liseden rasgele alınan 7 lisede bulunan toplam 471 öğrenciye anket uygulanmıştır. Çalışma soncunda; hedef bilinci oluşan öğrencilerin daha başarılı olduğu, cinsiyet farkının matematik başarı puanı ile düşük ilişkili olduğu, matematiği kalıcı bir şekilde öğrendiğine inanan öğrencilerin üniversite de okumak istedikleri, matematiği öğrenemeyen ve bu dersten korkan öğrencilerin daha başarısız olma eğiliminde oldukları, öğretmenin kullandığı dili anlaşılır bulan öğrencilerin başarıya daha eğilimli oldukları, çalışma masası ve çalışma odası olmayan öğrencilerin matematiği daha az sevdiği, okulun fiziksel olanaklarının ve öğrencinin sınıfta oturduğu yerin başarı kategorisi ile pozitif bir ilişkide olduğu ve ebeveynlerinin eğitim düzeyi düşük olan öğrencilerin daha başarılı olduğu bulunmuştur.Article Effect of Abemaciclib and Curcumin Administration on Sex Hormones, Reproductive Functions, and Oxidative Dna Expression in Rats(Taylor & Francis Ltd, 2024) Huyut, Zuebeyir; Ucar, Bunyamin; Yildizhan, Kenan; Altindag, Fikret; Huyut, Mehmet TahirThis study investigated whether abemaciclib (ABE) administration had any adverse effects on ovarian and sex hormones in female rats, and the protective effect of curcumin. Forty female rats were equally divided into the sham control, DMSO, curcumin (CMN), ABE, and ABE+CMN groups. Pharmaceuticals were administered by gavage daily for 28 days. Serum sex hormones were measured in an autoanalyzer operating with a microparticle immunoassay method. In addition, histopathological examination and 8-OHdG expression were performed on the ovarian tissue. Progesterone and testosterone levels were significantly decreased, while estradiol levels were significantly increased, in the ABE group compared to the sham and DMSO groups. In addition, there were significant differences in sex hormone levels in the CMN and/or CMN+ABE groups compared to the ABE group. There was decreased expression of 8-OHdG in the ABE+CMN group compared to the ABE or CMN only groups. This study exhibited that ABE administration can adversely affect functions and histology of the ovarian tissue, but CMN therapy may be protective against the adverse effects on ovarian in ABE-induced rats.Article Effect of Curcumin on Lipid Profile, Fibrosis, and Apoptosis in Liver Tissue in Abemaciclib-Administered Rats(Taylor & Francis Ltd, 2023) Huyut, Zubeyir; Ucar, Bunyamin; Altindag, Fikret; Yildizhan, Kenan; Huyut, Mehmet TahirAbemaciclib (ABEM) is an important antitumor agent for breast cancer treatment. However, the side-effects of ABEM are unclear in the liver. This study investigated the protective effect of curcumin (CURC) on liver damage caused by ABEM. The rats were divided into five groups with eight animals in each group; Control, DMSO (150 mu L for per rats), CURC, 30 mg/kg/day), ABE (26 mg/kg/day), and ABE + CURC (26 mg/kg/day ABE, 30 mg/kg/day) groups. Injections were administered daily for 28 days. The levels of AST, LDH, HDL, LDL, triglyceride, and total cholesterol in serum, and hepatic tissue fibrosis, caspase-3, Bax, and TNF-alpha expression were higher in the ABE group compared to the control group (p < 0.05). Also, these parameters in the ABEM + CURC group were lower than in the ABE group (p < 0.05). The results showed that ABE administration could cause liver damage and increase fibrosis in the liver. In addition, it was shown that co-administration of CURC with ABE could suppress the levels of AST, LDH, HDL, LDL, triglyceride, and total cholesterol in serum, and fibrosis, caspase-3, Bax, and TNF-alpha expressions in the liver. These data are the first in the literature. Therefore, the administration of CURC following ABE may be a therapeutic agent in preventing liver damage.Article Effect of Ferritin, Inr, and D-Dimer Immunological Parameters Levels as Predictors of Covid-19 Mortality: a Strong Prediction With the Decision Trees(Cell Press, 2023) Huyut, Mehmet Tahir; Huyut, ZubeyirBackground and objective: A hyperinflammatory environment is thought to be the distinctive characteristic of COVID-19 infection and an important mediator of morbidity. This study aimed to determine the effect of other immunological parameter levels, especially ferritin, as a predictor of COVID-19 mortality via decision-trees analysis.Material and method: This is a retrospective study evaluating a total of 2568 patients who died (n = 232) and recovered (n = 2336) from COVID-19 in August and December 2021. Immunological laboratory data were compared between two groups that died and recovered from patients with COVID-19. In addition, decision trees from machine learning models were used to evaluate the performance of immunological parameters in the mortality of the COVID-19 disease. Results: Non-surviving from COVID-19 had 1.75 times higher ferritin, 10.7 times higher CRP, 2.4 times higher D-dimer, 1.14 times higher international-normalized-ratio (INR), 1.1 times higher Fibrinogen, 22.9 times higher procalcitonin, 3.35 times higher troponin, 2.77 mm/h times higher erythrocyte-sedimentation-rate (ESR), 1.13sec times longer prothrombin time (PT) when compared surviving patients. In addition, our interpretable decision tree, which was constructed with only the cut-off values of ferritin, INR, and D-dimer, correctly predicted 99.7% of surviving patients and 92.7% of non-surviving patients.Conclusions: This study perfectly predicted the mortality of COVID-19 with our interpretable decision tree constructed with INR and D-dimer, especially ferritin. For this reason, we think that it may be important to include ferritin, INR, and D-dimer parameters and their cut-off values in the scoring systems to be planned for COVID-19 mortality.Article Effects of Exogenous Ghrelin Treatment on Oxidative Stress, Inflammation and Histological Parameters in a Fat-Fed Streptozotocin Rat Model(Taylor & Francis Ltd, 2025) Ergul Erkec, Ozlem; Huyut, Zubeyir; Acikgoz, Eda; Huyut, Mehmet TahirIn this study, the anti-inflammatory, antioxidative, and protective effects of ghrelin were investigated in a fat-fed streptozotocin (STZ) rat model and compared with metformin, diabetes and the healthy control groups. Histopathological evaluations were performed on H&E-stained pancreas and brain sections. Biochemical parameters were investigated by enzyme-linked immunosorbent assay. Blood glucose levels were significantly decreased with ghrelin or metformin treatments than the diabetes group. STZ administration increased brain, renal and pancreatic IL-1 beta, TNF-alpha and MDA while decreasing GPX, CAT, SOD, and NGF levels. Ghrelin increased renal GPX, CAT, NGF pancreatic GPX, SOD, CAT, NGF and brain SOD, NGF while it decreased renal, pancreatic and brain IL-1 beta, TNF-alpha and MDA levels. Ghrelin reduced neuronal loss and degeneration in the cerebral cortex and hippocampus and greatly ameliorated diabetes-related damage in pancreas. In conclusion, the data suggested that ghrelin is an effective candidate as a protectant for reducing the adverse effects of diabetes.Article Farklı Ölçek Seviyelerindeki Değişkenlerin Analizinde Kısıtlı Ordinasyon Yöntemlerinin Başarısı(2021) Keskin, Sıddık; Huyut, Mehmet TahirDoğadaki olaylar, birbiriyle ilişkili birçok değişkenin ayrı ayrı veya birlikte etkisiyle meydana gelir. Değişkenler arası doğrusal ve doğrusal olmayan ilişki yapısı ile farklı ölçek düzeylerindeki veri setlerinin analizi için kullanılan yöntemlerin tanıtılması ve kullanılması önemlidir. Bu tür verilerin analizinde kullanılan yöntemler arasında Gereksizlik Analizi ve Kanonik Uyum Analizi yer almaktadır. Yukarıda belirtilen tekniklerle ilgili çalışmaların genellikle ekolojistler tarafından yapıldığı ve sağlık alanında sınırlı sayıda çalışma olduğu görülmüştür. Bu nedenle çalışmada, belirtilen yöntemlerin uygulamaları farklı ölçek düzeylerindeki değişkenleri içeren bir Kardiyoloji veri seti üzerinde gerçekleştirilmiş ve performansları karşılaştırılmıştır. Performans kriteri olarak Belirleme Katsayısı (R2 ) ve MAPE (Ortalama Mutlak Yüzde Hata) değeri hesaplandı. Elde edilen sonuçlara göre, farklı ölçek türlerindeki (kardiyolojik veri seti) değişkenler arasındaki ilişki yapılarını inceleyen CCA ve RDA'nın, varyasyonu yeterince açıkladığı görülmüştür. Ayrıca her iki yöntemin de düşük MAPE değeri (% 10'dan az) ile iyi sınıflandırıldığı ve koordinasyon diyagramı gerçekleştirdiği vurgulanmıştır. Ayrıca, kısıtlı koordinasyon diyagram modellerinin koroner kalp hastalığı verileri arasındaki ilişkilerin belirlenmesinde tatmin edici sonuçlar verdiği ve benzeri sağlık alanlarında da kullanılabilirliği görülmüştür.Correction Forecasting of Oxidant/Antioxidant Levels of Covid-19 Patients by Using Expert Models With Biomarkers Used in the Diagnosis/ Prognosis of Covid-19 (Vol 100, 108127, 2021)(Elsevier, 2024) Huyut, Mehmet Tahir; Huyut, ZubeyirArticle Forecasting of Oxidant/Antioxidant Levels of Covid-19 Patients by Using Expert Models With Biomarkers Used in the Diagnosis/Prognosis of Covid-19(Elsevier, 2021) Huyut, Mehmet Tahir; Huyut, ZubeyirBackground: Early detection of oxidant-antioxidant levels and special care in severe patients are important in combating the COVID-19 epidemic. However, this process is costly and time consuming. Therefore, there is a need for faster, reliable and economical methods. Methods: In this study, antioxidant/oxidant levels of patients were estimated by Expert-models using biomarkers, which are effective in the diagnosis/prognosis of COVID-19 disease. For this purpose, Expert-models were trained and created between the white-blood-cell-count (WBC), lymphocyte-count (LYM), C-reactive-protein (CRP), Ddimer, ferritin values of 35 patients with COVID-19 and antioxidant/oxidant parameter values of the same patients. Error criteria and R2 ratio were taken into account for the performance of the models. The validity of the all models was checked by the Box-Jenkis-method. Results: Antioxidant/Oxidant levels were estimated with 95% confidence-coefficient using the values of WBC, LYM, CRP, D-dimer, ferritin of different 500 patients diagnosed with COVID-19 with the trained models. The error rate of all models was low and the coefficients of determination were sufficient. In the first data set, there was no significant difference between measured antioxidant/oxidant levels and predicted antioxidant/oxidant levels. This result showed that the models are accurate and reliable. In determining antioxidant/oxidant levels, LYM and ferritin biomarkers had the most effect on models, while WBC and CRP biomarkers had the least effect. The antioxidant/oxidant parameter estimated with the highest accuracy was Native-Thiol divided by Total-Thiol. Conclusions: The results showed that the antioxidant/oxidant levels of infected patients can be estimated accurately and reliably with LYM, ferritin, D-dimer, WBC, CRP biomarkers in the COVID-19 outbreak.Correction Forecasting of Oxidant/Antioxidant Levels of Covid-19 Patients by Using Expert Models With Biomarkers Used in the Diagnosis/Prognosis of Covid-19 (Vol 100, 108127, 2021)(Elsevier, 2022) Huyut, Mehmet Tahir; Huyut, ZubeyirArticle In Vivo Biochemical Evaluations of Some Β-Lactam Group Antibiotics on Glutathione Reductase and Glutathione S- Transferase Enzyme Activities(Pergamon-elsevier Science Ltd, 2019) Turkan, Fikret; Huyut, Zubeyir; Huyut, Mehmet Tahir; Calimli, Mehmet HarbiObjectives: The aim of this study was to investigate whether some of the cephalosporin group antibiotics have inhibition effects on GR and GST enzymes with important functions in the metabolic pathway. Methods: In this study, some selected cephalosporin group antibiotics on GST and GR enzyme was carried out using 96 rats. 16 groups (16 x 6) were created from these rats, divided to another 4 groups (4 x 24). The resulting groups were named as sham groups, cefazolin groups, cefuroxime groups and cefoperazone groups, respectively. The antibiotics used were injected to cefazolin, cefuroxime and cefoperazone groups. The inhibition effects of the antibiotics were measured in the different time intervals (1st, 3th, 5th, 7th). The statistical investigation of the results was performed using the SPSS software program. Results: Results revealed the complex effects of the tested substances on GR and GST activity at different time intervals and in different tissues (p < 0.05). This indicated that the tested substances could be exposed to different interactions in vivo. Conclusion: The tested antibiotics showed some significant inhibition effects on the GST and GR enzyme activity in some tissues of brain, eye and muscle. The interaction of enzyme - the drug is a key factor to highlight the toxicological mechanism. For this reason, the results obtained from in vivo experiments are crucial to explane the physiological properties of the enzymes.Correction In Vivo Biochemical Evaluations of Some Β-Lactam Group Antibiotics on Glutathione Reductase and Glutathione S-Transferase Enzyme Activities (Vol 231, 116572, 2019)(Pergamon-elsevier Science Ltd, 2023) Turkan, Fikret; Huyut, Zubeyir; Huyut, Mehmet Tahir; Calimli, Mehmet HarbiArticle Investigation of the Effects of Cephalosporin Antibiotics on Glutathione S-Transferase Activity in Different Tissues of Rats in Vivo Conditions in Order To Drug Development Research(Taylor & Francis Ltd, 2020) Turkan, Fikret; Huyut, Zubeyir; Taslimi, Parham; Huyut, Mehmet Tahir; Gulcin, IlhamiGlutathione S-transferases are multifunctional enzymes for the cellular defense against xenobiotics and provide protection for organism. In this study, the inhibition effects of some antibiotics were investigated against GST obtained from albino-rats kidney, liver, and heart tissues. Ninety-six albino-rats were randomly divided into 16 groups (n:6). The first four groups were control groups that were administrated blank enjection and decapitated at 1-7 h. The other groups were administrated the antibiotics. In all tissues, GST activity was increased in antibiotics groups at 1st and 3rd hours compared to control groups, while it began to fall at 5th and 7th hours (p < .05). In kidney tissues, it was lower than the same control group the cefuroxime and cefoperazone groups at 7th hours (p < .05). In addition, almost all antibiotic groups of kidney tissues had higher GST activity at all hours than those of control groups, but it was higher only at 5th hours in heart tissues (p < .05).Article Oxidative Stress Enzyme Nox1 Is a New and Important Biomarker for Childhood Appendicitis(Springer india, 2023) Avci, Veli; Ayengin, Kemal; Huyut, Zubeyir; Huyut, Mehmet Tahir; Soysal, Lokman; Bilici, SalimDelayed appendicitis diagnosis may result in perforation and an increased risk of mortality. This study aimed to assess the diagnostic value of ischemia-modified albumin, nicotinamide adenine dinucleotide phosphate oxidase 1, 2, and 4 levels in the diagnosis of non-complicated and complicated appendicitis. The study included 60 pediatric patients who presented to our clinic with a complaint of abdominal pain and underwent surgery with a diagnosis of appendicitis between November 2020 and December 2021 and also included 30 controls. Cases were divided into three groups: (i) non-complicated appendicitis (n = 30), (ii) complicated appendicitis (n = 30), and (iii) control (n = 30). The nicotinamide adenine dinucleotide phosphate oxidase 1 and 4 and ischemia-modified albumin levels were higher in non-complicated and complicated appendicitis compared to the control (p < 0.001). In addition, considering the odds ratio values, the most effective biomarkers in the diagnosis were nicotinamide adenine dinucleotide phosphate oxidase 1 and 2, and procalcitonin, while the most effective biomarkers in the prognosis were nicotinamide adenine dinucleotide phosphate oxidase 1 and 2, and neotrophil/lymphocyte ratios. The data suggested that since the most successful biomarker nicotinamide adenine dinucleotide phosphate oxidase 1, with a value of 0.98- area under the curve, is the most successful biomarker in both diagnosis and prognosis of the disease, it can be used as an important biomarker in childhood appendicitis.Article What Is the Impact and Efficacy of Routine Immunological, Biochemical and Hematological Biomarkers as Predictors of Covid-19 Mortality(Elsevier, 2022) Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, CumaIt remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Odds ratios of the parameters affecting one-month mortality were calculated by running multiple-logistic-regression analysis. The cut off values and diagnostic efficiencies of the parameters that posed a risk for mortality were obtained via receiver operating curve analysis. It was determined that the C-reactive protein (CRP), D-dimer, procalcitonin, erythrocyte-sedimentation-rate (ESR), troponin values were at abnormal levels until death occurred in the patients who died. In addition, the procalcitonin levels were consistently high in patients who died. The patients who died generally had a sustained increase in their leukocyte and neutrophil levels and biochemical variables, and an ongoing decrease in lymphopenia and eosinopenia levels. Although significant changes were observed in liver function tests, cardiac troponin, hemogram values, kidney function tests and parameters related to inflammation in deceased patients, high ESR, international-normalized-ratio (INR), prothrombin-time (PT), CRP, D-dimer, ferritin and red-cell-distribution width (RDW) values, respectively, were the most effective predictive mortality risk biomarkers of COVID-19. In addition, neutrophilia, leukocytosis, thrombocytopenia, erythrocytopenia were other risk predictors of mortality. Indicators was found in this study can be successfully used to predict mortality from COVID-19.Correction What Is the Impact and Efficacy of Routine Immunological, Biochemical and Hematological Biomarkers as Predictors of Covid-19 Mortality? (Vol 105, 108542, 2022)(Elsevier, 2023) Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, CumaCorrection What Is the Impact and Efficacy of Routine Immunological, Biochemical and Hematological Biomarkers as Predictors of Covid-19 Mortality? (Vol 105,108542,2022)(Elsevier, 2025) Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, CumaArticle Zilan Çayındaki (Van/ Türkiye) Balık Bolluğu, Dağılımı ve Bazı Fizikokimyasal Parametrelerle İlişkisi(2022) Akkus, Mustafa; Huyut, Mehmet TahirSon yıllarda, nehir düzenleme girişimleri, barajlar ve atık su deşarjı nehirlerin su kalitesini ve fiziksel habitat yapılarını olumsuz etkilemekle kalmadı, aynı zamanda balık stoklarını da olumsuz etkiledi. Bu çalışmanın amacı, Van Gölü'nün en büyük akarsuyu olan Zilan Çayı'nda yaşayan balık türlerinin yoğunluğu ile bu akarsudaki fizikokimyasal parametreler arasındaki çoklu ilişki yapısını incelemektir. Balık yoğunluğu Zilan Çayı üzerinde yer alan 12 istasyondan alınan kayıtlardan öğrenildi. İstasyonlardan su sıcaklığı, habitat skoru, pH, iletkenlik, çözünmüş oksijen (DO), fosfat (PO4), nitrat (NO3), bulanıklık ve yükseklik değerleri elde edildi. Elde edilen parametrelerin balık yoğunluğu ile korelasyon yapısı kanonik uyum analizi (KUA) ile incelendi. KUA eksenleri, balık yoğunluğunun fizikokimyasal parametrelere tepkisini tam olarak açıkladı. KUA sonucunda türlerin daha az iletken, düşük nitrat ve pH seviyelerine sahip ortamlarda yoğunlaştığı gözlemlenmiştir. Türler irtifaya aşırı duyarlıydı ve orta/düşük irtifalarda daha yoğun bulundu. Ayrıca türlerin habitat skoru yüksek ve oksijenden zengin istasyonlarda yoğunlaştığı gözlemlendi. Türün orta/düşük sıcaklığı daha çok tercih ettiği ve düşük katı içerikli ortamlarda yoğunlaştığı gözlemlenmiştir. Bu çalışmadan elde edilen verilerin Zilan Çayı'nda korunacak alanların yönetimine katkı sağlaması beklenmektedir.