Browsing by Author "Ilhan, M"

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Morphological Quantitative Changes in the Number of Lymphocytes, Macrophages and Plasma Cells in the Uterus and Lymph Nodes of Rats Exposed To the Systemic Administration of Bcg
(Tohoku Univ Medical Press, 2003) Kanter, M; Gul, A; Meral, I; Koc, A; Ilhan, M; Erdogan, E
KANTER, M., GUL, A., MERAL, I., Koc, A., ILHAN, M. and ERDOGAN, E. Morphological Quantitative Changes in the Number of Lymphocytes, Macrophages and Plasma Cells in the Uterus and Lymph Nodes of Rats Exposed to the Systemic Administration of BCG. Tohoku J. Exp. Med., 2003, 199 (4), 219-228 - This study was designed to investigate the effect of systemic administration of BCG on the morphological quantitative changes in the number of lymphocytes, macrophages and plasma cells in the uterus and lymph nodes of rats. Thirty female virgin Wistar Albino rats, aging 6 months and weighing between 200-250 g, were assigned to the two experimental groups; BCG treated and controls (n = 15). BCG group received 0.1 ml BCG in tail skin and control group received 0.1 ml saline at the same place. Two weeks after injections, rats in both groups were anesthesized with a high dose of ether and decapitated. Uterus and ileocecal lymph nodes were processed to determine alpha napthyl acid esterase (ANAE)-positive T lymphocytes and macrophages. The plasma cells were stained with the methyl green-pyronin method. It was found that the numbers of T lymphocytes, macrophages and plasma cells in the uterus and the ileocecal lymph nodes of BCG treated group significantly increased indicating the presence of an immune response to the systemic BCG administration. It was concluded that the systemic administration of BCG increases humoral and cellular immunity in endometrium, myometrium and regional lymph nodes. The immune deficiency system plays an important role in the pathogenesis of endometriosis. Therefore, the endometriosis might be prevented by using periodical administration of BCG. However, further experimental and clinical studies associated with these issue are required.
Palmoplantar Keratoderma Is Associated With Esophagus Squamous Cell Cancer in Van Region of Turkey: a Case Control Study
(Bmc, 2005) Ilhan, M; Erbaydar, T; Akdeniz, N; Arslan, S
Background: Esophagus squamous cell cancer (ESCC) is the most common cancer in women with 20.2% and second in men with 10.7% relative frequency among all cancer cases diagnosed in Van Region in the east of Turkey. Ninety percent of all esophageal cancer cases are ESCC and 20 - 30% of them have family history of esophageal cancer. The most clear defined hereditary predisposition associated with ESCC is palmoplantar keratoderma (PPK). To examine the relationship between ESCC and PPK, we have carried out this case control study. Methods: The case group consisted of 48 subjects who had new diagnosis of ESCC and did not receive any chemo or radiotherapy. The control group consisted of 96 healthy individuals who were visitors of their relatives in the hospital. Two control persons who matched for age, gender, living place (urban/rural) and region were selected for each case. All subjects were evaluated for PPK by dermatologist. Evaluation was graded as none, mild, evident and severe. None and mild subjects were classified as negative for PPK; and others as positive. Relationship between ESCC and PPK was evaluated with odds ratios and confidence intervals for cases with or without family history of ESCC. Results: The PPK frequencies were 92.3% in ESCC cases with family history, 62.5% in ESCC cases without family history, 70.8% in all ESCC cases, and 28.1% in the control group. Odds ratios for cases with or without family history of esophageal cancer, and for the whole case group were found as 30.7 (95% CI = 3.8 - 247.4), 4.3 ( 95% CI = 1.9 - 9.8) and 6.2 ( 95% CI = 2.9 - 13.3) respectively. Conclusion: Presence of PPK lesions represents genetic susceptibility for ESCC. This susceptibility for ESCC is the highest among those who have PPK lesions and a positive family history of esophageal cancer. Furthermore, a PPK sufferer has an increased risk of developing ESCC even if there is no family history of esophageal cancer.
Primary Malignant Fibrous Histiocytoma Presenting as an Intussusception: Report of the Small Intestine of a Case
(Springer, 2002) Kotan, C; Kosem, M; Alici, S; Ilhan, M; Tuncer, I; Harman, M
Malignant fibrous histiocytoma occurs most commonly in the extremities and trunk, but rarely in the visceral organs. Malignant fibrous histiocytoma of the small intestine is an extremely rare condition. To our knowledge, only ten cases of primary tumors involving the small intestine have been described up to now. Among them only one case has been reported to lead to intussusception. This case report documents the appearance of a storiform-pleomorphic type primary malignant fibrous histiocytoma of the ileum, which led to intussusception, in a 58-year-old man with a 3-month history of dyspepsia, weight loss, general fatigue, and nonspecific abdominal pain. The patient was well with no sign of disease at 8 months after surgery. The clinical and pathologic characteristics of malignant fibrous histiocytoma of the small intestine as found in the literature are also reviewed.
Renal Involvement in Brucellosis
(Oxford Univ Press, 2005) Sahin, I; Arabaci, F; Eminbeyli, L; Ilhan, M; Onbasi, K; Sahin, HA