Browsing by Author "Ilhan, Mahmut"

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Analysis of 3065 Cancer Cases in an Eastern Part of Turkey: the Results of Hospital-Based Registries From Van Region
(Oxford Univ Press, 2004) Topcu, Nazan; Ilhan, Mahmut; Koca, Dogan; Kosem, Mustafa; Sahin, Kevser; Sahin, Idris; Yetkin, Aysin
C-Reactive Protein as an Acute Phase Protein in Cancer Patients
(Humana Press inc, 2007) Bolayirli, Murat; Turna, Hande; Orhanoglu, Timur; Ozaras, Resat; Ilhan, Mahmut; Ozguroglu, Mustafa
The aim of our study was to determine the rate of elevation of c-reactive protein in cancer patients and to evaluate its correlation with other acute phase proteins. A total of 104 patients with various types of cancer who admitted clinic were included in our study. Serum levels of c-reactive protein, lactate dehydrogenase, ferritin, haptoglobin, plasma fibrinogen levels and erythyrocyte sedimentation rate were measured. The serum levels of c-reactive protein was found to be increased in 74% of cancer patients, with 81.3% and 64.4% in metastatic and non-metastatic group, respectively. Our study showed that c-reactive protein and fibrinogen demonstrated better characteristics than other acute phase proteins to differentiate between cancer patients and healthy individuals and also to differentiate between healthy individuals and patients with infection. C-reactive protein, ferritin, fibrinogen, erythrocyte sedimentation rate, and haptoglobin showed similar characteristics to differentiate metastatic and non-metastatic cancer patients whereas, LDH demonstrated the lowest performance. C-reactive protein was not found to be superior to other acute phase proteins in the differential diagnosis of cancer and infection and in differentiating early stage disease from advanced stage.
Evaluation of Western Blot Method for the Detection of Antibodies To Helicobacter Pylori Antigens in Patients With Gastric Carcinoma and Cases With Epigastric Complaints
(Ankara Microbiology Soc, 2010) Guducuoglu, Huseyin; Berktas, Mustafa; Bozkurt, Hamza; Ozer, Turkan Toka; Bulut, Guelay; Ozturk, Oznur; Ilhan, Mahmut
Helicobacter pylori proteins CagA (cytotoxin-associated gene A) and VacA (vacuolating cytotoxin A) are among the virulence factors of this species. CagA gene carrying H.pylori strains are particularly associated with gastric adenocarsinoma. This study was conducted to evaluate Western Blot (WB) method to determine specific H.pylori antibodies in a group of patients with gastric cancer and in a control group with no malignancy. A total of 99 patients with gastric cancer (94 adenocarcinoma, 2 adenosquamous cell carcinoma, 3 non-Hodgkin lymphoma) and 150 control cases with epigastric complaints such as nausea, vomiting, diarrhea, gastroesophageal reflux and abdominal pain, were included to the study. H.pylori IgG-ELISA was positive in all study (mean age: 56.7 +/- 1.2 years, 62 male) and control (mean age: 24.2 +/- 1.3 years, 64 male) patients. Specific antibodies against CagA, VacA, OMP (outer membrane protein)-67, urease-A, urease-B, HSP (heat shock protein) and flagellin antigens determined by a commercial WB-based kit (RIDA Blot Helicobacter, R-Biopham GmbH, Germany). Interestingly, no anti-VacA positivity was detected in none of the patient and control groups. The positivity rates for H.pylori CagA, OMP-67, urease A, urease-B, flagellin and HSP specific antibodies were as 78%, 54%, 37%, 60%, 53% and 82% in the gastric cancer group and 85%, 71%, 55%, 43%, 61% and 75% in the control group, respectively. There was no statistically significant difference (p> 0.05) between gastric carcinoma and control groups in terms of CagA, HSP and flagellin antibodies (p> 0.05). On the other hand, a statistically significant difference was found between the 2 groups in terms of urease-A, urease-B and OMP-67 (p< 0.01). These results suggested that this test should be assessed again by the manufacturer for its detection power directed towards specific H.pylori antibodies, especially for Vac-A. Further molecular and clinical studies are necessary to determine the factors that affect H.pylori virulence and disease prognosis.
Expression of Cd44s in Advanced Stage Esophageal Squamous Cell Carcinomas and Other Clinicopathological Prognostic Factors
(Akad Doktorlar Yayinevi, 2009) Izmirli, Mustafa; Bayram, Irfan; Senol, Serkan; Ilhan, Mahmut
CD44s is an adhesion molecule which is a member of the cell adhesion molecules family hyaladherins. CD44s has some effects including tumor-endothel interaction, cell motility and migration, cell adhesion and tumor invasion, tumor progression, and metastasing. In this study, we aimed to evaluate the CD44s expression and some other prognostic factors in patients with esophageal squamous cell carcinoma. Between 1999 and 2004, pathological specimens of 35 patients were examined by the Yuzuncu Yil University (YYU) Medical Faculty, Pathology Department and other clinical and laboratory findings were collected from Oncology Department patient files. CD44s staining was positive in 32 patients and negative in 3. The intensity of stained CD44s was positive in 30 and negative in 5 patients. Thirteen patients were well-differentiated, 18 were mid-differentiated, and 4 were poorly differentiated. Inflamatuary reactions were observed in 23 cases. The median survival was 5.3 months and the one year, two year and five year survival rates were 34.2%, 8.6% and 2.9% respectively. Treatment modality, clinical stage and tumour size at the diagnosis time was significant at univariate analysis and only treatment modality was significant in multivariate analysis. Very high CD44s expression was observed in sq cell osephageal cancer patients. CD44s may be an important marker in prognosis. Treatment modality was found as an independent factor on prognosis of osephageal cancer.
Incidence of Palmoplantar Keratoderma Has Been Increased in Esophageal Cancer in Van Region of Turkey: the Early Results of a Case-Control Study
(Oxford Univ Press, 2004) Ilhan, Mahmut; Akdeniz, Necmettin; Arslan, Sefket; Sahin, Idris; Sahin, Kevser
A Study of Oxidative Stress Parameters in Anti-Helicobacter Pylorus Immunoglobulin G Positive and Negative Gastric Cancer Patients
(Yonsei Univ Coll Medicine, 2009) Noyan, Tevfik; Guducuoglu, Hueseyin; Ilhan, Mahmut
Purpose: Helicobacter pylorurs (HP) is a Gram-negative spiral-shaped microaerophitic bacterium, which colonizes in the gastric mucosa of humans. The gastric human pathogen HP causes chronic gastritis and ulcers, and has a strong relationship with gastric cancer. The aim of this study was to determine advanced oxidation protein products (AOPP) levels, activities of myeloperoxidase (MPO) and catalase (CAT) in two groups. Materials and Methods: For this aim, one group included 30 patients with gastric cancer (Group 1) and the other included 30 subjects with non-gastric cancer and Anti-HP immunoglobulin (Ig) G antibody positive (group 2). Anti-HP IgG antibody test values were found as positive in fifty percent of group I and all of the group 2 patients. Results: Significantly increased AOOP levels were found in group 1 (p < 0.05) compared to group 2. There were no significant differences between the groups in regard to activities of M PO and CAT. In addition, AOPP level, MPO and CAT activities were similar among the Anti-HP IgG positive and negative subgroups of group 1 patients. Conclusion: The result of this study indicated that gastric cancer patients were characterized by increased protein oxidation, whereas there was no significant difference in oxidative stress parameters and antioxidant enzyme activity between the Anti-HP IgG positive and negative gastric cancer patients.