Browsing by Author "Ilik, Zehra Akman"

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Addressing Radiotherapy-Induced Fibrosis: the Potential of Platelet-Rich Plasma and Infliximab for Improved Breast Cancer Management
(Springer, 2024) Binici, Serhat; Guven, Mustafa; Ozdemir, Abdulselam; Ilik, Zehra Akman; Demirhan, Birhan; Uygur, Serhat; Iliklerden, Umit Haluk
Breast cancer treatment encompasses various therapeutic modalities, including surgery, radiotherapy, and chemotherapy. Breast-conserving surgery has been an integral part of breast cancer management. However, radiotherapy, an important component of breast cancer management, can lead to complications, particularly fibrosis, affecting reconstructive surgery outcomes. We conducted an in vivo study using 48 female Wistar Albino rats, employing segmental mastectomy and radiotherapy to simulate post-mastectomy conditions. The rats were divided into six groups: control, mastectomy, mastectomy + radiotherapy, mastectomy + platelet-rich plasma (PRP) + radiotherapy, mastectomy + infliximab + radiotherapy, and mastectomy + infliximab + PRP + radiotherapy. Edema, hyperemia, inflammation, and fibrosis were assessed as indicators of tissue response. Histopathological analysis revealed that mastectomy + infliximab and mastectomy + infliximab + PRP groups showed significant reductions in fibrosis compared to other groups. Edema, hyperemia, and inflammation were also less severe in these groups compared to the control group. Radiotherapy-induced fibrosis is a major concern in breast reconstruction. Our study suggests that local PRP application and systemic infliximab administration, either alone or in combination, could mitigate the adverse effects of radiotherapy. This approach has the potential to improve reconstructive outcomes in patients undergoing or having the possibility to undergo radiotherapy. This is the first study showing the effectiveness of infliximab and PRP combination on wound healing. The provided experimental rat model might offer guidance for further research. This study provides insights into optimizing outcomes in reconstructive breast surgery, paving the way for further research and clinical studies.
The Role of Elastography in Reducing Unnecessary Biopsies in Bi-Rads 4a and 4b Breast Lesions
(Springer india, 2024) Toprak, Nursen; Yokus, Adem; Gunduz, Ali Mahir; Durmaz, Fatma; Ilik, Zehra Akman
Many benign breast lesions in the Breast Imaging Reporting and Data System (BI-RADS) 4 category defined by ultrasonography (US) undergo unnecessary biopsies. This study aims to investigate the efficiency of acoustic radiation for impulse elastography (ARFI) in diagnosing BI-RADS 4 breast lesions. The ARFI elastography technique was utilized to assess the lesions both qualitatively and quantitatively. By using quantitative elastography measurement, we found that the shear wave velocity (SWV) of BI-RADS 4a lesions was significantly lower compared to the SWV of BI-RADS 4b and 4c lesions (p = 0.00). In qualitative evaluation, pattern 1 only defined benign lesions, and a negative predictive value (NPV) of 100% was obtained. Using quantitative, qualitative and combined methods, the Likelihood ratios was determined to be 1.81, 2.8 and 4.7 respectively. In addition to the ultrasound examination of BI-RADS 4 lesions, the addition of combined elastography assessment increases the accuracy of BI-RADS. BI-RADS 4a lesions can be followed in a similar way as BI-RADS 3 lesions.