Browsing by Author "Imre, Okan"

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Can Artificial Intelligence Be Used Against the Potential Risks of Short Examination Times in Hospitals
(Pera Yayincilik Hizmetleri, 2024) Imre, Gurkan; Imre, Okan
Mean Platelet Volume and Red Cell Distribution Width Levels in Initial Evaluation of Panic Disorder
(Dove Medical Press Ltd, 2016) Asoglu, Mehmet; Aslan, Mehmet; Imre, Okan; Kivrak, Yuksel; Akil, Oznur; Savik, Emin; Altindag, Abdurrahman
Background: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV) in patients with panic disorder (PD) are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW) levels combined with MPV levels in patients with PD. Patients and methods: Between January 2012 and June 2015, data of 30 treatment-naive patients (16 females, 14 males; mean age: 37 +/- 10 years; range: 18-59 years) who were diagnosed with PD and 25 age-and sex-matched healthy volunteers (10 females, 15 males; mean age: 36 +/- 13 years; range: 18-59 years) (control group) were retrospectively analyzed. The white blood cell count (WBC), MPV, and RDW levels were measured in both groups. Results: The mean WBC, MPV, and RDW levels were 9,173.03 +/- 2,400.31/mm(3), 8.19 +/- 1.13 fl, and 12.47 +/- 1.14%, respectively, in the PD group. These values were found to be 7,090.24 +/- 1,032.61, 6.85 +/- 0.67, and 11.63 +/- 0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0.003, respectively). However, there was no significant difference in the platelet number between the patients with PD and healthy controls (P<0.05). Conclusion: Our study results are the first to demonstrate that the RDW levels combined with MPV levels significantly increase among patients with PD. We believe that increased RDW and MPV levels can be used as a novel marker for PD.
Red Cell Distribution Width, Mean Platelet Volume, and Vitamin B12 Levels in Patients With Schizophrenia: an Observational Study
(E-century Publishing Corp, 2016) Asoglu, Mehmet; Aslan, Mehmet; Canbolat, Oznur; Imre, Okan; Savik, Emin; Kivrak, Yuksel; Altindag, Abdurrahman
Objectives: Increasing evidence suggests an association between inflammation and schizophrenia. The aim of this study was to evaluate vitamin B-12, mean platelet volume (MPV) and red cell distribution width (RDW) levels in patients with schizophrenia. Materials and methods: Fifty-six patients diagnosed with schizophrenia and 30 age-and sex-matched controls were included in the study. Serum B-12, MPV and RDW levels were measured in all patients. Results: RDW levels were significantly higher in patients with schizophrenia than in the controls (P<0.001). MPV levels were increased in patients with schizophrenia; however, this increase was not statistically significant (P>0.05). Serum B-12 levels were significantly lower in patients with schizophrenia than controls (P<0.001). Conclusions: Our results demonstrated that schizophrenic patients had high RDW and MPV levels along with decreased B-12 levels. Increased inflammation may play a pathophysiological role in the development of atherosclerosis in schizophrenic patients.