Browsing by Author "Inci, F."

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Pantoprazole May Improve Beta Cell Function and Diabetes Mellitus
(Springer, 2014) Inci, F.; Atmaca, M.; Ozturk, M.; Yildiz, S.; Koceroglu, R.; Sekeroglu, R.; Kebapcilar, L.
Background Proton pump inhibitors induce hypergastrinemia by suppressing gastric acidity. Gastrin has incretin-like stimulating actions on beta cells. Proton pump inhibitors have been shown to decrease glycosylated hemoglobin. Aim We aimed to observe changes in beta cell function in diabetic and non-diabetic subjects given pantoprazole for an acid-related ailment. Methods Seventy-nine male patients (38 non-diabetic and 41 type-2 diabetic receiving only metformin therapy) were followed for 12 weeks after pantoprazole 40 mg/day was given. Fasting plasma glucose, HbA1c, fasting insulin, Pancreatic B cell function (HOMA-B), proinsulin and c-peptide levels were measured before and after the treatment. Results In non-diabetic patients (n = 38), FPG decreased, whereas c-peptide, log-HOMA-B, increased significantly (p = 0.002, p = 0.03, p = 0.042, respectively) after 12 weeks of pantoprazole administration. In type 2 diabetic patients, FPG, HbA1c and weight decreased, whereas log-HOMA-B, c-peptide and log-proinsulin levels increased significantly after pantoprazole treatment (p = 0.003, p = 0.007, p < 0.001; p < 0.001; p = 0.017, p = 0.05, respectively). After pantoprazole treatment, pancreatic B-cell function was correlated with c-peptide and insulin and inversely with FBG and HbA1c levels in the whole group (r = 0.37, p = 0.001; r = 0.60, p < 0.001, r = -0.29, p = 0.011 and r = -0.28, p = 0.013, respectively). After pantoprazole treatment, HbA1c was correlated with FBG (r = 0.75, p < 0.001) and inversely with only log-HOMA-B level (r = -0.28, p = 0.013). Conclusions Pantoprazole administration seems to correlate with increased beta cell function. Pantoprazole administration improves HbA1c, HOMA-B, c-peptide and proinsulin levels. Since beta cell loss plays a significant role in the pathogenesis of type 2 diabetes, PPI-based therapies may be useful in the treatment of diabetes.
Posttraumatic Growth in Mothers After Infant Admission To Neonatal Intensive Care Unit
(Children's Hospital Zagreb, 2015) Boztepe, H.; Inci, F.; Tanhan, F.
This descriptive and cross-sectional study investigated social support and posttraumatic growth in 210 mothers whose newborns were hospitalized at neonatal intensive care unit. The study population consisted of all mothers living in the Niʇde provincial center whose babies were admitted to the Level 1 Neonatal Intensive Care Unit between December 2007 and November 2008. The Posttraumatic Growth Inventory, the Impact of Event Scale and the Multidimensional Scale of Perceived Social Support were administered in the mothers' homes. Posttraumatic growth was reported in 75.70% (n=210) mothers. The impact of event and perceived social support were highly (97.40%) predictive of posttraumatic growth. Traumatic events are frequently experienced within the healthcare system. Current research fi ndings are therefore extremely valuable for preventing the negative impact of traumatic events on individuals and for transforming the experience into an opportunity for growth.