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Browsing by Author "Isik, A.F."

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    Diaphragmatic Hydatid Disease
    (ARSMB-KVBMG, 2006) Isik, A.F.; Sagay, S.; Ciftci, A.
    Hydatid disease caused by echinococcus granulosus is still a serious problem in both underdeveloped and developing countries. Clinical signs of the disease are not specific. Most patients have no symptom or sign when a hydatid cyst is discovered. Symptoms depend on its complications, location and size. Parasite can settle in every organ and tissue in the human body. We report two cases with diaphragmatic hydatid disease with no other cyst present.
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    Enzymatic Dissection for Palliative Treatment of Esophageal Carcinoma: an Experimental Study
    (2005) Isik, A.F.; Ozturk, G.; Ugras, S.; Karaayvaz, M.
    Patients with esophageal carcinoma generally lose their chance of curable surgical treatment when symptoms become evident. At this stage chemoradiotherapy and palliative treatment methods are the only options. We investigated the potential use of enzymatic treatment in tissue loosening to improve the esophageal passage especially in patients with advanced esophageal carcinoma. Specimens were prepared from resection materials (one adenocarcinoma, two squamous cell carcinomas) which were removed from three consecutive patients. They were treated with pancreatin at 2.5%, 5% and 10% of concentrations. Macroscopic and histopathologic examinations were performed to evaluate the effect. At 2.5% enzyme concentration no macroscopically change was observed in adenocarcinoma while mild softening occurred in the tissue samples of squamous cell carcinoma. Histopathologic examination revealed tissue and cell necrosis destruction at 5 and 10% concentrations in the latter samples. We observed clear destruction of squamous cell carcinoma tissue in both macroscopically and microscopically with in vitro enzyme application. This procedure, not only helps to open esophageal passage, but may also delay the growth of tumour and support the chemoradiotherapy. Enzymatic tumoral dissection (tumourolysis) is a promising method to alleviate the symptoms of esophageal carcinoma. © 2005 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.