Browsing by Author "Isik, Mesut"

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The Evaluation of Thiol/Disulfide Homeostasis and Oxidative Dna Damage in Patients With Obsessive Compulsive Disorder
(Korean Coll Neuropsychopharmacology, 2022) Kurhan, Faruk; Alp, Hamit Hakan; Isik, Mesut; Atan, Yavuz Selim
Objective: In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods: Thirty-five patients previously diagnosed with OCD in Van Yuzuncu Yil University Department of Psychiatry and thirty-three healthy volunteers were included in the study. The severity of the symptoms was measured using the Yale-Brown Obsessive-Compulsive Scale. Five ml of blood samples were taken from the patient and control groups. The samples were stored at appropriate conditions until use. Leukocyte DNA was isolated and the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine were detected to assess the oxidative DNA damage. The level of oxidative DNA damage was expressed as 8-0HdG/10(6) dG. Total thiol/native thiol levels were measured for thiol/disulfide homeostasis. The level of disulfide was determined by subtracting the native thiol value from the total thiol value and the result was divided by two. Results were given as percentages. Results: The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group. Conclusion: Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.
An Innovative Approach To Lifelong Delayed Ejaculation: Does Attachment Style Play a Role
(Springer, 2022) Demir, Murat; Isik, Mesut; Araz, Seyhmuz; Ozveren, Huseyin; Kirli, Umut; Ertas, Kasim
Purpose To examine whether there is a correlation between attachment styles, which is a developmental psychology theory, and lifelong DE. Methods The research was planned as prospective, multi-centric and cross-sectional study. Thirty patients who were consecutively admitted to the urology outpatient clinic and diagnosed with lifelong DE and 30 age-matched healthy controls were included in the study. All participants gave a detailed medical history and underwent a complete physical examination, and their laboratory and endocrine (prolactin and testosterone) results were evaluated. Additionally, all patients had to fill out socio-demographic information form, the Experiences in Close Relationships-Revised (ECR-R) Questionnaire, Arizona Sexual Experiences Scale (ASEX), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Results The mean age of the DE patients was 33.5 +/- 7.5 years. In the DE group, insecure attachment (both anxious and avoidant attachment), anxiety and depression scores were found to be significantly higher (p < 0.001, effect size medium or large) than the control group. Ejaculation times (both for vaginal intercourse and masturbation) were correlated with both insecure (anxious and avoidant) attachment types, as well as their anxiety and depression scores (p < 0.001). The ASEX satisfaction, ejaculation and total scores were found to be higher in DE patients (higher scores indicating greater sexual dysfunction) than in the control group. Conclusion The large and significant relationships found between lifelong DE and attachment insecurities point to childhood developmental processes. The findings may help us better understand lifelong DE. There is a need for further extensive research on this subject.
Investigation of Hormone Levels in Postpartum Psychosis
(Kare Publ, 2022) Isik, Mesut; Ozdemir, Osman; Ucler, Rifki
Objective: The etiology of postpartum psychosis (PP) remains unclear. In this study, we examined thyroid-stimulating hormone, free T4, free T3, cortisol, prolactin, follicle-stimulating hormone, luteinizing hormone (LH), and dehydroepiandrosterone sulfate (DHEAS) levels in PP. Method: The study included 23 patients who were hospitalized with the diagnosis of PP within the first 4 weeks after delivery and 30 age-matched healthy controls. Organic etiological factors were excluded. Blood samples were obtained from all participants at the same time of the day. In PP patients, blood samples were obtained within the first 24 h after hospitalization. Results: Mean ages of PP and control groups were 26.2 +/- 5.5 and 27.6 +/- 5.1 years, respectively. The frequency of vaginal delivery was significantly higher in the PP compared with the control group (p=0.011). The fT3 levels were significantly lower in the PP compared with the control group, while the fT3 levels were within normal physiological limits (p=0.034) and no significant differences were found with regard to other hormones. To examine the effect of breastfeeding on the results, the control group was further divided into two subgroups: breastfeeding (BFC) and non-breastfeeding (NBFC). The fT4 levels (within normal physiological limits) and prolactin levels were significantly higher in the PP compared with NBFC (p=0.013 vs p=0.007). LH levels were 3.11 +/- 3.47 mIU/mL in the PP group, 1.48 +/- 2.45 mIU/mL in BFC and 4.56 +/- 3.69 mIU/mL in NBFC, but for the LH levels, the only significant difference was between the control groups (p=0.027). Conclusion: The results of thyroid function tests in our study suggest a condition that develops impaired thyroid functions secondary to acute psychotic episode rather than an underlying thyroid disease. Comprehensive prospective studies, including follow-up data, may better explain the relationships between thyroid function and PP. In our study, there was no evidence for the possible role of DHEAS, prolactin, and LH hormones. However, changes in the hormone profile according to breastfeeding status suggest that the effects of breastfeeding on hormones may also be important.
An Isotretinoin-Induced Manic Episode in a Patient With a Family History of Bipolar Disorder
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Ozdemir, Pinar Guzel; Ozdemir, Osman; Isik, Mesut; Bilgili, Serap Gunes
Manic Episode With Psychotic Features Induced by a Herbalife Production
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Guzel Ozdemir, Pinar; Ozdemir, Osman; Isik, Mesut
The Mediating Effect of Attachment Insecurity on Circadian Consequences of Childhood Trauma
(Taylor & Francis inc, 2022) Isik, Mesut; Kirli, Umut
Circadian preferences have been associated with mental health as well as social and physical health in recent years. However, factors associated with circadian preferences have not been fully elucidated. The main aim of this study is to investigate the associations of childhood trauma and attachment styles with circadian preferences. A total of 673 participants were evaluated using the Morningness-Eveningness Questionnaire (MEQ), the Childhood Trauma Questionnaire 28 (CTQ-28), and the Experiences in Close Relationships-Revised (ECR-R) questionnaire. The results indicated that 14.9% (n = 100) of the participants were morning type, 20.6% (n = 139) were evening type, and 64.5% (n = 434) were intermediate type. Both childhood trauma and attachment-related anxiety/avoidance scores were associated with being evening type (p < .01). Moreover, attachment-related anxiety and avoidance fully mediated the association between childhood trauma and circadian preferences. The present study showed that attachment styles might be associated with circadian preferences. Further studies are needed to replicate these results and to infer explanatory mechanisms for these cross-sectional associations.
The Mental Health of Healthcare Professionals During the Covid-19 Pandemic
(Turkiye Sinir ve Ruh Sagligi dernegi, 2021) Isik, Mesut; Kirli, Umut; Ozdemir, Pinar Guzel
Objective: The aim of this study is to investigate the anxiety, depression, insomnia and post traumatic stress disorder (PTSD) symptoms and the assocaited sociodemographic, clinical and professional factors during the COVID-19 pandemic in healthhcare workers. Method: A total of 509 participants joined an online survey to complete the data acquisition tools consisting of a Sociodemographic and Clinical Questionnaire, the Hospital Anxiety and Depression Scale (HADS), the Insomnia Severity Index (ISI) and the Post Traumatic Stress Disorder-Short Scale (PTSD-SS). Results: The 509 participants of the study consisted of physicians (69.2%) and nurses (30.8%). On the basis of the scores above the cut-off points of the pscyhometric scales used, the mental symptoms of the participants were ranked as 54.2% on depression, 26.3% on anxiety, 20.8% on insomnia and 8.8% on PTSD. The corresponding scores of the 20-30 year old, the female and the nursing participants were significantly higher as compared to the others (p<0.001, for all). Significant differences were not found in these scores with respect to working or not working directly with COVID-19 patients, or having a family member with or without COVID-19 infection (p>0.05). Having a history of suspected COVID-19 infection was significantly associated with insomnia (p=0.026 and PTSD (p=0.008). Also, the anxiety and PTSD scores of the participants with a history of mental disorder diagnosis were significantly higher in comparison to the others (p<0.001). Conclusion: The results indicated that females, nurses, participants in the 20-30 year age group and with a history of mental disorder diagnosis were in the high risk group for impaired mental health, irrespective of their professional positions. Close monitoring and early intervention are essential for these high-risk individuals.
The Relationship Between Overactive Bladder and Attachment: a Preliminary Study
(Wiley, 2021) Isik, Mesut; Demir, Murat
Aim There are strong relationships between overactive bladder (OAB) and psychological factors. The aim of this study was to examine the relationship between OAB and attachment. Methods Patients who presented with OAB symptoms and were first diagnosed with OAB were included in the study. Patient and control groups were matched in terms of age and gender. A urological and psychiatric examination was performed on each participant. The severity of patients' OAB symptoms was assessed using the Overactive Bladder-V8 Questionnaire (OAB-v8). The characteristics of attachment patterns were evaluated using The Close Relationships Scale Revised. Results The OAB and control groups included 41 and 43 participants, respectively. No significant difference was found between the two groups with regard to alcohol abuse, daily cigarette consumption, marital status, and gender. The prevalence of anxious attachment was significantly higher in the OAB group than in the control group (p < 0.001), whereas no significant difference was found with regard to avoidant attachment (p = 0.18). A significant relationship was found between the OAB-v8 score and anxious attachment in OAB patients (r = 0.50; p < 0.001). Conclusions Our findings suggest that insecure attachment, especially anxious attachment is associated with OAB and the severity of OAB symptoms. More extensive and longitudinal studies can better show the relationship between attachment and OAB. Future research may focus on the possibility of causality between attachment and OAB.
The Role of Thought Suppression in Conversion Disorder in Relation To Depression, Symptom Interpretation and Sleep Hygiene: a Case-Control Study
(Univ Sao Paulo, inst Psiquiatria, 2020) Ozdemir, Pinar Guzel; Kirli, Umut; Isik, Mesut; Tapan, Suheda
Background: Thought suppression has been associated with a number of psychiatric disorders. However, the association with conversion disorder (CD) has not been investigated yet. Objective: To investigate the role of thought suppression in CD. Methods: Eighty consecutive outpatients with a diagnosis of CD and sixty age, sex and neighborhood-similar controls were evaluated using Beck Depression Inventory-I (BDI-I), White Bear Suppression Inventory (WBSI), Symptom Interpretation Questionnaire (SIQ) and Sleep Hygiene Index (SHI). Cases and controls were compared in regard to thought suppression scores considering their status of high depression scores via a logistic regression model. The reciprocal associations of thought suppression with other clinical dimensions in CD were assessed. Finally, structural equation modelling was applied to untangle the possible connections. Results: CD patients had significantly higher scores of thought suppression than the control group. However, the difference was below the significance level when CD patients without comorbid high depression scores were taken into account. Thought suppression was associated with the clinical severity of CD. According to the structural equation model, older age and somatic attributions to the common bodily sensations were the significant correlates of thought suppression among CD patients. Discussion: Thought suppression may be considered as a non-specific marker of clinical severity in CD.
Temporomandibular Dislocation Secondary To Modified Electroconvulsive Therapy
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2019) Isik, Mesut; Esin, Gulsah
Vitamin B12, Folate Levels and Somatoform Dissociation in Conversion Disorder
(Pakistan Medical Assoc, 2020) Ozdemir, Pinar Guzel; Gur, Tugba; Cokluk, Erdem; Isik, Mesut; Tapan, Suheda
Objective: To evaluate the association of folate and vitamin B12 levels in patients with conversion disorder, and to illuminate the aetiology of conversion disorder by examining depression and somatoform dissociation. Method: The case-control study was conducted from March 2014 to May 2015 at the Medical Centre of Yuzuncu Yil University, Van, Turkey, and comprised patients diagnosed with conversion disorder and healthy controls. Blood samples were taken from both groups for vitamin B12 and folate levels. Data was collected using the Beck Depression Inventory and Somatoform Dissociation Scale. Data was analysed using SPSS 18. Results: Of the 100 subjects, 55(55%) were cases with a mean age of 27.05 +/- 9.04 years and 45(45%) were controls with a mean age of 26.56 +/- 5.96 years. The mean level of B12 was 283.93 +/- 122.96 in cases and 324.62 +/- 128.82 in controls (p=0.05). The mean level of folic acid was 5.47 +/- 1.84 in cases and 6.07 +/- 2.26 in controls (p>0.05). Conclusions: Physicians need to be vigilant about vitamin B12 levels in patients with conversion symptoms.
Vortioxetine-Induced Amenorrhea: a Case Report
(Lippincott Williams & Wilkins, 2022) Isik, Mesut; Kurhan, Faruk; Ulkevan, Tuba; Ozdemir, Pinar Guzel
Background: Vortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented. Case: The patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Twoweeks after discontinuation of vortioxetine, the patient had a menstrual period. Conclusions: Further research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.