Browsing by Author "Kaba, Mehmet"

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Are the Urology Operating Room Personnel Aware About the Ionizing Radiation
(Brazilian Soc Urol, 2015) Tok, Adem; Akbas, Alparslan; Aytan, Nimet; Aliskan, Tamer; Cicekbilek, Izzet; Kaba, Mehmet; Tepeler, Abdulkadir
Purpose: We assessed and evaluated attitudes and knowledge regarding ionizing radiation of urology surgery room staff. Materials and Methods: A questionnaire was sent by e-mail to urology surgery room personnel in Turkey, between June and August 2013. The questionnaire included demographic questions and questions regarding radiation exposure and protection. Results: In total, 127 questionnaires were answered. Of them, 62 (48.8%) were nurses, 51 (40.2%) were other personnel, and 14 (11%) were radiological technicians. In total, 113 (89%) participants had some knowledge of radiation, but only 56 (44.1%) had received specific education or training regarding the harmful effects of radiation. In total, 92 (72.4%) participants indicated that they used a lead apron and a thyroid shield. In the subgroup that had received education about the harmful effects of radiation, the use ratio for all protective procedures was 21.4% (n = 12); this ratio was only 2.8% (n = 2) for those with no specific training; the difference was statistically significant (p = 0.004). Regarding dosimeters, the use rates were 100% for radiology technicians, 46.8% for nurses, and 31.4% for other hospital personnel; these differences were statistically significant (p < 0.001). No significant relationship between working period in the surgery room, number of daily fluoroscopy procedures, education, task, and use of radiation protection measures was found. Conclusions: It is clear that operating room-allied health personnel exposed to radiation do not have sufficient knowledge of ionizing radiation and they do not take sufficient protective measures.
Case Report: Y Chromosome Microdeletion in an Infertile Patient With Mosaic Klinefelter Syndrome
(Kamla-raj Enterprises, 2015) Cetinkaya, Mehmet; Kaba, Mehmet; Cetin, Esin Sakalli; Candan, Sukru
Among genetic factors which contribute about 10-15 percent of male infertility, the most common genetic causes of male infertility are Klinefelter's Syndrome (KS) and Y chromosome microdeletions respectively. Most of the KS patients carry 47, XXY karyotype and almost 15 percent of them are mosaic with variable phenotype. These genetic abnormalities characterized by hypogonadism, azoospermia or oligospremia etc. A 41-year-old male presented with primary infertility with small hard testes and upper limit of FSH and LH. Total azoospemia was showed on semen analysis. 47,XXY/46,XY mosaicism was found in the karyotype analysis from the whole blood culture. Molecular investigation revealed a single deletion of AZFa region (M259 STS in DDX3Y locus). This case illustrates a rare deletion of AZFa region and is differ from previously reported in literature.
Comparative Study in Distal Hypospadias Repair: a Meatal-Based Flaps Technic Vs. Tubularized Incised Plate Urethroplasty
(Bmc, 2024) Kilic, Sinan; Kaba, Mehmet; Gecit, Ilhan
ObjectivesHypospadias is the most common anomaly of the male genital system after undescended testis. More than 200 surgical repair techniques have been described for the treatment of hypospadias due to many different meatus localisations and other accompanying anomalies. Kutlay defined a new technique in 2010 with 10 patients with distal hypospadias patients. We compared this new technique with tubularized incised plate urethroplasty (TIP) which is one of the most frequently performed methods. Methods148 patients with hypospadias who underwent surgery at the Urology and Pediatric Surgery Clinic during the period of January 2010 to December 2022 in the first and 2nd clinic, were retrospectively analyzed. The study focused on the remaining 83 patients with distal hypospadias for the purpose of comparison. ResultsThe mean age of group one was 10.0 (+/- 6.9, range 2-27), while for group two it was 10.8 (+/- 5.9, range 3-23). There was no statistically significant difference between the two groups in terms of anatomical position of the meatus, stricture and fistula complications (p > 0.5). ConclusionThe Kutlay technique has been described as an easy-to-learn and feasible method with reliable results. No significant difference in complications was observed in this study compared with TIP, which is known as the standard technique worldwide. We would like to suggest that the method be considered for further evaluation with larger patient groups and different techniques.
Comparisons the Level of Trace Elements Levels on Patients With Bladder Tumor and Common Urinary Bladder Tissues
(2014) Canbey, Özcan; Kaba, Mehmet
Giriş: Bu çalışmamızda mesane tümörü olan ve mesane tümörü olmayan hastaların mesane dokularında Zn, Cu, Pb, Cd, Co, Mg, Mn, Fe düzeylerinin bakılması amaçlandı. Materyal ve Metod: Yerel etik kurul onayı (BADK22) ve hastalardan bilgilendirilmiş onam formu alındıktan sonra Ocak 2014 ve Haziran 2014 tarihleri arasında Yüzüncü Yıl Üniversitesi Dursun Odabaşı Tıp Merkezi üroloji polikliniğine başvuran 30'u mesane tümörü, 30'u da malignite dışı nedenle olmak üzere toplam 60 hasta prospektif olarak çalışmaya dahil edildi. Çalışmaya dahil edilen mesane tümörleri daha önce servisimizde mesane tümörü tanısı almış ve 3 aylık kontrollerinde tekrar tümör saptanan hastalardan oluşmaktaydı. Malignite dışı nedenle başvuran hastaların hiçibirinde herhangi bir malignite tanısı mevcut değildi ve bunlar mesane taşı, üreter taşı, mesane divertikülü, üreterosel, üreterovezikal bileşke obstrüksiyonu, mikroskopik hematüri v.b gibi nedenlerle başvuran hastalardan oluşmaktaydı. Çalışmaya dahil edilen bütün hastaların preopertif hazırlıkları tamamlandıktan sonra ameliyathane şartlarında anestezi altında sistoskopi ile üretral olarak mesaneye girildi ve mesaneden doku örnekleri alındı. Bu dokular serum fizyolojik içine alındı ve -20 derecede saklandı. Daha sonra alınan bu dokularda atomik absorbsiyon spektrofotometresi yöntemiyle Zn, Cu, Pb, Cd, Co, Mg, Mn, Fe düzeylerine bakıldı. Bulgular: Bu çalışmadaki mesane tümörlü hastaların 24'ü erkek 6'sı kadındı. Hastaların en küçüğü 37, en büyüğü 86 yaşındaydı. Mesane tümörlü hastaların yaş ortalaması 68±10,66' idi. Mesane tümörü olmayan hastaların 23'ü erkek 7'si kadındı. Hastaların en küçüğü 31, en büyüğü 81 yaşındaydı. Mesane tümörü olmayan hastaların yaş ortalaması 56,60±12,92' idi. Çalışmada Mn, Mg, Zn, Fe düzeyleri mesane tümörlü dokularda anlamlı olarak düşük bulundu (p<0,01). Pb, Cu, Co, Cd düzeyleri mesane tümörlü dokularda anlamlı olarak yüksek bulundu (p<0,01). Sonuç: Eser elementlerin ve ağır metallerin mesane kanseri etyolojisinde ve fizyopatogenezinde rolü olduğu ve bazı antioksidan eser elementlerin (Zn gibi) ileride tedavide kullanılabileceği düşünülmektedir. Bu tez çalışmasının, bundan sonra bu konuda yapılacak çalışmalara ışık tutacağı kanısındayız. Bu maddelerin kanser gelişimine nasıl yol açtığı veya olası koruyucu etkilerinin daha iyi anlaşılmasında daha kapsamlı ve moleküler düzeyde yapılacak araştırmalar ışık tutacaktır. Anahtar kelimeler: Mesane tümörü, kanser, eser elementler, Cu, Zn, Mg, Mn, Fe, Pb, Cd, Co
Conservative Approach in the Treatment of Renal Trauma in Children
(Karger, 2014) Pirincci, Necip; Kaba, Mehmet; Gecit, Ilhan; Gunes, Mustafa; Tanik, Serhat; Ceylan, Kadir
Objective: Our aim was to evaluate the role of a conservative approach in the treatment of renal trauma in the pediatric age group. Materials and Methods: A total of 31 pediatric patients with renal trauma (male = 25, female = 6) in whom we used a conservative approach in our clinic between the years 2002 and 2010 were included in the study. Patients were assessed according to the type of trauma, type of treatment, findings of radiological imaging, concomitant other organ injuries and complications occurring during follow-up. Results: Surgery was required in just 4 of 31 pediatric patients who were treated with the conservative approach. Of the patients who underwent surgery, only one child needed nephrectomy. No complications were detected in the clinical and radiological follow-up of the patients who received the conservative approach. Conclusions: The main objective in the treatment of renal trauma occurring in childhood is to protect the kidneys. If the hemodynannic findings are stable, a conservative approach should be the first preferred method of treatment in every grade of renal trauma that can occur in childhood. Copyright (C) 2013 S. Karger AG, Basel
Dickkopf-1 Levels in Turkish Patients With Bladder Cancer and Its Association With Clinicopathological Features
(Asian Pacific Organization Cancer Prevention, 2014) Kaba, Mehmet; Pirincci, Necip; Benli, Erdal; Gecit, Ilhan; Gunes, Mustafa; Yuksel, Mehmet Bilgehan; Kemik, Ahu Sarbay
Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
Evaluation of Antioxidant Enzyme Levels, Oxidative Stress Markers and Serum Prolidase Activity in Testicular Cancer
(Sage Publications Ltd, 2024) Kaba, Mehmet; Kilic, Sinan; Demir, Halit
Introduction: Testicular cancer is a significant malignancy affecting males, and understanding the underlying biochemical changes associated with the disease is essential for improved management and treatment strategies. Prolidase enzyme, has been implicated in various disease processes. The assessment of serum prolidase activity and its relationship with testicular cancer can provide valuable insights into the pathophysiology of the disease. The objective of this study was to investigate serum prolidase activity, oxidative stress markers, and antioxidant enzyme levels in patients with testicular cancer and evaluate their potential associations, aiming to enhance our understanding of the biochemical alterations and potential implications for testicular cancer management. Methods: A total of 33 male patients diagnosed with testicular cancer were included, along with 35 age-matched male volunteers as the control group. Serum samples were collected and stored at -20 degrees C until analysis. The measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels was performed. Results: The findings demonstrated significantly elevated serum prolidase activity and malondialdehyde (MDA) levels in testicular cancer patients compared to the control group (all, p < 0.05). Conversely, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), and glutathione-S-transferase (GST) levels were significantly lower in testicular cancer patients (p < 0.05). Conclusion: In this study, serum prolidase activity and biochemical markers associated with oxidative stress were investigated in testicular cancer patients. Oxidative stress markers and serum prolidase activity were found to be elevated in testicular cancer. Long-term prospective studies are needed to determine the effectiveness of antioxidant use in cancer treatment.
A Giant Pedunculated Urothelial Polyp Mimicking Bladder Mass in a Child: A Rare Case
(Hindawi Ltd, 2014) Kaba, Mehmet; Kaba, Sultan; Kaya, Tacettin Yekta; Eren, Huseyin; Pirincci, Necip
Ureteral fibroepithelial polyps are rarely seen benign tumors with mesodermal origin. These polyps can involve kidney, pelvis, ureter, bladder, and urethra. The most common symptoms are hematuria and flank pain. The choice of treatment is either endoscopic or surgical resection of polyp by sparing kidney. Here, we presented a pediatric case with giant, fibroepithelial polyp that mimics bladder tumor, originating from middle segment of the ureter.
Haptoglobin Levels in Turkish Patients With Bladder Cancer and Its Association With Clinicopathological Features
(Asian Pacific Organization Cancer Prevention, 2012) Pirinicci, Necip; Gecit, Ilhan; Gunes, Mustafa; Kemik, Ahu Sarbay; Yuksel, Mehmet Bilgehan; Kaba, Mehmet; Aslan, Mehmet
Although alteration in the haptoglobin phenotype has been reported in patients with bladder cancer, serum haptoglobin levels have not been evaluated. We hypothesized that serum haptoglobin can be used as a biomarker. The aim of this study was to evaluate the expression of haptoglobin in bladder cancer and to determine the relationship with clinicopathological features. A total of 68 serum specimens obtained before surgery were used to investigate haptoglobin expression using the sandwich ELISA technique. Serum haptoglobin levels were higher in the patients with bladder cancer compared to healthy controls (p<0.0001). Additionally, the levels of haptoglobin protein increased with increasing tumor grades (p<0.001) and were significantly higher in patients with metastatic disease and the presence of lymphovascular involvement, lymph node metastases and increasing tumor burden (p<0.0001). This study suggests that elevated haptoglobin levels are associated with a higher stage, grade, and extent of distant metastasis and larger tumor size. Haptoglobin may therefore provide a useful diagnostic and treatment biomarker for patients with bladder cancer.
Levels of Serum Trace Elements in Renal Cell Carcinoma Cases
(Asian Pacific Organization Cancer Prevention, 2013) Pirincci, Necip; Gecit, Ilhan; Gunes, Mustafa; Kaba, Mehmet; Tanik, Serhat; Yuksel, Mehmet Bilgehan; Demir, Halit
Trace elements which are essential components of biological structures may also be toxic when present at levels above the amounts required for biological function. In our study, trace element levels were measured with furnace atomic absorption spectrophotometry in 33 newly diagnosed renal cell carcinoma cases (preoperative) and 32 healthy controls. When compared with the control group, it was found that the levels of cadmium (Cd), lead (Pb) were higher and the levels of zinc (Zn), iron (Fe) and manganese (Mn) were lower in the patient group. These changes may be important in the formation of renal cell carcinoma, a question which should be explored with postoperative comparative studies.
A Rare Complication Observed During Percutaneous Nephrolithotomy: Foreign Body Migration From the Right Kidney To the Left Lung
(Georg Thieme verlag Kg, 2015) Kaba, Mehmet; Pirincci, Necip; Kaba, Sultan; Cobanoglu, Ufuk; Eryilmaz, Recep; Eren, Huseyin
Percutaneous nephrolithotomy (PNL) is the first-line treatment in large, multiple stones and lower calyceal stones. Majority of complications associated with PNL are minor and clinically insignificant. It was seen that distal piece (2 cm in size) of ureter catheter observed at pelvis was found at the parenchyma of left lung on the perioperative fluoroscopy in the patient undergoing PNL for right kidney stone. We presented this complication to stress that a foreign body can pass into circulation presumably through venous injury and can migrate to the lung.
The Relationship Between Micrornas and Bladder Cancer: Are Micrornas Useful To Predict Bladder Cancer in Suspicious Patients
(Springer, 2023) Kaba, Mehmet; Pirincci, Necip; Demir, Murat; Kaba, Sultan; Oztuzcu, Serdar; Verep, Samed
PurposeRecent studies indicate that circulating micro RNAs (miRNAs) are novel class of non-invasive biomarkers with diagnostic and prognostic information. We evaluated the miRNA expressions in bladder cancer (BC) and their associations with disease diagnosis.MethodsWe profiled the expressions of 379 miRNAs in the plasma samples from patients with non-muscle invasive bladder cancer (NMIBC) (n = 34) and non-malignant urological diseases as a control group (n = 32). Patients were evaluated regarding with age, miRNA expressions, by using descriptive statistics. miRNA expression in extracted RNA was quantified using the NanoString nCounter Digital Analyzer.ResultsThe analysis of plasma miRNA levels in the marker identification cohort indicated that plasma (miR-1260a, let-7a-3p miR-196b-5p, miR-196a-5p, miR-99a-5p, miR-615-5p, miR-4301, miR-28-3p, miR-4538, miR-1233-3p, miR-4732-5p, miR-1913, miR-1280) levels were increased in NMIBC patients compared to control subjects. There were no significant differences other parameters studied between groups.ConclusionsThe analysis of serum plasma miRNA (miR-1260a, let-7a-3p miR-196b-5p, miR-196a-5p, miR-99a-5p, miR-615-5p, miR-4301, miR-28-3p, miR-4538, miR-1233-3p, miR-4732-5p, miR-1913, miR-1280) levels could be useful plasma biomarkers for BC.
Renal Anjiomyolipomdan Dolayı Massif Retroperitoneal Kanama: Bir Olgu Sunumu
(2015) Canbey, Özcan; Ergün, Müslüm; Taken, Kerem; Kaba, Mehmet; Pirinççi, Necip
Anjiomyolipomlar matür yağ dokusu, düz kas demetleri ve kan damarlarının değişen oranda meydana gelen benign mezenkimal tümörlerdir. Anjiomyolipomlar asemptomatik olabilmekle beraber bazen hematüri, palpabl kitle, ağrı şikayeti ile de ortaya çıkabilmektedir. 4 cm ve üzeri tümörler, spontan kanama riski taşırlar, massif kanama yaparak mortaliteye sebep olabilirler. Renal anjiomiyolipomlarda tümör boyutuna bağlı olarak tedavi çoğunlukla konservatif olmakla birlikte tekrarlayan kanama atakları veya masif kanama varlığında cerrahi rezeksiyon uygulanır. Biz kanamadan dolayı nefrektomiye giden 9 cm lik renal anjiomyolipom olgusunu sunduk. Büyüme paternlerinden dolayı anjiomyolipomların yakın takip edilmesi gerektiğini düşünmekteyiz.
Serum Adenosine Deaminase, Catalase and Carbonic Anhydrase Activities in Patients With Bladder Cancer
(Elsevier Espana, 2012) Pirincci, Necip; Gecit, Ilhan; Gunes, Mustafa; Yuksel, Mehmet Bilgehan; Kaba, Mehmet; Tanik, Serhat; Aslan, Mehmet
OBJECTIVES: The relationship between adenosine deaminase and various cancers has been investigated in several studies. However, serum adenosine deaminase activity and carbonic anhydrase and catalase activities in patients with bladder cancer have not previously been reported. Therefore, the aim of this study was to measure serum adenosine deaminase, carbonic anhydrase and catalase activities in patients with bladder cancer. MATERIALS AND METHODS: Forty patients with bladder cancer and 30 healthy controls were enrolled in the study. Serum adenosine deaminase, carbonic anhydrase and catalase activities were measured spectrophotometrically. RESULTS: Serum adenosine deaminase, carbonic anhydrase and catalase activities were significantly higher in patients with bladder cancer than controls (all significant, p < 0.001). CONCLUSIONS: These markers might be a potentially important finding as an additional diagnostic biochemical tool for bladder cancer.
Serum Adenosine Deaminase, Catalase, and Carbonic Anhydrase Activities in Patients With Renal Cell Carcinoma
(Taylor & Francis Ltd, 2017) Pirincci, Necip; Kaya, Tacettin Yekta; Kaba, Mehmet; Ozan, Tunc; Gecit, Ilhan; Ozveren, Huseyin; Ceylan, Kadir
Objectives: To determine whether serum levels of adenosine deaminase (AD), catalase (CAT), and carbonic anhydrase (CA) enzymes may be useful biomarkers in the diagnosis of renal tumors and may lead to early diagnosis of renal tumors. Material and methods: The study included 33 patients with renal cell carcinoma (RCC) and 31 healthy controls. The activity of serum AD, CA, and CAT was determined and analyzed using the Giusti spectrophotometric method, H2O2 substrate, and C0(2) hydration, respectively. Results: Serum AD and CA activity were significantly higher in patients with RCC than in controls. However, serum CAT activity was significantly lower in patients with RCC than in controls. Conclusion: These markers might be potentially important as an additional biochemical tool for diagnosing RCC. We believe multidisciplinary studies are needed to plan patients' preoperative and postoperative treatment and to create follow-up protocols.
Serum Levels of Trace Elements in Patients With Prostate Cancer
(Asian Pacific Organization Cancer Prevention, 2014) Kaba, Mehmet; Pirincci, Necip; Yuksel, Mehmet Bilgehan; Gecit, Ilhan; Gunes, Mustafa; Ozveren, Huseyin; Demir, Halit
Background: Trace elements are major components of biological structures; however, excessive levels of these elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements were measured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnace atomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co, Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostate cancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however, further prospective studies are needed to identify relationships between prostate cancer and trace elements.
Serum Levels of Trace Elements in Patients With Testicular Cancers
(Brazilian Soc Urol, 2015) Kaba, Mehmet; Pirincci, Necip; Yuksel, Mehmet Bilgehan; Gecit, Ilhan; Gunes, Mustafa; Demir, Murat; Demir, Halit
Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9 +/- 11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4 +/- 10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20 degrees C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
Serum Prolidase Activity, Oxidative Stress, and Antioxidant Enzyme Levels in Patients With Prostate Cancer
(Elsevier Science inc, 2024) Kaba, Mehmet; Pirincci, Necip; Demir, Halit; Verep, Samed
Objectives: We aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with prostate cancers and to evaluate their relationships with each other. Materials and methods: A total of 34 male patients with prostate cancer and with a mean age of 64.2 +/- 4.4 were included in the study. The control group comprising 36 male patients (mean age 61.2 +/- 3.4) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GPx), Catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20 & ring;C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in prostate cancer patients than in controls (all, P < 0.05), while SOD, GPx, and CAT levels were significantly lower (P < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in prostate cancer. (c) 2024 Elsevier Inc. All rights reserved.
Serum Prolidase Activity, Oxidative Stress, and Antioxidant Enzyme Levels in Patients With Renal Cell Carcinoma
(Sage Publications inc, 2016) Pirincci, Necip; Kaba, Mehmet; Gecit, Ilhan; Gunes, Mustafa; Yuksel, Mehmet Bilgehan; Tanik, Serhat; Demir, Halit
Objectives: Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. Materials and Methods: A total of 37 male patients with renal cell cancer and with a mean age of 56.28 +/- 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 +/- 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20 degrees C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.