Browsing by Author "Kaba, Sultan"

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Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders With Mean Platelet Volume and Vitamin D
(int Scientific information, inc, 2017) Garipardic, Mesut; Dogan, Murat; Bala, Keziban Asli; Mutluer, Tuba; Kaba, Sultan; Aslan, Oktay; Ustyol, Lokman
Background: The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. Material/Methods: The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. The hematological parameters of the patients, including MPV, vitamin B12, and vitamin D, were assessed. Results: The study included a total of 79 children and adolescents aged 2-18 years (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASDs group, and 25 in the control group. There was no statistically significant difference in hematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D. In the ADHD group, there was a negative correlation between both vitamins and MPV (p<0.05). Partial correlation analysis of the ADHD group showed that MPV in particular was negatively correlated to vitamin D, and not to vitamin B12 (p: 0.03). Conclusions: Both ADHD and ASDs may accompany increased risk for cardiovascular disease due to the presence of vitamin B12 and D deficiency and their own characteristics. Therefore, these disorders should be closely followed up.
Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome: Expanding the Phenotype
(Alliance Communications Group Division Allen Press, 2016) Kaba, Sultan; Dogan, Murat; Bulan, Keziban; Demir, Nihat; Uner, Abdurrahman; Bulut, Mehmet Deniz; Kocaman, Selami
We present a 3-month-old girl who displayed typical clinical characteristics of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). She was referred to our clinic with an initial diagnosis of Down syndrome. Clinical features of elevated follicle stimulating hormone and low estradiol levels in the case were diagnosed as BPES syndrome and were consistent with BPES type 2. To date, there are no cases of BPES with cleft palate and cardiomyopathy, suggesting that these novel findings can be part of this condition.
Çocuklarda Obezite İlişkili Kardiyovasküler Risk Faktörlerini Öngörmede Antropometrik Ölçümlerin Önemi
(2016) Başaranoglu, Murat; Arı, Sevil Yuca; Kaba, Sultan; Sal, Ertan; Bala, Keziban Aslı; Kocaman, Selami; Cesur, Yaşar
Amaç: Çocuklarda obezite ilişkili kardiyovasküler risk faktörlerini öngörmede antropometrik ölçümlerin prognostik önemini saptamak. Gereç ve Yöntem: Obezitesi olan 6-17 yaşlarındaki 100 çocuk vaka grubuna dahil edildi. Yaş ve cinsiyet bakımından benzer 100 sağlıklı çocuk kontrol grubuna dahil edildi. Vaka ve kontrol grubundaki çocukların antropometrik ölçümleri yapıldı ve kan basınçları ölçüldü. Kan lipidleri, HbA1c, açlık glukozu ve insülin düzeyleri hem vaka hem kontrol grubunda ölçülürken, oral glukoz tolerans testi sadece vaka grubunda yapıldı. Vücut yağ oranı bioimpedans vücut analizörü kullanılarak ölçüldü. Antropometrik ölçümlerin prognostik önemi ROC eğrisi kullanılarak değerlendirildi. Bulgular: Vaka grubundaki çocukların ortalama yaşları 11.44 ± 2.38 (48 kız 52 erkek), kontrol grubundaki çocuların yaş ortalamaları ise 11.46 ± 2.33 (48 kız 52 erkek) idi. Vaka grubundaki antropometrik ölçümlerin hepsi, kontrol grubundan daha yüksek bulundu. Obezite grubunda hipertansiyon, dislipidemi ve bozulmuş OGTT sırasıyla 26, 33, 37 çocukta bulundu. Herhangi bir kardiyovasküler risk faktörünü gösteren kesim noktası değeri vücut ağırlığı standart deviasyon skoru (SDS) için +2.6, vücut kitle indeksi (VKİ) SDS için +1.98, vücut yağ oranı için %27.1, subskapular deri kalınlığı için 29 mm, bel/boy oranı için 0.59 ve kalça/ boy oranı için 0.93 olarak bulundu. Sonuç: Antropometrik ölçümlerden subskapular deri kalınlığı ve bel/boy oranı obezite ilişkili kardiyovasküler risk faktörlerini öngörmede kullanılabilecek en iyi parametrelerdir.
Comparative Nephroprotective Effects of Silymarin, N-Acetylcysteine, and Thymoquinone Against Carbon Tetrachloride-Induced Nephrotoxicity in Rats
(Kowsar Publ, 2017) Ustyol, Lokman; Demiroren, Kaan; Kandemir, Ibrahim; Erten, Remzi; Bulan, Kezban; Kaba, Sultan; Basunlu, Mehmet Turan
Background: Many pharmacological agents may lead to kidney damage. Preventing nephrotoxicity reduces the risk of morbidity and mortality, as well as decreasing hospitalization costs. Objectives: In this study, we investigated the comparative nephroprotective effects of silymarin, N-acetylcysteine (NAC), and thymoquinone (TQ) in animal models (rats) in which we induced nephrotoxicity using carbon tetrachloride (CCl4). Methods: This animal experimental study was conducted at the experimental animals center of Yuzuncu Yil University, Turkey, in 2015. Thirty-eight adult male Wistar rats were used in this study. We defined five experimental groups and treated them for four weeks. The first group (n = 8) was given no medicine. The second group (n = 8) was given only CCl4 (1.5 ml/kg, intraperitoneally (IP), in olive oil, twice a week). The third group (n = 6) was given TQ (10 mg/kg, IP, in dimethyl sulfoxide (DMSO), daily) and CCl4 (1.5 mL/kg). The fourth group (n = 8) was given silymarin (100 mg/kg, IP, in DMSO, daily) and CCl4 (1.5 mL/kg), while the fifth group (n = 8) was given NAC (10 mg/kg, IP, daily) and CCl4 (1.5 mL/kg). The kidneys of all the rats in every group were evaluated histologically using light microscopic methods at the end of the fourth week. A grading scheme was used to score the histological alterations related to tubular injury: absent (-), mild (+), moderate (++), severe (+++), and quite severe (++++). Results: In terms of the mean values of tubular damage, the first group had a mean of 0.0, the second group had 3.88 +/- 0.35, the third group had 1.00 +/- 0.89, the fourth group had 2.13 +/- 1.13, and the fifth group had 2.75 +/- 1.04. The results showed that, histopathologically, CCl4 had quite a severe toxic effect on the tubules when compared to the control group, although the glomeruli were intact. Silymarin, TQ, and NAC all showed statistically significant nephroprotective effects (P < 0.01). However, of the three, TQ was the most powerful nephroprotective agent (P < 0.01). Conclusions: In conclusion, we suggest that TQ may be used as a prophylactic agent against nephrotoxicity, especially in instances of tubular injury. However, human-based studies are still needed.
Cystinosis in Eastern Turkey
(Walter de Gruyter Gmbh, 2016) Dogan, Murat; Bulan, Keziban; Kaba, Sultan; Cesur, Yasar; Ceylaner, Serdar; Ustyol, Lokman
Background: This study was conducted to investigate CTNS (cystinosin, lysosomal cystine transporter) gene mutations and the clinical spectrum of nephropathic cystinosis among patients diagnosed with the disease in a single center in Turkey. Methods: Patients' clinical and laboratory data were extracted from an electronic health registry. Molecular CTNS gene analysis was performed using either next-generation sequencing or Sanger sequencing. Results: Eleven patients (age range: 1.5-12 years) from nine families were identified. The presenting complaint was growth retardation in seven patients; polydipsia and polyuria in three patients; and vomiting in two patients. At presentation, electrolyte loss was noted in all patients, of which eight patients presented with metabolic acidosis, and three patients presented with metabolic alkalosis. All patients also presented with proteinuria and -glucosuria, and four patients developed varying degrees of renal insufficiency, for which peritoneal dialysis was initiated in one patient. Cystine crystals were detected via ocular examination in one patient at presentation. No cystine crystals were detected among patients who underwent bone marrow aspiration. In the CTNS gene, a p.T7FX7 (c.18-21del4bp) mutation was detected in three patients, whereas a p.E227E (c.681 G > A) (homozygous) mutation was detected in eight patients. Conclusions: We detected two distinct mutations, p.T7FX7 (c.18-21del4bp) and p.E227E (c.681 G > A) (homozygous), in the CTNS gene in 11 patients with cystinosis from the East Anatolian region of Turkey. Patients with a homozygous c.681 G > A (p.E227E) mutation are more likely to develop chronic renal failure and should be monitored closely, whereas patients with a p.T7FX7 (c.18-21del4bp) mutation have a milder phenotype. Additionally, metabolic alkalosis does not exclude cystinosis, although cystinosis is a cause of proximal renal tubular acidosis.
Dermatological Findings of Vitamin B12 Deficiency and Resolving Time of These Symptoms
(Taylor & Francis Ltd, 2014) Demir, Nihat; Dogan, Murat; Koc, Ahmet; Kaba, Sultan; Bulan, Keziban; Ozkol, Hatice Uce; Dogan, Sekibe Zehra
Aim: The mucocutaneous changes observed during vitamin B12 deficiency in children have been published only as case studies and small case series. In this study, we aimed to demonstrate the frequency of mucocutaneous changes (particularly hyperpigmentation) seen during vitamin B12 deficiency and resolving time of these symptoms with vitamin B12 treatment. Material and methods: This prospective study was conducted at the pediatrics outpatient clinic of Harran and Yuzuncu Yil University Faculty of Medicine, among 57 patients, aged between 6 and 24 months, who were diagnosed with vitamin B12 deficiency following various examinations and tests. A detailed examination was performed in respect to skin and mucosal findings. Patients with vitamin B12 deficiency were administered intramuscular cyanocobalamin. Prospective examination was continued, and resolving time of symptoms after treatment was recorded. Results: The mean age of the patients enrolled in the study was found to be 12.75 +/- 4.75. Hyperpigmentation was reported in 49 (85.96%) patients enrolled in the study; atrophic glossitis in 40 (70.17%), brittle and matt hair in 13 (22.80%), skin lesions (particularly diaper dermatitis) in eight (15.78%) and cheilosis in four (7.01%) patients. Three months after the treatment initiation, hyperpigmentation improved in 87.75%, atrophic glossitis in 97.5% and brittle and matt hair in 92.3% of the patients. Five patients (8.77%) with continuing pigmentation by the end of sixth months were considered as nonresponsive to the treatment. Conclusion: Deficiency of vitamin B12 should be considered in the differential diagnosis of infants who present with skin and mucosal lesions.
Evaluation of the Hemostatic Disorders in Adolescent Girls With Menorrhagia: Experiences From a Tertiary Referral Hospital
(Springer india, 2016) Karaman, Kamuran; Ceylan, Nesrin; Karaman, Erbil; Akbayram, Sinan; Akbayram, Hatice Tuba; Kaba, Sultan; Oner, Ahmet Fayik
Bleeding disorders are a common cause of menorrhagia in the adolescent age group. We aimed to evaluate the incidence of hemostatic disorders, using clinical and laboratory findings of bleeding disorders in adolescent girls with menorrhagia. A retrospective chart review used to evaluate adolescent girls with menorrhagia who were referred to Yuzuncu Yil University Pediatric Hematology clinic between January 2010 and December 2014. Out of 52 patients referred for investigation, 50 patients were included in the study. The mean age and mean menarche age were 14.8 +/- 1.42 (range: 12-17) and 12.47 +/- 0.55, respectively. In 42 % (n = 21) of patients, anemia was detected. In 22 % (n = 11) of patients, a bleeding disorder was detected: five cases with von Willebrand disease, two cases with acute immune thrombocytopenic purpura, one case with Bernard-Soulier syndrome, one case with Glanzmann thrombasthenia, one case with aplastic anemia and one case with factor X deficiency. The remaining 39 out of the 50 patients were finally diagnosed with dysfunctional uterine bleeding. When compared the patients with bleeding disorders and without bleeding disorders, bleeding from other sites, including gingival bleeding or epistaxis, low platelet counts and prolonged activated partial thromboplastin time were found statistically more frequent in patients with bleeding disorders (p < 0.05). Menorrhagia in adolescents is frequently associated with underlying bleeding disorders. Adolescents with heavy menstrual bleeding and a history of nose or gingival bleeding should be evaluated for congenital bleeding disorders.
Factors Affecting Thyroid Volume and the Incidence of Nodules With Goiter School-Aged Children
(Istanbul Univ, 2024) Kaba, Sultan; Dogan, Murat; Yavuz, Alpaslan; Kilic, Sinan
Objective: This study aimed to analyze the associations between age, sex, anthropometric factors, and thyroid volume as well as to determine the prevalence of goiter and thyroid nodules in school children. Methods: This study included schools governed by the Ministry of Education in Van province. Sonographic evaluations of thyroid glands were conducted in children aged 6-17 years, and measurements of weight, height, waist circumference, hip circumference, and skinfold thickness were obtained from the participants. Results: A total of 2284 school children were included in the study. The median age of the participants was 11.08 years. It was observed that thyroid volume exhibited a positive correlation with age, body surface area, body mass index, height, weight, waist circumference, hip circumference, triceps skinfold thickness, and subscapular skinfold thickness (p < 0.008). When assessing the association between age and goiter prevalence based on World Health Organization parameters, 10.2% of children and adolescents developed goiter, and 0.8% of these cases also had a nodule. Among girls, the rates were 9.4% and 1% for goiter and nodules, respectively, whereas among boys, the rates were 11.3% and 0.7%, respectively. Conclusions: Thyroid volume was affected by age, weight, subcutaneous tissue thickness, waist circumference, and BSA. Goiter remains a serious public health problem among school-age children in Van province.
A Giant Pedunculated Urothelial Polyp Mimicking Bladder Mass in a Child: A Rare Case
(Hindawi Ltd, 2014) Kaba, Mehmet; Kaba, Sultan; Kaya, Tacettin Yekta; Eren, Huseyin; Pirincci, Necip
Ureteral fibroepithelial polyps are rarely seen benign tumors with mesodermal origin. These polyps can involve kidney, pelvis, ureter, bladder, and urethra. The most common symptoms are hematuria and flank pain. The choice of treatment is either endoscopic or surgical resection of polyp by sparing kidney. Here, we presented a pediatric case with giant, fibroepithelial polyp that mimics bladder tumor, originating from middle segment of the ureter.
Glanzmann Thrombasthenia Mimicking Early Neonatal Sepsis
(2015) Demir, Nihat; Peker, Erdal; Kaba, Sultan; Tuncer, Oğuz; Garipardıç, Mesut
Glanzmann trombastenisi pıhtı oluşumunun ilk basamağındaki anormalikten kaynaklanan otozomal resesif geçişli kalıtsal bir hastalıktır. Ekimotik mukokütenöz leziyonlarla ve kana diateziyle ilişkili olgularda, eğer trombosit sayısı normal, kanama zamanı uzun ise Glanzamann trombastenisi ayırıcı tanıda düşünülmelidir. Burada ikiz eşi olarak doğan, diğer ikizi intauterin exitus olan ve yaygın intravasküler koagulopati ve sepsis tablosuyla gelen ardından GT tanısı konan bir olgu sunuldu.
Hormone Disorder and Vitamin Deficiency in Attention Deficit Hyperactivity Disorder (Adhd) and Autism Spectrum Disorders (Asds)
(Walter de Gruyter Gmbh, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Mutluer, Tuba; Aslan, Oktay; Dogan, Sekibe Zehra
Background: The aim of this study was to analyze thyroid hormones and antibodies, ferritin, vitamins B12 and D, adrenal and gonadal steroid levels, and celiac antibodies in children diagnosed with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods: Between February 2014 and July 2014, a total of 77 children and adolescents (31 girls, 46 boys) who were admitted to the Van Training and Research Hospital were included in the study. The study population was divided into three groups including ADHD (n=34), ASD (n=16), and age-and sex-matched healthy controls (n=27). The diagnosis of ADHD was made on the basis of Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) and DSM-4 Turkish version with the diagnostic interview and Disruptive Behavior Disorder Rating Scale (DBDRS). The diagnosis of ASD was based on the DSM-4 and DSM-5 Turkish version with the diagnostic interview and the Childhood Autism Rating Scale (CARS). The blood samples were obtained between 8: 00 and 9: 00 A.M. Results: There was a statistically significant difference in vitamin B12 and D levels and ferritin values among the three groups. The ASD group had the highest ferritin and the lowest vitamins B12 and D levels. Vitamin D levels of the ADHD group were significantly lower compared to the healthy controls. Conclusions: Our study results highlight the importance of supplementation of vitamins B12 and D in the ASD and ADHD patients.
Immune Thrombocytopenic Purpura in a Case of Propionic Acidemia: Case Report
(Lippincott Williams & Wilkins, 2014) Bulan, Keziban; Dogan, Murat; Kaba, Sultan; Dogan, Sekibe Zehra; Akbayram, Sinan; Oner, Ahmet F.
Investigation of the Effect of the Efficiency of Noise at Different Intensities on the Dna of the Newborns
(Medknow Publications & Media Pvt Ltd, 2016) Ceylan, Nesrin; Kaba, Sultan; Karaman, Kamuran; Celiker, Metin; Basbugan, Yildiray; Demir, Nihat
Hearing loss can occur in newborns exposed to high-level noise; noise exposure can cause more physiological stress and can lead to DNA damage. This study was designed to determine DNA damage in newborn rats exposed to sound at different concentrations. For this purpose, 28 newborn (3-6 days old) rats were divided into four groups of 7 rats in each group (Control and Groups of 40 decibel (dB), 70 dB, and 110 dB]. In the experimental groups, 40 dB, 70 dB, and 110 dB (7.5-15 kHz) of sound was applied to the experimental groups for 30 min a day for 7 days. DNA damage levels in the serums obtained from this study were determined by the enzyme-linked immunosorbent assay (ELISA) method. According to this, it was determined that DNA damage in the group exposed to 110 dB showed a statistically significant increase (P < 0.05) compared to the compared to the control, 40 dB, and 70 dB groups. Related to the subject, it was concluded that DNA damage may occur in newborns exposed to 110 dB or higher sound in neonatal units, wards, and home environments with newborn babies. Mothers should be warned about this situation and noise should be kept under 110 dB volume in the environments with the newborns.
The Levels of Vitamin B12, Folate and Homocysteine in Mothers and Their Babies With Neural Tube Defects
(Taylor & Francis Ltd, 2016) Peker, Erdal; Demir, Nihat; Tuncer, Oguz; Ustyol, Lokman; Balahoroglu, Ragip; Kaba, Sultan; Karaman, Kamuran
The aim of the present study was to determine the serum levels of vitamin B-12, folate, and homocysteine (Hcy) in mothers and their babies, and to assess the association between these levels and neural tube defect (NTD). The study group included 92 baby-mother pairs, where the babies had NTD, and the control group included 102 pairs, where the babies had no NTD, from May 2012 to May 2015. Plasma vitamin B-12, folate, and Hcy levels of the babies and mothers were measured, and compared with each other. NTD was diagnosed in 2.6% of our babies. The vitamin B-12 levels in the mothers and the babies in the study group were determined as 166.2 +/- 63.7 pg/mL and 240.3 +/- 120.3 pg/mL, and in the control group as 1 9 0 +/- 80.2 pg/mL and 299.5 +/- 151.4 pg/mL, respectively. There was a significant difference between the two groups in terms of both the mothers' and the babies' vitamin B-12 levels (p = 0.024 and p = 0.003, respectively). The plasma folate levels of the mothers in the study group (5.2 +/- 3 ng/mL) were significantly lower than control group (6.4 +/- 4.3 ng/mL, p = 0.032). The plasma Hcy level of the mothers in the study group (9.3 +/- 3.8 mu mol/L) was significantly higher than the control group (7 +/- 3.8 mu mol/L, p<0.001). High plasma Hcy levels and low plasma folate and vitamin B-12 levels are risk factors for NTD. Our results show that the risk for NTD can be decreased by fortification of mothers-to-be, particularly in rural areas with folate and vitamin B-12 deficiency, which would lower the plasma Hcy level.
Mean Platelet Volume and Vitamin D Deficiency
(Galenos Yayincilik, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Garipardic, Mesut; Aslan, Oktay; Dogan, Sekibe Zehra; Kocaman, Selami
Aim: To evaluate whether vitamin D deficiency has an effect on mean platelet volume (MPV). Materials and Methods: This was a retrospective study. The children followed-up at the pediatrics endocrinology polyclinic and diagnosed as nutritional rickets were included in this study. The patient group was created, and by screening the files of 478 case files, those compatible with the patient group for age and gender, were taken as the control group. Results: A total of 684 children and adolescents cases between the ages 0.1-18 years were included in the study. The cases were divided into 3 groups according to the vitamin D levels. Those with vitamin D levels of less than 15 ng/mL were classified as the vitamin D deficiency group, those between 15-20 ng/mL were classified as the insufficiency group, and those between 20-100 ng/mL were classified as the normal Vitamin D level group. There was no statistically significant difference between the groups in terms of age and gender. There was no significant difference observed between the groups in terms of the MPV levels. There was no statistically significant correlation determined in the correlation analysis between the vitamin D level and the MPV (p>0.05). In the multiple regression analysis, it was observed that vitamin D had no statistically significant effect on MPV. In the performed partial correlation analysis, when hemoglobin, hematocrit, calcium, phosphorus and parathyroid hormone were selected as controlling factors, again, there was no statistically significant correlation observed between the MPV and the vitamin D (r=-0.19, p>0.05). Conclusion: In the pathophysiology of the cardiac dysfunctions appearing as a result of vitamin D deficiency, we wished to emphasize that the hypothesis of the probable effect of vitamin D on MPV should be questioned in more detail.
Nadir Bir Tip 1 Diyabet Sunumu; Şiddetli Hiperlipidemi Çocuklar ve Hiperlipideminin Yönetimi: Olgu Sunumu
(2016) Kaba, Sultan; Ceylan, Nesrin; Doğan, Murat; Cesur, Yaşar; Bulan, Keziban
Diyabetik ketoasidoz, diyabetin en sık, yaşamı tehdit eden, akut bir komplikasyonudur. Lipemik seruma yol açan şiddetli hiperlipidemi, nadiren diyabetik ketoasidoz vakalarında görülür. Burada, ketoasidoz ile başvuran ve sütlü plazma görünümü ve şiddetli hiperlipidemisi olan 10 yaşında bir kız sunulmuştur. Biyokimya çalışmaları için alınmış kan örneğinde süt görünümü vardı. Laboratuvarda, aşırı lipemik numune nedeniyle kan örneği değerlendirilemedi; bu nedenle, yenilenmiş ölçüm yapıldı. İkinci ölçümde, glukoz, trigliserid, toplam kolesterol, düşük yoğunluklu lipoprotein (LDL-kolesterol) ve yüksek yoğunluklu lipoprotein (HDL kolesterol) seviyelerinin yükselmiş olduğu tespit edildi. Diyabetik ketoasidoz, asidotik solunum ve aseton kokusu olan bilinçsiz hastamızda ilk klinik tanı olarak kabul edildi. Bu olgu sunumu ile serum lipit düzeylerinin diyabetik ketoasidozda ve düşük glikoz kontrollü diyabetik çocuklarda ölçülmesi gerektiğini vurguladık. Ayrıca, bu vakada hiperlipidemi yönetimini paylaşmak istedik. Aynı zamanda, kan ölçümlerinin hiperlipidemi koşullarında hatalı olabileceği akılda tutulmalıdır; böylece, hiperlipidemi varlığında laboratuvarı stimüle etmek ikinci bir ölçüm gerektirebilir
A Rare Complication Observed During Percutaneous Nephrolithotomy: Foreign Body Migration From the Right Kidney To the Left Lung
(Georg Thieme verlag Kg, 2015) Kaba, Mehmet; Pirincci, Necip; Kaba, Sultan; Cobanoglu, Ufuk; Eryilmaz, Recep; Eren, Huseyin
Percutaneous nephrolithotomy (PNL) is the first-line treatment in large, multiple stones and lower calyceal stones. Majority of complications associated with PNL are minor and clinically insignificant. It was seen that distal piece (2 cm in size) of ureter catheter observed at pelvis was found at the parenchyma of left lung on the perioperative fluoroscopy in the patient undergoing PNL for right kidney stone. We presented this complication to stress that a foreign body can pass into circulation presumably through venous injury and can migrate to the lung.
The Relationship Between Micrornas and Bladder Cancer: Are Micrornas Useful To Predict Bladder Cancer in Suspicious Patients
(Springer, 2023) Kaba, Mehmet; Pirincci, Necip; Demir, Murat; Kaba, Sultan; Oztuzcu, Serdar; Verep, Samed
PurposeRecent studies indicate that circulating micro RNAs (miRNAs) are novel class of non-invasive biomarkers with diagnostic and prognostic information. We evaluated the miRNA expressions in bladder cancer (BC) and their associations with disease diagnosis.MethodsWe profiled the expressions of 379 miRNAs in the plasma samples from patients with non-muscle invasive bladder cancer (NMIBC) (n = 34) and non-malignant urological diseases as a control group (n = 32). Patients were evaluated regarding with age, miRNA expressions, by using descriptive statistics. miRNA expression in extracted RNA was quantified using the NanoString nCounter Digital Analyzer.ResultsThe analysis of plasma miRNA levels in the marker identification cohort indicated that plasma (miR-1260a, let-7a-3p miR-196b-5p, miR-196a-5p, miR-99a-5p, miR-615-5p, miR-4301, miR-28-3p, miR-4538, miR-1233-3p, miR-4732-5p, miR-1913, miR-1280) levels were increased in NMIBC patients compared to control subjects. There were no significant differences other parameters studied between groups.ConclusionsThe analysis of serum plasma miRNA (miR-1260a, let-7a-3p miR-196b-5p, miR-196a-5p, miR-99a-5p, miR-615-5p, miR-4301, miR-28-3p, miR-4538, miR-1233-3p, miR-4732-5p, miR-1913, miR-1280) levels could be useful plasma biomarkers for BC.
The Relationship of Gastrin Levels With Obesity Anthropometrics, Lipid, Glucose, and Insulin Levels in Children and Adolescents With Obesity
(Georg Thieme verlag Kg, 2015) Kaba, Sultan; Dogan, Murat; Bala, Keziban Asli; Karaman, Kamuran; Kocaman, Selami
The aim of the study was to compare the gastrin levels in obese and healthy children and to investigate the relationship of gastrin with obesity anthropometrics, lipid, and baseline insulin levels, and oral glucose tolerance test scores. Gastrin was significantly lower in the obese group compared with the control group (p > 0.001). Gastrin level displayed a negative correlation with body weight, body weight standard deviation, and insulin levels in oral glucose tolerance test at 120 minutes, a positive correlation with glycohemoglobin A(1c). The results revealed that there is a significant difference between the gastrin levels in obese and healthy children.
Seroprevalence of Hepatitis a and Associated Factors Among 1-15 Year Old Children in Eastern Turkey
(E-century Publishing Corp, 2015) Karaman, Serap; Karaman, Kamuran; Kizilyildiz, Baran Serdar; Ceylan, Nesrin; Kaba, Sultan; Parlak, Mehmet; Ceylan, Abdullah
Background: Hepatitis A is a common infectious disease during childhood worldwide. Recently, great deal of changes in the epidemiology has been reported. The seroepidemiologic studies of this infection are not sufficient in Eastern region of Turkey. Objective: To investigate the seroprevalence and association with socio-demographic variables of hepatitis A in 1-15 year old children in Van. Patients and Methods: This study was performed on 510 one to fifteen year old children from outpatient pediatric clinics in Yuzuncu Yil University, Faculty of Medicine during last three months of 2009. Anti-HAV IgG was measured in sera by enzyme-linked immunosorbent assay. The information about subjects was recorded on standardized forms and a chart review survey was performed. Results: The overall ratio for seropositivity was 54.9%. Statistical significance was found between hepatitis A seroprevalence and age, collective use of domestic items, fresh water resources, localization and type of toilet and the number of households. Conclusion: This study provided the most recent data of seropositivity and revealed the preliminary indication of epidemiological shift in seroprevalence of Hepatitis A virus in a region with high endemicity.