Browsing by Author "Kahraman, T."

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Antioxidant and Anti-Inflammatory Effect of Olive Leaf Extract Treatment in Diabetic Rat Brain
(De Gruyter Open Ltd, 2023) Berköz, M.; Kahraman, T.; Shamsulddin, Z.N.; Krośniak, M.
Objectives: Olive (Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were investigated. Methods: A total of 28 male rats were divided into four equal groups as control, diabetic (single dose of 45 mg/kg streptozotocin, i.p.), OLE (500 mg/kg/day), and diabetic + OLE groups. The study was terminated 21 days after the diabetes model was formed. At the end of the study, all the animals were sacrificed and blood and brain tissues were isolated. Relative brain weights, complete blood count, blood glycated hemoglobin, serum glucose, total protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, insulin, gonadal hormone levels, production and messenger ribonucleic acid (mRNA) levels of proinflammatory cytokines and mediators, total thiol, total oxidative stress, and total antioxidant status levels and fatty acid composition in brain tissue were measured in all study groups. Results: In diabetic rats, relative brain weight and serum insulin level decreased, glycated hemoglobin, oxidative stress, production and mRNA level of proinflammatory cytokines and mediators increased, hyperglycemia, hypercholesterolemia and hypertriglyceridemia, degraded fatty acid composition, anemia, leukopenia, and thrombocytopenia occurred. After OLE treatment, a remarkable improvement in most of these parameters, except gonadal hormones, has been observed in diabetic rats. Conclusions: This study suggests that olive leaf can be a precious neuroprotective agent in diabetes. © 2021 Walter de Gruyter GmbH, Berlin/Boston.
Dietary Nitrate and Nitrite Levels in an Endemic Upper Gastrointestinal (Esophageal and Gastric) Cancer Region of Turkey
(2003) Türkdoǧan, M.K.; Testereci, H.; Akman, N.; Kahraman, T.; Kara, K.; Tuncer, I.; Uygan, I.
Background/aims: The aim of this study was investigate nitrate and nitrite levels in some traditional foods and drinking water in Van, an endemic upper gastrointestinal (esophageal and gastric) cancer region of Eastern Turkey. Methods: Cheese with added herbs, drinking; water, bread baked by wood fire and bread baked by burning animal manure specimens collected in the Van region were analyzed by Stahr's modification method. Nitrite was reduced to nitrate by the following three reagents: hydrazine sulphate ((NH2) 2SO4), CuSO4 and NaOH. Nitrate was then determined by coupling reagent containing sulphanlyamide, phosphoric acid and N-1-naphtyl ethylendiamine dihydrochloride. Results: Nitrate and nitrite levels of all traditional foods and nitrite levels of drinking water were very significantly elevated compared to standard values (p<0.001-0.01). Conclusions: These findings suggest that the influence of a traditional diet rich in nitrate and nitrite is significant in the development of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Turkey.
Feasibility of Exergaming for Upper Extremity Rehabilitation in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Ozdogar, A. T.; Emec, M.; Kaya, E.; Karakas, H.; Dastan, S.; Kahraman, T.; Ozakbas, S.
Feasibility of Exergaming for Upper Extremity Rehabilitation in People With Multiple Sclerosis: Prospective Clinical Trial
(Springer Heidelberg, 2024) Ozdogar, A. T.; Emec, M.; Kaya, E.; Karakas, H.; Dastan, S.; Kahraman, T.; Ozakbas, S.
BackgroundExergaming has been suggested as a rehabilitation method since it is more motivational for people with multiple sclerosis (MS, pwMS). However, the major disadvantage of this method is the lack of specific scenarios designed for pwMS.ObjectivesThis study aims to assess the feasibility of exergaming, which was developed for pwMS.MethodsThis unblinded prospective clinical trial was performed in the outpatient MS Clinic of Dokuz Eyl & uuml;l University Hospital. Exergaming scenarios were developed in collaboration with medical personnel consisting of physiotherapists and doctors, and computer engineers. A total of 30 participants who had definite MS diagnoses were included. The exergaming scenarios were implemented using the Microsoft Kinect. A physiotherapist applied custom-made exergames for one session. All the participants were assessed immediately after the session. The User Satisfaction Evaluation Questionnaire was used to assess the user's satisfaction with the system and exergaming.ResultsThe mean age was 41.5, the mean Expanded Disability Status Scale was 4.5 (range between 0 and 7), and the mean disease duration was 10.0 years. Twenty patients were relapsing-remitting, and 10 were secondary-progressive. The mean scores of the User Satisfaction Evaluation Questionnaire were 4.33 (SD = 0.84) for helpfulness for rehabilitation, 1.63 (SD = 1.1) for not disturbing, 4.50 (SD = 1.07) for understandability, 4.0 (SD = 0.91) for easiness to control, and 4.33 (SD = 0.84) for enjoyability.ConclusionThese results showed that our custom-made exergaming scenario could be feasible in upper extremity rehabilitation in MS. More research is needed to investigate its effectiveness in the rehabilitation of upper limbs.
Initrate and Nitrite Levels of Drinking Water in Bitlis Province, Turkey
(2009) Alemdar, S.; Kahraman, T.; Agaoglu, S.; Alisarli, M.
In this study, nitrate and nitrite levels of drinking water in city of Bitlis were investigated. A total of 164 water samples, collected from the tank and tap water in Spring and Autumn were used as material. Analysis performed through spectrometric techniques showed that all samples contained some levels of nitrate and nitrite. The average nitrate and nitrite levels were 5.68±0.31 and 1.32±0.09mg L-1, respectively. The effects of residential areas and season on the nitrate and nitrite levels were found to be statistically significant (p<0.05). Nitrate levels of tank and tap water were in accordance with recommended standards. However, 12 and 100% of tank water samples and 7.02 and 100% of tap water samples collected respectively in Spring and Autumn did not meet the national standards for nitrite levels. In addition, 3.58% of tap water collected in Autumn did not meet the international standards. © Medwell Journals, 2009.
A Man With Multiple Sclerosis Running From Restless Legs Syndrome
(Springer International Publishing, 2023) Kahraman, T.; Ozdogar, A.T.
Medical treatments are in the foreground treatment of restless legs syndrome (RLS). Although the benefits of exercise have become more evident, research on exercise has not included people with multiple sclerosis (MS) and RLS. This case report examined how aerobic exercise affects RLS symptoms in a male with MS and RLS. The RLS diagnostic criteria were used to diagnose RLS. Because RLS symptoms can affect many aspects, comprehensive assessment tools were chosen. Aerobic exercise training was applied for 24 sessions with a physical therapist using a recumbent exercise bike. The sessions started with 20 min, with 2-3 min of warm-up, 15 min of loading, and 2-3 min of cool-down, and reached 30 min at the end of 12 weeks. As a result, aerobic exercise might be a promising method for improving RLS severity, sleep quality, gait, and health-related quality of life in people with MS and RLS. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. All rights reserved.
Nitric Oxide Oxidation Products in the Serum of Patients With Gastric and Esophageal Cancer and Helicobacter Pylori
(1999) Turkdogan, M.K.; Testereci, H.; Kahraman, T.; Dilek, F.H.; Akman, E.
Nitric oxide (NO) oxidation products (nitrate and nitrite) were analysed in the serum of 12 gastric cancer (Ca), (12 gastric Ca, 12 esophageal Ca) and 12 healthy controls with modified Stahr's method. Helicobacter pylori (H. pylori) infection was diagnosed histopathologically in the gastric cancer and control groups. In the gastric Ca group mean, serum nitrate and nitrite levels (11.65 ppm and 3.40 ppm) were significantly higher than the esophageal Ca and control groups (p<0.05 and p<0.001). In the esophageal Ca group the mean serum nitrate level (7.16 ppm) was higher than the control group (4.73 ppm, p<0.05) while the nitrite level (1.53 ppm) was not significantly different from the control group (1.70 ppm). H. pylori infection was significantly higher in the gastric Ca group (56.40%) than the control group (36.66%, p<0.05). In conclusion, we observed the highest serum NO product levels in the gastric Ca group although the dietary intake of nitrated foods was similar in both of the Ca groups. This observation indicates the important role of H. pylori infection in the etiopathogenesis of gastric cancer related to the synthesis of NO and consequent the carcinogen nitroso compounds.
Serum and Tissue Levels of Vitamin a and E in Gastric and Esophageal Cancer
(1996) Turkdogan, M.K.; Testereci, H.; Kahraman, T.; Tuncer, I.; Algun, E.; Yoruk, I.H.
Vitamin A and Vitamin E have antioxidant properties and their role in the prevention of gastrointestinal cancers by way of scavenging lipid peroxidation products is very important. Vitamin A ester (retinol acetate) and vitamin E isomers (alpha, gamma and total tocopherols) have been investigated in the serum samples and tissue biopsies of 7 esophageal, 12 gastric cancer patients and a control group consisting of 12 healthy subjects. The serum mean retinol acetate level was significantly higher in the gastric cancer group but not in patients with esophageal cancer when compared to the control group. Serum mean tocopherol levels were low in both cancer groups when compared to the control group but this did not reach biological significance. Tissue mean retinol acetate and tocopherol levels were found significantly low in both of the cancer groups (p<0.03 and p<0.08). These findings suggest that the low tissue levels of the antioxidant vitamin A and E may be related to the etiopathogenesis of the gastrointestinal cancers.