Browsing by Author "Kamis, Gulsum Zuhal"

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Acute Dystonia Following Epileptic Seizure After Bupropion Intoxication
(Springer-verlag Italia Srl, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal; Cim, Emine Fusun Akyuz
Bupropion is an effective treatment for major depressive disorder and smoking cessation. In this paper, we present a case report about dystonia in the head and the neck after epileptic seizures due to 4200 mg of extended-release bupropion intake, and we aim to take attention to the rare neuropsychiatric side effects that may occur after the use of high doses of bupropion.
A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels in Obsessive Compulsive Disorder
(Aves, 2022) Kurhan, Faruk; Kamis, Gulsum Zuhal; Alp, Hamit Hakan; Cim, Emine Fusun Akyuz; Atli, Abdullah
Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 +/- 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9 +/- 5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson's correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P= .001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P. .001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.
Evaluation of the Electroconvulsive Therapy's Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography
(Oxford Univ Press, 2024) Kurhan, Faruk; Yildiz, Veysi; Kamis, Gulsum Zuhal; Karatas, Kubra; Batur, Muhammed
Background and Hypothesis: Schizophrenia is a complex disorder thought to have neurodevelopmental and neurodegenerative aspects. Optical coherence tomography (OCT) measurements of schizophrenia patients revealed that the retinal layers of these patients were thinner than those of healthy controls. This study aimed to examine retinal changes in first-episode psychosis patients treated with electroconvulsive therapy (ECT) via OCT. Study Design: Thirty first-episode psychosis patients (13 men, 17 women) aged 18 to 65 years who had no comorbidities and no smoking, alcohol, or substance use disorders and who were treated with ECT were included in the study. The patients were evaluated using OCT before treatment and after an average of 7.4 sessions of ECT in remission, and the results were compared. Study Results: Statistically significant increases were observed in retinal layer thickness, inner plexiform layer, outer plexiform layer, and total retinal thickness within the 1 mm ring (P = .015, P = .045, and P = .025, respectively). The inner nuclear layer thickness significantly increased within the 6 mm ring (P = .037). Conclusions: In conclusion, ECT noticeably affected retinal structures, particularly according to similar measurements, indicating potential improvements in and the ability to reverse neuronal degeneration after one month of treatment. This study highlights the potential impact of ECT on retinal structures in individuals experiencing first-episode psychosis, as it can enhance specific retinal layers and reverse neuronal degeneration.
Frequency of Post Traumatic Stress Disorder and Associated Factors Among Survivors of Van Avalanche: 6-Month Follow-Up Study
(Turkiye Sinir ve Ruh Sagligi dernegi, 2024) Kurhan, Faruk; Kamis, Gulsum Zuhal; Dinc, Dilem; Tekin, Ishak; Isik, Mesut; Alhan, Cafer; Okmen, Anil Cemre
Objective: We aimed to evaluate the frequency of Post Traumatic Stress Disorder (PTSD), to determine the risk factors, and to monitor the change of symptoms after 6 months among individuals who survived the avalanche disaster in Van. Method: Face-to-face interviews were conducted with 35 people who were rescued from two consecutive avalanche disasters in Van 2 months and 6 months after the avalanche disaster. The socio-demographic and clinical data of the cases were evaluated. The Post Traumatic Stress Disorder Symptom Scale-Self Report version (PSS-SR) and clinical interviews were used for PTSD diagnosis. The level of trauma was assessed by using the Impact of Event Scale (IES). Results: All participants were rescuers who went to the avalanche site for rescue mission. Of the cases, 16 were volunteers from the local community and 19 were professional rescuers. The frequency of PTSD was 71.4% in the early assessment, and 57.1% in the long term. Staying in avalanche for more than 30 minutes, the absence of a history of disaster exposure and being in the group of volunteers were found to increase the risk for PTSD development. Conclusion: There is a high risk of developing PTSD as a result of an avalanche. People who will intervene with the disasters should be educated and prepared in terms of preventing negative psychological consequences of the disaster. The relationship between the severity of trauma and PTSD was replicated in our study.
Hair Loss Associated With Paroxetine Use: a Case Report
(Turkiye Sinir ve Ruh Sagligi dernegi, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal
Diverse dermatological side effects in relation to using psychotropic agents, include the serious outcomes as hypersensitivity and Stevens-Johnson syndrome as well as milder forms as ecchymosis and hair loss. Whereas hair loss is frequently associated with mood stabilizers, rarely it is also attributed to antidepressants. Selective serotonin reuptake inhibitors (SSRIs) which arc the first choice treatment for depression, anxiety disorders and obsessive-compulsive spectrum disorders, are the most commonly used antidepressant drugs. Psychiatric comorbidities have been known in many dermatological diseases and their treatment have positive effects on the course and outcome as well as on the adaptation process to the disease. Due to their favorable side effect profile, for comorbid cases SSRIs are frequently used. Here we present a case of hair loss during paroxetine in a 24-yearold male with social anxiety disorder. In this case the hair loss improved after discontinuing and recurred after resuming paroxetine. After replacing paroxetine with sertraline, another SSRI, alopecia did not recur.
Isotretinoin Induced Psychotic Mania: a Case Report
(Turkiye Sinir ve Ruh Sagligi dernegi, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal
Biological, genetic and psychosocial factors may play a role in the aetiology of bipolar mood disorder (BPD). BPD episodes might be triggered by isotretinoin, a retinoid derivative of vitamin A with a role in cellular proliferation and differentiation. Due to its association with depression, suicidal ideation and suicide attempts, American Food and Drug Administration (FDA) issued a placement of a label warning for isotretionin. Personal or family history of psychiatric disorders was emphasized in the literature for the risk of mood episodes following isotretionin treatment. Here we aim to present the case of an 18-year old young male adult, without personal or family history of a psychiatric disorder, who developed psychotic mania within the first week of isoretinoin which was prescribed for acne vulgaris. Psychotic mania symptoms receded within one week after starting olanzapine (10 mg/day). We believe this case is significant in demonstrating the occurence of a manic episode after isoretinoin in individuals lacking a personal or family history of psychiatric diagnoses.
Relationship Between Obsessive-Compulsive Symptoms and Anxiety Levels During the Covid-19 Pandemic in Healthcare Professionals Vs. Non-Healthcare Professionals
(Tech Science Press, 2022) Kurhan, Faruk; Kamis, Gulsum Zuhal; Cim, Emine Fusun Akyuz; Atli, Abdullah; Dinc, Dilem
The present study investigated the effect of the COVID-19 pandemic on anxiety levels, contamination and responsibility/control obsessions and associated OC behaviors in healthcare versus non-healthcare professionals. The study also aimed to examine the relationship between anxiety levels and obsessive-compulsive (OC) symptom levels, gender, age, educational level, and personal and family history of chronic diseases. The 664 participants included 395 (59.5%) men and 269 (40.5%) women and comprised 180 (27.1%) healthcare professionals and 484 (72.9%) non-healthcare professionals. The survey included three data collection tools: (i) Sociodemographic data form, (ii) Beck Anxiety Inventory (BAD, and (iii) the Dimensional Obsessive-Compulsive Scale Abriged (DOCS-A) pre- and post-pandemic forms. The BAI scores established a moderate positive correlation with post-pandemic DOCS-A total scores and a weak positive correlation with pre-pandemic DOCS-A total scores (p < 0.001 for both). Pre- and post-pandemic DOCS-A total and subdimension scores were significantly higher in women than in men (p < 0.05). Participants with a personal history of chronic diseases had higher BAI and DOCS-A scores compared to participants with no such history (p < 0.001 and p < 0.001, respectively). The results indicated a significant increase in OC symptoms during the pandemic period compared to the pre-pandemic period and a moderate correlation between the anxiety levels and OC symptom severity. It was also revealed that female gender and personal or family history of chronic diseases posed a higher risk for the increase in anxiety and OC symptoms and healthcare professionals had a higher risk of developing anxiety symptoms compared to non-healthcare professionals.