Browsing by Author "Kanberoğlu, G.S."

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Development of a MOF-Based Oxytetracycline-Selective PVC Membrane Potentiometric Sensor
(John Wiley and Sons Inc, 2025) Kanberoğlu, G.S.; Kaya, N.
Oxytetracycline is widely used in veterinary medicine to protect animals from infections, treat existing conditions, and mitigate stress-related events such as vaccination, transportation, and medication. However, an overdose of oxytetracycline may lead to several adverse effects, including renal dysfunction, altered mental status, hepatotoxicity, and gastrointestinal disorders. Therefore, accurate determination of oxytetracycline is essential to ensure both therapeutic efficacy and patient safety. In this study, a polyvinyl chloride (PVC) membrane-based potentiometric sensor selective for oxytetracycline was developed using MIL-53 (Materials of Institut Lavoisier) as the ionophore. The optimal membrane composition consisted of 3% MIL-53, 64% nitrophenyloctylether (NPOE), 1% potassium tetrakis(4-chlorophenyl)borate (KTpClPB), and 32% PVC. The sensor exhibited a linear response in the concentration range of 1.0 × 10−2 to 1.0 × 10−⁷ M, with a Nernstian slope of 53.1 mV/decade. The pH working range was determined to be 4.56–11.00. It can be concluded that the developed solid contact potentiometric sensor offers satisfactory analytical properties. Analytical application of the sensor was successfully implemented in pharmaceutical formulations, physiological serum, and different water samples. © 2025 Wiley-VCH GmbH.
Development of Potentiometric Sensor for Determination of Isoprenaline in Pharmaceutical Drug
(TUBITAK, 2020) Kanberoğlu, G.S.; Özarslan, O.
In this study, a potentiometric ion-selective electrode (ISE) was developed for the determination of isoprenaline, a pharmaceutical active substance. For this purpose, initially, IP-PM, IP-TCA, IP-TPB, IP-REY, IP-PTA ion pairs were synthesized. The synthesized ion pairs were used as the ionophore in the structure of the electrode membrane. In order to ensure membrane optimization, PVC membrane ion selective electrodes were produced in various compositions using the synthesized ion pair and the potentiometric performance characteristics of these electrodes were investigated. It was determined that the best potentiometric performance characteristics were obtained with the PVC membrane electrode in the composition of 3.0% isoprenaline-tetrafenylborate ion pair, %64.0 nitrophenyloctylether, 32.0% polyvinylchloride and %1.0 Tetrakis (4-chlorophenyl) boron potassium compound. The linear operating range of this electrode is 5.0x 10-6 M-1.0x 10-1 M and the slope at the 10-fold concentration change is 45.3 mV; determination limit, 5.0x10-6 M, pH working range, 2.6-3.6 and 5.7-7.9; response time < 5s. The electrode exhibited a reproducible potentiometric response. Isoprenaline content was determined in drug by using the isoprenaline selective electrode. © 2020, TUBITAK. All rights reserved.