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Browsing by Author "Kankaya, E"

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    Article
    Bioavailability and Pharmacokinetics of Oxytetracycline in Cultured Rainbow Trout Following Intramusicular Administration
    (indian veterinary Journal, 2004) Dagoglu, G; Turel, L; Yilmaz, O; Yarsan, E; Oto, G; Kankaya, E
    Aquaculture production of rainbow trout has increased in Turkey in the recent years. There is great concern over the use of drugs for fish production. Bacterial diseases, if untreated, may lead to great economic losses in the form of fish mortality and reduced growth. Thus aquafarming uses a wide variety of drugs for prevention and treatment of disease in cultured fish. Among these drugs, oxytetracycline (OTC) is a broad-spectrum antibiotic used for the treatment of a variety diseases including vibriosis, furunculosis, enteric redmouth, bacterial haemorrhagic septicemia, fin rot, gill disease columnaris and edwardsiellosis (Black et al., 1991; Unb, 1996). There is a paucity of information on the pharmacokinetics of OTC in farmed fish. The pharmacokinetics of OTC may be changed by parameters such as fish species, age, water temperature and salinity, route of administration and other conditions. Therefore the present study was performed to investigate the pharmacokinetics, i.e. absorption, distribution and elimination, of OTC in rainbow trout (Oncorhynchus mykiss) after intra-muscular administration.
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    Article
    Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus Mykiss) Following Administration of Medicated Feed
    (Scientific Technical Research Council Turkey, 2003) Türel, I; Dagoglu, G; Yilmaz, O; Kankaya, E; Sen, F
    The pharmacokinetics of oxytetracycline (OTC) were investigated in rainbow trout in freshwater at 10.5 degreesC. A group of 70 fish received OTC, an intravascular injection (i.v.) of 5 mg/kg body weight. Another group of 105 fish were fed medicated feed containing a dose of 100 mg/kg body weight. OTC. plasma concentrations were determined by high performance liquid chromatography. The pharmacokinetic parameters were described by a two-compartment open model giving distribution half-lives of 0.907 h and 16.058 h, and elimination half-lives of 33.5 h and 27 h for Lv. and oral administration of OTC, respectively. After i.v. administration of OTC, other pharmacokinetic parameters estimated were the area under the curve (AUC: 145.078 +/- 4.45 mug.ml(-1).h(-1)) and mean residence time (MRT: 40.604 +/- 1.150 h). Following oral administration, AUC was 34.46 +/- 1.189 mug.ml(-1).h(-1); MRT was 59.272 +/- 1.541 h; C-max was 0.577 mug/ml and T-max was 36 h. The oral bioavailability (F) of OTC in rainbow trout was found to be only 1.187%.