Browsing by Author "Kaplan, S."

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Dose-Dependent Effects of Diclofenac Sodium on the Nervous System
(Nova Science Publishers, Inc., 2021) Kaplan, A.A.; Yurt, K.K.; Marangoz, A.H.; Ragbetli, M.Ç.; Kaplan, S.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prostaglandin inhibitors used for the alleviation of pain, inflammation, myocardial infarction and stroke. Prostaglandins are also important chemical mediators in the human body, being involved in both normal and abnormal functioning of organs and systems. Diclofenac sodium (DS) is reported to cross from the human placenta to the foetus during the first and second trimesters. The drug crosses the placental barrier to prevent the biosynthesis of prostanoids and passes into the foetal circulation, where it causes significant side-effects and sometimes malformations in newborns. Experiments have suggested that exposure to DS during the prenatal period produces teratogenic effects on the CNS and neuroanatomical anomalies in animal models. However, it has also been suggested that used in low doses, DS may produce beneficial effects on neurological systems, especially in terms of prenatal development. The aim of this chapter is to fill this knowledge gap by means of quantitative and qualitative analysis in order to identify the probable neuroprotective/neurotoxic effect on the nervous system of DS administration in differing doses. Another aim is to report potential results regarding its use during the prenatal period. The chapter will also add further information to the existing literature regarding the effects of DS on the spinal cord, brain, cerebellum and peripheral nerves. © 2021 by Nova Science Publishers, Inc. All rights reserved.
Effects of Hemarthrosis on Postural Balance in Children With Hemophilia a
(Wiley, 2018) Karaman, K.; Kaplan, S.; Cetin, M.; Geylan, H.; Sahin, A. Yasar; Arslan, O.; Oner, A. F.
Evaluation of Postural Balance During Monopedal Stance in Haemophilic Children: Have Target Joint in Knee
(Wiley, 2019) Tat, N. M.; Tat, A. M.; Oner, A. F.; Antmen, A. B.; Kaplan, S.; Can, F.
Prenatal Exposure To Diclofenac Sodium Changes the Morphology of the Male Rat Cervical Spinal Cord: a Stereological and Histopathological Study
(2011) Özyurt, B.; Kesici, H.; Alici, S.K.; Yilmaz, S.; Odaci, E.; Aslan, H.; Kaplan, S.
Diclofenac sodium is one of the most commonly used non-steroidal anti-inflammatory drugs. It may cause alteration in the nervous system during neuronal development. However, there is no investigation concerning its role in the cervical spinal cord. Pregnant rats were divided into two groups, namely drug-treated and control (saline-injected) groups. To obtain the offspring of the drug-treated group, a dose of 1. mg/kg daily diclofenac sodium (Voltaren, 75. mg/3. ml ampoule, Novartis) was injected into the pregnant rats beginning from the 5th day after mating to the 20th day of the pregnancy. To obtain the control group of offspring, serum physiological at a 1. ml/kg daily dose was injected into the pregnant control rats during the same period. Male offspring were obtained after delivery and each group was divided into two subgroups: 4-week-old and 20-week-old. The total neuron number in diclofenac sodium-treated rats was significantly lower than in the control group animals. The total volume of the cervical spinal cord segments (C1-C4) was also estimated. There was a significant difference between the volumes of the two groups, especially in the 20-week-old subgroup. This may suggest that development of neurons and volume of cervical spinal cord are affected in prenatal animals after administration of diclofenac sodium. © 2011 Elsevier Inc.
Stereological and Histopathological Evaluation of Ovary and Uterine Horns of Female Rats Prenatally Exposed To Diclofenac Sodium
(informa Healthcare, 2013) Guven, D.; Altunkaynak, B. Z.; Ayranci, E.; Kaplan, S.; Bildircin, F. D.; Kesim, Y.; Ragbetli, M. C.
In this study, we investigated the morphometric and histological alterations of the ovary and uterine horns in 4-week-old rats that were prenatally exposed to diclofenac sodium (DS). For this purpose, pregnant rats were divided into two groups: the control and drug-treated groups. Beginning from the 5th day after mating through the 15th day of pregnancy, DS (1 mg/kg daily) was intraperitoneally injected in the treated group. No injection was given to the rats in the control group. After spontaneous delivery, male off spring were obtained. At the end of the 4th week, ovary and uterine horn samples were removed. Following dissection and routine histological preparation, histopathological and stereological investigations were carried out. Our results indicate that DS application leads to a decrease in the mean volume fraction of the uterine horn. Moreover, there was an increased volume fraction in some structures of the ovary; like the cortex, medulla and zona granulosa. There was no difference found between the two groups in terms of the mean volume of the antrum and the Graafian follicle fraction. Finally, in light of our findings, we may suggest that DS may lead to adverse effects in rats that are prenatally subjected to this drug.