Browsing by Author "Kara, Erdal"

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Clinical and Laboratory Features of Cd5-Negative Chronic Lymphocytic Leukemia
(int Scientific Literature, inc, 2017) Demir, Cengiz; Kara, Erdal; Ekinci, Omer; Ebinc, Senar
Background: Chronic lymphocytic leukemia (CLL) usually expresses CD5 antigen. However, 7-20% of patients are CD5 negative. We report here a series of 19 CD5-negative B-CLL cases. Material/Methods: We reviewed 19 consecutive CD5-negative B-CLL cases seen in our medical center from 2009 to 2015 and compared them with 105 CD5-positive B-CLL cases. The two groups were compared in terms of clinical parameters, laboratory parameters, and survival characteristics. Results: Lymphadenopathy was present in 31.5% of the CD5-negative group and 51.4% of the CD5-positive group (p=0.029). Splenomegaly was present in 42.1% of the CD5-negative group and 16.1% of the CD5-positive group (p=0.029). There was no difference between the groups in terms of Binet A, B, and C stages (p=0.118, p=0.051, and p=0.882, respectively). The median thrombocyte count was 144x10(9)/L and 160x10(9)/L in the CD5- negative and CD5- positive groups, respectively (p=0.044).There was no difference between the two groups in terms of median neutrophil count (p=0.169). The mean lymphocyte count was 43.2 +/- 4.0x10(9)/L and 36.7 +/- 3.2x10(9)/L in the CD5-negative and CD5-positive groups, respectively (p=0.001). There was no difference between the groups in terms of autoimmune hemolytic anemia and autoimmune thrombocytopenia. In five-year follow-up, 84.2% of CD5-negative patients and 90.5% of CD5-positive patients were alive (p=0.393). Conclusions: We found more isolated splenomegaly, less lymphadenopathy, a higher lymphocyte count, and a lower thrombocyte count in the CD5-negative group. There was no difference between the groups in terms of clinical stage, autoimmune phenomena, hemoglobin and neutrophil count, and survival.
Development of Agranulocytosis After Discontinuation of Methimazole: an Unusual Case
(Hindawi Ltd, 2015) Ucler, Rifki; Atmaca, Murat; Candar, Omer; Alay, Murat; Goy, Burhan; Kara, Erdal; Demir, Yusuf
Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. We herein describe a case of a 41-year-old woman who was previously administered methimazole (MMI) for ten days and developed ATD-induced agranulocytosis and symptoms of an upper respiratory tract infection after three weeks following discontinuation of MMI treatment. A thorough hematologic and serological evaluation did not disclose an alternative cause for the agranulocytosis. After receiving empirical antibiotic treatment, she responded successfully with clinical improvement of her symptoms and resolved neutropenia on the seventh day. This case is atypical because agranulocytosis developed after discontinuation of MMI, which strengthens the importance of remaining alert for signs of agranulocytosis even after discontinuation of ATD treatment.
The Impact of Low Molecular Weight Heparin on Obstetric Outcomes Among Unexplained Recurrent Miscarriages Complicated With Methylenetetrahydrofolate Reductase Gene Polymorphism
(Via Medica, 2017) Cetin, Orkun; Karaman, Erbil; Cim, Numan; Dirik, Deniz; Sahin, Hanim Guler; Kara, Erdal; Esen, Ramazan
Objectives: The association between methylenetetrahydrofolate reductase gene polymorphisms and unexplained recurrent miscarriage is elusive. The recommendations for improving pregnancy outcomes in these patients keep changing based on the available evidence. The aim of this study is to analyze the impact of low molecular weight heparin on obstetric outcomes of recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphism. Material and methods: We reviewed medical records of 121 patients with a history of recurrent miscarriage complicated by methylenetetrahydrofolate reductase gene polymorphisms, retrospectively. From among them, 68 patients were treated only with folic acid and iron. The remaining 53 patients were treated with folic acid, iron and prophylactic doses of low molecular weight heparin. The subsequent pregnancy outcomes of these patients were noted. Results: The live birth rate was higher in patients with anticoagulant therapy than in patients without anticoagulant therapy (48.5% vs. 69.8%, respectively, p: 0.015) and the congenital anomaly rate was lower in anticoagulant therapy group (17.6% vs. 3.8%, respectively, p: 0.022). The other obstetric outcomes were found to be similar between the two groups. Conclusions: The current study demonstrated that low molecular weight heparin improved the live birth rates among unexplained recurrent miscarriage patients complicated with methylenetetrahydrofolate reductase gene polymorphisms. However, the routine use of low molecular weight heparin did not improve the late pregnancy complications in these selected patients in the eastern region of our country. Further studies are needed to discriminate the effect of anticoagulation on the live birth rate of each of methylenetetrahydrofolate reductase gene polymorphism type.
Mean Platelet Volume and Platelet Distributed Width Levels in Abo Blood Groups
(Wiley-blackwell, 2016) Celik, Hakim; Aslan, Mehmet; Kirmit, Adnan; Altiparmak, Ibrahim Halil; Kara, Erdal; Karakilcik, Ali Ziya
Megaloblastik Anemi Tanılı 34 Hastanın Laboratuvar Parametreleri Açısından Değerlendirilmesi
(2016) Demir, Cengiz; Kara, Erdal; Ebinç, Senar; Ekinci, Ömer
Amaç: Çalışmamızda megaloblastik anemili olgularımızın başvuru sırasındaki demografik, hematolojik ve biyokimyasal parametrelerine ait özellikleri sunmayı amaçladık. Gereç ve Yöntem: Çalışmaya megaloblastik anemi tanılı 34 olgu dâhil edildi. Olguların yaşı, cinsiyeti, kemik iliği biyopsi sonuçları, kan sayımı parametreleri (hemoglobin, lökosit sayısı, trombosit sayısı, MCV, RDW), laktat dehidrogenaz, vitamin B12, folik asit, bilirubin değerleri retrospektif olarak incelendi. İstatistik analiz için SPSS istatistik paket programı kullanıldı. Bulgular: 34 olgumuzun 24'ü kadın, 10'u erkek idi. Olguların yaş ortalaması 52 yıl idi. Olguların hepsinde anemi, vitamin B12 eksikliği ve LDH yüksekliği mevcuttu. MCV değeri 14 olguda (%38.2), indirekt bilirubin değeri ise 17 olguda (%50) normal aralıkta idi. RDW değeri 21 olguda (%64.7) normalden yüksek saptandı. Sonuç: Megaloblastik anemide sıklıkla MCV ve indirekt bilirubin yüksekliği olmakla birlikte olguların önemli bir kısmında bu değerler normal aralıkta bulunabilir. Makrositoz ile seyreden aplastik anemi ve MDS'nin aksine megaloblastik anemide RDW normalden daha yüksek görülebilmektedir
A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism
(Hindawi Ltd, 2015) Ucler, Rifki; Kara, Erdal; Atmaca, Murat; Olmez, Sehmus; Alay, Murat; Dirik, Yaren; Bora, Aydin
Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction. beta-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for maintaining adequate levels of hemoglobin. Hypogonadism is one of the potential complications of hemochromatosis, usually seen in patients with a severe iron overload, and it shows an association with diabetes and cirrhosis in adult patients. We describe a patient with mild transfusional hemochromatosis due to beta-thalassemia major, presenting with central hypogonadism in the absence of cirrhosis or diabetes. Our case showed an atypical presentation with hypogonadotropic hypogonadism without severe hyperferritinemia, cirrhosis, or diabetes. With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related complications, such as osteoporosis, anergia, weakness, sexual dysfunction, and infertility, could be more effectively managed in these patients.
The Relationship Between Platelet Indices and Abo Blood Groups in Healthy Adults
(Wiley, 2019) Celik, Hakim; Duzenli, Ufuk; Aslan, Mehmet; Altiparmak, Ibrahim Halil; Kirmit, Adnan; Kara, Erdal; Karakilcik, Ali Ziya
Background ABO blood groups have been suggested to have a high correlation with cardiovascular diseases (CVDs). It has also been postulated that platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are very important in the development and progression of CVDs. However, despite these common associations with CVDs, as far as we know, there are no studies investigating platelet indices in ABO blood groups. Thus, the aim of this study was to investigate whether platelet indices are associated with ABO blood groups. Methods The study included 301 healthy volunteers (99 women and 202 men; mean age: 32.59 +/- 7.52 years) whose blood groups were determined by the gel column method using agglutination techniques. Platelet indices were studied by an automated blood counter. Results No considerable differences in age, gender, or Rh factors were observed among ABO blood groups. MPV was detected to be considerably lower in O and A blood group subjects than in AB and B blood group subjects. Similarly, PDW was significantly lower in O and A blood group subjects than in B blood group subjects. Additionally, MPV in the O blood group subjects was significantly lower than in the non-O blood group subjects. Conclusions Because MPV and PDW are used as markers of CVDs, individuals with O and A blood groups in this study may be considered to have a lower risk of CVDs than AB and B blood group subjects. However, prospective cohort studies involving a greater number of volunteers are needed to elucidate these relationships.
Successful Management of Pulmonary Hemorrhage and Aspergillosis in a Patient With Acute Myeloid Leukemia (aml-M3)
(Elsevier Science Bv, 2015) Gunbatar, Hulya; Demir, Cengiz; Kara, Erdal; Esen, Ramazan; Sertogullarindan, Bunyamin; Asker, Selvi
A 35-year-old man presented with a one month history of gingival bleeding. He was diagnosed with Acute Myeloid Leukemia (AML-M3). During treatment he developed alveolar hemorrhage for which he was treated with a steroid. After the steroid treatment he developed a nodule, a cavitary lesion and atelectasia in the left lung. He was treated with voriconazole. After therapy with voriconazole his lesion significantly decreased. This case illustrates the efficacy and safety of antifungal therapy with voriconazole for aspergillosis complicated by AML. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.