Browsing by Author "Karaaslanli, Abdulmutalip"

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Gallic Acid Showed Neuroprotection Against Endoplasmic Reticulum Stress in Rats
(Acta Cirurgica Brasileira, 2025) Karaaslanli, Abdulmutalip; Tuncer, Mehmet Cudi; Asir, Firat; Korak, Tugcan
Purpose: We aimed to investigate the role of gallic acid treatment on spinal cord tissues after spinal cord injury (SCI) and its relationship with endoplasmic reticulum (ER) stress by histochemical, immunohistochemical, and in-silico techniques. Methods: Thirty female Wistar albino rats were divided into three groups: sham, SCI, and SCI+gallic acid. SCI was induced by dropping a 15-g weight onto the exposed T10-T11 spinal cord segment. The SCI+gallic acid group received 25 mg/kg of gallic acid intraperitoneally daily for one week. Histopathological, immunohistochemical, and silico analyses were performed. Results: Histological analysis revealed improved neural cell survival and tissue integrity in the SCI+gallic acid group compared to the SCI group. Caspase-12 expression was significantly increased in the SCI group, indicating elevated ER stress and apoptosis. Gallic acid treatment resulted in a marked reduction in caspase-12 expression in neurons, neuroglia, and endothelial cells, suggesting decreased ER stress. Conclusion: Gallic acid exhibits significant neuroprotective effects against ER stress and cellular damage in a rat model of SCI. The in-silico analysis revealed apoptotic and immune-related pathways in which gallic acid showed neuroprotective effects by regulating caspase-12. These results suggest that gallic acid may be a promising therapeutic agent for mitigating secondary damage post-SCI.
The Role of Dynamic Cervical Magnetic Resonance Imaging in Determining the Level of Posterior Decompression in Cervical Spondylotic Myelopathy
(Elsevier Science inc, 2025) Serifoglu, Luay; Karaaslanli, Abdulmutalip
BACKGROUND: Cervical spondylotic myelopathy (CSM) is a leading cause of spinal cord dysfunction in adults, often progressing silently. Static magnetic resonance imaging (MRI) is the standard imaging tool but may miss compression caused by neck movement. Dynamic MRI, by capturing flexion and extension views, provides a clearer picture of spinal cord compression, aiding surgical planning and improving outcomes. However, its use is limited due to higher costs and specialized requirements, making its clinical value essential to assess. METHODS: Eighty-two CSM patients undergoing posterior decompression surgery were divided into 2 groups: static MRI-based planning (n = 43) and combined static and dynamic MRI-based planning (n = 39). Neurological outcomes were evaluated using modified Japanese Orthopaedic Association and visual analog scale scores preoperatively and postoperatively. Compression levels identified on static and dynamic MRI were compared. RESULTS: Demographic characteristics were similar between groups. Dynamic MRI identified additional compression levels, mainly at C5-C6 and C6-C7, in 18 patients. Patients in the dynamic MRI group showed significantly greater improvements in modified Japanese Orthopaedic Association scores (mean: 15.8 +/- 1.6 vs. 14.5 +/- 1.8, P = 0.01) and visual analog scale scores (mean: 3.2 +/- 1.4 vs. 4.5 +/- 1.8, P = 0.01) compared to the static MRI group. CONCLUSIONS: Dynamic cervical MRI enhances the identification of compression levels overlooked by static MRI, improving surgical precision and postoperative outcomes in CSM patients. Incorporating dynamic MRI into routine preoperative evaluations may be particularly beneficial for complex, multilevel cases.