Browsing by Author "Karaca, F."

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The Effects of Melatonin Application on Some Haematological Parameters and Thyroid Hormones and Testosterone in Male Goats' Non-Breeding Season
(2004) Dönmez, N.; Karaca, F.; Belge, F.; Ateş, C.T.
In the present study, the effects of melatonin application on some haematological parameters, testosterone and thyroid hormones in male goat in out of breeding season were investigated. In this study 16 Coloured Mohair male goats were used. At the beginning of the study the animals were randomly divided into two equal groups as control and test groups. Melatonin (Regulin, Hoechst) was implanted in the test group. Thirty and 70 days after melatonin implantation, blood samples were obtained from both control and melatonin groups for determination of erythrocyte and leukocyte counts, haemoglobin concentration, haematocrit level, plasma testosterone, T3 and T 4 concentrations. T3 and T4 levels were lower both 30 and 70 days after melatonin implantation in the test group compared to the values obtained from the control group. However, important decreases (P<0.05) were seen only in T3 concentration obtained from the melatonin group on day 70 of the experiment. Testosterone values increased in the melatonin-implanted group for 30 and 70 days after implantation, but results were not significant. Accordingly, it is believed that the effects of melatonin implantation on certain haematological parameters, testosterone and thyroid hormone levels in male goats in the non-breeding season, should be taken into consideration.
The Effects of Radiotherapy on Arterial Diameters in Patients With High-Grade Glial Tumors Who Have Undergone Adjuvant Radiotherapy
(Wolters Kluwer Medknow Publications, 2023) Karaca, F.; Mentes, S.; Boga, Z.; Akkaya, H.; Keskin, S.; Gulek, B.
Background and Aims:Our purpose was to evaluate the M2 branch of the middle cerebral artery (MCA) in high-grade glial tumor patients who undergo adjuvant radiotherapy (RT). For this purpose, the diameter of the M2 branch was measured and evaluated by means of contrast-enhanced magnetic resonance imaging (CE-MRI) before and after RT. Post-radiotherapeutical measurements were made 1, 3, 5, and 7 months after the procedure; and vascular diameter alterations were evaluated. Materials and Methods:CE-MRI examinations were performed on the 32 patients enrolled in the study, who had undergone radiotherapy of the temporoparietal region. MRI examinations were performed prior to RT (RT0) and 1 (RT1), 3 (RT2), 5 (RT3), and 7 (RT4) months after RT. The M2 branch of the MCA was evaluated on MRI images, and the vessel diameter was measured in millimeters (mm), and then comparisons were made. Results:Statistically significant results were obtained during RT0-RT1, RT0-RT2, RT0-RT3, RT0-RT4, RT1-RT2, RT2-RT4, and RT3-RT4, and comparisons of the diameters of the M2 branch of the right MCA were performed (P < 0.05). When the same measurements and comparisons were made for the M2 branch of the left MCA, statistically significant results were found for the RT1-RT2, RT1-RT3, and RT1-RT4 comparisons (P < 0.05). Conclusion:Our study showed that the MCA M2 branch diminished in size following RT. This was demonstrated by means of CE-MRI controls performed up to 7 months after the completion of the RT procedures.
Evaluating Interleukin-16 Expression in Patients With Grade-3 and Grade-4 Glial Cell Tumors and Healthy Individuals
(Wolters Kluwer Medknow Publications, 2023) Karaca, F.; Keskin, S.; Mentes, S.; Boga, Z.; Cavus, G.; Koksal, F.
Background: This study evaluated the change in IL-16 levels in patients with high-grade glial tumors undergoing radiotherapy (RT) and healthy individuals (control group).Materials and Methods: Serum IL-16 levels of 35 high-grade glioma patients receiving radiotherapy (RT) and 30 healthy individuals were compared. We compared the IL-16 levels before (RT0) and after the (RT1) and IL-16 levels were measured and the relationship of this change with other characteristics such as age, gender, weight, height, and blood test results. Results: The RT0-IL-16 level was approximately 15 pg/ml higher than the RT1 measurement in the patient group. The mean RT0-IL-16 levels in the patient group were approximately 10 pg/ml higher than the mean IL-16 levels in the control group. Likewise, at the RT1 time-point, the mean IL-16 levels for the patient group were approximately 5 pg/ml lower than the mean IL-16 for the control group. The mean RT0-RT1-IL-16 value tended to be higher in female patients than in male patients. Conclusion: The application of RT reduces the overall IL-16 levels, suggesting the efficacy of RT, as well as the role of IL-16 in tumorigenesis.
Evaluation of Hematologic and Biochemical Parameters in Patients With Early Stage Uterine Malignancy Receiving Radiotherapy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Karaca, F.; Menteş, S.; Keskin, S.
Surgery is the primary choice of treatment for this disorder. Radiotherapy is an important step of treatment in this cancer after surgery due to the stage of the disease. Lack of prospective randomised data for survival limits the use of adjuvant radiotherapy. Hovewer adjuvant radiotherapy is suggested for high risk patients to reduce locoregional recurrence. The aim of this study is to define the statistical difference of hemogram, transaminases, kidney function tests and electrolyte changes in patients before starting radiotherapy, the end of radiotherapy, with the onset of acute side effects, and three months after finishing radiotherapy with the onset of chronic side effects. 18 patients with early stage endometrial malignancy attending to Adana Numune Training and Research Hospital have been included. This study has assessed the changes in hemogram, blood transaminases, urea, creatinin and electrolyte values of patients before radiotherapy, at the last week of radiotherapy and three months after radiotherapy. The values were statistically significant for AST, Ca, LDH, urea, Hb and HTC values before treatment, at the end of the treatment and three months after treatment (p<0.05). The effect of radiotheraphy seen as lower values of hemoglobin and hematocrite in endometrial malignancy patients resolved and become normal after three months of the radiotherapy. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Il-17a Expressions in High-Grade Glial Tumors Receiving Radiotherapy
(Wolters Kluwer Medknow Publications, 2022) Karaca, F.; Keskin, S.; Mentes, S.; Okten, A., I; Cavus, G.; Arslan, A.; Koksal, F.
Aim: In this study, we aimed to investigate the interleukin-17A (IL-17A) levels in patients with high-grade glial tumors before receiving radiotherapy, immediately after radiotherapy, and 3 months after radiotherapy. Patients and Methods: A total of 33 patients who applied to Adana City Training and Research Hospital, Department of Radiation Oncology between December 2016 and May 2018 was included in this study. A total of three blood samples was taken from each patient to assess IL-17A levels before and after radiotherapy and 3 months after the completion of radiotherapy. Results: The differences in IL-17A levels between genders were not statistically significant. IL-17A levels progressively decreased after the radiotherapy and 3 months after the radiotherapy as compared to the levels before radiotherapy. However, this was not statistically significant. IL-17A levels in the non-surviving patients were high before and after radiotherapy as compared to the surviving ones, but this was also not statistically significant. Conclusion: As compared to the period before radiotherapy, IL-17A levels tend to decrease in the period of acute and chronic phases of radiotherapy in all patient groups.
Preliminary Report on Induction of Estrus With Multiple Ecg Injections in Colored Mohair Goats During the Anestrus Season
(Elsevier Science Bv, 2009) Karaca, F.; Tasal, I.; Alan, M.
This trial was conducted to evaluate the effectiveness of multiple eCG injections in the induction of estrus and pregnancy in Colored Mohair goats during the anestrus season. It was also aimed to determine total dose of eCG required for induction of estrus. Ten multiparous and lactating goats were used. The goats were randomly divided into two groups and treatments were started on May 22. Group eCG (n = 5) was treated with eCG intramuscularly for 6 days. Daily dosages of eCG from May 22 to May 27 were 300 IU, 200 IU, 200 IU, 100 IU, 100 IU and 50 IU, respectively. Goats in control group received no treatment. Blood samples were taken from animals in each of the two groups just before and after the beginning of the treatments and serum progesterone concentrations were assayed by RIA. Starting on the fourth day after the first treatments, goats were exposed to fertile bucks twice daily for 30 min to detect standing heat. The estrus goats were allowed to be mated by the bucks. Pregnancies were determined 40 days after mating by real-time ultrasonography. One goat on day 5 and three goats on day 7 exhibited behavioral estrus in eCG group (80%) after the first eCG injection. Three of them (75%) became pregnant. None of the goats in the control group exhibited behavioral estrus. Mean serum progesterone concentrations had prominent elevations indicating ovulation in eCG group, but not in control group, after 20 days from the first treatments. Progesterone concentrations of eCG group were significantly different than those of control group on days 20 and 28 (P < 0.05). The results suggest that divided multiple injections of a total 950 IU eCG are effective without progestagen pretreatment in the induction of estrus and obtaining successful pregnancy and live kids in Colored Mohair goats during the anestrus season. (c) 2008 Elsevier B.V. All rights reserved.