Browsing by Author "Karadag, A.S."

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A Case of Fulminant Varicella Infection With Purpura Fulminans, Hepatitis, and Rhabdomyolysis
(2012) Karadag, A.S.; Bilgili, S.G.; Calka, O.; Çeçen, I.; Akbayram, S.
Varicella zoster virus causes varicella which is a common disease. Generally it is self-limiting, and treatment is often unnecessary, but severe or life-threatening complications are rarely seen. We report a case of fulminant varicella complicating with purpura fulminans, hepatitis, and probable rhabdomyolysis in a previously healthy child.
Correlation Study Between Clinical Classification and Disability Index in a Holistic Evaluation of Acne Severity and Impact in Turkey
(Edizioni Minerva Medica, 2021) Ozlu, E.; Karadag, A.S.; Aksoy, B.; Bilgili, S.G.; Gonul, M.; Yavuz, İ.H.; Chen, W.C.
BaCKgrouND: this study provides a comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. METHODS: In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). RESULTS: In 1331 evaluated patients (mean: 21,51±4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r=0.862), or CADI (r=0.686), respectively (P=0.001 each). Adult women with back acne and adolescent with décolleté expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in décolleté area, including neck, was 32.3%. CoNCluSIoNS: Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Décolleté acne deserves special attention in clinical assessment. © 2020 EDIZIONI MINERVA MEDICA
Cutaneous Metastasis of the Small Cell Lung Cancer
(2011) Simsek, G.G.; Karadag, A.S.; Turksen, Z.
Effect of Systemic Isotretinoin Therapy on Mucociliary Clearance and Nasal Surface Mucosa in Acne Patients
(2013) Takci, Z.; Simsek, G.G.; Karabulut, H.; Buran, Y.; Karadag, A.S.
Background: Currently, there are no studies investigating the topical or systemic effects of retinoids on human nasal mucosa. We aimed to investigate the effect of systemic isotretinoin therapy on mucociliary transport and nasal surface mucosa using the saccharine test (ST) and nasal cytology techniques. Methods: A total of 30 patients with severe or moderate acne were enrolled in this study. The median prescribed dose of isotretinoin was 0.75 mg per kg per day. Clinical and biochemical examinations were carried out periodically. The ST and nasal cytology were performed before treatment and during the third month of therapy. Results: Of the 30 patients who initially agreed to participate in the research, 21 completed the study (18 female and 3 male, mean ± standard deviation (SD) aged 20.9 ± 4.7 years, range 15-32 years). There was a significant difference between the mucociliary clearance time for subjects in the pre- and post-treatment periods (173.8 ± 89.2 seconds vs 245.2 ± 191.6 seconds, respectively; P=.009). Cytological examination revealed that the squamous cell ratio was significantly lower and the reactive changes of the respiratory epithelium were significantly higher 3 months after isotretinoin therapy than before therapy (P=.010, P=.002, respectively). There were mild signs of inflammation according to the number of neutrophilic leukocytes (8.3% vs 26.6%, P=.06) after 3 months of isotretinoin therapy. Conclusion: Systemic isotretinoin alters the mucociliary transport, decreases the squamous cell ratio, increases the reactive changes in the respiratory epithelium significantly, and increases neutrophils in the nasal surface mucosa in the third month of treatment. Copyright © 2013 Journal of Drugs in Dermatology.
Specific and Non-Spesicific Dermatoses of Pregnancy in the Emergency Department
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Bilgili, M.A.; Bilvanisi, S.K.; Bilgili, S.G.; Okyay, A.G.; Dursun, R.; Karadag, A.S.
Dermatological changes both specific to pregnancy and nonspecific to it may be observed during gestation. In this study, specific and nonspecific dermatoses of pregnancy were investigated in patients admitted with dermatologic complaints to the emergency department. This information will be useful in identifying common and important dermatoses of pregnancy that need to be recognized at the point of primary care, so that the proper initial treatment and referrals can be instituted. Pregnant patients admitted with dermatological complaints to the emergency service were enrolled in the study. We retrospectively collected clinical and laboratory findings, diagnoses, administered treatments and admission rates. Of the 4,280 pregnant patients admitted to the emergency service, 99 pregnant patients had dermatological complaints. While pregnancy-specific dermatoses were detected in 22 % of the patients, dermatoses nonspecific to the pregnancy were found in 78 % of them. Listed in descending order, specific dermatoses of pregnancy were atopic eruption of pregnancy (12%), polymorphic eruption of pregnancy (6%), intrahepatic cholestasis of pregnancy (2%), and pemphigoid gestationis (2%). Urticaria and angioedema were the most frequently diagnosed diseases among the dermatoses nonspecific to the pregnancy. There are many dermatoses are seen in the pregnancy, while urticaria and angioedema are the most common. Atopic eruption of pregnancy and the polymorphic eruption of pregnancy are the most common specific dermatoses. It was seen that the frequency of dermatological causes was quite low among the pregnant patients applying to the emergency service. However, some of these dermatoses may necessitate early diagnosis and immediate treatment. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.