Browsing by Author "Karadas, S."

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Acetaminophen Intoxication Is Associated With Decreased Serum Paraoxonase and Arylesterase Activities and Increased Lipid Hydroperoxide Levels
(Sage Publications Ltd, 2014) Karadas, S.; Aslan, M.; Gonullu, H.; Kati, C.; Duran, L.; Olmez, S.; Demir, H.
Background: Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication. Methods: A total of 20 patients with acetaminophen intoxication and 25 healthy controls were enrolled. Serum total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) levels, and paraoxonase and arylesterase activities were measured spectrophotometrically. Results: The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower in patients with acetaminophen intoxication compared with controls (all, p < 0.001), while the serum LOOH levels were significantly higher (p < 0.001). Conclusions: Our results suggest that decreased PON1 activity seems to be associated with increased oxidative stress in patients with acetaminophen intoxication. Measuring serum PON1 activity may be useful in assessing the development of toxicity risk in acetaminophen toxicity. It would be useful to recommend vitamins with antioxidant effects such as vitamins C and E along with medical treatments.
Delayed Diagnosis of Selective Immunoglobulin Deficiency: a Case Report
(Ondokuz Mayis Universitesi, 2016) Kars, V.; Celepkolu, T.; Yilmaz, A.; Esmer, F.; Karadas, S.
Selective immunoglobulin A deficiency (SIgAD) is the most common of all primary immunodeficiency diseases; however, the pathogenesis has not been fully understood. Although most people with SIgAD are asymptomatic, some may present with recurrent infections; such as respiratory disorders, gastrointestinal tracts disorders, and allergic disorders. Herein, we report a case with SIgAD who presented with the complaints of pruritus, dental caries and chronic sinopulmonary infections. © 2016 OMU.
Iatrogenic or Fracture-Related Nerve Injuries in Supracondylar Humerus Fracture: Is Treatment Necessary for Nerve Injury
(verduci Publisher, 2013) Guner, S.; Guven, N.; Karadas, S.; Ceylan, M. F.; Turktas, U.; Gokalp, M. A.; Gozen, A.
BACKGROUND: Supracondylar humerus fractures are very common types of elbow fractures in children between the ages of three and ten years. Totally displaced supracondylar humerus fractures can be associated with neurovascular injuries, and treatment can be complicated by iatrogenic neurovascular injury, compartment syndrome, malunion, and elbow stiffness AIM: The aim of this study was to describe the clinical outcome of nerve injuries associated with supracondylar humerus fractures in children observed over a period of seven years. PATIENTS AND METHODS: Children with displaced supracondylar humerus fracture who were treated with closed reduction and percutaneous cross K-wire fixation were reviewed retrospectively at the Medical School Hospital of Yuzuncu Yil University from May 2004 to October 2012. RESULTS: There were 91 patients available for follow-up. Nerve injury was observed in 11 (12.1%) of 91 patients with supracondylar humerus fractures. In 10 (90.1%) of these 11 cases, nerve functions recovered completely (excellent outcome) and in one (9.9%) case partial recovery was seen (good outcome). CONCLUSIONS: Iatrogenic or fracture-related nerve injury in a supracondylar humerus fracture is a benign condition which may be resolved spontaneously and observation appears to be a good and valuable method for treatment of this complication.
Mean Platelet Volume as an Indicator of Disease in Patients With Acute Pulmonary Embolisms
(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Sunnetcioglu, A.; Karadas, S.
Mean platelet volume (MPV) is a simple and easy method of assessing platelet function in routine clinical practice. The data concerning MPV in pulmonary embolism are controversial. Therefore, the aim of this study was to evaluate MPV levels and platelet numbers in patients with acute pulmonary embolisms. This retrospective study was conducted in the emergency department of the Medical Faculty Hospital of Yuzuncu Yil University between January 2010 and April 2012. The study enrolled 67 patients with acute PE (36 females and 31 males) and 53 healthy controls (31 females and 22 males). The platelet number and MPV values in patients with acute pulmonary embolism were reviewed. There were no statistically significant differences between the acute PE patients and the controls with respect to the MPV values and platelet numbers (both, p>0.05). The MPV values were inversely correlated with the platelet number in the patients with acute PE (r:0.388; p<0.001). These results suggest that MPV is not a reliable indicator for diagnosing acute pulmonary embolism. Further studies are necessary to confirm these findings. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.
Serum Adenosine Deaminase Activity in Cutaneous Anthrax
(International Scientific Literature Inc., 2014) Sunnetcioglu, M.; Karadas, S.; Aslan, M.; Ceylan, M.R.; Demir, H.; Oncu, M.R.; Aypak, C.
Background: Adenosine deaminase (ADA) activity has been discovered in several inflammatory conditions; however, there are no data associated with cutaneous anthrax. The aim of this study was to investigate serum ADA activity in patients with cutaneous anthrax. Material/Methods: Sixteen patients with cutaneous anthrax and 17 healthy controls were enrolled. We measured ADA activity; peripheral blood leukocyte, lymphocyte, neutrophil, and monocyte counts; erythrocyte sedimentation rate; and C reactive protein levels. Results: Serum ADA activity was significantly higher in patients with cutaneous anthrax than in the controls (p<0.001). A positive correlation was observed between ADA activity and lymphocyte counts (r=0.589, p=0.021) in the patient group. Conclusions: This study suggests that serum ADA could be used as a biochemical marker in cutaneous anthrax. © Med Sci Monit, 2014.
Serum Paraoxonase Activity and Oxidative Stress Levels in Patients With Cutaneous Anthrax
(Sage Publications Ltd, 2017) Karadas, S.; Aslan, M.; Ceylan, M. R.; Sunnetcioglu, M.; Bozan, N.; Kara, H.; Demir, H.
Introduction: Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) levels in patients with cutaneous anthrax. Materials and methods: Fifteen patients with cutaneous anthrax and 15 healthy controls were enrolled in this study. The serum MDA levels, SOD levels, paraoxonase, arylesterase, and catalase activities were measured using a spectrophotometer. Results: The serum SOD levels, paraoxonase, arylesterase, and catalase activities were significantly lower in patients with cutaneous anthrax than in controls (for all, p < 0.001), whereas MDA levels were significantly higher (p < 0.001). No significant correlation was found between serum paraoxonase activity, arylesterase activity, SOD levels, and MDA levels (all, p > 0.05) in patients with cutaneous anthrax. Conclusions: The current study was the first to show decreased antioxidant levels and increased oxidant levels in patients with cutaneous anthrax. Therefore, decreased PON1 activity may play a role in the pathogenesis of cutaneous anthrax.