Browsing by Author "Karagoz, A."

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Elastic Characteristics of the Aorta in Patients With a New Diagnosis of Metabolic Syndrome
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Çakmak, E.Ö.; Findikcioglu, U.; Erdogan, E.; Zencirci, E.; Karagoz, A.; Celik, F.S.E.; Soylu, Ö.
Metabolic syndrome (MS) is a known risk factor of cardiovascular disease. However, it is not identified whether MS made alterations in the elasticity of the aorta in the early period before significant atherosclerosis occurred. The purpose of the study was to evaluate aortic elastic properties of patients who were newly diagnosed with MS. The research was performed among 100 patients of newly diagnosed MS (49 males; mean age 46 ± 9 years) with normal sinus rhythm, and 55 cases without MS (29 males; mean age 45 ± 9 years), matched by age. All participants underwent comprehensive physical and cardiological examination, biochemical examination, anthropological measurement and echocardiography. Aortic diameter change was significantly lower in MS group compared to control group (0.014 ± 0.04 vs 0.25 ± 0.1, p <0.01), aortic stiffness was significantly higher in the MS group (10.65 ± 4.52 vs 5.7 ± 2.42, p<0.01) compared to the age-matched control group. Multiple regression analysis shows that there is an independent relationship with each of the age, body mass index, HDL cholesterol and systolic blood pressure. Aortic stiffness index was higher in newly diagnosed MS patients compared to the control group. The vascular system can be affected even without diabetes, hypertension, hyperlipidemia, and coronary artery disease, which is excluded by history and noninvasive evaluation. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Prevalence of Rotavirus Genotypes in Children Younger Than 5 Years of Age Before the Introduction of a Universal Rotavirus Vaccination Program: Report of Rotavirus Surveillance in Turkey
(Public Library of Science, 2014) Durmaz, R.; Kalaycioglu, A.T.; Acar, S.; Bakkaloglu, Z.; Karagoz, A.; Korukluoglu, G.; Temel, F.
Background: Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. Methods: Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rotavirus Surveillance Network. Rotavirus antigen was detected in the laboratories of participating hospitals by commercial serological tests such as latex agglutination, immunochromatographic test or enzyme immunoassay. Rotavirus G and P genotypes were determined by reverse transcription polymerase chain reaction (RT-PCR) using consensus primers detecting the VP7 and VP4 genes, followed by semi-nested type-specific multiplex PCR. Results: RT-PCR found rotavirus RNA in 1644 (78.2%) of the samples tested. The highest rate of rotavirus positivity (38.7%) was observed among children in the 13 to 24 month age group, followed by children in the age group of 25 to 36 months (28.3%). A total of eight different G types, six different P types, and 42 different G-P combinations were obtained. Four common G types (G1, G2, G3, and G9) and two common P types (P[8] and P[4]) accounted for 95.1% and 98.8% of the strains, respectively. G9P[8] was the most common G/P combination found in 40.5% of the strains followed by G1P[8] (21.6%), G2P[8] (9.3%), G2P[4] (6.5%), G3P[8] (3.5%), and finally, G4P[8] (3.4%). These six common genotypes included 83.7% of the strains tested in this study. The rate of uncommon genotypes was 14%. Conclusion: The majority of the strains analyzed belonged to the G1-G4 and G9 genotypes, suggesting high coverage of current rotavirus vaccines. This study also demonstrates a dramatic increase in G9 genotype across the country. © 2014 Durmaz et al.