Browsing by Author "Karahan, Tugba"

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Microwave-Assisted Fabrication of Agruni Trimetallic Nps With Their Antibacterial Vs Photocatalytic Efficiency for Remediation of Persistent Organic Pollutants
(Springer, 2024) Kocak, Yilmaz; Tiri, Rima Nour Elhouda; Aygun, Aysenur; Meydan, Ismet; Bennini, Nihed; Karahan, Tugba; Sen, Fatih
Antibiotic-resistant bacteria have long been a concern and become a public health problem around the world. Therefore, various methods are being tried to develop new-generation therapeutic agents against antibiotic resistance. One of these methods is biogenic nanoparticle (NP) synthesis. Besides the antibacterial properties of biogenic NPs, it also contributes to the solution of the environmental toxic waste problem. In this study, we present a more environmentally friendly microwave approach to produce AgRuNi trimetallic nanoparticles (AgRuNi TNPs). The structural properties and chemical composition of TNPs were characterized by several techniques such as XRD, TEM, FTIR etc. The average particle size of AgRuNi TNPs was found to be 3.61 +/- 0.63 nm. For the removal of a persistent organic pollutant, such as methyl orange (MO) under solar irradiation, the photocatalytic activity of AgRuNi TNPs to remove MO dye was examined. The photodegradation percentage (%) of AgRuNi TNPs against MO dye after 300 min was calculated as 92%. Additionally, the antibacterial efficacy of the generated nanoparticles against gram (+) and gram (-) was evaluated. Overall, the current method to produce AgRuNi TNPs is based on the principles of green chemistry and pharmaceutical technology and shows promise for the creation of highly effective photocatalytic systems and the development of drug delivery systems to generate antibacterial activity.
Production of Plant-Based Zno Nps by Green Synthesis; Anticancer Activities and Photodegradation of Methylene Red Dye Under Sunlight
(Springer Heidelberg, 2024) Demir, Canan; Aygun, Aysenur; Gunduz, Meliha Koldemir; Altinok, Bahar Yilmaz; Karahan, Tugba; Meydan, Ismet; Sen, Fatih
Discharging wastewater from factories into streams without cleaning them causes environmental pollution and threatens the health of living beings. The photocatalysis method developed for easy, fast, and low-cost wastewater cleaning attracts considerable attention and therefore needs to synthesize efficient photocatalysts. In addition, the synthesized non-toxic catalysts can be tested as anticancer agents and may be suitable candidates to solve the issues facing cancer therapy today. Therefore, the synthesis of biogenic nanomaterials has gained importance. Plant-mediated green synthesis stands out in the simple, fast, cheap, and non-toxic production of nanoparticles (NPs). NPs produced by green synthesis are frequently used in biological applications such as anticancer and photocatalyst applications for cleaning wastewater. In this article, zinc oxide nanoparticles (ZnO NPs) were obtained using Zingiber officinale extract. The plant extract functions as a reducing, capping, and stabilizing agent in the green production of ZnO NPs. The synthesis of ZnO NPs was characterized using UV-Vis spectroscopy, FTIR, XRD, and TEM. TEM results show that ZnO NPs have sizes in the range of 10-45 nm. The anticancer activity of ZnO NPs was examined against HT29 (ATCC (R) HTB-38 (TM)) colorectal cancer cell line and HepG2 (ATCC (R) HB-8065 (TM)) hepatocellular cancer cell line by MTT assay. The IC50 values of ZnO NPs against HT29 and HepG2 cancer cell lines after 48 h were calculated as 20 mu g/mL and 45 mu g/mL, respectively. Additionally, the photocatalytic activity of ZnO NPs was tested against methylene red azo dye under sunlight and 87.96% (pH 7) photodegradation was obtained at the end of the 120th minute. It is predicted that ZnO NPs can be used effectively in both anticancer studies and environmental improvement.