Browsing by Author "Karahocagil, Mustafa K."

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Apparent Vaccine-Thimerosal Induced Hypersensitivity, Myelodysplastic Syndrome and Pancytopenia
(J infection developing Countries, 2007) Karsen, Hasan; Akdeniz, Hayrettin; Karahocagil, Mustafa K.; Baran, Ali I.; Erten, Remzi
A case of hypersensitivity reaction, myelodysplastic syndrome and pancytopenia, which developed after an administration of thimerosal-containing tetanus vaccine, is presented and discussed.
Brucellosis in Pregnancy: Results of Multicenter Id-Iri Study
(Springer, 2019) Inan, Asuman; Erdem, Hakan; Elaldi, Nazif; Gulsun, Serda; Karahocagil, Mustafa K.; Pekok, Abdullah U.; Beeching, Nicholas J.
Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
An Outbreak of Botulism in a Family in Eastern Anatolia Associated With Eating Silzme Yoghurt Buried Under Soil
(Taylor & Francis As, 2007) Akdeniz, Hayrettin; Buzgan, Turan; Tekin, Murat; Karsen, Hasan; Karahocagil, Mustafa K.
Cases of botulism in a family in eastern Anatolia were studied. In late September 2005, an outbreak of botulism developed in our region, first in 2 patients, a teenage boy and his mother, in whom the disease culminated in respiratory insufficiency and death. An additional 8 cases of botulism were identified later; most of them presented to our medical centre the next d. These patients with milder symptoms recovered gradually. All the patients received anti-botulinum toxin. The investigation of the source of the outbreak showed an unexpected vehicle for botulism infection in the these patients, suzme (condensed) yoghurt buried under soil. Type A botulinal toxin was detected in the yoghurt sample. The clinical diagnosis was also confirmed by a mouse bioassay performed with the serum samples of the patients. The most common symptoms were dry mouth, difficulty in speaking and swallowing, and change in voice quality. The 10 identified patients with botulism constitutes the largest-ever outbreak of botulism reported in Turkey to date. The present study shows the importance of considering a diagnosis of botulism soon after patients present with acute cranial nerve dysfunction and of promptly treating suspected cases with antitoxin.
Radiological Findings in Hepatobiliary Fascioliasis
(Ortadogu Ad Pres & Publ Co, 2009) Avcu, Serhat; Bora, Aydin; Arslan, Halil; Karahocagil, Mustafa K.; Sunnetcioglu, Mahmut
Objective: In this study, radiological findings of 24 relatives were evaluated who were diagnosed with hepatobiliary fascioliasis with serologic testing and examination of family members. Material and Methods: Twenty-four patients were evaluated by abdominal ultrasonography (US), 23 patients by computed tomography (CT) and 4 patients by magnetic resonance cholangiopancreatography (MRCP). Liver function tests, routine biochemistry, IgE and eosinophil levels were analysed in all patients. Ressults: Abdominal US detected pathology in 13 patients and no pathology in 11. CT was performed in 23 patients, and hepatobiliary lesions were detected in 20. Of the 6 cases with biliary dilatation, 4 peripheral enhancements of the bile ducts were noticed on CT examination. Mild biliary dilatation was observed in all of the 4 patients who were evaluated with MRCP and filling defects in the bile ducts were found in 2 of them. ELISA test for Fasciola hepatica was positive in all 24 patients. IgE level was elevated in 19 patients, and eosinophil level was elevated in 17 patients, Leucocyte level was elevated in 14 patients, and alcatene phosphatase level was elevated in 10 patients. Conclusion: In acute phase, CT is and high IgE and eosinophil levels with typical CT findings are significant in the diagnosis. The peripheral enhancement of extrahepatic bile ducts may be a clue for biliary involvement of the disease. MRCP is a useful method in demonstrating biliary dilatation and intraluminal filling defects, which correspond to parasites.