Browsing by Author "Karakus, Y."

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Chronic Immobilization Stress in Rats: Fluoxetine and Amisulpride Protects Against Chronic Immobilization Stress-Induced Biochemical Alterations
(Wiley-blackwell, 2016) Oto, G.; Ekin, S.; Karakus, Y.; Oksuz, E.; Ustun, R.; Ozdemir, H.
Protective Effect of Borax and Boric Acid on Total Sialic Acid and Lipid-Bound Sialic Acid Levels Against 3-Methylcholanthrene and Benzo(A)pyrene Induced Oxidative Stress in Rats
(Wiley-blackwell, 2016) Ekin, S.; Oto, G.; Gok, F.; Karakus, Y.; Yildiz, D.
Synthesis, Characterization, Antioxidant Properties and Dft Calculation of Some New Pyrimidine Derivatives
(Taylor and Francis Ltd., 2019) Akbas, E.; Ergan, E.; Sahin, E.; Ekin, S.; Cakir, M.; Karakus, Y.
In this study, 5-benzoyl-4-(4-(methylthio)phenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxo (1), oxo (2) and imino (3) pyrimidine derivatives were prepared via Multicomponent Cyclocondensation Reactions (MCRs). The compounds thiazolo[3,2-a]pyrimidin-3(5H)-one (4) and thiazin-4(6H)-one (5) were obtained via the reaction of compound 1 with bromoacetic acid and 3-bromopropionic acid, respectively. Structures were determined by using FT-IR, 1H/13C NMR and elemental analyses. Also the compounds 4 and 5 were analyzed by X-ray single crystal analysis. All compounds were investigated as corrosion inhibitors using density functional theory (DFT) at the level of B3LYP/6-31G (d, p). According to the calculations, the compound 3 appears to be a good inhibitor for corrosion. On the other hand, total antioxidant properties were measured in vitro by DPPH•, ABTS•+ test, hemolysis of phenylhydrazine erythrocytes and metal chelating effect. The results were compared with standard antioxidants such as trolox and α-tocopherol. These data revealed that compounds 1, 2 and 5 are more active with respect to 3 and 4 in scavenging the radicals. © 2018, © 2018 Taylor & Francis Group, LLC.