Browsing by Author "Karakus, Yagmur"

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Antioxidant Enzyme Activities, Total Sialic Acid, Vitamin, and Trace Element Status in the Patient With Osteoporosis and Osteopenia
(Springer, 2024) Karakus, Yagmur; Ekin, Suat; Ilter, Server; Ediz, Levent; Ekin, Emre Can
In this study, osteoporosis (OS), osteopenia (OP), postmenopausal women with osteoporosis (PMOS) and osteopenia (PMOP), and control participants were evaluated for erythrocyte. CAT, GSH-Px, SOD enzyme activities, MDA, GSH, serum phylloquinone, cholecalciferol, retinol, alpha-tocopherol, TSA, TAS, Co, Mn, Fe, Zn, Cu, Se, Ni, Cd, Pb, Mg, Ca, P, K, Cl levels, and the relations of parameters (F-L-BMD, LT-FT-score) were assessed. In this study, element analyses were carried out using ICP-OES and vitamin determination using the HPLC method. Statistical analyses showed that the OS group had significantly lower FBMD (p < 0.001), LBMD (p < 0.001), GSH (p < 0.01), GSH-Px (p < 0.001), CAT (p < 0.001), alpha-tocopherol (p < 0.05), retinol (p < 0.05), cholecalciferol (p < 0.001), phylloquinone (p < 0.01), Se (p < 0.01), Fe (p < 0.05), Cu (p < 0.05), Co (p < 0.001), Zn (p < 0.001), and Mg (p < 0.01) levels than the control group. However, levels of SOD (p < 0.05) and MDA (p < 0.01) are significantly higher than the control group. It was revealed that there is a significant correlation between Mn-L BMD (r = 0.426; p = 0.024), retinol-L BMD (r = 0.502; p = 0.007), cholecalciferol-L BMD (r = - 0.520; p = 0.005), and with OP; also between retinol-L BMD (r = 0.607; p = 0.008) and with PMOS; also between K-F BMD (r = - 0.504; p = 0.009), Co-LT score (r = - 0.432; p = 0.031) and with PMOP. Our study demonstrates that lower retinol, Co, and Mn and increased OSI and K levels are significantly related to decreased L BMD and F BMD status and oxidative stress in OP, PMOS, and PMOP. A deficiency of Zn, Co, Se, cholecalciferol, and phylloquinone can be a risk factor for the progression of OS, OP, PMOS, and PMOP and could have a negative effect on bone density.
Assessment of Antioxidant Enzymes, Total Sialic Acid, Lipid Bound Sialic Acid, Vitamins and Selected Amino Acids in Children With Phenylketonuria
(Springernature, 2018) Ekin, Suat; Dogan, Murat; Gok, Fazilet; Karakus, Yagmur
Background: In this study, children with phenylketonuria and healthy control subjects were assessed for glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) activity, malondialdehyde (MDA), glutathione (GSH), retinol, cholecalciferol, alpha-tocopherol, phylloquinone, total sialic acid (TSA), lipid bound sialic acid (LSA), total antioxidant (TAS), total oxidation (TOS), and amino acid levels, and the relationships of these variables with phenylketonuria were evaluated. METHODS: The study included 60 children with phenylketonuria and 30 control subjects. Children with phenylketonuria were divided into hyperphenylalaninemia (HPA) and amino acid mixture (AAM) groups. RESULTS: The HPA group had significantly lower levels of GSH-Px, CAT, GSH, TAS, alpha-aminobutyric acid, and taurine levels (p < 0.01, p < 0.05, p < 0.05, p < 0.001, p < 0.01, p < 0.05, respectively) than the control group. Additionally, the AAM group had significantly lower levels of CAT, TAS, and phylloquinones (p < 0.05, p < 0.05, p < 0.05, respectively) than the control group. It was observed in our study that in the HPA group, a significantly strong positive linear correlation was observed between phenylalanine and alpha-aminoadipic acid (r = 0.777; p = 0.002). CONCLUSIONS: It was concluded that the levels of alpha-aminoadipic acid and phylloquinone might be an appropriate choice for the determination of phenylketonuria in parallel with the levels of phenylalanine. alpha-aminobutyric acid and phylloquinone as a supplement can decrease HPA damage.
The Evaluation of Serum Total Sialic Acid and Lipid-Bound Sialic Acid Levels in Chronically Exposed Rats To 7,12-Dimethylbenz(a)anthracene and Fluoride
(Amer inst Physics, 2017) Oto, Gokhan; Ekin, Suat; Uyar, Hasan; Ozdemir, Hulya; Yildiz, Damla; Karakus, Yagmur
In this study, changes in serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were examined in chronically exposed rats to 7,12-dimethylbenz(a)anthracene (DMBA) and fluoride. This study demonstrated that the TSA, LSA levels increased more in DMBA-treated groups compared to the fluoride treated groups. The result obtained has shown that the harmful effect of DMBA which is also causing more cell membrane damage on human and animal health should be taken into consideration.
The Role of Trace Element, Mineral, Vitamin and Total Antioxidant Status in Women With Habitual Abortion
(Taylor & Francis Ltd, 2021) Sami, Awaz Sayfallah; Suat, Ekin; Alkis, Ismet; Karakus, Yagmur; Guler, Seyithan
Objective: In this study, women with habitual abortus (HA) and healthy control groups were determined for zinc (Zn), copper (Cu), manganese (Mn), selenium (Se), iron (Fe), cobalt (Co), chromium (Cr), nickel (Ni), lead (Pb), magnesium (Mg), calcium (Ca), sodium (Na), potassium (K), retinol, cholecalciferol, alpha-tocopherol, phylloquinone, total antioxidant (TAS) and total oxidation status (TOS) levels, also, and the relationships of these variables with HA were evaluated. Material and methods: The study included 39 women with HA and 39 healthy control subjects. In this study, trace element and mineral analyses by ICP-OES and vitamin analyses were determined using HPLC method. Results: Statistical analysis found that in the HA group was significantly lower than the control group with regarding cholecalciferol, phylloquinone, TAS, Se, Zn, Cu, Mg, K and Na levels (p < .05, p < .01, p < .01, p < .001, p < .05, p < .05, p < .01, p < .01 and p < .05). However, HA group was also significantly higher than control group regards to TOS, OSI and Ca forward slash Mg levels (p < .05, p < .001, p < .05). In the HA group, significantly positive correlations were observed between phylloquinone and Ca (r = 0.495; p = .027), also, indicates negative significant correlation between cholecalciferol and Co (r = -0.598; p = .031). Conclusion: Our findings indicate that the results could be helpful in the monitoring of women with HA in terms of deficiency. It is important that in terms of the evaluation of phylloquinone, cholecalciferol Se, Zn, Cu, Mg and Ca/Mg ratio is required to consider.
Synthesis, Dft Calculations, Spectroscopy and in Vitro Antioxidant Activity Studies on 4-Hydroxyphenyl Substituted Thiopyrimidine Derivatives
(Elsevier, 2018) Akbas, Esvet; Ekin, Suat; Ergan, Erdem; Karakus, Yagmur
4-Hydroxyphenyl substituted thiopyrimidine derivatives have been synthesized with the starting compound 5-benzoyl-6-phenyl-4-(4-hydroxyphenyl)-1,2,3,4-tetrahydro-2-thioxopyrimidine (1). The compounds optimized geometrically with DFT in Gaussian at the B3LYP/6-31G (d, p) level in order to obtain information about the 3D geometries and electronic structures. The structures were characterized on the basis of H-1 NMR, C-13 NMR, FT-IR, and elemental analysis. All compounds tested in vitro in order to assess their antioxidant activity. On the biological properties including of free radical scavenging ability (DPPH center dot), ABTS(center dot+) assay, PhNHNH2 (phenyl hydrazine) induced haemolysis of erythrocytes and metal chelating activities were performed. The results were compared to standard antioxidants, such as alpha-tocopherol and trolox. The conclusion shows that the compounds thioxopyrimidine (1), dihydropyrimido [2,1-b][1,3]thiazin-4(6H)-one (4) and dihydropyrimidin-2(1H)-ylidene) malonate (5) exhibit a stronger antioxidant activity than the other derivatives. (C) 2018 Elsevier B.V. All rights reserved.