Browsing by Author "Karaman, E."

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Amniocentesis Results of Van and Surrounding Provinces Between 2018 and 2020: a Tertiary Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Küçükbaş, G.N.; Dirik, D.; Karaaslan, O.; Karaman, E.; Kolusari, A.; Aymelek, H.S.; Şahin, H.G.
Amniocentesis is one of the safest procedures of prenatal diagnosis. This study aimed to show amniocentesis indications, rate of successful amniocyte culture, complications and outcomes of these pregnancies undergoing prenatal diagnosis in eastern part of Turkey, especially Van province and its nearby. Between 2018 and 2020, 253 patients were referred to our center for amniocentesis and 120 patients giving consent were enrolled from Van and its surrounding provinces. The most frequent indication was high risk in prenatal screening tests whereas the highest chromosomal abnormality was found in fetuses with abnormal ultrasonographic findings. Overall, 11.6% of fetuses had chromosomal anomaly. The most abundant chromosomal abnormality was Trisomy 21, followed by trisomy 18 and 13. Except one case with amniotic leakage no complications were found. Eleven pregnancies were terminated whereas one fetus was born with Turner syndrome and two pregnancies resulted with stillbirth. In conclusion, fetuses with abnormal ultrasound screening had higher chromosome anomaly diagnosed by amniocentesis and compatible with the literature, amniocentesis is a safe and successful method of prenatal diagnosis of chromosomal abnormalities. Van and its surrounding provinces showed a high rate of chromosomal anomaly when prenatal diagnosis was done. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Analysis of Patients With Cytology Negative and Hpv 16/18 Positive on Cervical Cancer Screening Program: Experience From a Single Center in Eastern Region of Turkey
(Lippincott Williams & Wilkins, 2017) Karaman, E.; Alkis, I.; Kolusari, A.
Clinical Evaluation of Pulmonary Thromboembolism in Gynecologic Oncology Operations: Analysis of Nine Patients in a University Hospital
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Karaman, E.; Aydıner, B.; Çilingir, B.M.; Hacıoğlu, L.
To investigate the cases of pulmonary thromboembolism (PTE) and to analyze the risk factors in patients undergoing gynecologic oncology operations. Material and methods: The medical records of all patients who underwent gynecologic oncology surgery from January 2015 to September 2022 were collected from the hospital’s database. Cases with the di agnosis of PTE were retrieved and analyzed retrospectively. Dokuz cases of clinically apparent PTE were identified in the medical records. The mean age of the patients was 56.1 ±3.4. The mean BMI was 27.2±1.4. The majority of the cases were advanced stage ovarian malignancy who underwent a major surgery including pelvic-paraaortic lymphadenectomy (5/9). Dyspnea and shortness of breath was the main complaint. Tachypnea was the main finding in all cases. The leukocytosis and the thrombocytosis were notable in PTE cases. PTE remains as one of the fatal complications after gynecologic surgeries. In our case-cohort, increasing age, obesity and the complexity of surgery are significant predictors of pulmonary embolism in gynecologic oncology operations. Further multicenter studies stratifying risk factors are warranted to reach a proper prophylactic strategy and prevent PTE. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effect of Neuromuscular Electrical Stimulation Therapy on Stress Urinary Incontinence Recurrence: a Randomized Prospective Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Karaman, E.; Kaplan, Ş.; Kolusarı, A.
The urinary incontinence poses a health problem in community. The standard care for stress urinary incontinence (UI) i s surgical therapy. However there are several methods for prevetion of UI recurrence in these patients. Here, we aimed to evaluate the effect of functional electrical stimulation therapy on stress urinary incontinence recurrence in the postoperative period. Patients who had stress UI and underwent anti-incontinence surgery in our University's Hospital Gynecology Department were randomly divided into two groups. The group 1 received postoperative electrical stimulation of pelvic floor muscles twice in a week (30 minutes) for 4 weeks plus Kegel's exercise and group 2 received only postoperative Kegel's exercise for prevetention of UI recurrence. After completion of therapy, the patients were assesed for urinary recurrence by Wagner's Quality of Life scores Turkish version, pad test and urinary diary. A total of 48 patients were included in the study. All patients had anti-incontinence surgery of which 39 had transvaginal tape (TVT), 7 had transobturator tape (TOT) procedure an 2 had Burch colposuspension. The main predominant diagnosis was Stress UI in all cases. 20 patients included in group 1 and underwent electrical stimulation with Kegel's exercise and 28 patients included in group 2 which had only Kegel's exercise in postoperative period of one month. The demographic characteristic in terms of age, body mass index, gravidity, parity and co-morbid disease did not show any statistical difference(P>0.05). The rate of recurrence in UI was significantly lower in Group 1 than Group 2, respectively (2/20, 10% vs 5/28, 17.8%, p<0.05). The mean Qulaity of life scores in group 1 was statistically significantly lower than group 2(7.3±6.2 vs 18.4±6.52, p<0.05). The pad test result did not show any statistical difference (5.4±4.2 gr vs 7.4±6.4 gr, p>0.05). The electrical stimulation of pelvic floor muscles in postoperative period seems to be effective in prevention of UI recurrence and may be a good strategy to improve the Quality of Life of patients. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effect of Super-Oxidized Water on the Tissues of Uterus and Ovary: an Experimental Rat Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Aras, A.; Karaman, E.; Çim, N.; Yıldırım, S.; Kızıltan, R.; Yılmaz, Ö.
Super-oxidized solutions are known to be potent disinfectants for external surfaces and also for wound care. There are limited data about the use of superoxidized water in the intraperitoneal organs. The aim of the present study was to evalaute its effect on the uterus and ovary when applied via intraperitoneal infusion in a rat model. Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into three groups (10 rats/group). Group1(control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2(single dose group) rats received single dose of 10 mg/kg pH-neutral SOW intraperitoneally. Group 3(multiple doses group) rats received multiple doses of 10 mg/kg pH-neutral SOW intraperitoneall at first, third and fifth days. All animals were sacrificed at one week after infusion. The macro- and microscopic histopathological examinations were performed for each rat. All rats remained healthy follow up of one week. The macroscopic examinations of the three groups showed no significant differences. No toxicity findings were found in three groups. The microscopic examinations revealed active endometial glandular structures in uterus and functional follicules at different stages of maturation in ovary. There were no significant differences with regards to the microscopic findings between three groups. Intraperitoneal infusion of pH-neutral SOW does not result in any significant toxicity and complications on the tissues of uterus and ovary. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effectiveness of Laparoscopic Training Box on Learning Curve in Gynecology Residents
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Karaman, E.; Şahin, H.G.
Laparoscopy poses a significant role in routine surgical operations recently. However, it needs a surgical skill and educatio n programs to be applied safely and effectively. The aim of this study was to investigate the impact of laparoscopic training box practice on the learning curve in gynecology residents. The study was conducted over for 6 months at our hospital laparoscopic simulation room. Twenty gynecology reside nts; aged range of 26 to 35 years, of either sex, who had not to have senior experience on laparoscopy were attended the education program. Each participant was given a list of tasks to perform during the six months of a training program. Each resident were allowed to work on a training box every two days of the week for six months. The baseline and sixth months evaluation scores were recorded. The recommended tasks were as: task 1 (loops and wire), task 2 (pea on a peg), task 3 (post and sleeve), task 4 (wire chaser), task 5 (holding the needle), and task 6(suturing and knot tying). Each task’s time was measured from start to completion and the time was recorded at baseline and the sixth months of the training program. The mean age of the participants was 28.3±1.8 and 12 were female and 8 were male residents. The mean scores of time taken to perform tasks at baseline evaluation were as follows: task 1 (32±8, second), task 2(34±6, second), task 3(50±10, second), task 4(34±5, second), task 5(60±12, second), task 6(300±100, second). The mean scores of time taken to perform tasks at 6th month of the evaluation were as follows: task 1 (22±4, second), task 2 (18±6, second), task 3 (34±8, second), task 4 (22±4, second), task 5 (40±8, second), task 6(250±50, second). When analyzing the improvement in surgical skill about concerning the time of task completion. There was a statistically significant difference between the baseline and at the 6th months of the training program (p<0.05). The present study confirmed that laparoscopic training box improved the surgical skills of gynecology residents and was found to be effective for improvement of learning curve in the education of minimally invasive surgery practice. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Epidemiology and Clinical Features of Preeclampsia
(Nova Science Publishers, Inc., 2020) Karaman, E.; Dirik, D.; Karaaslan, O.; Rapisarda, A.M.C.; Fichera, M.; Karaman, Y.
Preeclampsia is one of most important hypertensive disorders of pregnancy. It is characterized by the new onset of hypertension and proteinuria, or of hypertension and significant end-organ dysfunction with or without proteinuria, in the last half of gestation or postpartum. It complicates about 2-8% of gestations and it is a well-known cause of maternal-perinatal morbidity and mortality. The risk factors for development of preeclampsia include genetic factors, sperm exposure, maternal smoking, pre-existing medical conditions (such as hypertension, diabetes mellitus, chronic kidney disease and anti-phospholipid syndrome), and miscellaneous ones such as nulliparity, older maternal age and obesity. The clinical presentation of preeclampsia is varied. The main symptoms are headache, visual symptoms (including blindness), epigastric pain or nausea and vomiting. Preeclampsia is classified as mild and severe based on the degree of hypertension, laboratory and clinical findings. The most severe form is the development of eclampsia and HELLP syndrome. © 2020 by Nova Science Publishers, Inc. All rights reserved.
Evaluation of Fetal Central Nervous System Anomalies Diagnosed Prenatally: Prenatal and Postnatal Outcomes
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Bağcı, M.; Uçkan, K.; Şahin, H.G.; Karaaslan, O.; Karaman, E.; Başkıran, Y.
Introduction: The aim of this study is to examine the diagnosis types and rates of patients with central nervous system (CNS) anomalies detected in the prenatal period between 2021-2022 in our perinatology clinic and to contribute to the literature. Materials and Methods: Our study included 191 patients with CNS anomaly and whose pregnancy results were reached. Demographic characteristics of the patients, additional detected anomalies, fetal Magnetic Resonance Imaging (MRI) and genetic results, o bstetric and neonatal results were evaluated if requested. Results: Neural tube defects (NTD) were found most frequently at 75.3%, and among these, acrania was found most frequently at 27.2%. While 74.3% of the detected CNS anomalies were isolated anomalies, it was found that 5.2% were accompanied by additional CNS anomalies and 21.9% were accompanied by additional extracranial anomalies. Abnormal karyotype was obtained in 12.1% of the pa tients who wanted to have a prenatal diagnosis test. It was found that 11% of the patients requested fetal MRI and ventriculomegaly was the most common fetal MRI indication. While the pregnancies of 56.5% of the patients were terminated, 37.7% of them gave live bir ths. The rate of surgical intervention in live-born babies with CNS anomalies was found to be 56.9%. A total mortality rate of 43% was found in live-born babies. Conclusion: Since CNS anomalies are associated with serious morbidity and mortality; Prenatal diagnosis is very important so that families can be offered a pregnancy termination option and those who will continue to be pregnant should be informed about the treatment and rehabilitation processes of their babies. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Hemoglobin A1c Levels in Endometrial Cancer Patients: a Retrospective Study in Turkey
(Asian Pacific Organization for Cancer Prevention, 2015) Karaman, E.; Karaman, Y.; Numanoglu, C.; Ark, H.C.
Background: Hemoglobin A1c(HgA1c) is a marker of poor gylcemic control and elevation HgA1c is associated with increased risk of many cancers. We aimed to determine the HgA1c levels in endometrial cancer cases and any relationship with stage and grade of disease. Materials and Methods: A retrospective data review was performed between June 2011 and October 2012 at a tertiary referral center in Turkey. The study included 35 surgically staged endometrial cancer patients and 40 healthy controls. Preoperative HgA1c levels drawn within 3 months before surgery were compared. Also the relationships between HgA1c levels and stage, grade and hystologic type of cancer cases were evaluated. Results: The mean HgA1c levels were statistically significantly higher at 6.19±1.44 in endometrial cancer cases than the 5.61±0.58 in controls (p=0.027). With endometrial cancer cases, the mean HgA1c level was found to be 6.62±1.40 for stage I and 6.88±1.15 for stages II-IV (p=0.07). The figures were 6.74±1.65 for endometrioid and 6.63±1.41 for non-endometrioid type tumors (p=0.56). Mean HgA1c levels of 6.72±1.14 for grade 1 and 6.62±1.42 for grade 2-3 were observed (p=0.57). Conclusions: HgA1c levels in endometrial cancer patients were statistically higher than healthy controls. However, HgA1c did not show any significant correlation with stage, grade and histologic type in endometrial cancer cases.
Evaluation of Maternal Thyroid Autoimmune Status in Gestational Trophoblastic Disorders
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Karaman, E.; Çetin, O.; Çim, N.; Kolusarı, A.; Güler, S.; Yıldızhan, R.; Şahin, H.G.
To investigate the maternal autoimmune status of patients with molar pregnancies. The study was conducted at Yuzuncu Yil University, Department of Obstetrics and Gynecology between January 2012 and June 2016. The medical records of patients who were diagnosed and followed for complete and partial molar pregnancies were reviewed retrospectively. The data of patients who were studied for maternal thyroid auto-antibodies including AntiThyroid peroxidase (TPO) and Anti-Tyroglobulin (Tg) were included in the study. The mean maternal age of complete molar pregnancies were significantly higher than partial molar pregnancies (p=0.010). There were no significant differences between two groups in terms of beta-hCG, TSH, and free T4 (p=0.815, p=0.204, and p=0.072, respectively). None of the patients were anti-TPO positive in the study. There was no significant difference in anti-thyroglobulin positivity between the two groups (p=0.950). Maternal thyroid autoantibody status did not show any difference between the partial and complete molar pregnancies. Thyroid dysfunction seen in molar pregnancies seems to be due to the stimulation of follicular cell receptors with hCG rather than auto-antibodies against thyroid gland. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Peripartum Hysterectomy; Ten Years of Experience of a Tertiary Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Dirik, D.; Karaman, E.; Okyay, T.Y.; Kucukbas, G.N.; Karaaslan, O.; Alkiş, I.; Kolusari, A.
The objective of this study is to assess the 10-year incidence of peripartum hysterectomy that was performed in the province of Van, Turkey, as well as its clinical results. In this study, we retrospectively examined all patients who underwent peripartum hysterectomy, which was performed at Van Yuzuncu Yil University Dursun Odabas Medical Center between 2010 and 2020. 99 patients who underwent hysterectomy due to severe bleeding, which could not be stopped despite conservative tre atments within 24 hours following the delivery, were included in the study. The overall rate of peripartum hysterectomy was 99 of 22242 or 4.4 per 1,000 deliveries. The mean maternal age was 31.98 ± 5.41 years. The most common indications for peripartum hysterectomy are placental adhesion disorders (70.7%), uterine atony (25.2%), and uterine rupture (4%). Ultimately, the most common indication for peripartum hysterectomy is placental adhesion disorders. The rise in the number of cesarean section might have increased the incidence of placental adhesion disorders. Thus, patients should be provided with healthcare in centers that have adequate equipment and staff. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Fertility Preservation in Benign Gynecological Diseases: Current Approaches and Future Perspectives
(Avicenna Research Institute, 2019) Sleiman, Z.; Karaman, E.; Terzic, M.; Terzic, S.; Falzone, G.; Garzon, S.
Although fertility preservation is a growing topic in the management of oncological diseases, different benign gynecological pathologies are able to compromise the ovarian reserve due to mechanisms related to the pathology itself or secondary to the performed treatments. Endometriosis, benign ovarian tumors, adnexal torsion, familiarity and genetic syndromes are all benign conditions that can compromise the ovarian reserve. Endometriosis and particularly endometriomas provide a direct damage to ovarian reserve, with different mechanisms, and an indirect damage related to surgery. Similarly, benign ovarian tumors can provide a detrimental effect on ovarian reserve for the surgical treatment, especially for bilateral or recurrent tumors, and in case of secondary adnexal torsion with late diagnosis. Different fertility preservation options are available and should be considered particularly in cases with bilateral or recurrent pathology and/or surgery. In general, the identification of patients at risk of early ovarian failure, for benign gynecological disease or based on known genetic causes or familiarity, is of paramount importance in order to apply fertility preservation techniques before the complete depletion of ovarian reserve. © 2019 Avicenna Research Institute. All rights reserved.
Is There Any Association Between Fetal Nervous System Anomalies and Heavy Metal-Trace Element Levels in Amniotic Fluid
(I R O G Canada, inc, 2018) Cim, N.; Tolunay, H. E.; Boza, B.; Bilici, M.; Karaman, E.; Cetin, O.; Sahin, H. G.
Aim: In this study the authors aimed to evaluate whether there are any causal relationship between heavy metals-trace elements and fetal malformations of central nervous system (CNS). Materials and Methods: The study group consisted of pregnancies with fetal congenital nervous system anomaly (anencephaly, acrania, neural tube defects, etc.) in 16-22 weeks (n=36). Pregnancies with the same weeks of pregnancy who underwent amniocentesis due to high risk in triple test with the result of normal karyotype constituted the control group (n=30). In the both groups the authors analyzed the heavy metals and trace elements in amniotic fluid. Metals and elements were measured by using atomic absorption spectrophotometer technique with a UNICAM-929 spectrophotometer. Results: When compared, the groups were similar in terms of age, parity, BMI, and gestational week (p > 0.05). In fetal congenital anomaly group the authors detected low levels of copper (Cu) and zinc (Zn) rather than control groups (p < 0.05). In fetal congenital anomaly group they detected high levels of lead (Pb) and cadmium (Cd) rather than control groups (p < 0.05). Iron (Fe), manganese (Mn), cobalt (Co), nickel (Ni), and Cd levels were similar and there was no significantly difference between the groups (p > 0.05). Conclusion: This study can contribute benefits to the literature in terms of clarifying the pathogenesis of fetal congenital nervous system anomalies.
Management of Gastric Cancer With Liver Metastasis in a Pregnant Woman
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Cim, N.; Karaman, E.; Toktas, O.; Gunes, G.; Elci, E.; Andıc, E.; Yildizhan, R.
The complaints and symptoms of gastric cancer are non-specific and many of these symptoms are frequently masked by factors related to normal pregnancy. A 38 year-old woman with G10P8A1 and at 31 weeks of pregnancy was admitted to a maternity outpatients’ clinic complaining of nausea, vomiting and constipation during the previous 4 days. On palpation a solid lesion of 1.5 cm was palpable in the subxiphoid region. A solid nodule with largest diameter of 5 cm was observed on the liver and suspected to indicate metastasis. Under endoscopic examination, ulcerovegetan, fragile and malignant mass that surrounded and narrowed the gastric antrum and extended to an angular notch was seen. The biopsy that was taken from lesion was revealed to be the result of a malignant epithelial tumor of poorly differentiated adenocarcinoma. During the explorative laparotomy, a tumoral mass with multiple peripheral lymphadenopathies was observed in the posterior gastric antrum, pancreas and colon median entry-invasive artery. Multiple metastases were present in the omentum and liver with a large amount of acid in the abdomen. The patient was considered inoperable due to the gastric cancer being in a terminal stage and adjuvant chemotherapy was planned. Early diagnosis and treatment is important for the prognosis of gastric cancer. The complaints and symptoms of gastric cancer are non-specific and many of these symptoms are similar to those seen during a normal pregnancy. If the same symptoms recur during pregnancy or there is a failure to respond to therapy, the gastrointestinal system should be evaluated endoscopically. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Maternal and Fetal Outcomes in Caesarean Sections Repeated Fourth and Fifth Times
(Univ West indies Faculty Medical Sciences, 2021) Karaman, E.; Cim, N.; Cetin, O.; Oruc, H.; Gunes, G.; Yildizhan, R.
Objective: To evaluate the maternal and fetal outcomes associated with caesarean sections (CS) repeated fourth and fifth times. Methods: We performed a retrospective study of 110 patients undergoing CS repeated fourth and fifth times between May 2014 and May 2015. The patients were divided into two groups: group 1 had CS repeated four times (n = 90) and group 2 had CS repeated five times (n = 20), and the maternal and fetal outcomes of the groups were retrospectively evaluated. Results: There were no statistically significant differences between fourth and fifth CS groups with regard to the maternal age, gravida, body mass index, gestational age at birth, birth-weight, and Apgar scores at 5 minutes (p > 0.05). We found no significant differences between the fourth and fifth CS groups in terms of injury to peripheral organs, intra-abdominal adhesions, caesarean hysterectomy, uterine dehiscence or rupture, time during operation, length of hospital stay, and need for blood transfusions (p > 0.05). Compared with the elective cases, perioperative complications and length of hospital stay were significantly higher in the urgent group (p = 0.034 and p = 0.005). Conclusion: Women with CS repeated four or five times have increased risks for perioperative complications. Placenta previa with or without accreta and intra-abdominal adhesions seem to be the major causes of increased morbidity.
Maternal Serum Ischemia Modified Albumin Level Does Not Change in the Presence of Intrauterine Growth Restriction
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Çetin, O.; Karaman, E.; Tolunay, H.E.; Boza, B.; Cim, N.; Alisik, M.; Şahin, H.G.
Maternal vascular hypoperfusion is the most common cause of fetal growth restrict ion. Maternal oxidative status features are identifiable on placental pathology, and antepartum diagnostic methods are rapidly evolving. The current study was constructed to determine the maternal oxidative status by measuring serum ischemia modified album in (IMA) levels in pregnancies complicated with idiopathic intrauterine growth restriction (IUGR). The current study was designed as a descriptive and cohort trial. A total of 87 pregnant women; 45 healthy controls and 42 pregnancies complicated with idiopathic IUGR were included to the study population. Maternal serum IMA concentration was measured prior to the administration of any medication. The perinatal outcomes of patie nts were also recorded. Maternal serum IMA concentration in pregnancies complicated by idiopathic IUGR was higher than in healthy controls. There was no significant difference between the groups (0.54±0.04 versus 0.55±0.06 ABSU, p: 0.314). IUGR is a significant pregnancy complication. Elevated oxidative stress which leads to an ischemic microenvironment is associated with IUGR. Maternal serum IMA which is a possible marker for oxidative stress is not increase in pregnancies complicated with idiopathic IUGR. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Novel Therapies for Preeclampsia
(Nova Science Publishers, Inc., 2020) Mousavi, S.N.; Rapisarda, A.M.C.; Kahramanoglu, O.; Lin, L.-T.; Karaman, E.; Arcidiacono, G.; Fichera, M.
Preeclampsia is a serious condition that has complicated pregnancies for centuries. The angiogenic imbalance is a hallmark of preeclampsia, and angiogenic markers have proved to be effective tools for early diagnosis and prognosis of affected pregnancies. The only effective treatment for preeclampsia remains delivery, but novel therapies are being developed to ameliorate complications and prolong gestation. The aim of this chapter is to provide an updated overview of the most recent innovations and discoveries in the field of the treatment of preeclampsia. © 2020 by Nova Science Publishers, Inc. All rights reserved.
Ovarian Torsion During Pregnancy: a Case of Malignant Ovarian Cancer
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Hacıoğlu, L.; Karaman, E.; Dirik, D.; Karaaslan, O.; Kolusarı, A.; Şahin, H.G.; Gül, A.
Ovarian torsion is an acute and emergency condition during pregnancy. It is caused mainly by the benign cystic mass in the ovary. However, ovarian cancer may be seen as a cause which is very rare during pregnancy. Here, we aim to present a case of pregnant women with ovarian torsion and diagnosed with malignant ovarian tumor. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Pathogenesis of Placenta Accreta Spectrum
(Springer International Publishing, 2022) Karaman, E.; Dirik, D.; Karaaslan, O.
This chapter covers the underlying mechanisms and pathological processes that leads to the development of placenta accreta. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
Phytotherapy in Endometriosis: an Up-To Review
(De Gruyter Open Ltd, 2020) Corte, L.D.; Noventa, M.; Ciebiera, M.; Magliarditi, M.; Sleiman, Z.; Karaman, E.; Garzon, S.
Endometriosis is a benign gynecological disease which symptoms can provide a severe impact on patient's quality of life with subsequent impact on psychological well-being. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Nevertheless, the efficacy of conventional medical treatments is limited or intermittent in most of the patients due to the associated side effects. Therefore, a woman with endometriosis often search for additional and alternative options, and phytotherapy might be a promising alternative and complementary strategy. Different medicinal plants, multicomponent herbal preparations, and phytochemicals were investigated for pharmacological proprieties in endometriosis therapy. In most of the cases, the effect on endometriosis was related to phenolic compounds, such as flavonoids and phenolic acids reporting anti-inflammatory, proapoptotic, antioxidant, and immunomodulatory functions. Moreover, some phytochemicals have been related to a strong phytoestrogenic effect modulating the estrogen activity. Although promising, available evidence is based on in vitro and animal models of endometriosis with a limited number of well-performed clinical studies. There are almost none randomized control trials in this area. Therefore, properly constructed clinical trials are mandatory to achieve more conclusive results about the promising role of phytotherapy in the management of endometriosis. © 2019 Walter de Gruyter GmbH, Berlin/Boston.