Browsing by Author "Karaman, K."

Now showing 1 - 19 of 19

Acute Immune Thrombocytopenic Purpura Following Combined Vaccine
(Wiley-blackwell, 2015) Akbayram, S.; Karaman, K.; Akbayram, H. T.; Garipardic, M.; Oner, A. F.
An Analysis of Children With Brucellosis Associated With Haemophagocytic Lymphohistiocytosis
(2016) Karaman, K.; Akbayram, S.; Kaba, S.; Karaman, S.; Garipardiç, M.; Aydin, I.; Öner, A.F.
This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic disorder. All patients had an anamnesis for recently consumed unpasteurised homemade dairy products or had a contact history with sheep and/or cows. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titres were 1: 1280 in seven patients. Blood culture was positive for Brucella melitensis in three patients (42%). Bone marrow cultures were positive for B. melitensis in four patients (57%). Fever was present in all patients (100%) with haemophagocytic lymphohistiocytosis. The other most common symptoms were malaise, myalgia, anorexia, sweating and weight loss. In addition, sweating was observed in five patients, and lymphadenopathy, petechiae, and weight loss were observed in one patient. Hepatomegaly, splenomegaly, and hepatosplenomegaly were found in four (57%), six (85%) and four (57%), patients, respectively. Haemophagocytosis was documented in bone marrow examinations of all children except in two cases. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis.
Carotid Intima-Media Thickness and Lipid Profile in Children Patients With Hypothyroidism
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Çetin, M.; Eren, A.; Bitkin, E.Ç.; Yürektürk, E.; Goya, C.; Karaman, K.
Hypothyroidism is a condition where there is a decrease or absence of thyroid hormone production as a result of a disorder occurring anywhere in the hypothalamo-pituitary-thyroid axis. There are very few studies in the literature reporting on the effect of hypothyroidism on lipid metabolism and carotid intima-media thickness (CIMT) in children. The present study was designed to determine whether hypothyroidism is associated with an increase in the CIMT and lipid levels in patients under thyroid hormone replacement therapy. The study included 30 children (under thyroid hormone replacement therapy) diagnosed with hypothyroidi and a control group comprising 30 healthy, euthyroid children. All the patients were examined for clinical characteristics, and the serum lipid levels and the CIMT were measured. Mean age was 8.47 ± 5.22 years in the patient group and 8.82 ± 4.91 years in the control group. Patient group TSH value was significantly higher than control group (9.95 ± 18.43, 1.93 ± 1.04, p = 0.021, respectively). The t otal cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TG values were similar in both group (p = 0.065, p = 0.429, p = 0.219, and 0.391, respectively). CIMT values of the patient and control groups did not differ significantly ( 0.40 ± 0.08 and 0.39 ± 0.07, p = 0.920, respectively) In this study, contrary to the rare studies in the children's age group in the literature, no significant changes in lipid pr ofile and CIMT were detected in patients with hypothyroidism. Further prospective studies are needed to substantiate these findings in children with hypothyroidism. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Clinical and Haematological Manifestations of Typhoid Fever in Children in Eastern Turkey
(Univ West indies Faculty Medical Sciences, 2016) Akbayram, S.; Parlak, M.; Dogan, M.; Karasin, G.; Akbayram, H. T.; Karaman, K.
Objective: Typhoid fever can involve various organs, leading to a wide range of presentations: from uncomplicated to complicated typhoid fever. The haematological changes are common in typhoid fever and include anaemia, leucopaenia, thrombocytopaenia and bleeding diathesis. This study was undertaken in order to determine the clinical and haematological presentation of typhoid fever in children. Methods: In this study, records of children and adolescents with typhoid fever aged under or equal to 16 years, admitted to Yuzuncu Yil University Hospital between 2010 and 2014, were analysed retrospectively. Results: The cases (56%) were admitted to our hospital in July and October. Major symptoms of patients were abdominal pain (24%), arthralgia (21%) and fever (11%). In our study, decreased mean platelet volume (31%), eosinopaenia 20%), abnormal platelet count (19%), anaemia (16%), leucocytosis (16%) and eosinophilia (12%) were the most common haematological findings in the children. Conclusions: Typhoid fever is predominant in children at school age with a slight male predominance. Decreased mean platelet volume and abdominal pain might be useful as early diagnostic clues.
Clinical Outcome of Childhood Immune Thrombocytopenia: Experience From a Single Tertiary Center in Turkey
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Karaman, K.; Doğan, E.
Immune Thrombocytopenic Purpura (ITP) is the most common hemorrhagic disease in children. Intracranial hemorrhage is the most severe complication requiring the administration of treatment for immune thrombocytopenic purpur a. The present study aims to determine the clinical outcomes and factors affecting remission in childhood ITP. The study included 503 children diagnosed with ITP in a Pediatric Hematology Polyclinic. Patient files and electronic registries were accessed retrospectively to obtain sociodemographic details, and diagnostic and therapeutic characteristics. The mean age of the cases at the time of diagnosis was 6.18±4.30 years. Among all the cases, 446 (88.7%) were in remission. When the first treatments applied in cases with remission were evaluated, 190 (83.4%) patients had IVIG, 25 (56.8%) IVIG + pulse steroid, 34 (79%) pulse steroid, 7 (58%) IVIG + low dose steroid and 20 (83%) had low dose steroid treatment. Four cases developed intracranial hemorrhage during follow-up. The remission rate was significantly higher among the cases with low MPV (Mean platelet volume) values, high platelet counts and sedimentation values in the blood test at diagnosis (p<0.05). The responses to pulse steroids, low-dose steroids and IVIG for the initial treatment at diagnosis were similar, with none showing statistical superiority over any of the others (p>0.05). This study features the largest single-center study in pediatric ITP. The frequency of remission was higher in the ITP-diagnosed cases who were male, who were diagnosed at a younger age, who had no epistaxis on admission, who had a history of URTI, and who had a high platelet count and sedimentation value and a lower MPV value at diagnosis. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Concurrent Acute Rheumatic Fever and Acute Poststreptococcal Glomerulonephritis: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Çetin, M.; Gökçeoğlu, A.U.; Başaranoğlu, M.; Karaman, K.
Acute poststreptococcal glomerulonephritis and acute rheumatic fever are both postinfectious non-purulent sequelae of A group βhemolytic Streptococcus infections. In spite of prominent falls in the incidence, Acute Rheumatic Fever remains (ARF) an important cause of morbidity and mortality associated with acquired heart disease in underdeveloped territories. Acute poststreptococcal glomerulonephritis (APSGN) still remains a frequent form of glomerulonephritis in third-world countries, particularly in areas where the disease occurs in epidemics. Both diseases may be seen simultaneously in the same patient, but both diseases have different epidemiological, immunological and bacteriological features, however, this is a rare condition. We present a case of a 6.5 year old child with concurrent APSGN and ARF. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Determination of the Knowledge and Skills of Physicians Working in Emergency Services Against Judicial Incidents
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Moraligil, M.; Bozdemir, M.N.; İz, M.; Layik, M.E.; İz, F.B.A.; Karaman, K.
In our study, we aimed to determine the approach of physicians working in emergency services to forensic cases and to provide data for training on this subject. Our study was carried out between 10.06.2016-15.08.2016 with the physicians working in the emergency services across the country. In order to measure the level of knowledge of physicians in judicial cases, qualitative evaluation including questionnaires and cases were conducted. 496 physicians were participated in the study. The correct answer rates average of 74 questions asked to doctors about basic medical intervention was 85.6 ± 11.1%. Average of correct responding to questions about life-threatening was 70.3 ± 9.3% and the average of correct responding to all questions was 78.0 ± 7.7%. Among basic medical intervention, life-threatening and total, a positive correlation was found between the level of knowledge and age (p <0.05). The total and simple medical intervention knowledge of the men was found to be better than women (p <0.05). As a result, specialist doctors’ knowledge level was lower, general practitioners had the best knowledge level (p<0.05). It was detected that specialist physicians had a low level of knowledge in terms of basic medical intervention, life threatening condition and overall sum and it was determined that the best knowledge was possessed by practitioners (p<0.05). Life-threatening and the total level of knowledge was higher in physicians who attended the seminar (p<0.05). As a result, the knowledge level of physicians is inadequate on forensic medicine and should be increased with in-service training. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Effects of Hemarthrosis on Postural Balance in Children With Hemophilia a
(Wiley, 2018) Karaman, K.; Kaplan, S.; Cetin, M.; Geylan, H.; Sahin, A. Yasar; Arslan, O.; Oner, A. F.
Evaluation of the Causes of Early and Late Thrombocytopenia in the Newborn
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2018) Karaman, K.; Demir, N.; Çetin, M.; Geylan, H.; Değer, İ.; Başaranoğlu, M.; Öner, A.F.
Objective: Thrombocytopenia is the most common hematological disorder that is encountered in the neonatal intensive care unit (NICU). The incidence of thrombocytopenia in neonates may varies greatly depending upon admitted patients population of unit. This study was performed on neonates admitted to Yuzuncu Yil University of Dursun Odabaş Medical Center of NICU, the incidence and causes of thrombocytopenia. Material and Methods: This retrospective study was conducted on the medical records of all neonates hospitalized at our hospital between May 2012 and March 2015 and those with thrombocytopenia were included in the study. The laboratory results of these newborns were retrospectively screened from the computer program and files, and included in the study were those with a thrombocytopenia level of less than 150.000/μL. Results: About 2780 patients were admitted to our neonatal intensive care unit during the study period. Of the 2780 neonates, 117 (4.2%) had thrombocytopenia (60.7% early onset and 39.3% late onset). Seventy-two of them (61.5%) were preterm. Intrauterine growth restriction, maternal hypertension, respiratory distress syndrome and sepsis were more common causes. Severe thrombocytopenia (<50.000/µL rate was found in 27% of neonates. In addition, although the rate of thrombocytopenia in asfixia was reported in the literature as 12-14%, this rate was 6.8% in our cases. There was no relation between occurrence of thrombocytopenia and gender. Conclusion: This study reveals that the causes of neonatal thrombocytopenia may show variations. In our study, intrauterine growth restriction, maternal hypertension, respiratory distress syndrome, and sepsis seem to be important risk factors for thrombocytopenia in neonates. Copyright © 2018 by Türkiye Klinikleri.
Hematological Findings in 622 of Children With Brucellosis in Eastern Turkey
(Pergamon-elsevier Science Ltd, 2015) Akbayram, S.; Karaman, K.; Bayhan, G.; Akbayram, H.; Dogan, M.; Parlak, M.; Oner, A.
Identification of Three Novel Pathogenic Itga2b and One Novel Pathogenic Itgb3 Mutations in Patients With Hereditary Glanzmann's Thrombasthenia Living in Eastern Turkey
(Wiley, 2020) Karaman, K.; Yurekturk, E.; Geylan, H.; Yasar, A. S.; Karaman, S.; Cetin, M.; Oner, A. F.
Infantile Digital Fibromatosis (Inclusion Body Fibromatosis) Observed in a Baby Without Finger Involvement
(2013) Kaya, A.; Yuca, S.A.; Karaman, K.; Erten, R.; Dogan, M.; Bektas, M.S.; Ustyol, L.
A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. By superficial ultrasonography, multiple isoechoic hypoechoic lesions were observed among the muscle plan. In thoracolumbar magnetic resonance imaging, multiple massif lesions retaining peripheral contrast (the biggest was 1.7 × 1.4 cm large) had been observed under the skin muscle plans, between the muscles of the extremities. The biopsy was positive for smooth muscle actin, but negative for desmin, S100, and CD34. These findings were diagnosed as infantile digital fibromatosis (IDF) (inclusion body fibromatosis). The case was presented with an objective to illustrate and remind that IDF can be observed in babies without finger involvement.
Investigation of Correlations Between Joint Health, Functionality, and Mri Score in Hemophilic Arthropathy of the Elbow Joint: Cross-Sectional Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Tat, A.M.; Özkan, S.; Tat, N.M.; Karaman, K.; Öner, A.F.
Hemophilic arthropathy (HA) of the elbow joint should be examined separately from the knee and ankle because of the anatomical and biomechanical differences of the elbow. The aim is to investigate possible correlations between age, range of motion (ROM), muscle strength, upper extremity functions, joint health and radiological findings. Twenty-seven joints of 20 patients aged 11-30 years with findings of HA in elbow were evaluated. International Prophylaxis Study Group Magnetic Resonance Imaging (IPSG MRI) score was used in the radiological evaluation. In physical evaluations, ROM and muscle strength were measured by goniometer and digital dynamometer, respectively. Joint health was evaluated with Hemophilia Joint Health Score-Elbow Point (HJHS-EP) and upper extremity functionality with Quick-Disability of Arm Shoulder and Hand (Q-DASH). The age was strongly correlated with HJHS-EP, loss of extension and pronation ROM and moderately correlated with IPSG MRI score. HJHS-EP showed strong correlation with loss of extension. There were a moderate correlation between Q-DASH and muscle strength of the elbow. The IPSG MRI scores were not significantly correlated with physical examinations. The elbow joint should be evaluated both radiographically and physically and these assessments cannot be alternatives to each other. Even goniometric assessment of elbow extension alone may provide important information about joint health. Functionality can be improved by increasing muscle strength. Since the deterioration in physical and radiographic examinations with age, it is recommended to conservatively or surgically treat of the elbow joint with physiotherapy at early ages. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Levels of Vitamin B12, Folate, and Homocysteine in a Population With High Prevalence of Neural Tube Defects
(Springer, 2016) Peker, E.; Demir, N.; Tuncer, O.; Ustyol, L.; Balaharoglu, R.; Kaba, S.; Karaman, K.
Response To Letter: Effectivity of Pancreatic Enzyme Replacement Therapy in Malnourished Children
(Lippincott Williams and Wilkins, 2020) Güven, B.; Mis, M.D.; Karaman, K.; Yaşar, A.Ş.
Role of Circulating Nesfatin-1 in the Underweight Children With Poor Appetite
(verduci Publisher, 2015) Kaba, S.; Karaman, K.; Komuroglu, U.; Bala, K. A.; Demir, N.; Kocaman, S.; Ceylan, N.
OBJECTIVE: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. PATIENTS AND METHODS: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age-and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. RESULTS: Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p < 0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. CONCLUSIONS: Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.
Seropositivity of Toxoplasma Gondii Among Blood Donors and Patients With Hematologic Malignity
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Yıldız, S.; Esen, R.; Karaman, K.; Beyhan, Y.E.
Toxoplasma gondii (T. gondii) is an opportunistic parasite. Transmission from T. gondii-infected donors to recipients is possible through blood and organ transplantation. In this study, it was aimed to investigate the presen ce of T. gondii antibodies in healthy donors and in blood recipients with immunosuppressed hematological malignancies. A total of 92 patients included in the present study (46 donors and 46 patients). Sixteen of the hematological patients had lymphoblastic leukemia and 14 had acute myeloblastic leukemia. The presence of IgG and IgM Toxoplasma antibodies and IgG avidity values were investigated by ELISA. Twenty-two (47.8%) of patients and 11 (23.9%) of the donors were found to be positive for T.gondii IgG antibodies. IgG positivity was detected in all patient groups except those with aplastic anemia. The highest IgG positivity was found in acute myeloblastic leukemia (8) and lymphoblastic leukemia (5). IgM seropositivity was detected totally three cases (3.3%), two of 46 patients (4.3%) and one 46 of donors (2.2%). Although the number was low, all patients with chronic myeloid leukemia were detected both IgG and IgM positive (100%). Low avidity was found in all three of the IgM positive cases. Considering that toxoplasmosis is an infection that causes severe clinical symptoms and death, routine diagnostic methods that detect the presence of parasites in donor and patient groups will be beneficial for the prevention of T.gondii transmission. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Two Cases With Familial Hemophagocytic Lymphohistiocytosis
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2018) Geylan, H.; Karaman, K.; Çetin, M.
Hemophagocytic lymphohistiocytosis (HLH) is a fatal condition of severe hyperin-flammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. The perforin gene mutation was the first genetic deffect to be described in association with HLH. HLH is a distinct clinical entity characterized by fever, pancytopenia, splenomegaly and hemophagocytosis in bone marrow, liver or lymph nodes. We present phenotypical and labaratory description of two patients with familial HLH. The diagnosis of HLH was made according to the guidelines of the Histiocyte Society. Fever was present in two patients with hemophagocytic lymphohistiocytosis. The other most common symptoms were malaise and weight loss. Hepatosplenomegaly was present in two patients. Hemophagocytosis was documented in bone marrow examinations of two cases. Thrombocytopenia, neutropenia, hypertriglyceridemia and hyperferritinemia were found in two patients. Genetic analysis of the patients were performed, with the coding region of the perforin gene. Our cases had perforin gene muatation. HLH is a rare but mortal disease when not treated on time. Awareness of clinical symptoms and diagnostic criteria of HLH, initiation of early immunosuppressive treatment; life-saving as well as allowing for stem cell transplantation. © 2018 by Türkiye Klinikleri.
Validity and Reliability of the Turkish Version of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (The Cho-Klat)
(AVES, 2024) Tat, A.M.; Tat, N.M.; Karaman, K.; Öner, A.F.; Gönen, T.; Akbayram, S.; Öner, H.S.
Objective: The evaluation of health-related quality of life (HRQoL) is encouraged to assess the multidimensional impact of treatments and disease and to improve care in boys with hemophilia (BwH). However, validated HRQoL tools for BwH are not yet available for Turkish. The purpose of this study was to assess the validity and reliability of the Canadian Hemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT), version 2.0, which is multilingual valid tool, in Turkish. Methods: The procedure included 4 steps: linguistic translation, content validity, validity evaluation with the Pediatric Quality of Life (PedsQL), finally test-retest analysis for reliability assessment. The participants were questioned for the type and severity of hemophilia, medical treatment, and inhibitor status. Results: The primary Turkish version of the CHO-KLAT evolved with the cooperation of the Canadian and Turkish teams. Content validity was performed with 9 experts and latest version of Turkish CHO-KLAT was produced. This multicenter study was conducted with 53 BwH aged 4-18 for validity assessment, 52 BwH for test-retest reliability. The mean age of BwH was 11.6 (standard deviation (SD): 4.2). The means of CHO-KLAT and PedsQL were 64.1 (SD: 4.2) and 66.7 (SD: 15.3). As a result of the validity evaluation, a strong correlation was found between CHO-KLAT and PedsQL (r = 0.603; P < .001). The interclass correlation coefficient was 0.887 in the test-retest reliability. Conclusion: The Turkish version of CHO-KLAT 2.0 was validated. It is now available to be used in clinical studies for HRQoL assessment of Turkish BwH. © 2024 AVES. All rights reserved.