Browsing by Author "Karaman, S."

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An Analysis of Children With Brucellosis Associated With Haemophagocytic Lymphohistiocytosis
(2016) Karaman, K.; Akbayram, S.; Kaba, S.; Karaman, S.; Garipardiç, M.; Aydin, I.; Öner, A.F.
This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic disorder. All patients had an anamnesis for recently consumed unpasteurised homemade dairy products or had a contact history with sheep and/or cows. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titres were 1: 1280 in seven patients. Blood culture was positive for Brucella melitensis in three patients (42%). Bone marrow cultures were positive for B. melitensis in four patients (57%). Fever was present in all patients (100%) with haemophagocytic lymphohistiocytosis. The other most common symptoms were malaise, myalgia, anorexia, sweating and weight loss. In addition, sweating was observed in five patients, and lymphadenopathy, petechiae, and weight loss were observed in one patient. Hepatomegaly, splenomegaly, and hepatosplenomegaly were found in four (57%), six (85%) and four (57%), patients, respectively. Haemophagocytosis was documented in bone marrow examinations of all children except in two cases. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis.
Assessment of Thyroid Nodules in Children: a Single Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Bitkin, E.Ç.; Karaman, S.; Başaranoğlu, M.
Thyroid nodules in children are less common than adults, but with a higher risk of malignancy, metastasis and recurrence. Therefore, detection, follow-up and treatment of thyroid nodules in children is very important. Our study retrospectively analyzed the demographic features, concomitant diseases and ultrasonography (USG) findings of thyroid nodules in children and aimed to obtain information about incidence of malignancy. We retrospectively analyzed the clinical, laboratory, thyroid USG, Fine needle aspiration biopsy (FNAB) and surgical results of 45 pediatric patients with thyroid nodules. Forty-five patients were included in the study, female domination was present, and most of the patients were adolescents. Six (13.3%) of the patients had a family history of thyroid cancer, and one had a history of radiation. Thyroid-related disease was present in 53.3% of the patients. Five patients had non-thyroid disease. Thyroid function tests were within normal limits in 33 (73.3%) of the patients. In our patients with pediatric thyroid nodules, FNAB was underwent in 46.6% according to the nodule size, and malignancy was detected in 2.2% of our patient group. Careful evaluation of thyroid nodules that are rarely seen in adults but higher in malignancy than adults should be evaluated. Diagnostic research for thyroid cancer is mostly done in adult patients, our study contributes to the assessment of risk conditions in thyroid nodules in children. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Does Growth Hormone Therapy Enlarge Pituitary Adenomas
(Galenos Publishing House, 2022) Bitkin, E.Ç.; Kara, C.; Karaman, S.; Başaranoğlu, M.; Yokuş, A.; Tuncer, O.
Objective: Pituitary adenomas are detected incidentally in some cases of childhood growth hormone deficiency. Growth hormones may affect tumor growth. This study analyzed the reliability of growth hormone therapy in patients with non-functioning pituitary adenomas. Methods: The study group included 16 hypopituitary patients with incidentally detected non-functioning pituitary adenoma and treated with recombinant growth hormone. Age- and sex-matched 16 healthy children with incidental pituitary adenoma detected during investigation of chronic headache were selected as the control group. The data of the two groups were retrospectively reviewed and compared regarding the change in adenoma size over time. Results: Changes in adenoma size in the patient and control groups were -0.1 (-0.8-0.3) mm and -0.1 (-0.5-0.3) mm, respectively (p=0.664). Adenoma size growth was detected in 3 patients in the patient group and 5 patients in the control group (p=0.685). Conclusion: Our data suggest that recombinant growth hormone therapy does not produce pituitary adenomas, and thus its use is safe in growth hormone deficient children with incidentally detected non-functioning pituitary adenomas. © Copyright 2022 by Medical Journal of Bakırköy published by Galenos Yayınevi.
Evaluation of the Effect of Sound Intensity on Vital Signs in Neonatal Intensive Care Unit
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Başaranoğlu, M.; Karaman, S.; Sönmez, B.; Tuncer, O.
Newborns, and especially prematures, suffer acute and chronic damage from noise during hospitalization. Therefore, it is important to monitor the noise levels of both the in-tub and out-of-tub environment. In this study we aimed to evaluate the effects of sound level measurement, noise sources and sound level on the vital signs of infants in Neonatal Intensive Care Unit. We measured the sound levels at three different time point and two different sites during the day to determine the sources of the noise using the Benetech Sound Level Meter GM1352. During each measurement, the number of people in two sections of the NICU, the number of devices working, and the vital signs of the patients were recorded. The average noise level in the first region was 58.58±10.7 dB and the average noise level in the second region was 50.17±6.407 db. There was a significant decrease in SaO2 values, especially during periods when the volume was high (p<0.01). It was also determined that the number of breaths, pulse and sleeplessness levels increased during periods when the sound level rose above a certain level. As a source of noise the number of people working devices used and the presence of the nurse desk in the section were found. İt was determined that the recommended sound level in our unit was generally exceeded and that these levels had various adverse effects on infants. It is necessary to take measures to reduce the negative effects of noise on babi es. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Identification of Three Novel Pathogenic Itga2b and One Novel Pathogenic Itgb3 Mutations in Patients With Hereditary Glanzmann's Thrombasthenia Living in Eastern Turkey
(Wiley, 2020) Karaman, K.; Yurekturk, E.; Geylan, H.; Yasar, A. S.; Karaman, S.; Cetin, M.; Oner, A. F.
Major and Minor Bio-Element Status in Children With Febrile Seizure
(Comenius Univ, 2012) Akbayram, S.; Cemek, M.; Buyukben, A.; Aymelek, F.; Karaman, S.; Yilmaz, F.; Caksen, H.
Febrile seizures (FS) are the most common cause of seizures in children. The exact etiopathogenesis is unknown but involves factors like genetic predisposition and alterations in the levels of neurotransmitters and some trace elements. The study includes 48 consecutive children with FS, and 55 healthy age matched control subjects. Calcium, magnesium and potassium concentrations in the febrile study group were lower than in the control group (p<0.05). Iron and Gallium levels in the study group were lower than in the control group (p<0.01). Serum Selenium (p<0.001), Zinc (p<0.001) and Strontium (p<0.05) levels were significantly decreased in the study group when compared to the control group. There was no significant difference between the control and study groups in Serum Barium, Beryllium and Copper levels (p>0.05). The aim of the present prospective analytical case-control study was to determine whether there was any change in element levels in children with FS (Ref. 33). Full Text in PDF www.elis.sk.
Pituitary Imaging Findings in Pediatric Patients With Idiopathic Hypogonadotropic Hypogonadism
(Sciendo, 2023) Bitkin, E.C.; Toprak, N.; Karaman, S.
Objective. Idiopathic hypogonadotropic hypogonadism in children is a disease leading to a puberty absence. Some hypothalamic and pituitary defects cause hypogonadotropic hypogonadism. Pituitary magnetic resonance imaging is routinely performed in these patients. In our study, we provide an information about pituitary pathologies associated with an idiopathic hypogonado-Tropic hypogonadism in childhood. Methods. Twenty-Two patients, who were admitted to the pediatric endocrine outpatient clinic of our hospital because of their undeveloped secondary sex characteristics during adolescence, were included in our study. Age, gender, history, physical examination findings, and laboratory tests were recorded in patients. Pituitary magnetic resonance imaging results were examined. The criteria for the diagnosis of hypogonadism were: Absence of puberty or delayed puberty, clinical signs or symptoms of hypogonadism, and presence of low or normal gonadotropin levels. Results. In the present study, 22 patients were diagnosed with hypogonadotropic hypogonadism. The mean age of the patients was 15.90±1.09 years. Basal and stimulated luteinizing hormone and follicular stimulating hormone levels of the patients were found to be low. Prolactin, cortisol, adrenocorticotropic hormone, free thyroxine, and thyroid stimulating hormone levels were within normal limits in all patients. The pituitary magnetic resonance imaging revealed six patients with pituitary adenoma, one with empty sella turcica, and five with pituitary hypoplasia. Conclusions. The present data showed that in the presence of hypogonadotropic hypogonadism, the hypothalamic-pituitary abnormalities are more likely to be present in the children compared to the adult population. Thus, it can be strongly emphasized the importance of the pituitary imaging examination, especially in the idiopathic hypogonadotropic hypogonadism cases. © 2023 Eda Celebi Bitkin et al., published by Sciendo.
A Quadricuspid Aortic Valve That Was Misdiagnosed as Rheumatic Carditis: A 13-Year Case
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2021) Çetin, M.; Başaranoğlu, M.; Karaman, S.; Doğan, E.
Quadricuspid aortic valve anomaly is a very rare congenital heart anomaly. Its incidence is 0.01-0.04 percent. This anomaly is characterized by the presence of four aortic valves of the same or different sizes. This may often lead to progressive aortic regurgitation or rarely aortic valve stenosis. In aortic valve evaluation with transthoracic echocardiographic, if a careful examination is not performed, the diagnosis of quadricuspid aortic valve may be overlooked or may be misdiagnosed as insidious acute rheumatic carditis. Here, we presented a 13-year-old patient with quadricuspid aortic valve who was admitted to another center with chest pain, and was mistakenly diagnosed with insidious rheumatic carditis due to the aortic regurgitation detected on his transthoracic echocardiographic examination. We aimed to draw attention to this rare congenital heart valve disease. Copyright © 2021 by Türkiye Klinikleri.
Retrospective Evaluation of Our Patients With Lymphadenopathy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Karaman, S.; Uslu, E.; Başaranoğlu, M.; Kamaşak, T.; Bitkin, E.Ç.
Lymphadenopathy (LAP) is a common clinical finding in childhood. It is mostly reactive and has a good prognosis. Childhood cancers rarely occur. In our study, it was aimed to investigate the clinical and laboratory features of patients who were sent to the general child outpatient clinic due to LAP. The records of patients with LAP who applied to our General Children's outpatient clinics between January 2018 and December 2019 retrospectively. Age, gender, duration of complaint, treatment, systemic signs and symptoms, feat ures of lymph node, laboratory results was recorded The median age of 90 patients included in the study was 7 years; It takes place between 3-19 years. The complaints of the application were the most common neck swelling and submandibular and axillary sore after the second. Thirty (33%) of our cases had sore throat. Spleen and liver size were detected in 18 cases. In our study, 16% of cases were performed biopsy. Reactive hyperplasia in nine cases, nodular fasciitis in one case, granulomatous lymphadenitis in two cases, malignancy in two cases and Castleman Disease in one case were detected. We found that childhood lymphadenopathy frequently develops due to benign causes. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.