Browsing by Author "Karatas, Erkan"

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Cytotoxicity and Antibacterial Activity of Polyhedral Oligomeric Silsesquioxane Modified Ti3c2tx Mxene Films
(Nature Portfolio, 2025) Akinay, Yuksel; Karatas, Erkan; Ruzgar, Damla; Akbari, Ali; Baskin, Dilges; Cetin, Tayfun; Topuz, Mehmet
Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti3C2Tx MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92 degrees degrees in pure PLA thin films to 72.23 degrees on POSS-doped Ti3C2Tx MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti3C2Tx MXene films effectively inhibited the growth of E. coli and S. aureus by 65.93% and 80.63%, respectively, within 4 h. These inhibition rates were observed as 58.32% and 54.97% for E. coli and S. aureus, respectively, after 24 h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti3C2Tx MXene. The obtained results suggest that the POSS-doped Ti3C2Tx MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.
Ti 3 C 2 T X Mxene-Functionalized Hydroxyapatite/Halloysite Nanotube Filled Poly- (Lactic Acid) Coatings on Magnesium: in Vitro and Antibacterial Applications
(Keai Publishing Ltd, 2024) Topuz, Mehmet; Akinay, Yuksel; Karatas, Erkan; Cetin, Tayfun
Magnesium (Mg) stands out in temporary biomaterial applications due to its biocompatibility, biodegradability, and low Young's modulus. However, controlling its corrosion through next-generation polymer-based functional coatings is crucial due to the rapid degradation behavior of Mg. In this study, the function of 2D lamellar Ti3 C2 Tx (MXene) in Hydroxyapatite (HA) and Halloysite nanotube (HNT) hybrid coatings in biodegradable poly- (lactic acid) (PLA) was investigated. The morphological and structural characterizations of the coatings on Mg were revealed through HRTEM, XPS, SEM-EDX, XRD, FTIR, and contact angle analyses/tests. Electrochemical in vitro corrosion tests (OCP, PDS, and EIS-Nyquist) were conducted for evaluate corrosion resistance under simulated body fluid (SBF) conditions. The bioactivity of the coatings in SBF have been revealed in accordance with the ISO 23,317 standard. Finally, antibacterial disk diffusion tests were conducted to investigate the functional effect of MXene in coatings. It has been determined that the presence of MXene in the coating increased not only surface wettability (131 degrees, 85 degrees, 77 degrees, and 74 degrees for uncoated, pH, PHH, and PHH/MXene coatings, respectively) but also increased corrosion resistance (1857.850, 42.357, 1.593, and 0.085 x 10-6 , A/cm2 for uncoated, pH, PHH, and PHH/MXene coatings, respectively). It has been proven that the in vitro bioactivity of PLA-HA coatings is further enhanced by adding HNT and MXene, along with SEM morphologies after SBF. Finally, 2D lamellar MXene-filled coating exhibits antibacterial behavior against both E. coli and S. aureus bacteria. (c) 2024 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) Peer review under responsibility of Chongqing University
Use of Rotation Flap in Repair of Cleft Palate and Velopharyngeal Insufficiency
(Lippincott Williams & Wilkins, 2011) Isik, Daghan; Durucu, Cengiz; Isik, Yasemin; Atik, Bekir; Kocak, Omer Faruk; Karatas, Erkan; Bekerecioglu, Mehmet
Although cleft palate anomaly is frequent, the criterion standards in surgical treatment have not been determined yet. There are a few techniques described for cleft palate repair owing to the limited tissue in the palatal mucosa, the rigid structure of the palatal mucosa, and the limited vascularity of the hard palate. In this study, a novel cleft palate repair technique based on separating the soft palate from the hard palate as a musculomucosal flap and using it as a rotation flap has been described. The operation is evaluated individually for each anomaly because variations occur in the surgical technique according to the extension of the cleft toward the teeth in the palate. This operation was performed on a total of 28 patients (17 girls and 11 boys) aged between 1.5 and 16 years and presented to our clinic. Patients were assessed for speech analysis outcomes, tympanogram values, hearing functions, magnitude of palatal lengthening during the operation, and rate of fistulae. Statistically significant differences in values of the speech analysis and the audiometric assessment were determined between before and 6 months after surgery. Complete recovery of otitis was observed 1 month after surgery without another treatment in 9 (42.8%) of 21 patients who were detected to have serous otitis media preoperatively. Tension-free closure, lower risk of fistula, good restoration of velopharyngeal functions, ability to be performed on all types of cleft palate, ability to provide a good intraoperative exposure, and being a single stage seem to be the most important advantages of this technique.