Browsing by Author "Kaspar, Cigdem"

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Decreased Serum Selenium Levels Are Correlated With Diminished Coronary Flow Reserve Among Hemodialysis Patients
(Humana Press inc, 2013) Atakan, Aydin; Macunluoglu, Beyza; Kaya, Yuksel; Ari, Elif; Demir, Halit; Asicioglu, Ebru; Kaspar, Cigdem
Cardiovascular diseases are the main reason of high mortality among hemodialysis patients. Decreased serum selenium levels may have a role in accelerated atherosclerosis in this patient group. The hypothesis of this study was to show a correlation between decreased serum selenium levels and coronary flow reserve as an indicator of endothelial dysfunction and atherosclerosis in HD patients. Seventy-one chronic hemodialysis patients and age 65 and sex-matched healthy controls were included in the study. Plasma selenium levels were measured by spectrophotometry, and coronary flow reserve was assessed by transthoracic Doppler echocardiography. Serum selenium levels (34.16 +/- 6.15 ng/ml vs. 52.4 +/- 5.51 ng/ml, P < 0.001) and coronary flow reserve values (1.73 +/- 0.11 vs. 2.32 +/- 0.28, P < 0.001) were significantly lower in hemodialysis patients compared with controls, respectively. There was a significant positive correlation between coronary flow reserve and serum levels of selenium (r = 0.676, P < 0.001). A linear regression analysis showed that serum levels of selenium were independently and positively correlated with coronary flow reserve (regression coefficient = 0.650, P < 0.05). This study was the first to show a positive and independent correlation between decreased selenium levels and diminished coronary flow reserve as an indicator of endothelial dysfunction and atherosclerosis in hemodialysis patients. Our data suggest that decreased serum selenium levels may facilitate the development of endothelial dysfunction and disruption of coronary flow reserve which occur before the development of overt atherosclerosis.
Epicardial Fat Thickness Is Associated With Impaired Coronary Flow Reserve in Hemodialysis Patients
(Wiley, 2014) Atakan, Aydin; Macunluoglu, Beyza; Kaya, Yuksel; Ari, Elif; Demir, Halit; Asicioglu, Ebru; Kaspar, Cigdem
Cardiovascular disease (CVD) is the main cause of mortality in hemodialysis (HD) patients. Epicardial fat tissue (EFT) is a new risk factor in CVD. The aim of this study was to evaluate the association between EFT and coronary artery flow reserve (CFR), which is an early indicator of endothelial dysfunction in coronary vessels of HD patients. We performed a cross-sectional study including 71 chronic HD patients and 65 age- and sex-matched healthy controls. Epicardial fat tissue was significantly higher in HD patients when compared to healthy controls (6.53 +/- 1.01 mm vs. 5.79 +/- 1.06 mm, respectively, P < 0.001). On transthoracic Doppler echocardiography, CFR values were significantly lower in HD patients when compared to healthy controls (1.73 +/- 0.11 vs. 2.32 +/- 0.28, P < 0.001). Correlation analysis showed CFR values to be inversely correlated with EFT (r = -0.287, P < 0.05). Multiple linear regression analysis was used to define independent determinants of EFT in HD patients. Artery flow reserve, age, body mass index and total cholesterol levels were independently correlated with EFT thickness. This study demonstrated that EFT was significantly higher among HD patients compared to healthy controls. In addition, this study was the first to demonstrate an inverse correlation between EFT and CFR in this patient population.
Epicardial Fat Tissue Thickness Is Correlated With Diminished Levels of Co-Enzyme Q10, a Major Antioxidant Molecule Among Hemodialysis Patients
(Pergamon-elsevier Science Ltd, 2014) Macunluoglu, Beyza; Atakan, Aydin; Ari, Elif; Kaya, Yuksel; Kaspar, Cigdem; Demir, Halit; Alp, Hamit Hakan
Objectives: Accelerated atherosclerosis is the major cause of mortality in patients on chronic maintenance hemodialysis (HD). Epicardial fat tissue (EFT) is a new risk factor in cardiovascular disease (CVD). The aim of this study was to evaluate the relation between plasma coenzyme Q10 levels (Co-Q10) which is a potent physiologic antioxidant and EFT thickness in HD patients. Design and methods: Seventy one chronic HD patients and 65 age and sex matched healthy individuals were included in the study. Plasma Co-Q10 levels were performed by high-performance liquid chromatography (HPLC) measurements. EFT was measured by transthoracic echocardiograpy (TTE) performed with a VIVID 7 instrument. Results: Plasma Co-Q10 levels (1.36 +/- 0.43 vs 2.53 +/- 0.55, p < 0.001) were significantly lower in HD patients compared to controls. EFT was significantly increased in HD patients compared to healthy controls (6.53 +/- 1.01 vs. 5.79 +/- 1.06 mm respectively, p < 0.001). Correlation analysis showed that plasma Co-Q10 levels were inversely correlated with EFT (r = -0.263, p < 0.05). Multiple linear regression analysis was used to define independent determinants of EFT in HD patients. According to linear regression analysis, age, BMI, total cholesterol and Co-Q10 levels were found to be independent predictors of EFT (adjusted r(2) = 0.38, p < 0.001). Conclusion: This study demonstrated that EFT thickness was significantly higher among HD patients compared to healthy controls. In addition; this study was the first to demonstrate an inverse correlation between EFT thickness and Co-Q10 levels in this patient population. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Serum Cadmium Levels Are Independently Associated With Endothelial Function in Hemodialysis Patients
(Springer, 2012) Kaya, Yuksel; Ari, Elif; Demir, Halit; Gecit, Ilhan; Beytur, Ali; Kaspar, Cigdem
Hemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endothelial function in HD patients. Forty-eight chronic HD patients without known atherosclerotic disease and 42 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). The serum levels of iron, zinc, and manganese were lower, and levels of copper, magnesium, cobalt, cadmium, and lead were higher in HD patients compared to controls. Flow-mediated dilatation (FMD %) in HD patients was lower than that in the control group (7.27 +/- A 0.76 vs. 11.29 +/- A 0.82, P < 0.001). There was a significant negative correlation between FMD % and serum levels of cobalt (r = -0.313, P = 0.03) and cadmium (r = -0.524, P < 0.01). A linear regression analysis showed that serum cadmium levels were still significantly and negatively correlated with FMD % (regression coefficient = -0.526, P < 0.001). We first demonstrated that serum cadmium levels independently predict endothelial function in HD patients without known atherosclerotic disease.
Serum Coenzyme Q10 Levels Are Associated With Coronary Flow Reserve in Hemodialysis Patients
(Wiley, 2013) Macunluoglu, Beyza; Kaya, Yuksel; Atakan, Aydin; Ari, Elif; Kaspar, Cigdem; Demir, Halit; Kedrah, Alla Eldeen
Accelerated atherosclerosis is the major cause of mortality in patients on chronic hemodialysis (HD). The aim of this study was to evaluate the relation between coenzyme Q10 (CoQ10) levels and coronary flow reserve (CFR) in HD patients as an indicator of atherosclerosis. Seventy-one chronic HD patients and 65 age- and sex-matched healthy individuals were included in the study. Plasma CoQ10 levels were performed by high-performance liquid chromatography measurements. CFR was assessed by transthoracic Doppler echocardiography. Serum CoQ10 levels (1.36 +/- 0.43 vs. 2.53 +/- 0.55, P<0.001) and CFR values (1.73 +/- 0.11 vs. 2.32 +/- 0.28, P<0.001) were significantly lower in HD patients compared with controls. There was a significant positive correlation between CFR and serum levels of CoQ10 (r=0.669, P<0.001). A linear regression analysis showed that serum levels of CoQ10 were still significantly and positively correlated with CFR (regression coefficient=0.235, P<0.001). Our data have demonstrated that HD patients exhibit decreased plasma CoQ10 levels and CFR values. The study also showed for the first time that serum CoQ10 levels independently predict CFR in HD patients.