Browsing by Author "Kati, Celal"

Now showing 1 - 4 of 4

Serum Levels of Trace Elements and Heavy Metals in Patients With Acute Hemorrhagic Stroke
(Springer, 2014) Karadas, Sevdegul; Sayin, Refah; Aslan, Mehmet; Gonullu, Hayriye; Kati, Celal; Dursun, Recep; Demir, Halit
Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.
Serum Paraoxonase and Arylesterase Activities and Oxidative Stress Levels in Patients With Ssri Intoxication
(Springer, 2014) Kati, Celal; Karadas, Sevdegul; Aslan, Mehmet; Gonullu, Hayriye; Duran, Latif; Demir, Halit
Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with selective serotonin reuptake inhibitor (SSRI) intoxication. A total of 11 patients with SSRI intoxication and 20 healthy controls were enrolled. The serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as the paraoxonase and arylesterase activities, were measured spectrophotometrically. The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower (for all, p < 0.001), whereas the serum MDA levels were significantly higher in the patients with SSRI intoxication than in the controls (p < 0.001). These results indicated that decreased PON1 activity and increased oxidative stress represent alternative mechanisms in SSRI toxicity. More studies are needed to elucidate the role of PON1 activity in the etiology of SSRI intoxication.
Serum Prolidase Enzyme Activity and Oxidative Stress Levels in Patients With Acute Hemorrhagic Stroke
(Taylor & Francis Ltd, 2014) Gonullu, Hayriye; Aslan, Mehmet; Karadas, Sevdegul; Kati, Celal; Duran, Latif; Milanlioglu, Aysel; Demir, Halit
Background. It has been indicated that oxidative damage contributes to secondary brain injury in both ischemic and hemorrhagic stroke patients. Collagen is a major component of the extracellular matrix, and prolidase plays a role in collagen synthesis. The aim of this study was to evaluate the serum prolidase activity, nitric oxide (NO) levels, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with acute hemorrhagic stroke. Methods. Twenty-five patients with acute hemorrhagic stroke and 25 controls were enrolled. Serum prolidase activity, catalase activity, NO levels, TAC and TOS were measured spectrophotometrically. Oxidative stress index (OSI) was calculated. Results. Serum TAC levels and catalase activity were significantly lower in acute hemorrhagic stroke patients than controls (both, p < 0.001), while NO levels, TOS levels, OSI values and prolidase activity were significantly higher (all, p < 0.01). When patients with acute hemorrhagic stroke were divided according to gender, no differences were observed between females and males in respect to serum prolidase enzyme activity, NO levels, TAC levels, TOS levels and OSI values (all, p > 0.05). Conclusions. Findings from the study suggest an association between increased oxidative stress levels, decreased antioxidant levels and increased prolidase enzyme activity in patients with acute hemorrhagic stroke compared with controls. More studies are needed to elucidate mechanistic pathways on oxidative stress in patients with acute hemorrhagic stroke.
The Value of Electroencephalography in Differential Diagnosis of Altered Mental Status in Emergency Departments
(Pakistan Medical Assoc, 2014) Duran, Latif; Balci, Kemal; Yardan, Turker; Kati, Celal; Akdemir, Hizir Ufuk; Karadas, Sevdegul; Altuntas, Mehmet
Objective To evaluate the value of electroencephalography in patients with altered mental status in emergency departments Methods Demographical characteristics types and aetiologies of seizures and clinical outcomes of the patients were recorded Patients were divided into 4 groups according to the complaints of admission findings and symptoms of seizure stroke and symptoms of stroke related seizures syncope and metabolic abnormalities and other causes of altered mental status The electroencephalography findings were classified into 3 groups epileptiform discharges paroxysmal electroencephalography abnormalities and background slowing Electroencephalography abnormalities in each subgroup were evaluated SPSS 21 was used for statistical analysis Results Of the total 190 patients in the study 117(61 6%) had pathological electroencephalography findings The main reason for electroencephalography in the emergency department was the presence of seizure findings and symptoms in 98(51 6%) patients The ratio of electroencephalography abnormality was higher in patients who were admitted with complaints of metabolic abnormality related consciousness disturbances (p<0 001) A total of 124(65 3%) patients had neuroimagings Electroencephalography abnormalities were found to be significantly higher in patients with neuroimagings compared to those without neuroimagings (p<0 003) Conclusion Despite advanced neuroimaging techniques electroencephalography is still an important tool in the differential diagnosis of altered mental status such as epileptic seizures metabolic abnormalities pseudo seizures and syncope