Browsing by Author "Kati, I"

Now showing 1 - 16 of 16

Alterations in the Biochemical Markers of Renal Function After Sevoflurane Anaesthesia
(Wiley, 2005) Sekeroglu, MR; Kati, I; Noyan, T; Dülger, H; Yalçinkaya, A
Aim: This study has been carried out to see whether renal function is acutely altered in patients undergoing sevoflurane anaesthesia. For this purpose, the urinary levels of markers of renal tubular function, namely leucine amino peptidase (LAP), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and beta-2 microglobulin (beta-2M), and urinary albumin as a predictor of renal glomerular function were measured before and after sevoflurane anaesthesia. Methods: This study was comprised of 20 patients (11 males and nine females) aged 18-55, who underwent various elective surgical procedures under general anaesthesia. Urine samples of all patients were collected before and 1, 2 and 8 h after the anaesthesia. The levels of LAP, GGT, beta-2M, and albumin were then expressed as factored by urinary creatinine. In all patients, the anaesthesia was maintained with sevoflurane (2% end-tidal) at a high flow-rate (6 L/min). Results: Urinary beta-2M and LAP levels after anaesthesia were unchanged (P > 0.05). While urinary GGT and ALP levels were found elevated in the first hour, LDH levels were higher in the second hour (P < 0.05). They returned to normal levels in the later periods after the anaesthesia. Urinary albumin excretion (UAE) was significantly elevated in the second hour after the anaesthesia (P < 0.001). Although UAE was decreased in the eighth hour after the anaesthesia, it still remained higher than the pre-anaesthesia level (P < 0.001). Conclusion: These results suggest that a 2% end-tidal concentration of sevoflurane at a high flow-rate (6 L/min) acutely alters renal glomerular function but does not have a significant acute effect on biochemical markers of renal tubular damage.
A Boy With Organophosphate Poisoning Mimicking a Foreign Body Aspiration
(Elsevier Science inc, 2005) Çaksen, H; Demirtas, M; Tuncer, O; Odabas, D; Ceylan, N; Kati, I; Köseoglu, B
Brain Abscess Drainage by Use of Mr Fluoroscopic Guidance
(Amer Soc Neuroradiology, 2005) Ünal, O; Sakarya, ME; Kiymaz, N; Etlik, O; Kayan, M; Kati, I; Harman, M
We describe herein the use of MR fluoroscopic guidance in the drainage of abscess cavities. We percutaneously drained 12 brain abscesses in 11 patients. A 0.3T open MR imaging system was used. Sixteen drainages were performed in 12 abscesses. Repeat drainage was needed in three recurrences and one residual lesion. No serious complications were seen. MR fluoroscopy-guided percutaneous brain abscess drainage in an open MR imaging system is feasible.
Comparison of Propofol and Sevoflurane for Laryngeal Mask Airway Insertion
(Tohoku Univ Medical Press, 2003) Kati, I; Demirel, CB; Huseyinoglu, UA; Silay, E; Yagmur, C; Coskuner, I
In this study, we compared haemodynamic changes, laryngeal mask airway (LMA) insertion time, and complications in patients anesthetized by inhalation of sevoflurane with those of intravenous induction with propofol. One hundred patients, aged between 20-40 years were enrolled in this study. Group I received propofol (2.5 mg/kg IV) and group 2 received sevoflurane (6% + 50% N2O + 50% O-2) by inhalation using the tidal volume technique. LMA insertion time was found to be significantly longer in sevoflurane group than in propofol group. Mean arterial blood pressure was significantly lower within each group after induction in comparison to before induction values. In both groups, the LMA was successfully inserted in all patients. The quality of anaesthesia according to patients was significantly higher in the propofol group (80%) than in sevoflurane group (30%). Odor perception was significantly higher in sevoflurane group (84%) than in propofol group (38%). Apnoea was significantly higher in propofol group (40%) than in sevoflurane group (0%). Sevoflurane is an alternative to propofol for induction of anaesthesia and has a lower incidence of apnoea. Other complication rates are not higher than which propofol but the longer duration of induction time is a disadvantage. (C) 2003 Tohoku University Medical Press.
Comparison of the Analgesic Effect of Betamethasone and Diclofenac Potassium in the Management of Postoperative Haemorrhoidectomy Pain
(Taylor & Francis Ltd, 2005) Kisli, E; Baser, M; Güler, O; Aydin, M; Kati, I
Background: Outpatient postoperative haemorrhoidectomy pain remains a difficult problem. The purpose of this study is to compare the results of the use of betamethasone with diclofenac potassium in postoperative pain following haemorrhoidectomy. Material and methods : Closed haemorrhoidectomy was performed on 40 patients who were diagnosed grade III, grade IV haemorrhoid on physical examination. Patients were divided equally randomized into two groups, prospectively (betamethasone was used for 20 patients and diclofenac potassium was given for 20 patients). A verbal categorical scale was used to evaluate postoperative pain (for pain intensity, none = 0, mild = 1, moderate = 2 and severe = 3). Results : The amount of narcotics required on postoperative first, second and third day were significantly less in the betamethasone group than in the diclofenac potassium group (P < 0.001) (Pearson Chi-Square test). Conclusion : Results indicate that use of betamethasone provides more effective analgesia than diclofenac potassium for postoperative pain management in the haemorrhoidectomy patient.
Comparison of the Effects of Desflurane and Sevoflurane on the Qtc Interval and Qt Dispersion
(Taylor & Francis Ltd, 2005) Silay, E; Kati, I; Tekin, M; Guler, N; Huseyinoglu, UA; Coskuner, I; Yagmur, C
Objective -The effects of desflurane and sevoflurane on QT interval and QT dispersion have been investigated in a prospective, double-blind, randomized study of patients undergoing noncardiac surgery. Interventions - Sixty American Society of Anaesthesiologists physical status I-II adult patients were randomly assigned to two groups. Anaesthesia was induced with inhalation of desflurane (desflurane group) or sevoflurane (sevoflurane group) in increasing concentrations to 3 minimal alveolar concentration level. The maintenance of anaesthesia was provided with 2 minimal alveolar concentration agents in both groups until the end of the study. Electrocardiogram, heart rate and blood pressure were recorded as follows: before premedication, before induction, I and 3 min after the induction of anaesthesia, after the administration of vecuronium and after the tracheal intubation. The induction times and the complications were recorded. Measurements and results -The QTc interval was significantly more prolonged with desflurane than with sevoflurane at the first and third minute after the induction, and at the third minute after the administration of vecuronium.There were no significant differences in the QT dispersion between the two groups. Heart rate and blood pressure were found to be significantly higher in the desflurane group. Conclusion -The QTc interval was more prolonged with desflurane than sevoflurane, and QT dispersion was normal with both agents.
Does Benzydamine Hydrochloride Applied Preemptively Reduce Sore Throat Due To Laryngeal Mask Airway
(Lippincott Williams & Wilkins, 2004) Kati, I; Tekin, M; Silay, E; Huseyinoglu, UA; Yildiz, H
Sore throat is a common postoperative complaint. We investigated whether preemptive benzydamine hydrochloride (BH) treatment could prevent sore throat due to a laryngeal mask airway (LMA) cuff inflated with air. One-hundred ASA status I-II patients who underwent general anesthesia were randomly divided into two groups. In the first group, four puffs of BH were applied to the pharynx 30 min before the operation and 5 min before the induction of anesthesia. Distilled water with a similar bottle was applied with the same protocol in the second group. Anesthetic induction was provided with propofol and fentanyl. The pressure of the LMA cuff inflated with room air was measured after the first adjustment and after 30, 60, and 90 min of inflation in both groups. At the end of operation, the LMA was removed after the recovery of spontaneous breathing. After the operation, patients were asked about sore throat symptoms at the first, second, and fourth hours. There were no significant differences between groups for cuff pressures, cuff volumes, analgesic doses, or operation times. However, sore throat symptoms were significantly less severe for the BH group during both resting and swallowing. In conclusion, preemptive topical BH may decrease the incidence of sore throat due to LMA use.
The Effect of Co2 Insufflation Rate on the Postlaparoscopic Shoulder Pain
(Mary Ann Liebert inc Publ, 1998) Berberoglu, M; Dilek, ON; Ercan, F; Kati, I; Ozmen, M
Shoulder pain (SP) is frequently mentioned in recent literature following laparoscopic operations. In the literature, many causes have been declared to explain shoulder pain after CO2 insufflation, such as direct peritoneal irritation of the CO2 gas, excessive traction of the triangular ligament, and overstretching of the diaphragmatic muscle fibers due to the high rate of insufflation, This study was planned as multicentric, and 76 patients, aged between 35 to 45, were entered into the study. They were all selected by a randomized sampling method, with equal numbers of men and women, to achieve true evaluation. The low flowrate (LFR) group was insufflated with 2.5 L/min and the high flow-rate (HFR) group with 7.5 L/min. All cases were evaluated by subjective pain classification on postoperative day 3. According to the subjective pain scale method, shoulder pain average was 23.9 +/- 3.1 in the LFR group and 55.4 +/- 6.5 in the HFR group. The difference between these groups was significant (p > 0.01), There is no significant difference for the operation time (LFR%: 64 +/- 15 minutes, HFR: 61 +/- 20 minutes, p > 0.05), Our results suggest that there is a significant statistical relation between the postoperative shoulder pain levels and increased insufflation rates. For this reason, low insufflation rate significantly reduces the shoulder pain but does not increase the operation time. Therefore, a low insufflation rate should be applied in all cases for patients' comfort and safety.
Effect of N2o on Nausea and Vomiting Via Intraabdominal Pressure
(Comenius Univ, 2012) Yuce, H. H.; Goktas, U.; Kati, I; Cegin, M. B.; Soyoral, L.
Background and objective: In this study we aimed to investigate whether there is an effect of N2O on postoperative nausea and vomiting (PONV) via intraabdominal pressure (IAP). Methods: A total of 40 patients with risk class ASA I-II and age ranging between 20 and 50 years were enrolled in the study. The patients were monitored for electrocardiography (ECG), peripheral oxygen saturation (SpO(2)), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), end-tidal carbon dioxide (ETCO2) and body temperature. IAP was measured by a central venous pressure manometer placed in the urine catheter. Heart rate (HR), SpO(2), SBP, DBP, MBP, ETCO2, body temperature and IAP were measured before the induction of anesthesia and every 10 minutes throughout the operation. Nausea and vomiting were questioned at the first and second postoperative hours. The patients were randomly grouped into two groups. Induction in both groups was provided using 2 mg/kg propofol, 2 mu g/kg fentanyl and 0.1 mg/kg vecuronium, and endotracheal intubation was performed. The maintenance of anesthesia was provided by 40 % O-2 + 60 % N2O, 1-2 % sevoflurane and 50 mu g fentanyl + 2 mg vecuronium every 45 minutes in the first group. In the second group, 60 % dry air was used instead of 60 % N2O. Results: There was no significant difference in terms of HR, SpO(2), SBP, MBP, ETCO2, body temperature, nausea-vomiting and IAP. Conclusions: In conclusion, we think that N2O usage during the general anesthesia in patients without intraabdominal problems may increase IAP level for some degree whereas it does not increase PONV. In addition, N2O usage does not change ETCO2 values (Tab. 3, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.
The Effects of Halothane and Sevoflurane on Qt Dispersion
(Acta Cardiologica, 1999) Güler, N; Bilge, M; Eryonucu, B; Kati, I; Demirel, CB
QT dispersion is defined as the difference between QT (max) and QT (min) in the 12-lead surface EGG. It has been shown to reflect regional variations in ventricular repolarisation and is significantly greater in patients with arrhythmic events than in those without them. The aim of this study was to examine the effects of halothane and sevoflurane on QT and QTc dispersion during inhalational induction of anaesthesia. The effects on QT and QTc dispersion of halothane and sevoflurane have been investigated during induction of anaesthesia. Forty-six ASA (American Society of Anaesthesiologists) physical status I-II patients, aged 16-50 years, undergoing general anaesthesia were randomly allocated to receive either halothane or sevoflurane. The mean baseline values for QT and QTc dispersion were not significantly different between the two groups (P > 0.05). QT dispersion was increased with halothane compared with baseline values (50 +/- 16 ms vs. 29 +/- 9 ms, P < 0.01) and after sevoflurane compared with baseline (48 +/- 15 vs. 33 +/- 8 ms, P < 0.01). Also, QTc dispersion was increased with halothane compared with baseline values (48 +/- 13 ms vs. 31 +/- 9 ms, P < 0.001) and after sevoflurane compared with baseline (50 +/- 14 vs. 40 +/- 11 ms, P < 0.01). The QTc interval did not change by both sevoflurane (443 +/- 7 vs. 431 +/- 21 ms, P > 0.05) and halothane (419 +/- 33 vs. 431 +/- 19 ms, P > 0.05) compared with baseline. Both halothane and sevoflurane cause myocardial repolarisation abnormalities in man in terms of increased QTc dispersion. This may be relevant in the aetiology of arrhythmias in patients during anaesthesia with halothane or sevoflurane.
The Effects of Volatile Anesthetics on the Q-Tc Interval
(W B Saunders Co, 2001) Güler, N; Kati, I; Demirel, CB; Bilge, M; Eryonucu, B; Topal, C
Objective: To examine the effects of halothane, isoflurane, and sevoflurane on Q-Tc interval (corrected for heart rate) during inhalation induction of anesthesia. Design: Prospective, double-blind, randomized study. Setting: Departments of Cardiology and Anesthesiology in a university hospital. Participants: Patients undergoing noncardiac surgery. Interventions: A total of 65 American Society of Anesthesiologists physical status I-II patients, aged 16 to 50 years, undergoing general anesthesia, were randomly allocated to receive halothane, isoflurane, or sevoflurane. Measurements and Main Results: The time to reach the predetermined end-tidal concentrations of 3 minimum alveolar concentration was 6 to 10 minutes. When compared with preinduction values, heart rate decreased after halothane (p < 0.01) and sevoflurane (p < 0.05) administration; in contrast, heart rate increased after induction of anesthesia with isoflurane (p < 0.05). The mean QRS intervals were not significantly changed after halothane, isoflurane, or sevoflurane. The Q-Tc interval was increased with isoflurane compared with baseline (465 +/- 23 441 +/- 18 msec, p < 0.01), not changed with sevoflurane (441 +/- 17 434 +/- 19 ms, p > 0.05), and shortened with halothane (426 +/- 23 nu 445 +/- 21 msec, p < 0.01). Conclusions: Sevoflurane or halothane may be preferred to isoflurane patients with conditions that are known to induce a prolonged Q-Tc interval. The effects of Q-Tc interval changes resulting from different anesthetic agents on morbidity and the incidence of arrhythmias during anesthesia warrant further investigation. Copyright (C) 2001 by W.B. Saunders Company.
Mr Fluoroscopy-Guided Transthoracic Fine-Needle Aspiration Biopsy: Feasibilitty
(Radiological Soc North America, 2003) Sakarya, ME; Unal, O; Ozbay, B; Uzun, K; Kati, I; Ozen, S; Etlik, O
The purpose of this study was to evaluate the feasibility of using an open-configuration magnetic resonance (MR) imaging system with MR fluoroscopic guidance to perform percutaneous transthoracic fine-needle aspiration biopsy in patients with lung masses. Percutaneous transthoracic aspiration biopsy in patients with lung masses. Percutaneous transthoracic aspiration biopsies were performed with MR fluoroscopic guidance in 14 patients. The masses were 2-7 cm in diameter (mean, 4.1 cm). The needle was positioned by using a free-hand technique with MR fluoroscopic guidance. The needle tip reached the target lesion, and biopsy was performed. Analysis of the biopsy specimens facilitated a specific diagnosis in all patients. Pneumothorax was noted in two patients (14%) with chronic obstructive pulmonary disease. Study results showed that the described MR fluoroscopy-guided transthoracic biopsy technique can be used safely and successfully for lung masses. MR fluoroscopy can be used to reach the target lesion easily and accurately. (C) RSNA, 2003.
Mutism as a Complication of Total Intravenous Anesthesia by Propofol -: Reply
(Lippincott Williams & Wilkins, 2003) Kati, I; Demirel, CB; Anlar, O; Hüseyinoglu, UA; Silay, E; Elcicek, K; Elcicek, K.
A New Agent for Treatment of Acute Respiratory Distress Syndrome: Thymoquinone. an Experimental Study in a Rat Model
(Oxford Univ Press inc, 2005) Isik, AF; Kati, I; Bayram, I; Ozbek, H
Objective: Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are important clinical problems in thoracic surgery and critical care medicine. Most of the treatment methods are still supportive. Thymoquinone has anti-inflammatory, spasmolytic, bronchoditator and antibacterial effects. We studied its effects on ALI/ARDS in a rat model. Methods: ALI/ARDS was developed in 40 Sprague-Dawley mate rats (200-250 g in weight) by intratracheal instillation of human gastric juice (pH 1.2). Rats were treated with mechanic ventilator for 3 h. There were five groups: Control group (n = 11); Steroid group (n = 10); Ethanol group (n = 5); Thymoquinone group (n = 9) and Thymoquinone+Steroid group (n = 5). No instillation except gastric juice was applied in the first group. Thymoquinone was given in dosage of 6mg/kg, metilprednisolone in dosage of 10 mg/kg, ethanol 0.75 ml/kgintraperitoneatly (IP). Blood gas analysis and compliance measurement were done. At the end of the third hour, rats were sacrificed and their lungs were excised for histopathotogical examination. Results: In the thymoquinone group, the ratio of arterial oxygen to the fraction of inspired oxygen (PO2/FiO(2),) was significantly better compared to the other groups (P = 0.0000.043). Static compliance measurements revealed higher values in thymoquinone and thymoquinone+steroid groups. Histopathotogical examinations showed that affected lung tissue is tower in groups 2 and 4 (P = 0.000-0.027). Conclusions: This study revealed that thymoquinone improved oxygenation white both thymoquinone and steroids protect lung tissue from hazardous effects of human gastric juice (pH 1.2) histopathologically. (c) 2005 Elsevier B.V. All rights reserved.
An Unusual Complication of Total Intravenous Anesthesia
(Lippincott Williams & Wilkins, 2003) Kati, I; Demirel, CB; Anlar, O; Hüseyinoglu, UA; Silay, E; Elcicek, K
We report a case of mutism secondary to total IV anesthesia with propofol, as an unusual complication that we have not found in the literature. Pulse oximetry may produce skin damage after the administration of photosensitizing chemotherapeutic drugs. Surgery must often be performed in near darkness during photodynamic therapy. Limiting the duration of pulse oximetry and rotating sites allowed successful use of pulse oximetry in a long anesthetic during which verteporphin was administered.
Use of the Laryngeal Mask To Evaluate a Laryngeal Web
(Springer verlag, 1999) Çankaya, H; Kati, I; Egeli, E; Demirel, CB