Browsing by Author "Kati, I."

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Acute Myotoxic Effects of by Infusion of Prilocaine and Lidocaine in Rats
(Medwell online, 2009) Ragbetli, M. C.; Yalama, M.; Erdogan, E.; Cengiz, N.; Kati, I.; Ragbetli, C.
We assumed to examine the acute myotoxic effects of infusion of the local anesthetic lidocaine and prilocaine on the gluteus maximus muscle after continuous peripheral nerve blockade in rats. Eight adult female Sprague-Dawley average weighing 150-200 g rats were used in this study. Firstly, all of the animals were anesthetized with ketamine (50 mg kg(-1)) for 6 h. Then, prilocaine (right) and lidocaine (left) were used in equal volume (5 mg mL(-1)) for continuous peripheral nerve blockades of the posterior extremity at a rate of 0.3 mL h(-1) for a total period of 6 h in 5 animals. The remaining 3 animals as control group were treated with physiological saline on both sides at 0.3 mL h(-1) for a total period of 6 h. For routine histological observation, the infusion area was dissected and tissue samples including peripheral muscle were taken. For routine histological observation, the infusion area was dissected and tissue samples including peripheral muscle were taken. Method histological hazards as myotoxicite were not observed in skeletal muscle tissue after the infusion of prilocaine and lidocaine. There were no complications cases of local anesthesia. Prilocaine and lidocaine as local anesthetics might be applied safely by infusion.
Anaesthetic and Hemodynamic Effects of Continuous Spinal Anaesthesia Versus Single Dose Spinal Anaesthesia in Elderly Patients
(2001) Dimirel, C.B.; Kati, I.; Cem Tuncer, Y.; Hüseyinoǧlu, Ü.A.; Silay, E.
Forty patients (>70 years old) scheduled for retropubic transvesical prostatectomy were prospectively evaluated in order to compare quality of anaesthesia, complications and hemodynamic tolerance of titrated doses of plain bupivacaine using continuous spinal anaesthesia versus single dose spinal anaesthesia. Patients were randomized into two groups (Group K: continuous spinal anaesthesia, n: 20, Group S: single dose spinal anaesthesia, n: 20). The group S patients received 3 mL of 0.5% plain bupivacaine, and the group K patients received a starting dose of 1.5 mL of 0.5% plain bupivacaine, followed after 10 min by optional reinjection of 0.5 mL every 5 min until T10 level sensory block was reached. Onset of anaesthesia, hemodynamic variables, the need for ephedrine and complications were registered. Spinal anaesthesia was successful in all patients of both groups. Decreases in mean arterial pressure were significantly less pronounced in the group K than in the group S. The variations in heart rate were small and there was no significant difference between the two groups. The mean dose of ephedrine was significantly less in the group K than in the group S. No neurological complications related to the spinal anaesthesia technique were observed in either group. As a result of this study, the continuous spinal anaesthesia, using small titrated doses of 0.5% plain bupivacaine, is safe, efficient, and provides better hemodynamic stability than single dose spinal anaesthesia in elderly patients.
Anesthesia Management of Jansen’s Metaphyseal Dysplasia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Goktas, U.; Tekin, M.; Kati, I.
Metaphyseal chondrodysplasia is a rare autosomal dominant disorder characterized by accumulation of cartilage in specifically metaphysis of tubular bones. Hyperkalemia and hypophosphatemia were seen most of these patients. In this article we intended to draw attention to some issues releated with anesthesia hereby that a 9 year-old patient with Jansen’s metaphyseal dysplasia. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Anesthesia Mumps After the Cesarean Section in Pregnant Woman
(TIP ARASTIRMALARI DERNEGI, 2011) Kati, I.; Kurdoǧlu, Z.; Göktaş, U.; Aytekin, O.Ç.; Avcu, S.
Anesthesia mumps is characterized by acute transient swelling of the parotid gland association with general anesthesia. We presented a 25 years old pregnant woman with anesthesia mumps after 24 hours Cesarean section, and discussed treatment of anesthesia mumps and differential diagnosis. 25 years old woman underwent to operation for Cesarean section. Her Medical history had no chronic disease, and no allergies. Her mental and psychological status, neurological, other systematical examination findings and laboratory values were normal. General anesthesia was administered. Twenty four hours after the extubation, a large swelling of right more than left parotid region expanding down to the mandibular angle was noted. In conclusion we suggest that especialy obstetrical cases should be performed gently intubation and extubation and used medications should be attention. In additioal, anesthesia mumps of patients may fully recover within a few days without any treatment or with treatment.
Ankylosis of Temporomandibular Joint, Micrognathia and Difficult Intubation (Case Report)
(2004) Kati, I.; Tekin, M.; Hüseyinoǧlu, Ü.A.; Silay, E.
Fiberoptic bronchoscopy is widely used for tracheal intubation in cases where direct laryngoscopy could not be achieved. In this case report we have discussed the anaesthetic management of a 17-years-old male with temporomandibular joint ankylosis and micrognathia developed following a trauma in childhood. We concluded that; although several methods can be used in cases of difficult intubation, following a careful preoperative preparation and by taking preventive measures, fiberoptic intubation can be performed providing spontaneous breathing without any problem in patients having micrognathia and restricted mouth opening.
Bilateral Superficial and Deep Cervical Plexus Block for Thyroidectomy in Pregnancy
(Elsevier Sci Ltd, 2013) Goktas, U.; Isik, Y.; Kati, I.; Aytekin, O. C.; Bartin, S.
Catheter Related Pneumomediastinum
(2009) Göktaş, U.; Avcu, S.; Kati, I.; Özhan, C.
Central venous catheterization is usually used in situations such as major blood loss or where myocardial function is impaired. Pneumomediastinum is a rarely seen event associated with central venous catheterization. In this presentation, we wanted to highlight the importance of radiographic control in unrecognized cases with pneumomediastinum developed after repeated catheterizations.
Comparison of Bupivacaine With Bupivacaine Plus Fentanyl Administered Via Thoracic Epidural Catheter for Pain After Thoracotomy in Children
(2004) Demirel, C.B.; Kati, I.; Köseoǧlu, B.; Bakan, V.; Hüseyinoǧlu, Ü.A.; Silay, E.
In this study, we aimed to compare the analgesic and side effects of bupivacaine versus bupivacaine and fentanyl combination administered via epidural cathater. Sixty children, aged 3-12 years, ASA I or II physical status, undergoing thoracic surgery were studied. All patients were monitorized routinely. Anaesthesia induced with sevoflurane or thiopenton, atracurium and fentanyl, and meintained with O2 + air, sevoflurane, atracurium and fentanyl. At the end of the operations, epidural catheters were placed below two dermatomes of the surgical incision. In the First Group, 0.3 mL kg-1 bupivacaine 0.125 % was administered as a bolus through the catheter, and infusion in a dose of 0.3 mL kg-1 h-1 added. In the Second Group, 2 mg mL-1 fentanyl and bupivacaine 0.125% was administered as a bolus in a dose of 0.3 mL kg-1 and infusion in a dose of 0.3 mL kg-1 h-1 added. Pain scores were decreased lower than four points in all patients except two patients in the first group, and three patients in the second group. In the second group, sedation scores were higher and pupil's diameters were smaller than the first group. In conclusion, thoracal epidural analgesia seems to be favorable method for pain relief after thoracotomy. However, we must be careful for sedation if opioids will be added to local anesthetics.
Comparison of Preemptive Analgesic Effects of Epidural Tramadol and Morphine
(2001) Kati, I.; Demirel, C.B.; Abbasov, U.H.; Silay, E.
In this study we aimed to compare the efficiency of epidural tramadol versus morphine in preemptive analgesia and their side effects. We studied 45 ASA I-II class randomised 20-60 years old patients in three equal groups. After five minutes of the test dose 5 mL of 2 % lidocaine, 100 mg tramadol 75 mg tramadol, 4 mg morphine all diluted in 10 mL saline were administered epiduraly consequetively to the first, second and third group. After ten minutes sensorial block was controlled and anaesthesia induction and intubation was provided with thiopenthone (5 mg/kg), vecuronium (0.08 mg/kg), and fentanyl (2 μg/kg). Anaesthesia was maintained with O2/N2O and isoflurane. No other analgesic were given to the patients intraoperatively. In all patients, the visual analogue pain score was monitored every two hours, PaO2, PaCO2 and respiratory rate were monitored every six hours and SpO2 was continuously monitored every hour for the first 24 hours postoperatively. VAS was not found statistically significant during the first 15 hours among the groups. VAS was significantly different in the morphine group (p<0.01) during the following hours. PaO2, PaCO2 and breathing rates and side effects among all groups were not found statistically significant. We conclude that different doses of epidural tramadol are safe and efficient as a single dose of morphine for postoperative pain relief.
Comparison of the Effects of Intravenous Lornoxicam and Paracetamol on the Endocrine Stress Response and Analgesia in the Postoperative Period
(John Wiley & Sons Ltd, 2010) Ozhan, C.; Ozhan, M. O.; Caparlar, M. A.; Suzer, M. A.; Cekmen, N.; Eskin, M. B.; Kati, I.
Comparison of the Effects of Lma Inflated With Room-Air or N 2o+o2 on the Oropharyngeal Structures
(2003) Kati, I.; Çankaya, H.; Tekin, M.; Abbasov, Ü.H.; Silay, E.
In this study, we aimed to evaluate the effects of between different gases for LMA cuff inflation cuff pressure, oropharyngeal lesions and sore throat incidence. Fifty-five ASA I-II patients that underwent general anaesthesia were divited into two groups randomly. The patients were premedicated with midazolam 0.05 mg kg-1 intravenously. Routine monitors were placed, and anaesthesia was induced with intravenous propofol and fentanyl. LMA were inserted after loss of eyelash reflex. LMA cuff inflation was achieved with appropriate volume of 50 % N2O+50 % O2 and room-air respectively in groups I and II. The intracuff pressure was measured at initial, 30th, 60th and 90th minutes during surgery. At the end of the operation, LMA was removed after spontaneous respiration began and oropharyngeal examination was carried out immediately by rigid optic telescope. One hour later, the patients were questioned postoperatively about sore throat. Cuff pressures were significantly lower in group I when compared to group II at 30th, 60th and 90th minutes except for initial cuff pressure. In group II, cuff pressure was gradually and significantly dropped during the course. In group I, there was a negative linear correlation between time and lesion and positive linear correlation between lesion and sore throat. In group II, there was a positive linear correlation between pressure and lesion, pressure and sore throat and lesion and sore throat. Sore throat was significantly more frequent in group II. In conclusion, we suggested that usage of N2O-O2 mixture instead of room-air is suitable for LMA cuff inflation because of decreased sore throat and laryngeal mucous membrane injury.
Complete Atrioventricular Block Presenting With Arrest
(2011) Işik, Y.; Gümrükçüoǧlu, H.A.; Göktaş, U.; Akdaǧ, S.; Kati, I.
The most common cause of complete atrioventricular block is drug toxicity, coroner artery disease and degenerative disorders in adults. Here we present a case of complete AV block and sudden cardiac arrest in women while waiting to make examination of her child in another health center. A 29 years old woman had a normal vaginal delivery 2 mounts ago. About 14 minutes, resuscitated the patient was referred to our hospital. The first evaluation in the emergency department; consciousness closed, pupil dilation, pupil light reflex. +/+, intubated, heart rate 30 beats min-1, blood pressure: 90/60 mmHg and Glasgow Coma Score: 7. Complete atrioventricular block was detected in electrocardiography and single-chamber temporary cardiac pacemaker was inserted and the rhythm of 80 beatslmin arranged by cardiology department. The patient in this state transferred anesthesia intensive care unit and connected mechanical ventilation. Drug levels were normal in patient with suspected intoxication. Patient was extubated one day after the consciousness and transferred to cardiology clinic. When more than 72 hours to pass the first event we through that patient pacemaker-dependent. Dual chamber pace maker was inserted. The patient was discharged three days after pacemaker implantation. In conclusion, we reported a patient with atrioventricular block presented with life-threatening clinical manifestations due to peripartum cardiomyopaty and treated without sequela.
Difficult Tracheal Extubation (Case Report)
(2003) Demirel, C.B.; Kati, I.; Çankaya, H.; Hüseyinoǧlu, Ü.A.; Egeli, E.
Difficult tracheal extubation is hardly recognized by anesthesiologists as it is rarely encountered in comparison to difficult tracheal intubation. In patients, trials of extubation can be fatal when the real reason is not found. In most cases, the problem arises from an inability to deflate the cuff, commonly as a result of failure in the cuff-deflating mechanism. We present a patient who had operation for laryngo-fissur and chordectomy. The patient was intubated orally by direct laryngoscopy with a spiral endotracheal tube, which was used for the second time due to economical reasons. At the end of operation, the cuff could not be deflated via normal procedure. The patient was given anesthesia again and the cuff was exploded by a stile under direct laryngoscopy and extubation was performed. In patients with difficult tracheal extubation, it is better to do extubation after finding the real reason.
Effect of N 2o on Nausea and Vomiting Via Intraabdominal Pressure
(2012) Yuce, H.H.; Goktas, U.; Kati, I.; Cegin, M.B.; Soyoral, L.
Background and objective: In this study we aimed to investigate whether there is an effect of N 2O on postoperative nausea and vomiting (PONV) via intraabdominal pressure (IAP). Methods: A total of 40 patients with risk class ASA I-II and age ranging between 20 and 50 years were enrolled in the study. The patients were monitored for electrocardiography (ECG), peripheral oxygen saturation (SpO 2), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), end-tidal carbon dioxide (ETCO 2) and body temperature. IAP was measured by a central venous pressure manometer placed in the urine catheter. Heart rate (HR), SpO 2, SBP, DBP, MBP, ETCO 2, body temperature and IAP were measured before the induction of anesthesia and every 10 minutes throughout the operation. Nausea and vomiting were questioned at the first and second postoperative hours. The patients were randomly grouped into two groups. Induction in both groups was provided using 2 mg/kg propofol, 2 pg/kg fentanyl and 0.1 mg/kg vecuronium, and endotracheal intubation was performed. The maintenance of anesthesia was provided by 40 % O 2+ 60 % N 2O, 1-2 % sevoflurane and 50 g fentanyl + 2 mg vecuronium every 45 minutes in the first group. In the second group, 60 % dry air was used instead of 60 % N 2O. Results: There was no significant difference in terms of HR, SpO 2, SBP, MBP, ETCO 2, body temperature, nau-sea-vomiting and IAP. Conclusions: In conclusion, we think that N 2O usage during the general anesthesia in patients without intraab-dominal problems may increase IAP level for some degree whereas it does not increase PONV. In addition, N 2O usage does not change ETCO 2 values (Tab. 3, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.
Effects of Dexmedetomidine on the Duration of Anaesthesia and Wakefulness in Bupivacaine Epidural Block
(Lippincott Williams & Wilkins, 2007) Coskuner, I.; Tekin, M.; Kati, I.; Yagmur, C.; Elcicek, K.
Background. The purpose of this study was to examine the effects of intravenous dexmedetomidine on the duration of bupivacaine-induced epidural anaesthesia and level of wakefulness and the respective side-effects. Methods: Sixty ASA I-II patients were included in the study. Consecutive patients were allocated to groups according to the last digit (odd/even) of their admission numbers. All patients had epidural anaesthesia with bupivacaine 0.5% performed by the same experienced anaesthesiologist. In the first group, the patients were administered intravenous dexmedetomidine infusion just after the epidural block and continued during the operation, while those in the second group were administered physiologic saline infusion at the same amount and duration. Results: The recovery time of sensory block was significantly longer in the first group. The bispectral index values were lower in the first group than in the second. Also, heart rate was significantly lower in Group I than in Group II. Regarding side-effects, shivering was significantly less frequent in the first group, whereas there was a significant increase in the requirement of atropine in the first group as dexmedetomidine caused bradycardia. Conclusion: Intravenous administration of dexmedetomidine prolonged the duration of epidural anaesthesia, provided sedation and had few side-effects.
The Effects of Volatile Anaesthetic Agents in Myocardial Repolarization During Induction of Anaesthesia
(1999) Guler, N.; Bilge, M.; Eryonucu, B.; Demirel, C.B.; Kati, I.; Sayarlioglu, M.
QT dispersion may serve as a measure of variability in ventricular repolarization time and may be a means of identifying patients at risk of arrhythmias and sudden death after different clinical settings. The acute responses of QTc dispersion were assessed in 47 American Society of Anesthesiology (ASA) class 1 or 2 patients receiving volatile anaesthetic agents. Anaesthesia was induced with sevoflurane (n=16), halothane (n=17), or isoflurane (n=14), and the inspired concentration increased to reach an end- tidal concentration of 1% to 6%. Recordings of ECG, heart rate, blood pressures were obtained at the following times: prior to induction of anaesthesia, 1 min and 3 min after stable end-tidal concentration, 1 min and 3 min later vecuronium administration, and 1 min and 3 min after tracheal intubation. All the patients studied had normal values of QTc interval and QTc dispersion at rest. All anaesthetic agents significantly increased QTc dispersion compared with baseline values. Both isoflurane and sevoflurane increased QTc interval compared with baseline in contrast to halothane which did not change it significantly. Thus, anaesthetic agents cause myocardial repolarization abnormalities in man in terms of increased QTc dispersion. This may be relevant in the aetiology of arrhythmias in patients receiving anaesthesia without cardiovascular disease.
Epidural Analgesia After Lumbar Disc Surgery With Ropivacaine Plus Fentanyl or Bupivacaine Plus Fentanyl
(2005) Kati, I.; Demirel, C.B.; Cirak, B.; Huseyinoglu, U.A.
We compared the efficacy and safety of continuous epidural infusion of ropivacaine plus fentanyl versus bupivacaine plus fentanyl in the management of postoperative pain after lumbar laminectomy. Twenty-two patients who underwent elective lumbar laminectomy were randomly allocated to one of two groups. The patients were treated with ropivacaine 0.1% plus fentanyl 2 μg/ml in group 1, and with bupivacaine 0.1% plus fentanyl 2 μg/ml in group 2 via bolus epidural infusion (6-10 ml/h). General anesthesia was standardized. Postoperative pain was evaluated using VAS at 0, 1, 2, 3, 8, 20, 32, 48 hours after surgery. The amount of ropivacaine plus fentanyl or bupivacaine plus fentanyl used over the 48-h postoperative period was documented. The postoperative pain and sedation scores were not significantly different between groups throughout the study period. The total consumption of ropivacaine plus fentanyl over the 48-h period was significantly lower (p < 0.05) than that of bupivacaine plus fentanyl. There was no difference in the incidence of side effects. No patient developed respiratory depression or wound infection. We conclude that the use of ropivacaine-fentanyl mixture for patient epidural analgesia after lumbal disc surgery provides similar succesful pain relief as bupivacaine plus fentanyl, but patients receiving bupivacaine-fentanyl need a higer dose. © 2005 VSP.
Factor Vii Deficiency and Anesthesia
(2008) Göktaş, U.; Kati, I.; Tekin, M.; Çeǧin, M.B.; Korkut, M.
We suggest that recombinant factor VII concentrate could be used to prevent bleeding in the patients with congenital factor VII deficiency in the anesthesia procedure.
Histopathological Effects of Desflurane on the Liver and the Kidney Using Light Microscopy
(2010) Kati, I.; Tekin, M.; Tas, A.; Ragbetli, C.; Ugras, S.
The aim of this study was to histopathologically assess the toxic effect of desflurane on the liver and the kidney. The rats (n = 150) were grouped into five main and three subgroups according to the exposure time to the anesthetic agent. The first group was planned as 1 MAC Desflurane+N2O+O2, the second group as 1 MAC Desflurane+O2, the third group as 2 MAC Desfiurane+N2O+O2, the fourth group as 2 MAC Desflurane+O2 and the 5th group as the control group. Each group was given the anesthetic agent for 1, 3 or 6 h. The rats that were exposed to the anesthetic agent with an adequate dose and for an adequate period of time were sacrificed properly. Livers and kidneys were resected and examined by light microscopes following the routine tissue follow-up procedures. Significant histopathological changes were observed in all groups compared to the control group. However, the pathological findings of the group 2 MAC Desflurane+N2O+O2 at the 6th h with the light microscope was significantly more than those of other groups at all times. It was concluded that although, desflurane caused cellular changes in liver and kidney tissue, it did not cause any clinical changes. Nevertheless, further studies are required to support this opinion. © Medwell Journals, 2010.
The Histopathological Effects of Intraarticular Administration of Tramadol on Rabbit's Sinovia
(2003) Kati, I.; Demirel, C.B.; Uǧraş, S.; Abbasov, U.H.; Silay, E.; Timurkan, H.
The analgesic effect of tramadol is due to it's effect on opioid receptor together with the enhancing function of the spinal descending inhibitory pathway by inhibition of reuptake of both 5 hydroxytryptamine and norepinephrine. In this study we aim to invastigate the effects of intraarticular tramadol on synovia. Eighteen healtyh rabbits 0.5-1 years old and weighted between 1.8-2.5 kg were included in the study. All rabbits were divided into five groups as follow; Group 1 (n=4), group 2 (n=4), Group 3 (n=4), Group 4 (n=4), and control group (n=2). Tramadol (12.5 mg/0.5 mL), or saline (0.5 mL) were given, intraarticularly in to the back knees of the rabbits in the study groups and control group respectively. Rabbits in group 1 and control groups were sacrified at first day, group 2 at 7th day, group 3 at 15th day, and group 4 at 21 th day by letal dose of sevoflurane. Examination of sinovia of the all rabbits were normal and there was no differences between groups. In conclusion; Tramadol has no histopathological effect on rabbits sinovia and may be safely administered intraarticularly in human.