Browsing by Author "Kavak, S."

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Effects of High-Rate Frequency Modulation Treatment on Malondialdehyde in Diabetic Polyneuropathy
(Asian Journal of Chemistry, 2010) Kavak, S.; Dulger, H.; Tulgar, M.; Alkis, I.
This study is planned to investigate the effects of transcutaneous electrical nerve stimulation (TENS) treatment on patients which have diabetic polyneuropathy. Fourteen diabetic polyneuropathy patients suffering ischemic pain were examined during the cure. Malondialdehyde (MDA) and glycemia levels were determined by collecting 5 mL blood samples from 14 patients 24 h before beginning the treatment. In case 50 Hz signals as high-rate frequency modulation (HRFM; continuous pulses changed from 90 Hz to 55 Hz over 90 msec, 1.3 times a second), were applied to patients as long as 20 d for 20 min a day. Transcutaneous electrical nerve stimulation (TENS) treatment increased significantly free oxygen radicals (p < 0.05). The levels of MDA before TENS were compared to the levels of MDA after TENS and the end of the following term of 20 days by paired sample test and a meaningful increase was seen significantly (p < 0.01). Besides, glycemia levels were decreased significantly before TENS-after TENS treatment (p/< 0.01) and not changed before TENS and the end of the following term of 20 d (p > 0.05.). Moreover, it was observed that MDA levels were decreased significantly between in the final of the treatment and the end of the following term of 20 d (p < 0.01). Glycemia levels were not changed significantly after TENS and the end of the following term of 20 d (p > 0.05). According to this results, it is observed that TENS treatment has been positive effect on poly neuropathy.
Short-Term Levosimendan Treatment Protects Rat Testes Against Oxidative Stress
(Assoc Bras Divulg Cientifica, 2012) Yuksel, M. B.; Kavak, S.; Gecit, I.; Basel, H.; Gumrukcuoglu, H. A.; Demir, H.; Meral, I.
The objective of this study was to evaluate the effect of short-term levosimendan exposure on oxidant/antioxidant status and trace element levels in the testes of rats under physiological conditions. Twenty male Wistar albino rats were randomly divided into two groups of 10 animals each. Group 1 was not exposed to levosimendan and served as control. Levosimendan (12 mu g/kg) diluted in 10 mL 0.9% NaCl was administered intraperitoneally to group 2. Animals of both groups were sacrificed after 3 days and their testes were harvested for the determination of changes in tissue oxidant/antioxidant status and trace element levels. Tissue malondialdehyde (MDA) was significantly lower in the levosimendan group (P < 0.001) than in the untreated control group and superoxide dismutase and glutathione peroxidase (GSH-Px) levels were significantly higher in the levosimendan group (P < 0.001). Carbonic anhydrase, catalase and GSH levels were not significantly different from controls. Mg and Zn levels of testes were significantly higher (P < 0.001) and Co, Pb, Cd, Mn, and Cu were significantly lower (P < 0.001) in group 2 compared to group 1. Fe levels were similar for the two groups (P = 0.94). These results suggest that 3-day exposure to levosimendan induced a significant decrease in tissue MDA level, which is a lipid peroxidation product and an indicator of oxidative stress, and a significant increase in the activity of an important number of the enzymes that protect against oxidative stress in rat testes.