Browsing by Author "Kaya, Nurcan"

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Development of 5,5′-Bi(1,10 Pvc Membrane Potentiometric Sensor for Silver Determination
(Wiley, 2025) Gungordu Solgun, Derya; Kaya, Nurcan; Saydan Kanberoglu, Gulsah; Agirtas, Mehmet Salih
In this study, the selectivity of the 5.5 '-bi(1,10-phenanthroline) Compound (1) against Ag+ ions as a chemical sensor was investigated by both absorption and potentiometric methods. First, a 1 x 10(-5) M solution of Compound (1) in acetonitrile was prepared. For the selectivity test, 1 x 10(-2) M solutions of metal ions in acetonitrile were prepared. UV-visible absorption measurements were performed by adding metal ions to a 5.5 '-bi(1,10-phenanthroline) compound at certain concentrations. Among the studied metal ions, it was found to be selective only against silver ions. In addition, solid-state contact polyvinylchloride (PVC) membrane electrodes prepared using 5.5 '-bi(1,10-phenanthroline) as an ionophore were found to be selective against Ag+ ions among other ions. The optimum membrane composition of the measurement was determined as 3% 5.5 '-bi(1,10-phenanthroline) + 32% PVC + 64% o-nitrophenyl octyl ether (o-NPOE) + 1% potassium tetrakis(4-chlorophenyl) borate (KTpClPB). The potentiometric properties of the silver selective electrode were determined as linear working range 1.0 x 10(-7)-1.0 x 10(-3) M, detection limit 1.0 x 10(-7) M, pH working range 3.23-9.08, and response time 3 s. Absorption and potentiometric methods confirm the selectivity towards silver ions. The IRC analysis of the silver-containing complex, performed using the DFT/B3LYP method with the LanL2DZ basis set, reveals an activation energy of approximately 0.002 Eh, with the transition state energy at -1.433173 Eh.
Development of a Novel PVC Membrane Lidocaine-Selective Potentiometric Sensor Based on MIL-53 (Al) Metal Organic Framework as a Functional Material
(World Scientific Publ Co Pte Ltd, 2025) Gumus, Seyhmus; Kanberoglu, Gulsah Saydan; Kaya, Nurcan; Coldur, Fatih
Lidocaine is the most commonly used local anesthetic and can be used to reduce the feeling of pain caused by the stability of the nerve membrane and the pain that occurs at the end of the nerve signals in the skin. Due to the fact that lidocaine overdose causes side effects, determination of lidocaine is of great importance. The present study presents the development of a novel, simple, low-cost and reliable PVC membrane lidocaine hydrochloride-selective potentiometric sensor based on MIL-53(Al) metal organic framework (MOF) as a selective sensing functional material. The proposed sensor exhibited a linear potentiometric response for lidocaine hydrochloride in the concentration range of 1.0 x 10(-7)M-1.0 x 10(-1) M with the potential change of 55.4 mV/decade and a detection limit of 5.0 x 10(-8) M. The response time and the pH working range of the sensor were determined as 10 s and 2.37-7.45, respectively. These performance characteristics denote that the potentiometric lidocaine hydrochloride-selective sensor has quite superior properties. The potentiometric application of the lidocaine hydrochloride-selective sensor was successfully applied in pharmaceutical preparations.
Development of Mof Based Potentiometric Sensor for Determination of Rhodamine B
(2023) Kaya, Nurcan; Kanberoğlu, Gülşah Saydan
Rodamin B (RB), son zamanlarda Avrupa ve Çin'den gelen gıdalarda olası yasa dışı katkı maddeleri olarak tanımlanan en eski ve en yaygın kullanılan sentetik boyalar arasındadır (Avrupa Gıda Güvenliği Otoritesi (EFSA), 2005). Su, metanol ve etanolde oldukça çözünür olan bazik, kırmızı, katyonik bir boya olan ksanten boyaları sınıfına aittir. RB, insanlar tarafından yutulması halinde zararlıdır. Ciltte, gözlerde ve solunum yollarında tahrişe neden olur. Deneysel olarak, insanlara ve hayvanlara karşı kanserojen, üreme ve gelişimsel toksisite, nörotoksisite ve kronik toksisiteye sahip olduğu gösterilmiştir (Jain vd., 2007). Yoğun rengi ve hazır bulunabilmesi nedeniyle RB, doğal rengi geliştirmek için gıda ürünlerine, özellikle kırmızıbiber baharatlarına yasa dışı bir şekilde eklenmiştir (Qi vd., 2014). Bu tezde, iyonofor olarak MOF yapılarından MIL-53 (Al) kullanılarak bir PVC membran Rodamin B seçici potansiyometrik sensör geliştirilmiştir. Optimum mebran bileşimi olarak %6 MIL-53 (Al), %68 DOS, %26 PVC bileşimi belirlenmiştir. Optimum membran bileşiminde hazırlanan sensör, pH'ı 4.5'e ayarlanan Rodamin B için 58 mV/ 10 kat konsantrasyon değişimi ve 5.0×10−7M tayin limiti ile 1.0×10−6M-1.0×10−2M konsantrasyon aralığında doğrusal bir cevap sergiledi. Sensörün pH çalışma aralığı 4.49-8.08 olarak belirlendi. Sensörün cevap süresi 5 saniyeden düşük olarak bulundu. Bu performans özellikleri, potansiyometrik Rodamin B seçici sensörün oldukça üstün özelliklere sahip olduğunu göstermiştir. Rodamin B seçici sensörün potansiyometrik uygulaması, çeşme suyu, atık su ve Van Gölü suyunda başarıyla gerçekleştirilmiştir.
Fabrication of a High Electrochemical Performance MTOAC Sensor and Its Use in Perchlorate Measurement
(Springer, 2025) Kanberoglu, Gulsah Saydan; Kaya, Nurcan; Calimli, Mehmet Harbi; Coldur, Fatih
The detection of perchlorate in some environmental and medical samples has been investigated by various research groups. However, due to its low detection limit and wide operating range, sensitive and selective perchlorate detection presents several challenges and requires costly analytical methods. In this study, methyltrioctylammonium chloride (MTOAC) was successfully used as an ionophore for the determination of perchlorate (ClO4-). The MTOAC ionophore-containing sensor demonstrated superior potentiometric properties, including a fast response time of 15 s, a wide linear operating range of 1.0 x 10(- 2) to 7.5 x 10(- 8) M, a low detection limit of 6.8 x 10(- 8) M, a wide pH operating range of 3.36-9.65, and high repeatability at perchlorate concentrations of 10(- 4) to 10(- 6) M. Additionally, the MTOAC sensor showed high recovery (99.4-102.3%) in different water samples obtained from tap water, wastewater, spring water and Van Lake water. Compared to the sensors reported in the literature, the MTOAC sensor exhibited a wider linear working range and a lower detection limit. The low production cost, short response time, the absence of pretreatment, ease of use without requiring expertise, and the ability to operate even in turbid solutions make the MTOAC ionophore-containing membrane-based sensor a promising alternative for practical analytical applications.
Fabrication of a PVC-Membrane Potentiometric Sensor Based on a Bis (Trimethylaminoethylsulfanyl)diaminophthalocyanine Di(Methylsulfate) for Direct Determination of Donepezil in Pharmaceutical Formulation and Physiological Serum
(Elsevier, 2025) Kaya, Nurcan; Kanberoglu, Gulsah Saydan; Agirtas, Mehmet Salih
Donepezil hydrochloride is a cholinesterase inhibitor used in the treatment of Alzheimer's disease, which arises from damage to neurons in brain regions responsible for memory, learning, language, and reasoning. Overdose of donepezil may cause side effects such as fatigue, panic, sweating, vomiting, increased muscle tension, speech difficulties, and involuntary tremors. Therefore, accurate determination of donepezil is of great importance. In this study, a novel potentiometric sensor based on a poly (vinyl chloride) (PVC) membrane incorporating bis (trimethylaminoethylsulfanyl) diaminophthalocyanine di(methylsulfate) (13Pc) as the electroactive ionophore was developed. This work represents the first application of a phthalocyanine derivative as an ionophore for the determination of donepezil. The phthalocyanine derivative 13Pc, with its large conjugated It-system and strong electron-donating groups, enables selective interaction with the cationic form of donepezil. The optimum membrane composition was determined to be 3 % 13Pc, 32 % PVC, 64 % nitrophenyl octyl ether (NPOE), and 1 % potassium tetrakis(4-chlorophenyl) borate (KTpCIPB). The developed sensor exhibited a linear response over the concentration range of 1.0 x 10- 7 to 1.0 x 10- 2 M for donepezil hydrochloride, with a slope of 53.4 mV/decade and a detection limit (LOD) of 1.0 x 10- 7 M. The sensor's working pH range was 2.05 to 7.70, and the average response time was 10 s. The sensor was successfully applied for the determination of donepezil hydrochloride in pharmaceutical tablets and physiological serum samples. Additionally, the environmental sustainability of the developed potentiometric sensor was comprehensively evaluated using EVG (Efficiency, Validation, Greenness) and AGREE (Analytical GREEnness) assessment metrics.
A Novel Pvc-Membrane Potentiometric Sensor Based on Molecularly Imprinted Polymer for the Determination of Rhodamine B
(Springer Wien, 2025) Kanberoglu, Gulsah Saydan; Kaya, Nurcan; Coldur, Fatih; Hashemi-Moghaddam, Hamid; Soylak, Mustafa
A rhodamine B (RH-B)-imprinted functional polymer was synthesized by free radical polymerization, utilizing RH-B as the template, methacrylic acid as the functional monomer, and ethyleneglycol dimethylacrylate as the cross-linker. The synthesized RH-B-imprinted polymer was characterized by FT-IR measurements. A novel RH-B-selective potentiometric poly(vinyl chloride) (PVC) membrane sensor was fabricated using this newly synthesized RH-B-imprinted functional polymer as the ionophore. Membrane optimization studies revealed that the most satisfactory membrane composition, yielding the best potentiometric parameters, comprised 32.0% (w/w) PVC, 64.0% (w/w) dibutyl phthalate, 3.0% (w/w) RH-B-imprinted polymer, and 1.0% (w/w) potassium tetrakis(4-chlorophenyl)borate. Further investigations into the potentiometric performance characteristics of the optimum composition demonstrated that the sensor exhibited a linear response to RH-B within the concentration range of 1.0 x 10-7 to 1.0 x 10-2 M with a detection limit of 1.0 x 10-8 M and a near Nernstian slope of 67.37 mV/decade. The sensor's analytical proficiency was evidenced by its precise quantification of RH-B in RH-B-spiked rose-water samples, resulting in satisfactory recovery rates.