Browsing by Author "Kaya, Zekeriya"

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Age at Death in the Turkish Adult Risk Factor Study: Temporal Trend and Regional Distribution at 56.700 Person-years' Follow-Up
(Turkish Soc Cardiology, 2009) Onat, Altan; Ugur, Murat; Tuncer, Mustafa; Ayhan, Erkan; Kaya, Zekeriya; Kucukdurmaz, Zekeriya; Kaya, Hasan
Objectives: We analyzed the temporal trend and regional distribution of age at death due to all-causes and the sex-specific and age range defined by coronary mortality in the 18-year follow-up of the Turkish Adult Risk Factor Study. Study Design: The participants of the Turkish Adult Risk Factor Study who have been examined in even years were last surveyed in August 2008. A total of 1,582 individuals were surveyed, which constituted half of the surviving participants of the overall cohort. Information on death was obtained from first-degree relatives and/or health personnel of local health offices. Survivors were evaluated by history, physical examination, and 12-lead electrocardiography. The cumulative follow-up was 56,700 person-years. Results: Of 1582 participants, 868 (431 men, 437 women) were examined, in 604 subjects information was gathered, and 47 participants (26 men, 21 women) were ascertained to have died. Twenty-two deaths were classified as being of coronary origin. Cumulative assessment of the entire cohort in the age range of 45-74 years disclosed coronary mortality to be 7.64 per 1000 person-years in men and 3.84 in women and persisted to be the highest among 30 European countries, whereas overall mortality declined at a greater proportion. Overall mean ages at death were deferred within a 12-year period by 7.4 years in men and 6 years in women, to 71.9 and 74.8 years, respectively. The extension of this mean survival was similar among urban-rural areas and geographic regions. Conclusion: Coronary mortality declined modestly, but life expectancy of Turkish adults rose by a mean of nearly seven years in the 12 years to 2003-08 without showing major differences in sex, urban-rural dwelling or geographic regions.
Association of Resting Heart Rate and Arterial Stiffness in Healthy Adults
(Pera Yayincilik Hizmetleri, 2016) Altiparmak, Ibrahim Halil; Erkus, Muslihittin Emre; Kocaarslan, Aydemir; Gunebakmaz, Ozgur; Kaya, Zekeriya; Sezen, Yusuf; Demirbag, Recep
Introduction: The arterial stiffness and resting heart rate (HR) are independent predictors of cardiovascular diseases. There are a few data about the association of HR with arterial stiffness in healthy men subjects. We aimed to evaluate this relationship in healthy male adults in the present study. Materials and Methods: A total of 50 volunteer healthy-nonsmoking male individuals (mean age: 40 +/- 12 years) enrolled in this observational study. According to the HR, the individuals were classified as group I, who have HR 50-70 beats/min (n=25) and group II, who have HR 71100 beats/min (n=25). History of the enrolled adults was recorded and they were physically examined. Blood pressure, body mass index and waist/hip ratio were measured in accordance with standard protocol. Arterial age and aortic pulse wave velocity (aPWV)indicating direct measurement of arterial stiffness were calculated by TensioMed (TM) Arteriograph. Results: There were no statistically significant differences between two groups with regard to age, body mass index, waist/hip ratio, systolic and diastolic blood pressure (for all p>0.05). The arterial age and aPWV were significantly higher in group II than group I (both; p<0.001). HR shows significant positive correlation with systolic blood pressure, body mass index, arterial age and aPWV (for all p<0.001). Conclusion: We conclude a relation between the HR and the increased arterial age and aortic pulse wave velocity levels in healthy male individuals. However, further studies are needed to clarify the pathophysiologic mechanisms responsible for the association between high HR and arterial stifness.
Dynamic Circle Image in Left Ventricle Outflow Tract
(Wiley, 2011) Karapinar, Hekim; Kaya, Zekeriya; Aung, Soe Moe; Karavelioglu, Yusuf; Kaya, Hasan; Kirma, Cevat; Esen, Ali Metin
A 46-year-old man presented with a complaint of effort dyspnea. On transthoracic echocardiography a circle appeared in LVOT. It was seen freely floating, disappearing in every systole and appearing again in diastole. Turbulence was seen inside the circle with color Doppler. Transesophageal echocardiography showed aortic cusps and their coaptation to be normal. Aortic root diameters were normal at the annulus, sinus of Valsalva, and sinotubular junction. There were no signs of dissection, infective endocarditis or abscess. But as the probe was advanced, left sinus of Valsalva was found to be prolapsed, and ruptured into LVOT. (Echocardiography 2011;28:E9-E11).
Gamma Glutamyltransferase Levels and Its Association With High Sensitive C-Reactive Protein in Patients With Acute Coronary Syndromes
(Medknow Publications & Media Pvt Ltd, 2010) Emiroglu, Mehmet Yunus; Esen, Ozlem Batukan; Bulut, Mustafa; Karapinar, Hekim; Kaya, Zekeriya; Akcakoyun, Mustafa; Esen, Ali Metin
Background: Elevated Gamma-glutamyltransferase (GGT) level is independently correlated with conditions associatedwith increased atherosclerosis, such as obesity, elevated serum cholesterol, high blood pressure and myocardial infarction. It is also demonstrated that serum gamma-glutamyltransferase activity is an independent risk factor for myocardial infarction and cardiac death in patients with coronary artery disease. Although the relationship between gamma-glutamyltransferase and coronary artery disease has been reported, not many studies have shown the relationship between changes ofgamma-glutamyltransferase in acute coronary syndromes and a well established coronary risk factor high sensitive C-reactive protein. (hs-CRP). Aims: In this study, how gamma-glutamyltransferase levels changed in acute coronary syndromes and its relationship with high sensitive C-reactive protein if any were studied. Patients & Methods: This trial was carried out at Kosuyolu Cardiovascular Training and Research Hospital and Van Yuksek Ihtisas Hospital, Turkey. 219 patients (177 males and 42 females) presenting with acute coronary syndrome, and 51 control subjects between September 2007 and September 2008 were included in the study. Serum gamma-glutamyltransferase, high sensitive C-reactive protein, serum lipoprotein levels and troponin I were determined. Results: Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients compared to control. There was also correlation between gamma-glutamyltransferase and high sensitive C-reactive protein levels. Conclusion: Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients. In subgroup analyses, the higher difference with Non-ST elevation myocardial infarction and ST elevation myocardial infarction groups than unstable angina oectoris group proposes a relationship between gamma-glutamyltransferase and severity of acute coronary syndromes.
Ggt Levels in Type Ii Diabetic Patients With Acute Coronary Syndrome (Does Diabetes Have Any Effect on Ggt Levels in Acute Coronary Syndrome?)
(Springer-verlag Italia Srl, 2013) Emiroglu, Mehmet Yunus; Esen, Ozlem Batukan; Bulut, Mustafa; Karapinar, Hekim; Kaya, Zekeriya; Akcakoyun, Mustafa; Esen, Ali Metin
Elevated gamma-glutamyltransferase (GGT) level is independently correlated with conditions associated with increased atherosclerosis, such as obesity, elevated serum cholesterol, high blood pressure and myocardial infarction. It is demonstrated that serum GGT activity is an independent risk factor for myocardial infarction and cardiac death in patients with coronary artery disease. Diabetes is also a well-known cardiovascular risk factor and an equivalent of coronary artery disease. Although the relationship between GGT and coronary artery disease has been reported, there are limited data exploring the changes of GGT in acute coronary syndromes, especially in patients with diabetes. So, this study aimed to determine changes in GGT level in diabetic and non-diabetic acute coronary syndromes. This trial was carried out at Kosuyolu Cardiovascular Training and Research Hospital and Van Yuksek Ihtisas Hospital, Turkey. A total of 219 patients (177 men and 42 women) presenting with acute coronary syndrome) and 51 control subjects between September 2007 and September 2008 were included in the study. Serum gamma-glutamyltransferase and serum lipoprotein levels were determined. The resuls indicated that serum GGT levels were higher in acute coronary syndrome patients compared with control. In subgroup analyses, there was no difference between diabetic and non-diabetic subgroups. There was also weak correlation between GGT and blood glucose levels. There was no correlation between GGT and serum lipoprotein levels. In conclusion, serum GGT levels were higher in acute coronary syndrome patients. In subgroup analyses, There was no difference between diabetic and non diabetic subgroup.
Mortality and Coronary Events in the Turkish Adult Risk Factor Survey 2006: Mortality Is Declining in Women Whereas Overall Prevalence of Coronary Heart Disease Is on the Incline
(Turkish Soc Cardiology, 2007) Onat, Altan; Albayrak, Sinan; Karabulut, Ahmet; Ayhan, Erkan; Kaya, Zekeriya; Kucukdurmaz, Zekeriya; Tuncer, Mustafa
Objectives: We analyzed all-cause and coronary mortality, incidence and prevalence of coronary heart disease (CHD) in a cohort of the Turkish Adult Risk Factor Study which was surveyed in the summer of 2006 essentially in geographic regions other than Marmara and Middle Anatolia. Study design: The survey consisted of 1585 participants (776 men, 809 women; mean age 55.3 +/- 11.8 years), accounting for 49% of all living participants of the overall cohort. Information on death was obtained from first-degree relatives and/or health personnel of local health offices. Survivors were evaluated by history, physical examination, and 12-lead electrocardiography. New coronary event was defined as fatal or nonfatal myocardial infarction, new stable angina, and/or myocardial ischemia that had occurred after the former survey. Results: Of the participants, 946 were examined, 599 subjects were evaluated on the basis of information gathered, and 40 deaths ( 27 men, 13 women) were documented. Cumulative follow-up of the survey starting from 1990 increased to 45,490 person-years with the addition of 2,842 person-years. Fifteen deaths were attributed to CHD. Annual overall mortality and coronary mortality rates were 14.1 and 5.1 per 1000 adults, respectively. In the 45 to 74 years age bracket, overall mortality declined to 10.9 (p=0.09) and coronary mortality to 5.6 per thousand. A decreasing trend in mortality was pronounced in women. The mean age at death increased to 67.1 years in men, and to 75.9 years in women. The prevalences of CHD were found to be 3%, 11%, and 27% in age groups of 39-49, 50-59, and >= 60 years, respectively, which corresponded to an estimated population of 2.75 million. Conclusion: In the 45 to 74 years age bracket, overall and coronary deaths show a decreasing trend, particularly in women, which extends the mean age at death. However, the prevalence of CHD specific to age groups continues to rise, as well.
Tekharf 2006 Taramasında Ölüm ve Koroner Olaylar: Kadınlarda Mortalitede Azalma, Koroner Kalp Hastalığı Genel Prevalansında Artma
(2007) Erbilen, Enver; Bulur, Serkan; Albayrak, Sinan; Küçükdurmaz, Zekeriya; Kaya, Zekeriya; Karabulut, Ahmet; Ayhan, Erkan
Amaç: TEKHARF Çalışması’nın temelde Marmara ve İç Anadolu dışındaki bölgelerde oturan ve 2006 yazında taranan kohortunda tüm-nedenli, koroner kökenli ölüm ve koroner kalp hastalığına (KKH) ait insidans ve prevalans verileri incelendi. Çalışma planı: Taramada toplam 1585 kişi (776 erkek, 809 kadın; ort. yaş 55.3±11.8) izlendi; bunlar ülke genelinde hayattaki TEKHARF kohortunun %49’unu oluşturuyordu. Ölüm konusunda birinci derece akraba ve/veya sağlık ocağı personelinden bilgi alındı; yaşayanlarda bilgi edinmekten başka, fizik muayene ve 12 derivasyonlu EKG kaydı yapıldı. Yeni koroner olay, son taramadan beri gelişen, ölüme yol açan veya açmayan miyokard infarktüsü, yeni stabil angina ve/veya miyokard iskemisi şeklinde tanımlandı.Bulgular: Örneklemden 946’sı muayene edildi, 599 kişi hakkında bilgi edinildi ve 27 erkek ile 13 kadının öldüğü belirlendi. Yeni takip olarak eklenen 2842 kişi-yılı ile, 1990 yılından beri izlemede 45490 kişi-yılına ulaşıldı. Ölümlerden 15’i KKH kökenli sayıldı. Son tarama döneminde yıllık tüm ölüm oranı bin yetişkinde 14.1, koroner mortalite binde 5.1 düzeyinde bulundu. Kırk beş ile 74 yaş arası kesimde toplam yıllık mortalite son Türkiye taramasında binde 10.9’a (p=0.09), KKH’den ölüm prevalansı binde 5.6’ya geriledi. Gerilemeler kadınlarda belirgindi. Ortalama ölüm yaşının erkeklerde 67.1’ye, kadınlarda 75.9’a uzadığı görüldü. Koroner kalp hastalığı prevalansı 39-49 yaş grubunda %3, 50-59 yaş grubunda %11, 60 yaş ve üzerinde %27 bulundu. Bu prevalansın ülkede 2.75 milyon erkek ve kadını kapsadığı tahminine varıldı. Sonuç: Kırk beş ile 74 yaş arası kesimde tüm ölümler ile koroner kökenli ölümlerin özellikle kadınlarda azalma eğilimi içinde olduğu ve ortalama ölüm yaşının uzadığı görülmektedir. Buna karşılık, yaş gruplarına özgü KKH prevalansı hızla artma eğilimindedir.
Tekharf Taramasında Ölüm Yaşı: 56700 Kişi-yıllık İzlemede Dönemsel Eğilim ve Bölgesel Dağılım
(2009) Bulur, Serkan; Küçükdurmaz, Zekeriya; Onat, Altan; Kaya, Hasan; Kaya, Zekeriya; Uğur, Murat; Ayhan, Erkan
Amaç: TEKHARF Çalışması’nın 18 yıllık takibinde tüm-nedenli ölümdeki yaş verilerinin zaman dilimine ve bölgelere bağlı değişimi ve cinsiyete özgü ve belirli yaş kesimindeki koroner mortalite değerlendirildi. Çalışma planı: TEKHARF Çalışması’nın çift yıllarda taranan kohortu 2008 Ağustos ayında yeniden izlendi. Taramaya giren kohortun toplam sayısı 1582 kişi idi ve ülke genelinde hayatta bulunan izlenecek TEKHARF kohortunun yarısını oluşturuyordu. Ölüm konusunda birinci derece akraba ve/veya sağlık ocağı personelinden bilgi alındı; yaşayanlarda bilgi edinmekten başka, fizik muayene ve 12-derivasyonlu EKG kaydı yapıldı. Toplam takip süresi 56700 kişi-yılıydı. Bulgular: Örneklemin 868’i (431 erkek, 437 kadın) muayene edildi, 604 kişi hakkında bilgi edinildi ve 47 kişinin (26 erkek, 21 kadın) öldüğü belirlendi. Ölümlerin 22’si koroner kalp hastalığı (KKH) kökenli sayıldı. Tüm kohortun 18 yıllık takibinde 45-74 yaş kesiminde KKH kökenli ölümler erkeklerde 1000 kişi-yılında 7.64, kadınlarda 3.84 düzeyinde bulundu ve böylece 30 Avrupa ülkesi içinde en yüksek seviyede süregeldiği gözlemlendi; oysa, genel mortalitedeki gerileme daha yüksek orandaydı. Ortalama ölüm yaşı Türkiye genelinde 12 yıl içerisinde erkeklerde 7.4 yıl, kadınlarda altı yıl ertelenerek, 2003-08 döneminde sırasıyla ortalama 71.9 ve 74.8’e ulaştı. Ortalama ömürdeki bu uzama kentsel ve kırsal kesimler ile coğrafi bölgelerde benzerdi. Sonuç: Yetişkinlerimizde koroner mortalite az gerilemiş, ama ömür süresi son 12 yılda yedi yıla varan belirgin uzama göstermiştir; bu uzamanın erkek-kadın, kent-kır sakinleri ve coğrafi bölgelerde önemli farklar sergilemediği gözlenmiştir.
Volume Dependence of Blood Pool and Tissue Doppler Parameters: Confirmation by Blood Donor Model
(Elsevier Ireland Ltd, 2010) Karapinar, Hekim; Karavelioglu, Yusuf; Kaya, Zekeriya; Kaya, Hasan; Esen, Ozlem Batukan; Zehir, Regayip; Kirma, Cevat