Browsing by Author "Kaya, Zulkuf"

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Analysis of Ki-67 Immunoreactivity in Recurring and Nonrecurring Nasal Polyps
(B C decker inc, 2010) Kosem, Mustafa; Bulut, Gulay; Kaya, Zulkuf
Objective: Nasal polyps are common, abnormal lesions. Recurrence of the nasal polyposis is prevalent and a severe problem. The aim of this study was to investigate the relationship between Ki-67 immunoreactivity and the risk of recurrence of nasal polyps. Ki-67 staining of polypectomy material was tested as a risk factor for recurrence independent of etiologic factors or treatment modalities. Design: Retrospective study. Setting: University hospital. Main Outcome Measure: Ki-67 immunoreactivity. Methods: Pathologic specimens from patients with nonrecurrent and recurrent nasal polyps archived at the Department of Pathology were reviewed, and the most suitable blocks were chosen among the excision materials. Ki-67 antibody staining was investigated immunohistochemically using the avidin-biotin-peroxidase method. The percentages of nuclei immunostained for Ki-67 of at least 1000 epithelial cells in the most intensive staining areas at final magnification (3400) were calculated and defined as the labeling index. The Mann-Whitney U-test was used to compare the Ki-67 labeling index in the nonrecurring and recurring nasal polyp groups. Results: The mean Ki-67 labeling index was 1.4 +/- 1.972 (range 1-87 in 1000 epithelial cells) in the nonrecurrent nasal polyp group and 17.8 +/- 5.67 (range 82-446 in 1000 epithelial cells) in the recurrent nasal polyp group; the difference between the nonrecurrent and the recurrent group was significant (p < .01). Conclusion: The results of this study clearly demonstrate that proliferative activity in the surface epithelial cells of recurring nasal polyps is significantly higher than that in nonrecurring nasal polyps.
Minimal Invasive Excision of Intraorbital Dermoid Cyst
(Modestum Ltd, 2007) Atik, Bekir; Tan, Onder; Kaya, Zulkuf; Kiroglu, A. Faruk
Orbital dermoid cyst is a rare tumor for which the pathogenesis remains unclear. It is usually located in the lateral side of the orbita, and may also rarely be observed in the intraorbital region. In this cases, aggressive treatment is necessary for the success because recurrence rate is high. But it should work delicately because of the risk of the eye damage. We report three cases with intraorbital dermoid cysts who were successfuly treated by using a minimally invasive surgery. Eye movements and visual functions were normal in all patients. No recurrences or complications appeared postoperatively. We think that it is possible to excise dermoid cysts totally using a classical surgical technique, including an anterior approach, by careful dissection under loupe magnification.