Browsing by Author "Keles, M."

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Comparison of the Oxidant-Antioxidant Parameters and Sialic Acid Levels in Renal Transplant Patients and Peritoneal Dialysis Patients
(Elsevier Science inc, 2011) Emre, H.; Keles, M.; Yildirim, S.; Uyanik, A.; Kara, F.; Tamer, F.; Aydinli, B.
Objective. Several studies have shown that in end-stage renal failure, increased oxidative stress and reduced antioxidant system functions may play an important role in inflammation, atherosclerosis, and many other complications. Paraoxonase (PON) and arylesterase (ARE) are antioxidant and malondialdehyde (MDA) an oxidant agent. Increased sialic acid (SyA) levels in uremic patients is an acute-phase response showing tissue and organ damage. The aim of this study was to compare PON, ARE, MDA, and SyA among continuous ambulatory peritoneal dialysis (CAPD) and renal transplant patients. Methods. Twenty-six CAPD patients including 7 women and 19 men of overall mean age 40.5 +/- 10.66 years were included in this study. There were 28 preemptive transplant patients, namely 6 women and 22 men of overall mean age 36.5 +/- 10.97 years. CAPD was the initial sole replacement therapy. Serum PON, ATE, MDA, and SyA levels were measured at 13-15 months of treatment. Results. Higher PON (P = .015) and ARE (P = .002) and lower MDA (P = .002) and SyA (P = .000) values were determined among transplanted compared with CAPD patients. Conclusions. In the transplant group, antioxidant parameters were higher and oxidant parameters lower with less activation of SyA than in the CAPD group. We observed that renal transplantation had a constructive effect on the oxidant-antioxidant system and consequent tissue destruction, which were impaired in uremic subjects. This study showed that renal transplantation is a more appropriate replacement treatment than CAPD.
Effect of Kidney Transplantation on Smoking Habits of Kidney Donors
(Elsevier Science inc, 2015) Keles, M.; Avsar, U.; Avsar, Z.; Emre, H.; Cankaya, E.; Cansever, Z.; Aydinli, B.
Introduction. Smoking increases the risk for cardiovascular disease in kidney donors, as is the case with normal individuals; it may also result in the development and progression of chronic renal failure. The present study aimed to investigate the effect of kidney transplant on smoking habits of kidney donors. Method. The study included 98 donors in total (54 female, 44 male). A questionnaire was administered to donors about smoking status. Smoking status was asked about before surgery and 12 months postoperatively, and the preoperative and postoperative values were compared. The Fagerstorm test for nicotine dependence was administered to individuals who were still smokers and those who had smoked but quit. Results. The mean age of the participants was 48.27 +/- 10.8 years. The preoperative smoking status was 47% (n = 46), whereas the postoperative rate decreased to 29% (n = 28). This reduction in smoking rate was significant (P = .001). There was no difference in Fagerstrom levels between donors who continued smoking and those who quit smoking after the surgery (P = .583). Conclusions. A person who becomes a kidney transplant donor has the chance to quit smoking, which is a cardiovascular risk factor. In addition to the psychosocial benefits of being a donor, it should be noted that it might also provide some medical benefits. However, some patients continue smoking after surgery. Smoking should be questioned in the postoperative follow-ups of donors and the support required for smoking cessation should be provided.
Exfoliative Cytology of Oral Mucosa in Kidney Transplant Patients: a Cytomorphometric Study
(Elsevier Science inc, 2011) Keles, M.; Tozoglu, U.; Unal, D.; Caglayan, F.; Uyanik, A.; Emre, H.; Aydinli, B.
Objectives. The aim of this study was to investigate quantitative cytologic changes in oral mucosal smears collected from kidney transplant patients by modern stereologic methods. Methods. Smears were obtained from the clinically healthy buccal mucosa and floor of mouth of transplant patients (n = 21) and healthy volunteers (n = 27). Smears from each individual stained by the Papanicolaou method were analyzed using a stereologic method. Nuclear (NV) and cytoplasmic (CV) volumes were evaluated with Stereo Investigator software. Results. CV values were 123,012.71 +/- 15,840.96 fL in the floor of the mouth and 133,667.10 +/- 26,653.39 fL in the buccal mucosa of the kidney transplant patients. CV values were 133,746.93 +/- 14,210.67 fL in the floor of the mouth and 167,797.78 +/- 21,007.70 fL in the buccal mucosa of the control group. NV values were 945.68 +/- 65.85 fL in the floor of the mouth and 845.15 +/- 81.56 fL in the buccal mucosa of the kidney transplant patients and 485.17 +/- 18.03 fL in the floor of the mouth and 410.25 +/- 52.84 mu m(3) in the buccal mucosa of the control group. Significantly higher NV (P = .000) and NV/CV (P = .000) and lower CS (P = .000) values were found in the patient group compared with the control group. Conclusion. The findings suggest that there were alterations in oral epithelial cells, detectable by microscopy and cytomorphometry in kidney transplant patients.
Rhabdomyolysis and Acute Renal Failure as a Result of Bentazone Intoxication
(2011) Emre, H.; Keles, M.; Uyanik, A.; Emet, M.; Bilen, Y.; Bayraktutan, D.
Bentazone (Basagran®) is a commonly used and easily available agricultural herbicide. We report a 41- year-old-man who developed rhabdomyolysis with acute renal failure after bentazone toxicity. Four hours later after oral intake of liquid bentazone for suicidal attempt, the patient admitted to emergency service and his initial renal function tests were in normal range. However on the 15th hour of intake, urine output decreased, and blood urine nitrogen, creatinine and creatinine kinase levels were increased. On the fifth day of hospitalization, creatinine and creatinine kinase levels had turned to normal levels. As a result, bentazone intoxication may cause rhabdomyolysis with acute renal failure. Thus, renal functions must be followed up closely.