Browsing by Author "Keskin, M.E."

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The Effects of Sugammadex on Coagulation in Pregnant Rats
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Keskin, M.E.; Kaplan, H.S.; Gülhas, N.; Bayram, Y.; Basbugan, Y.
Some studies have reported that sugammadex affects coagulation parameters. However, the effects of sugammadex on coagulation in pregnant women have not been adequately evaluated. This study investigated the effects of sugammadex administration on routine coagulation tests and levels of coagulation factors (FII, FV, FVII, FVIII, FIX, and FX) in pregnant rats. After ethics committee approval (2019/06), 24 female Wistar albino rats (n = 12; 19–20 days of gestation; weight 230–380 g) were randomly divided into four groups: control (n = 6), sugammadex (n = 6), pregnant (n = 6), and pregnant sugammadex (n = 6). Ketamine (50 mg/kg) and xylazine (10 mg/kg) were administered intraperitoneally to all groups. Saline (SF) (1 ml/kg) was administered to the control and pregnant groups. Sugammadex was administered to the sugammadex and pregnant sugammadex groups at a dose of 16 mg/kg. Blood samples were collected at 30 min after SF and sugammadex administration in all rats. The levels of PT, INR, aPTT, fibrinogen and coagulation factors were measured in plasma obtained from blood samples. All animals were sacrificed by cervical dislocation after the procedure. The mean weights of the rats were significantly higher in the pregnant groups (pregnant and pregnant sugammadex groups) than in the non-pregnant groups (control and sugammadex groups). The mean PT and INR values were significantly lower in the pregnant than non-pregnant groups. No significant differences were observed in any of the parameters evaluated between the sugammadex-and SF-administered groups. Sugammadex administration did not affect routine coagulation tests or the levels of coagulation factors in pregnant rats. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Ultrasound-Guided Erector Spinae Plane Block Versus Intravenous Patient-Controlled Analgesia in Percutaneous Nephrolithotomy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Kaçar, C.; Güneş, H.Y.; Keskin, M.E.
Intravenous patient-controlled analgesia is frequently used to optimize postoperative analgesia in many surgeries. In recently, ultrasound-guided erector spinae plane block has begun to be widely used. Does ease of application, fewer complications and providing effective analgesia with a single injection make it more advantageous in postoperative pain management? The aim of this study is to compare the postoperative analgesic efficacy of the ultrasound-guided erector spinae plane block with that of the intravenous patient-controlled analgesia in percutaneous nephrolithotomy surgery. Sixty participants selected for elective percutaneous nephrolithotomy were included in this study. The patients were randomized into two groups using a closed-envelope method. An ultrasound-guided erector spinae plane block was applied with 20 mL of the local anesthetic mixture at the T-7 level in group erector spinae plane block. In the PCA group a loading dose of 50 mg tramadol was administered 10 minutes before extubation. Following the extubation, patient-controlled analgesia was initiated with a 20 mg bolus, a 30minute lockout period, with a 4hour tramadol limit of 200 mg, and a basal infusion rate of 5 mg/hour. Demographic data and ASA scores of the groups were similar. In the erector spinae plane block group, VAS scores, and analgesic requirement were significantly lower, and patient satisfaction were higher in the first 6hours postoperatively. However, in the PCA group, VAS score and analgesic requirement were lower than group ESP at the 12th hour postoperatively. Erector spinae plane block block and iv PCA are effective in PNL surgery. We believe that the erector spinae plane block performed under USG guidance is more effective and advantageous in the first 6 hours. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.