Browsing by Author "Keskin, Siddik"

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Activities of Cholinesterases, Adenosine Deaminase and Myeloperoxidase in Patients With Familial Mediterrenean Fever
(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2012) Ozkol, Halil; Ediz, Levent; Sekeroglu, Ramazan; Tekeoglu, Ibrahim; Keskin, Siddik
Objective: The aim of this study was to determine Acetylcholinesterase (AChE), Butyrilcholinesterase (BChE), Adenosine Deaminase (ADA) and Myeloperoxidase (MPO) activities in patients with Familial Mediterranean Fever (FMF) during attacks and attack-free periods. Although an inflammatory process is the main pathology in FMF, the activities of AChE, BChE and MPO which might be affected by inflammation has not yet been assessed in FMF. Materials and Methods: The subjects were divided into 3 groups: Group 1. FMF patients in acute attack period (FMF-AP); Group 2. FMF patients in attack-free period (FMF-AFP); Group 3. Healthy Control subjects (HC). The first two groups consisted of 41 and 35 patients, respectively. Thirty individuals without a history of other potential health problems constituted the healthy control (HC) group. We measured the activities of MPO, ADA, AChE and BChE in whole blood and serum of the study groups. Acute phase reactants (AFP) were also evaluated. Results: In the current study, while ADA and MPO activities increased, AChE decreased significantly in both whole blood and serum in FMF-AP group, BChE decreased in only whole blood in this group compared with FMF-AFP and HC groups (p<0.05). In FMF-AP group, both whole blood and serum ADA (r=0.313, r=0.267), and MPO (r=0.341, r=0.253) activities were correlated with C-reactive protein, respectively (all p values <0.001). Conclusion: Our study demonstrated that there are significant differences between FMF-AP and other groups in terms of AChE, BChE, ADA and MPO activities. Thus, we suggest that elevated ADA, MPO and decreased AChE and BChE activities may be considered as supportive markers to distinguish FMF attacks from attack-free periods. However, further larger-scale studies are needed to validate these results. Turk J Phys Med Rehab 2012;58:184-8.
Advanced Oxidation Protein Product (Aopp) Levels in Second- and Third-Degree Thermal Burns
(Oxford Univ Press, 2021) Mert, Handan; Acikkol, Suat; Calli, Iskan; Cibuk, Salih; Keskin, Siddik; Mert, Nihat
Burn is a systemic injury affecting the entire organism according to its etiology and severity. The aim of this study was to investigate plasma AOPP levels before and after treatment of second- and third-degree thermal burn patients and determine the changes in this parameter, and also, to find out the relationship between AOPP level and hospitalization period and total body surface area (TBSA). The study material consisted of pediatric patients with the complaint of second- and third-degree thermal burns aged between 1 and 18 years, with a burn area exceeding 10%. Blood samples were taken twice before and after treatment. AOPP level in blood plasma was measured in ELISA. It was observed that in the second-degree thermal burn group, AOPP level was 25.85 +/- 2.82 ng/ml before the treatment decreased to 22.16 +/- 3.62 ng/ml after treatment, whereas in the third-degree thermal burn group before the treatment AOPP was 25.96 +/- 3.49 ng/ml, and after the treatment dropped to 21.70 +/- 3.79 ng/ml, decreases were significantly important (P < .05). There was no statistically significant difference between the two groups in terms of AOPP levels (P > .05). Correlation analyses in the second- and third-degree thermal burn group did not show any correlation between AOPP levels and burn area and length of hospitalization period. As a result, AOPP level has been studied, for the first time, in burn cases. In both groups, the level of AOPP increased due to oxidative stress before treatment and decreased after treatment.
The Analysis of the Cases of Aspired Fuel Oil and Gasoline Through Siphonage Method
(Pakistan Medical Assoc, 2013) Gonullu, Hayriye; Karadas, Sevdegul; Oncu, Mehmet Resit; Dulger, A. Cumhur; Keskin, Siddik
Accidental aspiration of petroleum products in children can also be witnessed in adults working with petroleum products by siphonage or swallowing fire for demonstration purposes. Ten cases admitted to Yuzuncu Yil University Emergency Service due to fuel oil and gasoline aspiration in a three-year period were retrospectively analysed. All cases were males and their average age was determined as 32,4 +/- 7.83 years. Three of the patients aspirated gasoline and 7 fuel oil. Blood gas values in all patients were at normal levels and their average white blood cell values were 16590. The most frequent symptom for referral to our service was shortness of breath. Infiltration was confirmed in the chest X-ray of 2 patients with aspirated fuel oil and all cases of gasoline aspiration. All patients received methylprednisolone and IV proton-pump inhibitors for treatment. Eight patients were given antibiotics. All victims were discharged from the hospital after recovery. Aspiration of petroleum products which is normally rarely seen is witnessed more frequently in under developed countries. Since the findings determined by screening methods are often nonspecific, history is important for making a diagnosis.
Anom Approach for Statistical Evaluation of Some Antioxidant Enzyme Activities
(Frontiers Media Sa, 2022) Demir, Canan; Keskin, Siddik; Sen, Fatih
Free radicals are chemical molecules that are more reactive and have an unpaired electron. Free radicals formed inside the cell oxidize biomolecules, leading to cell death and tissue damage. Antioxidants are molecules that can stabilize or inactivate free radicals before they damage the cell. In this study; the availability of Malondialdehyde, Superoxide dismutase, Catalase and Reduced glutathione levels as markers for related diseases was evaluated by examining whether and in what range they may vary in some diseases. In study, nine groups consist of prostate cancer, cirrhosis, liver transplantation, chronic kidney damage, acute kidney injury, X-ray exposure, CT exposure, MR exposure and Osteonecrosis. Analysis of means is a method developed to compare group means with the overall mean and presents the results graphically in an easy-to-understand manner without the required for any post hoc test. In addition, related characteristics were categorized as "low and high" and Nonlinear Principal Component Analysis was conducted to visually present their relationship with related disease types in two-dimensional space. The upper and lower decision lines were found 3.123 and 2.794 mu mol/L, respectively for Malondialdehyde. Those with cirrhosis, chronic kidney disease, acute kidney disease and tomography exposure were included in the upper and lower decision lines. Those with prostate cancer, osteonecrosis, and X-ray exposure were above the upper decision line and are found higher than the overall mean. Those with lung transplantation and MR exposure appear to be below the lower decision line and lower than the overall mean. The present study provides the first comprehensive assessment of the availability of Malondialdehyde, Superoxide dismutase, Catalase and Reduced glutathione levels as markers for some related diseases. This study has shown that Analysis of means can be used as an alternative graphical procedure for multiple group comparisons with an overall mean in the studies regarding as biochemical characteristics and relating diseases. In addition, Nonlinear Principal Component Analysis can be useful aid for decision marker in some biochemical characteristics and related diseases.
Anom Approach for the Statistical Evaluation of Organic Acid Contents of Clones of the Grape Variety 'kalecik Karasi
(Hohere Bundeslehranstalt & Bundesamt Wein-& Obstbau Klosterneuburg, 2021) Keskin, Nurhan; Kunter, Birhan; Celik, Hasan; Kaya, Ozkan; Keskin, Siddik
Organic acids have an important effect on flavor, aroma and color in berries and wines of grapes and they also play an important role for the microbiological and biochemical stability of the wine. The variety 'Kalecik Karasi' is one of the exclusive red grape varieties of Turkey. The aim of this study is to evaluate and visualize the differences between the 23 clones of 'Kalecik Karasi' with respect to organic acids. As organic acids were considered: tartaric, malic, citric, succinic and fumaric acids. The berries of the vintages 2016 and 2017 were harvested with 23 % soluble solids and HPLC (High Performance Liquid Chromatography) was used to identify organic acid content. Using Analysis of Means (ANOM) method the mean of each group was compared to the overall or grand mean to identify statistically significant differences. Thus the differences between the 'Kalecik Karasi' clones in terms of organic acids were compared and visualized by this method. According to the results, for all organic acids, except for tartaric and fumaric acid, differences between means of clones and overall mean are statistically significant (p<0.05). Both ANOVA and ANOM can be appropriate for determining differences between the groups. However, ANOM provides a simple graphical representation for group means. Therefore, it can be concluded that this method can be suggested to visualize differences between the groups for easy interpretation.
Antioxidant Activity and Biochemical Compounds of Vitis Vinifera L. (Cv. 'katikara and Vitis Labrusca L. (Cv. 'isabella Grown in Black Sea Coast of Turkey
(Springer, 2021) Keskin, Nurhan; Ekbic, Hatice Bilir; Kaya, Ozkan; Keskin, Siddik
The antioxidant activity and phenolic compounds content of pomace from the berries of 'Isabella' and 'Katikara' grape varieties widely produced in the Eastern Black Sea region of Turkey were researched for use as a potential natural antioxidant source. The results of this study indicated that there were statistically significant differences (p < 0.05) between two varieties for some biochemical compounds. There are high positive correlations among antioxidant activity, phenolic compounds and 'Isabella'. Similarly, catechin, citric acid, epicatechin, tartaric acid, total phenolic, vitamin C, gallic acid and p-coumaric acid are strongly and positively correlated with each other. It was observed that 'Isabella' grapes presented higher antioxidant potential with relating presence of high content of phenolic compounds. Mineral elements, which are of great importance for cell protection and healthy teeth, bone and skin structure, were found widely in the 'Katikara' variety. As a result, we can concluded that consuming these two grape varieties will provide significant benefits in blood pressure, heart rhythm, muscle functions, protection of fluid balance in the body, reproduction and many other functions in the human body.
Artesunate Inhibits Melanoma Progression in Vitro Via Suppressing Stat3 Signaling Pathway
(Springer Heidelberg, 2021) Berkoz, Mehmet; Ozkan-Yilmaz, Ferbal; Ozluer-Hunt, Arzu; Krosniak, Miroslaw; Turkmen, Omer; Korkmaz, Duygu; Keskin, Siddik
Background Melanoma is a life-threatening cancer characterized with a potentially metastatic tumor of melanocytic origin. Improved methods or novel therapies are urgently needed to eliminate the development of metastases. Artesunate is a semi-synthetic derivative of artemisinin used for trarment of malaria and cancer. The purpose of this study was to investigate the anti-cancer effect of artesunate and the role on STAT3 signaling in A375 human melanoma cell line. Methods Melanoma cells were treated with artesunate at concentrations of 0-5 mu M for 24 and 48 h. The inhibition of cell viability, colony formation, migration, invasion, adhesion, percentage of apoptotic cells, and expressions of signal transducer and activator of transcription-3 (STAT3) and related proteins were examined. Results Artesunate inhibited cellular proliferation of cancer cells by induction of apoptosis at sub-toxic doses. Cells treated with artesunate showed an inhibition in adhesion to extracellular matrix substrate matrigel and type IV collagen. Artesunate treatment showed a decreased cellular migration, invasion, and colony formation in melanoma cells. Artesunate also inhibited STAT3 and Src activations and STAT3 related protein expressions; such as metalloproteinase 2 (MMP-2), MMP-9, Mcl-1, Bxl-xL, vascular endothelial growth factor (VEGF), and Twist. Moreover, overexpression of constitutively active STAT3 in A375 cells attenuated the anti-proliferative, apoptotic and anti-invasive effects of artesunate. Conclusion The results obtained from this study demonstrated that the anticancer activity of artesunate occurred via STAT3 pathway and its target proteins. Therefore, it can be suggested that artesunate may be an important candidate molecule in the treatment of melanoma.
Assessment of Gingival Biotype and Keratinized Gingival Width of Maxillary Anterior Region in Individuals With Different Types of Malocclusion
(Aves Press Ltd, 2018) Alkan, Ozer; Kaya, Yesim; Alkan, Eylem A.; Keskin, Siddik; Cochran, David L.
Objective: The aim of the present study is to evaluate the relationship of gingival thickness and width of keratinized gingiva with different malocclusion groups and amount of crowding. Methods: A total of 181 periodontally healthy subjects were enrolled in the present study. The study participants were divided into three malocclusion groups: Angle Class I, Angle Class II, and Angle Class III.Each group was divided into subgroups according to the amount of dental crowding, namely mild, moderate, and severe. The width of keratinized gingiva was calculated as the distance between mucogingival junction and free gingival margin, whereas gingival thickness was determined by a transgingival probing technique. Results:Tooth numbers 13 and 23 were observed to have thin gingival biotype. The width of keratinized gingiva for tooth numbers 13 and 23 was narrower in the severe crowding group than in the moderate and mild crowding groups. The relationship of gingival thickness and width of keratinized gingiva with Angle classification was not found to be significant. Conclusion: Although it is thought that there is a relationship between gingival thickness, width of keratinized gingiva, and Angle classification with regard to malaligned teeth, this cross-sectional evaluation of 181 patients failed to show a significant relationship.
Assessment of Hierarchical Factor Structure, Reliability and Validity of Penn State Worry Questionnaire Turkish Version
(Kure Iletisim Grubu A S, 2008) Boysan, Murat; Keskin, Siddik; Besiroglu, Luetfullah
Objective: Excessive, pervasive, and uncontrollable worry are included in the diagnostic criteria of generalized anxiety disorder. Pathological worry is thought to be the cognitive component of anxiety and to be used as a moladaptive defense mechanism However, negative outcomes of pervasive and uncontrollable worry are not restricted to anxiety disorders alone, A growing number of studies point out that pathological worry is associated with panic disorder, obsessive compulsive disorder, depression, sleep disorders and psychotic disorders, Also pervasive and uncontrollable worry is significantly correlated with medical problems such as heart diseases, diabetes and cancer. In order to assess levels of worry several instruments were developed; for example The Worry Domains Questionnaire (Tallis et at 19921, The Anxious Thoughts Inventory (Wells 1994), The Meta Worry Questionnaire (Wells 1995), The Meta Cognitions Questionnaire -30 (Wells, Cartwright-Hatton, 2004). However, Penn State Worry Questionnaire (PSWQ) is the most commonly utilized measure on assessing pathological worry, This self-report measure has been translated into many languages. The measure has shown excellent psychometric properties in studies among non-clinical and clinical populations. The aim of this study was to translate the instrument into Turkish and to assess the factor structure of the instrument in a Turkish sample. Method: Sample of the study comprised of 651 undergraduates of the Yuzuncu Yil University. Factor structures were obtained by using principal components analysis The Penn State Worry Scale, The Beck Depression Inventory, The Beck Anxiety Inventory, The Rosenberg Self-Esteem Scale, and General Self Efficacy Scale were administered. Model fitness of the factor structure was evaluated by using structural equation technique The Schmid-Leimon transformation was performed to provide higher order factor loadings. PSWQ total and sub-scale scores were correlated with depression, anxiety, self-esteem, and self-efficacy in order to assess convergent validity of the measure, Comparisons between correlations were carried out using the Z test. Results: Convergent validity between PSWQ total scores and other psychological variables was compatible with previous studies. Correlation between PSWQ total scores and Beck Depression Inventory was r = 0.45. PSWQ significantly correlated with Beck Anxiety Inventory r = 0.46. Correlation between PSWQ and Rosenberg Self Esteem Scale was r = -0.36. Inner consistency of the measure was 0.88. It was found that PSWQ consisted of General Worry, Excessive/Uncontrollable Worry, and Absence of Worry factors, a three factor hierarchical structure. Discussion: PSWQ is a valid and reliable measure in assessing pathological worry in a Turkish sample. Results have shown that factor structure of the measure obtained in a Turkish sample is consistent with international samples Translation of the measure into Turkish may contribute to assessing possible outcomes of pathological worry, which is thought to play an important role in the onset of psychopathology, among Turkish sample.
Associations Between the Levels of Depression and the Sense of Limitedness: a Psychometric Analysis
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2008) Boysan, Murat; Besiroglu, Luetfullah; Kara, Hayrettin; Kayri, Murat; Keskin, Siddik
Objective: The sense of limitedness is a cognitive orientation that represents individuals' limited, fixed, and interdependent attributions about interpersonal relations and life opportunities, which are sources for growth and motivation. The cognition is thought as a risk factor for onset of depression. The aim of this study was to assess the relationship between the sense of limitedness, depression, and other risk factors for depression in the study. Methods: The Limitedness Schemas Questionnaire was developed to assess the level of limitedness orientation as a cognitive style. Data were collected from 767 university students and 142 adult subjects via the Limitedness Schemas Questionnaire, the Beck Depression Inventory, the Beck Depression Inventory, the Rosenberg Self-Esteem Scale, and the Learned Helplessness Scale. Subscales of the Limitedness Schemas Questionnaire were obtained by using principle components analysis. Correlations between psychological variables and sense of limitedness were used for evaluation of convergent validity. Results: The Limitedness Schemas Questionnaire had an inner consistency of 0.89. A four-factor structure was obtained for the 30-item Limitedness Schemas Questionnaire. Total and subscale scores of Limitedness Schemas Questionnaire were significantly correlated with depression, anxiety, self esteem, and learned helplessness. Discussion: Results have shown that the Limitedness Schemas Questionnaire is a reliable and valid construct. Results also revealed that sense of limitedness may be a cognitive vulnerability factor for both depression and for other types of psychopathology. (Anatolian Journal of Psychiatry 2008; 9: 191-196)
Carcass Weight Estimation From Some Morphological Traits of Capoeta Capoeta Capoeta (Guldenstadt, 1772) Using Factor Scores in Multiple Regression Analysis
(Isoss Publ, 2012) Eyduran, Ecevit; Topal, Mehmet; Sonmez, Adem Yavuz; Keskin, Siddik
The aim of this study is to predict carcass weight from some morphological traits (total length, fork length, standard length, head length, body height and weight) by using jointly factor and multiple regression analyses. A total of 91 Capoeta capoeta capoeta fish was used to estimate carcass weight. The suitability of factor analysis was determined with Kaiser-Meyer-Olkin (KMO) measure of sampling adequacy (0.87) and Bartlett's test of sphericity (P < 0.01). VARIMAX rotation was used to facilitate interpretation of factor loadings (L-ik). Other morphological traits (total length, fork length, standard length, head length, body height, and weight) except for carcass weight were exposed to factor analysis. As a result of factor analysis, three latent variables were obtained from six morphological traits and considered as independent variables in multiple regression analysis. Additionally, carcass weight was used as a dependent variable in multiple regression analysis. The developed model was determined as CW = 0.484 FS1 - 0.324 FS2 + 0.755 FS3. The obtained results shown that, the three selected factors had significant effects (P < 0.01) and explained 95.3% of variation in carcass weight. With using factor scores in the multiple regression analysis, carcass weight was predicted successfully by using these morphological traits. According to these results, it could be suggested that carcass weight might be increased by improving these morphological traits. The developed model might allow us to obtain beneficial clues for selection programs to be conducted on other fish species.
Catalase and Carbonic Anhydrase Enzyme Activities, and Some Mineral-Heavy Metal Concentrations in Newborns With Congenital Malformations
(Ortadogu Ad Pres & Publ Co, 2011) Melek, Mehmet; Demir, Halit; Kirimi, Ercan; Meral, Ismail; Keskin, Siddik
Objective: The aim of this study is to evaluate the factors such as antioxidant condition and mineral-heavy metal level association that may play a role in development of congenital malformations. Material and Methods: Fifteen healthy neonates as control group and 15 neonates with various congenital malformations were included study. Erythrocyte cataly (CAT) which is an antioxidant enzyme, erythrocyte carbonic anydrase (CA) enzyme activities which play a important role in acid-base balance, serum copper (Cu), lead (Pb), zinc (Zn), cadmium (Cd), iron (Fe), manganese (Mn) and magnesium (Mg) were measured from venous blood samples of each subject. Results: Erythrocyte CAT enzyme activity, serum Zn and Fe levels were statistically significantly decreased (P<0.05) in the study group while serum Cu and Cd levels were statistically significantly high (P<0.05)in the study group when compared to the control group. A negative correlation between erythrocyte CA activity and serum Pb levels was found in the study group. In the control group, negative correlations were found between erythrocyte CAT activity and serum Pb levels; serum Mg and Cu levels; and serum Cd and Mn levels. In addition, in the control group a positive correlation between serum Zn and Cu levels; erythrocyte CA activity and serum Mn levels was found. Conclusion: Our results suggest that erythrocyte CAT enzyme activity and serum Cu, Zn, Fe and Cd levels may play a role in pathogenesis of congenital malformations. The oxidative stress that rise as a result of an imbalance between prooxidant and antioxidant reactions seems to be associated with congenital malformations. Further studies are needed to confirm the association of antioxidant condition and mineral-heavy metal levels in the pathogenesis of congenital malformations.
Changes in the Gingival Thickness and Keratinized Gingival Width of Maxillary and Mandibular Anterior Teeth After Orthodontic Treatment
(E H Angle Education Research Foundation, inc, 2021) Alkan, Ozer; Kaya, Yesim; Tunca, Murat; Keskin, Siddik
Objectives: To evaluate changes in the gingival thickness (GT) and keratinized gingival width (KGW) of the maxillary and mandibular central and lateral incisors and canines after fixed orthodontic treatment and their association with sagittal tooth movement (STM). Materials and Methods: In this study of both arches, 60 periodontally healthy subjects who had completed fixed orthodontic treatment were included. Using pretreatment and posttreatment lateral cephalograms, STM of the maxillary (1-NA angle and distance, and 1-SN angle) and mandibular (1-NB angle and distance, and IMPA angle) incisors were evaluated to divide the subjects into protrusion and retrusion groups. Pretreatment and posttreatment GT was identified via transgingival probing, and KGW was calculated from the free gingival margin to the mucogingival junction. Results: The intragroup pretreatment and posttreatment comparison results showed a significant decrease in the GT of the maxillary and mandibular anterior teeth in the protrusion and retrusion groups and a decrease in the KGW of the maxillary lateral incisors in the protrusion group. Pearson correlation coefficient analyses for maxillary and mandibular anterior teeth revealed that the GT changes were not significantly associated with STM. However, a positive correlation existed between the KGW of tooth numbers 13 and 41 and STM. Conclusions: STM was not significantly associated with decreased GT of the maxillary and mandibular anterior teeth, but it was positively correlated with the KGW of tooth numbers 13 and 41.
Comparison of Anxiety, Pain, and Quality of Life in Individuals With Mild or Moderate Malocclusion Between Conventional Fixed Orthodontic Treatment Versus Invisalign: a Randomised Clinical Trial
(Bmc, 2024) Tunca, Yasemin; Kaya, Yesim; Tunca, Murat; Keskin, Siddik
Background We evaluated anxiety, pain, and oral-health-related quality of life in individuals treated with conventional fixed appliances (Group A) and clear aligners (Group B) for moderate malocclusion during the initial phase of orthodontic treatment.Methods Sixty individuals, separated into Group A (n = 30) and Group B (n = 30), were included in the study. They completed the Anxiety Levels, Oral Health Impact Profile-14, and Oral Health Related Quality of Life - United Kingdom/Surveys after the application of attachments on days 0 (T1), 10 (T10), and 20 (T20). Their pain levels were evaluated with the Visual Analogue Scale on days 0, 2, and 6 in the 2nd and 6th hours and on the 1st, 3rd, 7th, 14th, and 21st days.Results Per the VAS questionnaire, pain levels in the 2nd hour, 6th hour, 1st day, and 3rd day were significantly lower in Group B than in Group A. In the OHIP-14 survey results, the comparison between Group A and Group B showed a significant difference only on the 1st day. The STAI and OHRQoL-UK survey results did not differ significantly between the groups.Conclusions We found no significant difference between the two groups in terms of anxiety levels, and pain among individuals in Group A was higher than in Group B only at the beginning of the treatment. No significant differences were observed in terms of individuals' quality of life.Trial registration NCT06133296 (retrospectively registered)- Registration Date:15/11/2023.
Comparison of the Sugar and Organic Acid Components of Seventeen Table Grape Varieties Produced in Ankara (Türkiye): a Study Over Two Consecutive Seasons
(Frontiers Media Sa, 2024) Kunter, Birhan; Unal, Osman Batur; Keskin, Siddik; Hatterman-Valenti, Harlene; Kaya, Ozkan
Sugars and organic acids not only have a significant impact on taste balance and sensory acceptance by consumers but also play a crucial role in the chemical equilibrium of grape juices and wines. Therefore, this study aimed to quantify the content and composition of sugars and organic acids in 17 grape varieties over two consecutive years using high-performance liquid chromatography. The variability in all the parameters studied was strongly influenced by both the grape cultivars and specific years (p <= 0.05). In grape berries, the primary sugars identified were fructose and glucose, which ranged from 6.50 to 11.10 g/L and from 5.83 to 12.12 g/L, respectively, over the two years. However, sucrose was not detected in any of the grape varieties examined. For the two respective years, the highest titratable acidity (TA) was found in Tekirdag cekirdeksizi (TeCe) (0.89 and 0.90 g/L), while the lowest was detected in Victoria (Vi) (0.48 and 0.51 g/L). Total soluble solids (TSS) peaked in Horoz Karasi (HoKA) (21.90 degrees Brix), whereas it reached its lowest point in Big Perlon (BiPe) (14.1 degrees Brix). The tartaric acid content in the grape berries, ranging from 1.48 to 10.33 g/L for the two years, exhibited similar characteristics to malic acid, which ranged from 1.09 to 9.62 g/L and from 1.03 to 9.68 g/L for the two respective years. The succinic, malic, tartaric, citric, and oxalic acid contents were notably higher in the Kyoho (Ky) variety than in the other varieties. When examining the dendrogram of the contents of organic acid and sugar for similarities, it was evident that 16 out of the 17 grape varieties had a high degree of similarity, except for Alphonse Lavallee (AlLa) and HoKa. The similarity levels among the varieties ranged from 99.49% to 72.36%. The highest similarity (99.49%) was observed between the AlLa and Baris (Ba) varieties. The lowest similarity was observed among the AlLa, HoKa, and Ky varieties. In summary, this study underscores that certain table grape varieties grown in Ankara exhibit significant variations in valuable organic acids and sugars, which are associated with potential health benefits when considering human consumption.
Comparison of Two Retention Appliances With Respect To Clinical Effectiveness
(Aves, 2019) Kaya, Yesim; Tunca, Murat; Keskin, Siddik
Objective: The aim of this study was to compare the clinical effectiveness of Essix and Hawley retainers during the retention period. Methods: A total of 30 subjects whose fixed orthodontic treatment results were evaluated according to the American Board of Orthodontics Phase III Objective Grading system were included in this study. After the removal of orthodontic attachments, the study participants were equally divided into two retention protocols: upper-lower Essix and upper-lower Hawley. The subjects were instructed to wear their retainers full time for 6 months, except during meals, and during nights only for 6 months. The clinical effectiveness of the retainers was evaluated according to the overjet, overbite, maxillary, and mandibular intercanine widths, intermolar widths, arch lengths, irregularity indexes, and lateral cephalometric measurements. All dental model and lateral cephalometric measurements were performed by the same investigator during three periods: pre-treatment, post-treatment, and post-retention. Results: The overjet, overbite, maxillary, and mandibular intercanine widths; intermolar widths; and arch lengths and lateral cephalometric measurements were not statistically significantly different between the groups and identified time periods. Although the maxillary and mandibular irregularity indexes increased from the post-treatment to post-retention periods, the difference was not statistically significant. Pre-treatment, post-treatment, and post-retention lateral cephalometric measurements were not statistically significantly different between and within the groups. Conclusion: According to the results of a repeated-measures analysis of variance with two factors, and although an increase was found in the maxillary and mandibular irregularity indexes, the clinical effectiveness of Essix and Hawley retainers was found to be similar during the retention period.
Computerized Occlusal Analysis of Essix and Hawley Retainers Used During the Retention Phase: a Controlled Clinical Trial
(Urban & Vogel, 2020) Alkan, Ozer; Kaya, Yesim; Keskin, Siddik
Aim The aim of this study was to evaluate the occlusal force distribution (OFD), individual tooth force (ITF), and occlusal surface area (OSA) of Essix and Hawley retainers, using T-Scan III (Tekscan Inc., South Boston, MA, USA) analysis. Materials and methods A total of 35 subjects were randomly assigned to one of the retention groups following fixed orthodontic treatment. While 18 of these subjects were provided with Essix retainers, 17 were given Hawley retainers. Computerized occlusal analysis of the patients' dentitions was performed using T-Scan III. The evaluations were made after debonding (T0) and at month 3 (T1), month 6 (T2) and 1 year (T3) after the retention phase. Results The changes in OFD were significant only in the Hawley group for the left/right half jaws and the right posterior quadrants when comparing the T2-T3 time interval. Also, the differences between the groups were significant only for the left half jaw for the T0-T2 time interval and for the right half jaw when comparing the T0-T2 and the T2-T3 time intervals. The changes in ITF were insignificant within groups, but significant between the groups for tooth 11 and 22. Although there was an increase observed in OSA for both groups, the difference between the groups was insignificant. However, the OSA increase in the Essix group for the left/right anterior quadrants was significant only for the T0-T2 and the T0-T3 time intervals, while in both groups, for the posterior left quadrant, the OSA was insignificant only for the T0-T1 time interval. Conclusions Although OSA increased when using both retention appliances, OFD did not change.
The Correlation of Serum Trace Elements and Heavy Metals With Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients
(Springernature, 2011) Ari, Elif; Kaya, Yuksel; Demir, Halit; Asicioglu, Ebru; Keskin, Siddik
Changes in essential trace elements and heavy metals may affect the atherosclerotic state of patients on maintenance hemodialysis (HD). The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio) and carotid artery intima-media thickness (CIMT) in HD patients. Fifty chronic HD patients without known atherosclerotic disease and 48 age- and sex-matched healthy individuals were included in the study. The serum levels of trace elements (iron, zinc, manganese, copper, and magnesium) and heavy metals (cobalt, cadmium, and lead) were measured by Atomic Adsorption Spectrophotometer (UNICAM-929). CIMT was assessed by carotid artery ultrasonography. The serum levels of iron, zinc, and manganese were lower; levels of copper, magnesium, cobalt, cadmium, lead, and copper/zinc ratio were higher in HD patients compared to controls. CIMT in HD patients were higher than the control group (0.64 +/- 0.11 vs 0.42 +/- 0.05, p < 0.001). There was a significant negative correlation between CIMT and serum levels of zinc (r = -0.70, p < 0.01), iron (r = -0.71, p < 0.01), and manganese (r = -0.47, p < 0.01), while there was a significant positive correlation between CIMT and serum levels of copper (r = 0.63, p < 0.01), magnesium (r = 0.77, p < 0.01), cobalt (r = 0.63, p < 0.01), cadmium (r = 0.48, p < 0.01), lead (r = 0.38, p < 0.01), and copper/zinc ratio (r = 0.68, p < 0.01). A linear regression analysis showed that serum levels of magnesium, cadmium, lead, and copper/zinc ratio were still significantly and positively correlated with CIMT. We propose that copper/zinc ratio, magnesium and toxic metals cadmium and lead are independent determinants of CIMT in maintenance HD patients without known atherosclerotic disease.
Current Status of Nitrous Oxide Use in Operating Rooms of Turkey
(Kuwait Medical Assoc, 2023) Demirkiran, Hilmi; Tekeli, Arzu Esen; Yardimci, Cevdet; Korkutata, Zeki; Keskin, Siddik; Gulhas, Nurcin
Objective: Investigating the justifications of nitrous oxide (N2O) use in Turkey's hospitals and usage trends during the last five years. Design: A cross-sectional study Setting: A total of 170 university hospitals, training and research hospitals, state hospitals and private hospitals in Turkey. Subjects: Clinical chiefs of 170 anesthesia departments Interventions: A survey was conducted. The Kruskal-Wallis, Mann-Whitney U, Kolmogorov-Smirnov, Chi-square and Fisher tests were performed. This trial was registered at Clinical Trials.gov (NCT04124562). Main outcome measure(s): Hospital type, frequency of N2O use, how many times general anesthesia was used in a month, number of cases N2O was used on the day of the study, the status of N2O use by anesthetists in the last five years, and the reasons for its use were questioned. Results: N2O use combined with inhaled anesthetics was reported by 119 (72.1%) clinical chiefs of anesthesia departments. The mean number of general anesthesia cases in one month in 165 (84.1%) clinics included in this study was reported to be 95,044. The number of cases using N2O combined with inhalational anesthetics was 1401 (39.6%) in one day. Regarding N2O usage in the last five years, 68 (41.2%) anesthetists responded that their usage rate had decreased, 48 (29.1%) stated that they had stopped using, and 47 (28.5%) anesthetists responded that their usage rate was unchanged. Stopping or reducing N2O use due to environmental or global climate and pollution concerns were observed more frequently in the operating rooms of the university hospitals (P<0.05). Conclusion: Despite a reduced usage rate of N2O in Turkey, it is still higher than that of European countries.
Determination of Appropriate Growth Models for Early Selection Possibilities in Goats
(Zoological Soc Pakistan, 2017) Cak, Bahattin; Yilmaz, Orhan; Keskin, Siddik; Bayril, Tahir; Tariq, Mohammad Masood
Growth models present a visual assessment of growth as a function of time and predict body weight at a specific age. We investigated the growth characteristics of Colored Mohair goat using four nonlinear growth models. Thirty (n=22 males and n=8 females) Colored Mohair kids were used. The kids were weighed at 2-week intervals from birth to 150 days. The Monomolecular, Gompertz, Richards and Three Parameter Logistic models were used. The best model was determined by considering the root mean square error, R-2% and asymptotic correlation coefficient criteria. We concluded that the Gompertz and Richards models were favourable for singletons and that the Richards model was favorable for determining twin Colored Mohair goat growth characteristics. Birth type should be considered in subsequent genetic evaluations. Furthermore, producing heavier carcasses (13-17 kg) in < 150 days may increase productivity and efficiency of the goat farming system.