Browsing by Author "Kilic, S."

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Antimicrobial Susceptibilities of Brucella Isolates From Various Clinical Speciemens
(Ivyspring International Publisher, 2011) Bayram, Y.; Korkoca, H.; Aypak, C.; Parlak, M.; Cikman, A.; Kilic, S.; Berktas, M.
Purpose: Brucellosis is a worldwide zoonotic disease and still constitutes a major public health problem. In the study we claimed to identify Brucella species from clinical samples of patients with active brucellosis from Van region of Eastern Anatolia and to determine in vitro antimicrobial susceptibilities of these strains to commonly used anti-Brucella agents and a possible new alternative tigecycline. Materials and Methods: A total of 56 Brucella isolates were enrolled the study and the identification of the isolates were based on conventional methods. In vitro activities of an-timicrobials were evaluated by the E test method. Results: All isolates were identified as B. melitensis. MIC90 values of doxycycline, strepto-mycin, rifampin, trimethoprim-sulfamethoxazole and tigecycline were 0.064 mg/L, 1 mg/L, 2 mg/L, 0.125 mg/L and 0.094 mg/L, respectively. Tigecycline had low MIC50 and MIC90 values against all B. melitensis strains; the highest MIC observed was 0.25 μg/mL. Conclusion: Our data suggest that tigecycline can be a therapeutic alternative option for the treatment of brucellosis. © Ivyspring International Publisher.
Clinical Characteristics, Quality of Life and Risk Factors for Severity in Palmoplantar Pustulosis: a Cross-Sectional, Multicentre Study of 263 Patients
(Oxford Univ Press, 2022) Solak, S. Sarikaya; Polat, A. Kara; Kilic, S.; Topal, I. Oguz; Saricaoglu, H.; Karadag, A. S.; Alpsoy, E.
Background Palmoplantar pustulosis (PPP) is a rare, chronic, inflammatory skin disease characterized by sterile pustules on palmar or plantar areas. Data on PPP are scarce. Aim To investigate the clinical characteristics and risk factors for disease severity in a large cohort of Turkish patients with PPP. Methods We conducted a cross-sectional, multicentre study of patients with PPP recruited from 21 tertiary centres across Turkey. Results In total, 263 patients (165 women, 98 men) were evaluated. Most patients (75.6%) were former or current smokers. The mean Palmoplantar Pustulosis Area and Severity Index (PPPASI) was 8.70 +/- 8.06 and the mean Dermatology Life Quality Index (DLQI) score was 6.87 +/- 6.08, and these scores were significantly correlated (r = 0.52, P < 0.001). Regression analysis showed that current smoking was significantly associated with increased PPPASI (P = 0.03). Coexisting psoriasis vulgaris (PsV) was reported by 70 (26.6%) patients. Male sex prevalence, PPP onset incidence, disease duration, DLQI, and prevalence of nail involvement and psoriatic arthritis (PsA) were significantly increased among patients with PPP with PsV. Of the 263 patients, 18 (6.8%) had paradoxical PPP induced by biologic therapy, and these patients had significantly increased mean DLQI and prevalence of PsA (r = 0.03, P = 0.001). Conclusion Our data suggest that smoking is a risk factor for both PPP development and disease severity. Patients with PPP with PsV present distinct clinical features and patients with biologic therapy-induced paradoxical PPP have reduced quality of life and are more likely to have PsA.
Diagnosis of Chronic Brucellar Meningitis and Meningoencephalitis: the Results of the Istanbul-2 Study
(Elsevier Sci Ltd, 2013) Erdem, H.; Kilic, S.; Sener, B.; Acikel, C.; Alp, E.; Karahocagil, M.; Pappas, G.
No detailed data exist in the literature on the accurate diagnosis of chronic brucellar meningitis or meningoencephalitis. A multicentre retrospective chart review was performed at 19 health centres to determine sensitivities of the diagnostic tests. This study included 177 patients. The mean values of CSF biochemical test results were as follows: CSF protein, 330.64 +/- 493.28mg/dL; CSF/ blood-glucose ratio, 0.35 +/- 0.16; CSF sodium, 140.61 +/- 8.14mMt; CSF leucocyte count, 215.99 +/- 306.87. The sensitivities of the tests were as follows: serum standard tube agglutination (STA), 94%; cerebrospinal fluid (CSF) STA, 78%; serum Rose Bengal test (RBT), 96%; CSF RBT, 71%; automated blood culture, 37%; automated CSF culture, 25%; conventional CSF culture, 9%. The clinician should use every possible means to diagnose chronic neurobrucellosis. The high seropositivitiy in brucellar blood tests must facilitate the use of blood serology. Although STA should be preferred over RBT in CSF in probable neurobrucellosis other than the acute form of the disease, RBT is not as weak as expected. Moreover, automated culture systems should be applied when CSF culture is needed.
Dream Anxiety Is an Emotional Trigger for Acute Myocardial Infarction
(2011) Selvi, Y.; Aydin, A.; Gumrukcuoglu, H.A.; Gulec, M.; Besiroglu, L.; Ozdemir, P.G.; Kilic, S.
Objective: The aim of the present study was to investigate the relationship between nightmares and acute myocardial infarction (AMI) occurring during sleep, and also to evaluate the influence of several related factors. Method: The sample comprised AMI patients who had been admitted to the coronary care unit. The patients were grouped into two categories; the asleep-AMI group consisted of 36 patients who had the onset of symptoms of AMI during sleep, and the awake-AMI group included 183 patients who had AMI while they were awake. The sleep quality and dream anxiety for the 1-month interval before AMI were assessed with Pittsburgh Sleep Quality Index (PSQI) and Van Dream Anxiety Scale (VDAS), respectively. Results: Asleep-AMI patients reported significantly poorer subjective sleep quality, significantly higher global PSQI scores, and displayed significantly higher nightmare frequency, difficulty in falling asleep after a nightmare, higher autonomic hyperactivity, dream recall frequency, daytime anxiety, psychological problems, and higher global dream anxiety scores than awake-AMI patients. Conclusion: The present study suggests that sleep anxiety and related emotions are associated with AMI during sleep. © 2011 The Academy of Psychosomatic Medicine.
The Mineralogy and Firing Behaviour of Pottery Clays of the Lake Van Region, Eastern Turkey
(Mineralogical Soc, 2017) Aras, A.; Kilic, S.
The present study focused on the mineralogical and chemical characterization and firing behaviour of clays from the Lake Van region and compared them with the same characteristics established for two ancient pot sherds. Four pottery clays collected from Kutki and Kusluk in the Kesan Valley to the south, from Kavakbasi to the southwest and from Bardakci village on the east coast of Lake Van were analysed by X-ray diffraction to identify mineralogical composition (bulk clays and <2 mu m fractions after heating at 300-500 degrees C and ethylene glycol solvation). Further analyses were conducted to determine the size distribution, chemical composition and physical properties of test bodies derived from these clays. The in situ weathered schist forming the primary micaceous red clays which are suitable for local pottery production are characterized by large muscovite-sericite-illite and small calcite contents. In contrast, the Bardakci clays are dominated by large smectite contents and are only used sparingly in mixtures of local pottery production because they undergo firing shrinkage and present drying and firing flaws in the fired bodies. Firing ranges of similar to 800-900 degrees C were inferred from the mineralogy and colours of the two ancient sherds from Kutki. As a result of mineralogical analysis of fired and unfired test bodies of these pottery clays and pot sherds, two different types of pastes were determined for pottery production in the Lake Van region: metamorphic and volcanic paste, the former characterized by a calcite-poor and mica-sericite-rich matrix and the latter by large smectite and small calcite contents.
Seroprevalence of Toxoplasmosis, Brucellosis and Listeriosis in Horses in Hakkari, Eastern Region of Turkey
(Ecole Nationale veterinaire Toulouse, 2007) Goez, Y.; Babuer, C.; Aydin, A.; Kilic, S.
The aim of this study was to detect the seroprevalences of Toxoplasmosis, brucellosis and listeriosis in horses from the Hakkari city, eastern region of Turkey. For this purpose, serum samples from 74 local horses were obtained and tested using IHA and Sabin-Feldman Dye tests (SFDT) for toxoplasmosis, Serum Tube Agglutination test (SAT) for brucellosis and Osebold Agglutination Test (OAT) for listeriosis. The toxoplasmosis seroprevalences detected with MAT and with SFDT were 13.5% and 28.3% respectively, the SFDT presenting a higher sensitivity. The seroprevalence of brucellosis was low in horses (9.5%) while a high seroprevalence of listeriosis (48.6%) was evidenced. No significant association between age or sex and toxoplasmosis or listeriosis infections was observed. By contrast, brucellosis seroprevalence was significantly higher in females than in males. These results suggest that horses from the Hakkari region can be considered as potential reservoirs for these infectious agents for other species and may contribute to the disease spreading and to direct (brucellosis, listeriosis) and indirect (toxoplasmosis) contamination of humans.