Browsing by Author "Kiran, Musa"

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The First Electroanalytical Study of Umifenovir (Arbidol) Used as a Potential Antiviral Drug for The Treatment of Sars-Cov a Voltammetric Quantification on The Boron-Doped Diamond Electrode by Using Anionic Surfactant Media
(Electrochemical Soc inc, 2023) Ozok, Hande Izem; Kiran, Musa; Yunusoglu, Oruc; Yardim, Yavuz
In this work, an electroanalytical procedure for sensing umifenovir (arbidol) by square wave adsorptive stripping voltammetry (SW-AdSV) was developed utilizing an anodically pretreated boron-doped diamond electrode. Measurements of umifenovir using cyclic voltammetry with phosphate buffer solution (PBS, 0.1 M, pH 2.5) revealed irreversible behaviour, adsorption-controlled as well as an ill-defined (+1.13 V, P-A1) and a well-defined (+1.47 V, P-A2) two oxidation peaks. Umifenovir oxidations depend critically on supporting electrolytes and pH. The second oxidation peak (P-A2) current of the umifenovir was enhanced by adding sodium dodecyl sulfate (SDS, anionic surfactant) in the chosen supporting electrolyte. Umifenovir was quantified using its second oxidation peak (P-A2) at about +1.39 V. Using the optimized condition, the oxidation peak current of P-A2 showed a linear relationship for umifenovir determination in the concentration range from 0.005 to 1.0 mu g ml(-1) (9.73 x 10(-9)-1.95 x 10(-6) M), with a detection limit of 0.0014 mu g ml(-1) (2.72 x 10(-9) M) in PBS (PH 2.5) with SDS. Finally, the developed approach was successfully utilized to determine umifenovir in the pharmaceutical formulation and urine samples. To the best of our knowledge, this is the first electroanalytical approach for voltammetric sensing of umifenovir.
A New Approach for the Voltammetric Sensing of the Phytoestrogen Genistein at a Non-Modified Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2022) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Sahin, Cihat; Kiran, Musa; Yardim, Yavuz
An effective electrochemical sensor was constructed using an unmodified boron-doped diamond electrode for determination of genistein by square-wave voltammetry. Cyclic voltammetric investigations of genistein with HClO4 solution indicated that irreversible behavior, adsorption-controlled and well-defined two oxidation peaks at about +0.92 (P-A1) & +1.27 V (P-A2). pH, as well as supporting electrolytes, are important in genistein oxidations. Quantification analyses of genistein were conducted using its two oxidation peaks. Using optimized experiments as well as instrumental conditions, the current response with genistein was proportionately linear in the concentrations range of 0.1 to 50.0 mu g mL(-1) (3.7x10(-7)-1.9x10(-4) mol L-1), by the detection limit of 0.023 mu g mL(-1) (8.5x10(-8) mol L-1) for P-A1 and 0.028 mu g mL(-1) (1.1x10(-7) mol L-1) for P-A2 in 0.1 mol L-1 HClO4 solution (in the open circuit condition at 30 s accumulation time). Ultimately, the developed method was effectively applied to detect genistein in model human urine samples by using its second oxidation peak (P-A2).