Browsing by Author "Kiroglu, F"

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Effects of Topical Chlorhexidine Applied To the Rabbit Nasal Mucosa
(Elsevier Sci Ltd, 2003) Çankaya, H; Özen, S; Kiroglu, F; Yurttas, V
Objective: To search the effects of administration of various concentrations of a wide-spectrum antimicrobial agent, chlorhexidine, to the nasal mucosa. Material and methods: About 0.20, 0.12, 0.06 and 0.03%, concentrations of chlorhexidine gluconate were applied to the rabbit nasal mucosa as one puff twice a day throughout 5 days. Another group, treated with serum saline to the nose, behaved as the control group. On the fifth day following drug administration, specimens were taken from nasal mucosa of the rabbits and examined under light microscope. Results: As a result of comparison between drug treated group and control group, with increasing drug concentrations progressively increased neutrophil infiltration in mucosa, ciliary loss in cells, and occasional metaplasia were observed. Conclusion: There is a linear, positive and strong association between concentrations of chlorhexidine and its irritative effects on rabbit nasal mucosa. While 0.20 and 0.12% concentrations of chlorhexidine cause excess irritation on the nasal cavity, 0.06 and 0.03% concentrations of chlorhexidine gluconate causes lower irritation and effects on the animals which have experimentally induced rhinosinusitis must be evaluated. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Primary Ewing's Sarcoma of the Paranasal Sinus With Intracranial Extension
(British inst Radiology, 2003) Harman, M; Kiroglu, F; Kösem, M; Ünal, Ö
Extraskeletal Ewing's sarcoma is often described as a tumour involving the soft tissues of the lower extremities and the paravertebral region. Involvement of the paranasal sinus is a very rare entity. We present a case of primary Ewing's sarcoma of the paranasal sinus extending into the middle cranial fossa in a 40-year-old female. CT and MRI findings of this unusual case are discussed. To our knowledge, this case is the first to be reported with CT and MRI documentation.
The Treatment Duration of Acute Maxillary Sinusitis: How Long Should It Be? a Nasal Smear Controlled Study
(int Rhinologic Soc, 2002) Kutluhan, A; Akdeniz, H; Kaya, Z; Kiroglu, F; Kiris, M; Ugras, S
The aim of this study was to determine the most appropriate duration of treatment in acute maxillary sinusitis. The study was performed prospectively on 40 adult patients with acute maxillary sinusitis diagnosed by sinus puncture. Patients were randomized as to several treatment periods and treated by various antibiotics according to culture-sensitivity results. Patients in group I received treatment for 7 days; groups 2, 3, and 4 received 14, 21, and 28 days, respectively. The patients were followed up with nasal smear findings on certain intervals during the 56-day follow-up period. Statistically significant differences were found beginning from the 21st day between group 1 and the other groups. However, there were no statistical differences among groups 2, 3 and 4. These findings show that the most appropriate duration of treatment in acute maxillary sinusitis should be at least 14 days according to nasal smear results.