Browsing by Author "Kiroglu, Faruk"

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8-Ohdg Levels in Patients With Allergic Rhiniti
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Onbasi, Kevser; Noyan, Tevfik; Cebi, Aysegl; Kiroglu, Faruk
Objective: Respiratory allergies like allergic rhinitis and allergic asthma are more frequently observed worldwide. Chronic inflammation in the respiratory tract is observed in these diseases. Oxidative stress contributes to this inflammation in the respiratory airways. 8-OHdG is a marker of oxidative stress. The aim of our study was to investigate the 8-OHdG levels in patients with respiratory allergy. Material and Methods: 23 patients with allergy consisting of 11 men and 12 women and 23 healthy controls were enrolled to the study. Results: 8-OHdG levels were found to be higher in allergic patients in comparison to healthy controls but it was not statistically significant. Conclusion: The reason for not significantly high levels of 8-OHdG levels as a marker of oxidative stress in respiratory allergy may attribute to the factor that the inflammation in respiratory allergy is less intensive in comparison to the inflammation in atopic dermatitis.
Clinical Outcomes of Suture Delay in Forehead Flap
(Lippincott Williams & Wilkins, 2012) Isik, Daghan; Kiroglu, Faruk; Isik, Yasemin; Goktas, Ugur; Atik, Bekir
The delay phenomenon is a surgical procedure performed to raise a wider skin flap and to improve the survival of skin flaps. Surgery, chemicals, sutures, and lasers can be used for the delay procedure. In this study, delayed forehead flaps created by suturing were used for coverage of nasal skin defects in eleven patients. In 7 patients, the cross-paramedian forehead flap was used to increase the extent of flap lengthening. In the first session, suture delay was performed on both sides of the forehead flap margin. In the second session, the flap was elevated and sutured to its new position, 7 to 10 days after the initial surgery. All flaps were completely viable, and patient satisfaction was optimal in all cases. The positive effect of surgical delay on flap survival has been shown in experimental and clinical studies. However, experimentally, suture delay or chemical delay procedures have been shown to be beneficial in flap survival only. Suture delay seems to be an inexpensive, effective, easily performed, a traumatic, and safe technique, especially among patients with systemic diseases such as diabetes or cardiovascular diseases, smoking patients who may lose the flap, or patients who need very wide and long flaps.
Effects of Topical Mitomycin and Trimetazidine on Myringosclerosis
(B C decker inc, 2008) Cankaya, Hakan; Kosem, Mustafa; Kiroglu, Faruk; Kiris, Muzaffer; Yuca, Koeksal; Ozturk, Guerkan; Erdogan, Ender
Introduction: Myringosclerosis, one of the most common complications of ventilation tube placement, is a kind of tympanosclerosis and is defined as subepithelial hyalinization of the tympanic membrane. There are two arguments in the development of myringosclerosis: inflammation triggering the development of myringosclerosis and free oxygen radicals released during inflammation causing myringosclerosis. Objective: The aim of the present study was to explore the effects on the development of myringosclerosis of mitomycin, which has anti-inflammatory effects, and trimetazidine, which is believed to inhibit free oxygen radicals when given systemically. Materials and Method: The study was carried out on rabbits. Animals were divided into five groups, with six rabbits in each group: three control groups (paracentesis only, paracentesis + tube placement, and no intervention), a trimetazidine group, and a mitomycin group. Mitomycin (0.4 mg/mL) and trimetazidine (20 mg/mL) were applied topically to the tympanic membrane, and the presence and degree of sclerosis were graded histopathologically after Masson's trichrome staining. Results: In the histopathologic examination, sclerosis that developed in the tympanic membranes of rabbits that had undergone paracentesis or paracentesis plus tube application or received trimetazidine was significantly more extensive than sclerosis in the membranes of unoperated animals and those that had been administered mitomycin. Conclusions: Paracentesis in rabbits, independent of tube placement, causes sclerosis of the tympanic membrane. Results show that topical use of mitomycin, due to its anti-inflammatory effect, had alleviating effects on myringosclerosis, whereas topical trimetazidine did not.
Treatment Modalities in Maxillofacial Fractures: Retrospective Analysis
(Ortadogu Ad Pres & Publ Co, 2009) Kiris, Muzaffer; Yuca, Koeksal; Celebi, Sezgin; Kiroglu, Faruk; Cankaya, Hakan
Objective: Our aim was to analyze patients treated for maxillofacial fractures due to trauma retrospectively and to discuss the results. Material and Methods: The study comprised 138 patients [aged between 2-76 years, (mean age 29.12 +/- 14.79) 102 men, 36 women] who had attended the Department of Otorhinolaryngology, Yuzuncu Yil University Medical Faculty during February 1995-October 2006, with maxillofacial fractures due to trauma. The patients were evaluated retrospectively for etiology, localization, treatment modalities and complications, and results were compared with other studies. Results: Traffic accidents were the most common cause of maxillofacial fractures (34%), followed by falls from high (21%). Distribution of maxillofacial fractures due to trauma were as follows; mandibular fractures in 64.6% and maxillary fractures in 20.2%. Among mandibular fractures, parasymphyseal fractures were the most common by 31.5% and coronoid fractures were the least common with 0.6%. The techniques used for treatment were miniplaque application, arch-bar Gillie's method and condilectomy; miniplaque technique being the most frequently used (67.7%). The most common complication was infection. Seven patients required tracheotomy in the emergency room for respiratory distress was. Conclusion: In this study, techniques and equipments used in the treatment process changed parallel to technological developments. While wire fixation and arch-bar procedures were more frequent in the earlier cases, titanium mini-plaques and microplaques had results that were more favorable with better outcomes and less complications.