Browsing by Author "Kivrak, A."

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Synthesis of Novel Benzothiophene Derivatives Via Cyclization Reactions
(Maik Nauka/interperiodica/springer, 2020) Hama, A. K.; Algso, M. A. S.; Kavak, E.; Kivrak, A.
The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.
Synthesis of Thiophenyl-Substituted Unsymmetrical Anthracene Derivatives and Investigation of Their Electrochemical and Electrooptical Properties
(Elsevier B.V., 2017) Kivrak, A.; Çalış, H.; Topal, Y.; Kivrak, H.; Kuş, M.
Novel thiophenyl-substituted anthracene derivatives (D-A) bearing a variety of electron-withdrawing groups were designed and synthesized for organic solar cells (OSCs). Their electrochemical and electro-optical properties were examined with strong donor-acceptor interaction. The electrochemical properties were examined by cyclic voltammetry (CV) measurements. These estimated values from CV measurements are in good agreement with the optical band gaps. HOMO, LUMO, and Eg values of designed organic materials were estimated. Furthermore, these new generation organic materials were fabricated to find their solar cell performances. © 2016 Elsevier B.V.
Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl)
(Maik Nauka/interperiodica/springer, 2021) Kavak, E.; Algso, M. A. S.; Konus, M.; Yilmaz, C.; Lazoglu, A.; Karaagac, S. U.; Kivrak, A.
2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.