Browsing by Author "Kivrak, A."

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Synthesis of Novel Benzothiophene Derivatives Via Cyclization Reactions
(Maik Nauka/interperiodica/springer, 2020) Hama, A. K.; Algso, M. A. S.; Kavak, E.; Kivrak, A.
The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.
Synthesis of Thiophenyl-Substituted Unsymmetrical Anthracene Derivatives and Investigation of Their Electrochemical and Electrooptical Properties
(Elsevier B.V., 2017) Kivrak, A.; Çalış, H.; Topal, Y.; Kivrak, H.; Kuş, M.
Novel thiophenyl-substituted anthracene derivatives (D-A) bearing a variety of electron-withdrawing groups were designed and synthesized for organic solar cells (OSCs). Their electrochemical and electro-optical properties were examined with strong donor-acceptor interaction. The electrochemical properties were examined by cyclic voltammetry (CV) measurements. These estimated values from CV measurements are in good agreement with the optical band gaps. HOMO, LUMO, and Eg values of designed organic materials were estimated. Furthermore, these new generation organic materials were fabricated to find their solar cell performances. © 2016 Elsevier B.V.
Synthesis, in Silico Evaluation of ADME/T Properties, as well as Antioxidant, Antibacterial, Anti-Inflammatory, and Anticancer Activities of Methyl(2-(phenylethynyl)phenyl)sulfane
(John Wiley and Sons Inc, 2025) Mahaleh, S.P.G.; Arici, O.O.; Kivrak, A.; Otur, C.; Kurt-Kizildogan, A.; Mutlu, D.; Babat, C.F.
Sulfur-containing compounds exhibit diverse biological activities, including anti-inflammatory, anticancer, antioxidant, antibacterial, and antidiabetic properties. In this study, for the first time, the biological properties of methyl(2-(phenylethynyl)phenyl)sulfane (MPPS), including its antioxidant, antimicrobial, cytotoxic, anti-inflammatory, and anticancer activities, were evaluated. According to the results, MPPS did not show any remarkable antioxidant activity. However, MPPS demonstrated modest antimicrobial activity against S. aureus ATCC 25923 (MIC value: 512 µg/mL) and B. subtilis ATCC 6633 as well as other indicator strains (MIC value: 256 µg/mL). Additionally, the MBC values of MPPS were found to be 512 µg/mL for the two gram-negative strains, E. coli ATCC 25922 and P. aeruginosa ATCC 27853. Furthermore, MPPS showed a dose-dependent cytotoxic effect in all tested cell lines. The EC50 values of MPPS were determined as 202.68 µM for PANC-1, 226.63 µM for LNCaP, and 166.27 µM for Ishikawa cells, respectively. MPPS significantly inhibited colony formation and induced apoptosis in the cancer cell line. Moreover, MPPS exhibited notable anti-inflammatory activity in RAW264.7 cells. These findings suggest that MPPS has potential for cancer treatment and as an anti-inflammatory and antimicrobial agent. However, further studies are required to confirm these effects. © 2025 Elsevier B.V., All rights reserved.
Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl)
(Maik Nauka/interperiodica/springer, 2021) Kavak, E.; Algso, M. A. S.; Konus, M.; Yilmaz, C.; Lazoglu, A.; Karaagac, S. U.; Kivrak, A.
2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.