Browsing by Author "Kiziltan, Remzi"
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Article An Analysis of 13 Patients With Perforated Gastric Carcinoma: a Surgeon's Nightmare(Bmc, 2008) Kotan, Cetin; Sumer, Aziz; Baser, Murat; Kiziltan, Remzi; Carparlar, M. AliBackground and Objectives: Perforation is a rare complication of gastric carcinoma and generally not diagnosed preoperatively. To clarify the clinicopathologic characteristics of patients with this condition we reviewed 13 cases of gastric cancer perforation who required emergency surgery. Methods: A total of 13 patients with gastric cancer perforation were retrospectively reviewed. The clinicopathological features including tumor stage and survival and also the type of treatment were analyzed and compared to literature data. Results: There were 13 patients (10 males and 3 females) with a mean age of 59.0 +/- 9.56 years. The incidence of perforated gastric cancer was 9.6% among gastric carcinoma and 4.2% of all gastric perforation cases. The perforation was more frequently in stage III-IV (2-10), but one case of stage II (T3N0M0) gastric cancer was also observed. None of the patients had curative resection or radical lymph-node dissection. Six (46%) patients were treated by palliative, local surgery. Emergency gastrectomy were performed in 7 (54%) patients. Overall 30-day mortality rate was % 46. The overall survival time was 128.2 +/- 184.8 days for all patients, it was 52.8 +/- 52.9 days for locally treated group, and 192.9 +/- 235.4 days for patients who underwent resectional surgery. The difference between the treatment groups was not significant Conclusion: Perforation usually occurs in advanced stages of gastric cancer. These patients had a poor prognosis because of the presence of advanced cancer.Article B7-H3: a Useful Emerging Diagnostic Marker for Colon Cancer(Hindawi Ltd, 2022) Bostanci, Ozgur; Sayin, Pinar; Kiziltan, Remzi; Algul, Sermin; Aydin, Mehmet Akif; Kemik, OzgurBackground. Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those that are replaced in colon cancer. Method. We measured preoperative serum B7-H3 concentrations of 90 patients aged 57-69 years diagnosed with colon cancer and 50 age-matched healthy individuals. B7-H3 levels were determined using the sandwich enzyme-linked immunosorbent assay (ELISA). Patients were categorized by stage based on the TNM staging system, and the serum levels of B7-H3 were compared between patients with different TNM stages. Result. No statistically significant difference was found between the patient and control groups in terms of age and gender. Preoperative serum B7-H3 levels were statistically significantly higher in patients with colon cancer than in the healthy group (p < 0.001). Preoperative serum B7-H3 concentration of the stage IV patients was significantly higher than those of the patients with stage I and stage II disease. In addition, higher serum B7-H3 levels were associated with lymph node status and distant metastasis in colon cancer. Conclusion. We showed that B7-H3 is highly expressed in colon cancer and can be used as a candidate diagnostic biomarker and a potential target in colon cancer in future.Article Colon Cancer Presented With Sigmoid Volvulus: a Case Report(Elsevier Sci Ltd, 2015) Aras, Abbas; Kiziltan, Remzi; Batur, Abdussamet; Celik, Sebahattin; Yilmaz, Ozkan; Kotan, CetinIntroduction: Sigmoid volvulus is the most prevalent type of colonic volvulus. Colon cancer is seen less where sigmoid volvulus is common, so it is rare to see that colon cancer is synchronous with sigmoid volvulus. PRESENTATION OF CASE: We would like to present a case of sigmoid volvulus caused by colon cancer in a male patient aged 80 who was referred to the hospital with toxaemic shock presentation. DISCUSSION: Sigmoid cancer can be presented as sigmoid volvulus to the emergency department. In intestinal obstruction early diagnosis is of crucial importance. Computarized tomography is a diagnosis tool that should be preferred both in the diagnosis of obstruction and in detecting its cause, localisation, degree and complications. CONCLUSION: When surgery is performed due to the urgent colonic obstruction in colonic volvulus diagnosed patients, a colon tumour should be considered in the same column loops or in the distal colon. We believe that CT is the method that should be preferred in large-bowel obstruction suspected patients. (C) 2015 The Authors. Published by Elsevier Ltd.Article The Diagnosis of Acute Appendicitis in Pregnant Versus Non-Pregnant Women: a Comparative Study(Assoc Medica Brasileira, 2016) Aras, Abbas; Karaman, Erbil; Peksen, Caghan; Kiziltan, Remzi; Kotan, Mehmet CetinObjective: To investigate whether the diagnosis of acute appendicitis is affected by pregnancy or not. Method: A retrospective study with the analysis of the medical records of all women suspected of having appendicitis who underwent appendectomy at our hospital between June 2010 and March 2015 were reviewed. The patients were divided into two groups according to whether they were pregnant or not during the surgery: group I, pregnant women, and group II, non-pregnant women. Results: During the study period, 38 pregnant women and 169 non-pregnant women underwent appendectomy. The time from admission to the operation was not statistically different (2.17 +/- 1.47 days in group I vs. 1.98 +/- 1.66 day in group II; p=0.288). The pregnant group had longer hospital stay than the nonpregnant group (p=0.04). Ultrasonography (USG) was used as the first diagnostic modality in 36/38 patients in group I and 161/169 in group II. The non-visualized appendix on ultrasound was seen in 17 patients in group I and 51 patients in group II, which was not statistically different. Sensitivity and specificity of USG in diagnosis of acute appendicitis were 61.29 and 80.00% in group I, and 93.0 and 31.6% in group II, respectively. Conclusion: Although the diagnosis of appendicitis in pregnant women is not delayed, careful assessment of these patients suspected of having appendicitis should be encouraged when USG examination is normal or nondiagnostic.Article Effect of Thymoquinone on the Healing of Left Colon Anastomosis: an Experimental Study(Springer international Publishing Ag, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Celik, Sebahattin; Yildirm, Serkan; Alp, Hamit Hakan; Aras, Abbas; Kotan, CetinAim: To evaluate the effect of thymoquinone on the healing of experimental left colon anastomosis in rats. Methods: Forty Wistar albino rats weighing 250-300 g were randomly divided into four groups (10 rats/group). Group 1 (control group) rats were not administered Thymoquinone (TQ) for 3 days after the operation. Group 2 was administered daily TQ for 3 days starting from the first day after the operation. Group 3 was not administered TQ for 7 days after the operation. Group 4 was administered daily TQ for 7 days starting from the first day after the operation. Thymoquinone was administered as a single dose oral gavage through a 4F feeding catheter per each day. The bursting strength of the anastomosis was measured on 3rd and 7th postoperative days (POD) and resection was performed. Subsequently, the hydroxyproline level in the resected tissue was measured and a histological evaluation was performed. Results: The bursting pressures of the anastomoses were measured to be statistically significantly greater on 7th POD in TQ administered groups compared to those without TQ administration. Tissues were stained with Masson's trichrome dye in order to evaluate the amount of fibrous tissue reaction for histopathological examination; there was no significant difference in the amount of fibrous tissue between groups 1 and 2, while a very marked increase in the fibrous tissue was detected in groups 3 and 4. Mean tissue hydroxyproline levels of the groups 3 and 4 on 7th POD were 1.30 and 2.72 mu g/g-protein, respectively. The difference between the groups was statistically significant (p = 0.001). Conclusions: TQ significantly increased the bursting pressure of the anastomosis, tissue hydroxyproline level, and fibrous tissue production.Article Epcam Is a New Potential Serum Biomarker for Early Gastric Cancer(Bayrakol Medical Publisher, 2023) Eroglu, Ersan; Kiziltan, Remzi; Algul, Sermin; Kemik, Ozgur; Altinli, EdizAim: Overexpression of epithelial cell adhesion molecule (EpCAM) has been shown in a wide spectrum of epithelial cancers. In this study we aimed to examine the utility of serum EpCAM levels as a new marker for early diagnosis of gastric cancer, and to determine its association with different stages of gastric cancer. Material and Methods: A total of 88 patients who underwent resection due to gastric cancer and 44 healthy subjects as the control group were included in the study. The diagnosis of gastric cancer was confirmed by a combination of upper gastrointestinal endoscopy, endoscopic ultrasonography, and histopathology. EpCAM levels were evaluated using the enzyme-linked immunosorbent assay (ELISA) method following the instructions of the manufacturer. Results: The mean preoperative EpCAM level was found as 235.7 +/- 34.2 pg/mL in the patient group and 42.5 +/- 2.38 pg/mL in the control group. The mean preoperative serum EpCAM level was found to be significantly higher in gastric cancer patients compared to the control group (p<0.001). In addition, mean EpCAM levels were higher in patients with class T4 and T2 compared to T1. Mean EpCAM levels were also significantly higher in N1 and N2 classes compared to N0, and in M1 compared to M0 (all, p<0.001). Discussion: The results of this study indicate that the elevated expression of the EpCAM levels can predispose to the development of gastric cancer. Thus, the analysis of this marker could be a useful biomarker for screening patients with gastric cancer.Article Inflammatory Myofibroblastic Tumor: a Rare Cause of Invagination in Adults(Professional Medical Publications, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Almali, Necat; Peksen, CaghanInflammatory myofibroblastic tumor (IMT) is a distinct pseudosarcomatous lesion arising in the soft tissues and interior organs of children and young adults. It is rarely seen in adults. It was first described in lungs. IMT can occur in any location in the body. However, it is seen most commonly in lungs, intestinal mesentery and liver. Non-mesenteric alimentary tract IMT's are quite rare. The presented case is an ileal IMT that caused small bowel invagination. A 38 year-old male patient presented to the emergency department with the complaint of diffuse abdominal pain, distension and no passage of gas or stools for two days. An abdominal examination revealed distension and tenderness in the abdomen with no guarding or rebound tenderness. Computerized tomography (CT) of the abdomen was ordered. CT revealed an image compatible with invagination of the right lower quadrant of the abdomen and a mass inside the lumen measuring 4x3x3cm. The mass causing invagination was detected during the surgical operation. A segmentary small bowel resection and ileoileal anastomosis was performed. The patient was discharged uneventfully on the postoperative sixth day. The diagnosis of IMT was confirmed histologically and immunochemically.Article Ingested Intraabdominal Foreign Bodies That Require Surgical Intervention(Turkish Assoc Trauma Emergency Surgery, 2016) Kiziltan, Remzi; Yilmaz, Ozkan; Aras, Abbas; Toktas, Osman; Batur, Abdulsamet; Agar, Fatma; Kotan, CetinBACKGROUND: The aim of the present study was to review cases that required surgical intervention to remove ingested foreign bodies. METHODS: Medical records of 7 patients who underwent surgical intervention at the Yuzuncu Yil University Department of General Surgery between 2009 and 2014 after ingesting foreign bodies were reviewed. RESULTS: Female: male ratio was 5:2; mean age was 25 (16-35). Four patients had swallowed pins, 1 patient had swallowed a sewing pin, 1 patient had swallowed a safety pin, and 1 patient had swallowed a wristwatch. The patient who had swallowed the wristwatch had psychiatric disorders. All other patients stated that they had swallowed the objects by accident. CONCLUSION: Most ingested foreign bodies pass smoothly through the gastrointestinal (GI) tract within a week, but those that migrate out of the lumen require surgical intervention due to complications including perforation, abscess, fistula, and peritonitis. Early diagnosis and intervention is crucial to reduce morbidity and mortality. It is believed that sharp and pointed objects that migrate outside of the lumen ought to be removed, lest they cause complications.Article Intraperitoneal Infusion of Neutral-Ph Superoxidized Solution in Rats: Evaluation of Toxicity and Complications on Peritoneal Surface and Liver(int Scientific information, inc, 2017) Aras, Abbas; Karaman, Erbil; Yildirim, Serkan; Yilmaz, Ozkan; Kiziltan, Remzi; Karaman, KamuranBackground: Superoxidized water (SOW) is known to be a potent disinfectant. The aim of this study was to evaluate the toxicity and complications on the peritoneal surface and liver after infusion of pH-neutral SOW into the peritoneal cavity of rats. Material/Methods: Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into 3 groups (10 rats/group). Group1 (control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2 (single-dose group) rats received a single dose of 10 mg/kg pH-neutral SOW intraperitoneally. Group 3 (multiple-doses group) rats received multiple doses of 10 mg/kg pH-neutral SOW intraperitoneally on days 1, 3, and 5. All animals were killed at 1 week after infusion. Blood specimens were taken to the laboratory and macroscopic and microscopic examinations were performed on each rat. Results: All 30 rats survived after the infusion. The gross-macroscopic examinations revealed no pathologic findings in any of the 3 groups. The microscopic examination of peritoneum and liver showed no signs of toxicity or complications in any of the 3 groups. There were no statistically significant differences among the 3 groups with regards to the blood biochemistry, including hemoglobin, hematocrit, platelets, aspartate aminotransferase, alanine aminotransferase, urea, or creatinine levels (p>0.05). However, the leucocyte counts were lower in group 3 than in groups 1 and 2, but this was not statistically significant (p=0.189). Conclusions: Intraperitoneal infusion of pH-neutral SOW does not result in any significant toxicity or complications on the liver and peritoneal surface. However, multiple infusions lead to low leucocyte counts and future studies with longer follow-up times are needed.Article Maternal and Fetal Outcomes After Laparoscopic Vs. Open Appendectomy in Pregnant Women: Data From Two Tertiary Referral Centers(Studio K, 2016) Karaman, Erbil; Aras, Abbas; Cim, Numan; Kolusari, Ali; Kiziltan, Remzi; Celik, Sebahattin; Anule, TurgutObjectives: Appendectomy is the most common cause of non-obstetric surgery in pregnant women. Our aim was to compare the clinical characteristics, pert-and post-operative data of pregnant women undergoing either laparoscopic appendectomy (LA) or open appendectomy (OA). Material and methods: This was a retrospective study of medical records of all pregnant women diagnosed and treated surgically for acute appendicitis at two referral centers of Yuzuncu Yil University Medical Faculty and Kafkas University Medical Faculty, from January 2010 to January 2015. Results: The study included 48 patients, divided to two groups (12 - LA and 36 - OA). There were no significant differences in demographic characteristics of the studied population, including age, BMI, gestational age at operation, gravidity, parity, and history of cesarean sections. A far as obstetric and fetal outcomes are concerned, no significant differences were found in terms of preterm delivery, fetal loss, delivery mode, birth weight, APGAR score, and maternal death between the two investigated groups. One perioperative complication of intra-abdominal abscess was noted in the OA group. However, the LA group had shorter hospital stay (3.25 +/- 2.45 vs. 4.28 +/- 3.31, p=0.004), earlier mobilization time (8.1 +/- 2.2 vs. 10.1 +/- 1.6, p=0.025), and shorter time to first flatus (2.3 +/- 0.3 vs. 4.0 +/- 1.6, p=0.032) as compared to the OA group. The OA group had statistically shorter operation time than the LA group (38.61 +/- 11.5 vs. 49.42 +/- 11.38, p=0.007). Conclusion: LA is related to shorter hospital stay, faster return to daily activities, and shorter time to first flatus. LA appears to be as safe and effective as OA in pregnant patients without increasing adverse perinatal outcomes.Letter Multiple Benign Metastasizing Leiomyoma of the Uterus in Lung and Retroperitoneum(Wolters Kluwer Medknow Publications, 2019) Sunnetcioglu, Aysel; Karaman, Erbil; Ozgokce, Mesut; Erten, Remzi; Kiziltan, Remzi; Cobanoglu, UfukArticle Nidogen-2: a New Biomarker in Colon Cancer Patients(Edizioni Luigi Pozzi, 2022) Kiziltan, Remzi; Cikman, Oztekin; Algul, Sermin; Aydin, Mehmet Akif; Kemik, OzgurAIM: In the present study, we followed Nidogen-2 levels and clinicopathological parameters of patients with colon cancer. MATERIAL AND METHODS: Eighty-eight patients (F/M, 43/45; Mean age +/- SD, 57.86 +/- 1.78 years) were included. The results of serum Nidogen-2 levels were shown with respect to stage, gender, age, and metastasis. Nidogen-2 levels in the sera of colon cancer patients and healthy donors were analyzed with ELISA. RESULTS: The expression levels were significantly higher in patients (1010.8 +/- 184.36 pg/mL) than in healthy subjects (51.85 +/- 1.44 pg/mL; p<0.001). Moreover, the Nidogen-2 expression significantly increased in the clinical stages of colon cancer (p<0.01). The Nidogen-2 levels did not vary by patient age or gender. DISCUSSION: Under normal conditions, Nidogen-2 is a basal membrane protein. Nidogen-2 is primarily expressed in the extracellular matrix. Nidogen-2 has been defined as a major means to analyze the molecular pathways involved in cancer development and progression. Besides its important functions, it has been hypothesized that secreted Nidogen-2 may be a diagnostic biomarker for cancer detection. CONLUSION: These findings suggest that increased expression of Nidogen-2 may have great pathological importance in the development of colon cancer and may also show a diagnostic value for colon cancer.Article A Novel Marker for Esophageal Cancer: Senescence Marker Protein-30(Bayrakol Medical Publisher, 2024) Kiziltan, Remzi; Aydin, Mehmet Akif; Algul, Sermin; Kemik, OzgurAim: Esophageal cancer is one of the most common malignancies causing the majority of cancer -related deaths worldwide. The aim of this study was to examine the importance of preoperative Senescence marker protein -30 (SMP30) levels in patients with esophageal cancer. Material and Methods: Medical records of 85 patients who were diagnosed with esophageal cancer were reviewed and compared with those of the control subjects. The tumor marker was measured with Enzyme -linked immunosorbent assay (ELISA). Results: No statistically significant difference was found between the patient and study groups in terms of age and gender. In our study, we found that serum SMP30 levels were significantly lower in esophageal cancer patients than in healthy controls. Discussion: We found that the adhesion of esophageal cancer cells was significantly reflected by preoperative serum levels of the studied marker, indicating the adhesive strength of cancer cells. SMP30 may be a novel strategy for clinical diagnosis of the disease.Article Nucleosome Assembly Protein 1-Like 1 (Nap1l1) in Gastric Cancer Patients: a Potential Biomarker With Diagnostic and Prognostic Utility(Taylor & Francis Ltd, 2024) Gul, Gungor; Aydin, Mehmet Akif; Algul, Sermin; Kiziltan, Remzi; Kemik, OzgurBackground: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients. Methods: A total of 85 patients [mean (SD) age: 60.9 (1.6) years, 49.4% were males] with newly-diagnosed gastric cancer and 40 healthy individuals [mean (SD) age: 60.7 (1.7) years, 52.5% were males] were included. Data on patient demographics (age, gender), TNM stages and tumor size, and the serum NAP1L1 levels were recorded. Results: Serum NAP1L1 levels were significantly higher in gastric cancer patients than in control subjects [12 (9.5-13.8) vs. 1.8 (1.5-2.4) ng/mL, p < 0.001]. Also, certain tumor characteristics such as tumor size of >4 vs. <4 cm (p < 0.001), M1 vs. M0 stage (p < 0.001), N2 vs. N0 and N1 stage (p < 0.001), and T4 vs. lower T stage (p < 0.001) were associated with significantly higher serum NAP1L1 levels in gastric cancer patients. Conclusions: Our findings revealed for the first time that serum levels for NAP1L1 were overexpressed in the gastric cancer, as also correlated with the disease progression. NAP1L1 seems to be a potential biomarker for gastric cancer, providing clinically important information on early diagnosis and risk stratification.Article Potential Diagnostic and Prognostic Significance of Plasma Prolidase Activity in Gastric Cancer(Future Medicine Ltd, 2017) Celik, Sebahattin; Kiziltan, Remzi; Yilmaz, Eyup M.; Yilmaz, Ozkan; Demir, HalitAim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 +/- 4.20, 54.35 +/- 4. 9 and 10.92 +/- 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%). Discussion/conclusion: PPA was significantly higher in patients with inoperable gastric cancer than in operable cases and the control group. A strong correlation was found between tumor volume and PPA.Article A Rare Complication of Biliary Stent Migration: Small Bowel Perforation in a Patient With Incisional Hernia(Hindawi Ltd, 2015) Yilmaz, Ozkan; Kiziltan, Remzi; Aydin, Oktay; Bayrak, Vedat; Kotan, CetinEndoscopic biliary stents have been recently applied with increasing frequency as a palliative and curable method in several benign and malignant diseases. As a reminder, although most of the migrated stents pass through the intestinal tract without symptoms, a small portion can lead to complications. Herein, we present a case of intestinal perforation caused by a biliary stent in the hernia of a patient with a rarely encountered incarcerated incisional hernia.Article Successful Treatment of a Large Pelvic Abscess Using Intraluminal Vac: a Case Report(Premchand Shantidevi Research Foundation, 2016) Aras, Abbas; Celik, Sebahattin; Kiziltan, Remzi; Yilmaz, Ozkan; Kotan, CetinThe most feared complication of the surgical treatment of rectal cancer is anastomotic leakage, which is related to high rates of mortality and morbidity. Here, we present a patient who could not be treated with surgical drainage but treated by intraluminal Vacuum Associated Closure (VAC). A 34-year-old male patient was treated for rectal cancer by low anterior resection, colorectal anastomosis, and diverting ileostomy following neoadjuvant CRT. The patient reported with a postoperative anastomotic disruption and a large pelvic abscess. Due to the continuation of foul-smell drainage inspite of perianal incision and drainage, intraluminal VAC was applied and the pelvic abscess and the foul-smell were successfully treated. The presence of an adequate anal sphincter tonus is a disadvantage in anastomotic leakage, since it prevents the emptying of the intestinal content and also precludes the drainage of the pelvic abscess. The endoluminal application of VAC, similar to the results of application of VAC in open wounds, has been demonstrated to decrease fibrin and necrotic tissue in the pelvic cavity and increase granulation tissue. VAC, which has long been used in the treatment of open wounds, is a promising method in the treatment of large pelvic abscesses due to anastomotic leakage following rectum resection.Article Symptomatic Bochdalek Hernia in Pregnancy: a Rare Case Report(Hindawi Ltd, 2017) Yetkinel, Selcuk; Peksen, Calhan; Kiziltan, RemziIntroduction. Symptomatic Bochdalek hernia in pregnancy is quite rare. To the best of our knowledge, there are a total of 44 cases reported in the literature between 1959 and 2016 (Hernandez-Aragon et al., 2015; Koca et al., 2016). Difficulty and delay in diagnosis may lead to life-threatening complications. Case Report. We report a case of Bochdalek hernia during the 30 gestational weeks' pregnancy in whom pregnancy continued after surgical repair which resulted in term birth. Discussion. Bochdalek hernia is diagnosed with an incidence of 1 in 2200-12500 live births, while symptomatic diaphragm hernia is much less in adults. The actual incidence of diaphragmatic hernias during pregnancy is still unknown. Symptoms may include abdominal distension, recurrent abdominal pain, nausea, vomiting, inability to defecate, dyspnea, and chest pain. The patient with diaphragmatic hernia may be asymptomatic until the late weeks of gestation, as in our case, or herniation may occur during advanced gestational weeks with increased intraabdominal pressure. Conclusion. In conclusion, diagnosis of the diaphragm hernia during pregnancy is very rare. Diagnosis is rarer in symptomatic patients due to its rarity and the duration of diagnosis may, therefore, be delayed. Diaphragm hernia should be kept in mind in symptomatic patients due to its high maternal and fetal mortality rates.Conference Object Torsion of Wandering Spleen as a Rare Cause of Acute Abdomen(Aves Yayincilik, Ibrahim Kara, 2007) Kisli, Erol; Lobut, Nuriye; Kiziltan, Remzi; Kotan, Cetin; Karaayvaz, MuammerSpleen is well fixed on the left side of diaphragm with peritoneal bonds. Wandering spleen is a rare medical condition with its yet unknown pathogenesis. Wandering spleen is mostly located in lower abdomen or pelvis. Diagnosis is difficult if it is not suspected. Spleen can often be palpated in lower abdomen. Rarely it can be symptomatic when there is torsion of splenic vascular pedicle and splenectomy should be performed in this case. We report and evaluate a case who underwent splenectomy due to torsion of wandering spleen resulted in acute abdomen with a review of relevant literature.Article Uncommon Caecum Diverticulitis Mimicking Acute Appendicitis(Hindawi Ltd, 2016) Yilmaz, Ozkan; Kiziltan, Remzi; Bayrak, Vedat; Celik, Sebahattin; Calli, IskanDiverticulum of the cecum is a rarely seen reason of acute abdomen and it is difficult to be distinguished from appendicitis. The diagnosis is generally made during operation. We have presented this case in order to remember that it is a disease which should be kept in mind in cases of right lower quadrant pain.