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Browsing by Author "Koc, Gulsah"

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    Article
    The Association Between Arg72pro C>g Polymorphism in the P53 Gene and the Risk of Obesity
    (Istanbul Training & Research Hospital, 2022) Koc, Gulsah; Soyocak, Ahu; Kaya, Zehra; Kankaya, Burak; Alis, Halil
    Introduction: The role of genetic factors in obesity has long been recognized, but their involved specific genes remained unidentified. The relationship between p53 gene single nucleotide polymorphisms and the risk of obesity has been investigated in recent years. Therefore, this study aimed to investigate the association of p53 Arg72Pro C>G (rs1042522) polymorphism with the risk of obesity in our study. Methods: This study included 52 patients with obesity (26 were females and 26 were males) and 52 normal-weight healthy controls. Genomic DNA isolation was performed from the blood samples of all participants. P53 Arg72Pro C>G (rs1042522) polymorphism was detected by real-time quantitative polymerase chain reaction from genomic DNA samples. Results: No significant associations were identified between Arg72Pro (rs1042522) P53 polymorphism and obesity risk. Glucose levels are significantly different between the obese and control groups with the CC and CG genotypes, but without difference in the GG homozygous genotype. Conclusion: Our study is one of the first to investigate the relationship between p53 codon 72 polymorphisms and obesity risk but revealed no correlation between them. The relatively small number of participants may limit our study. Further research is needed in a large cohort to associate the p53 gene Arg72Pro C>G (rs1042522) variant with obesity risk.
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    Article
    Investigation of the Association Between Mitochondrial Dna and P53 Gene Mutations in Transitional Cell Carcinoma of the Bladder
    (Spandidos Publ Ltd, 2016) Avcilar, Tuba; Kirac, Deniz; Ergec, Deniz; Koc, Gulsah; Ulucan, Korkut; Kaya, Zehra; Guney, Ahmet Ilter
    Bladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recruited for the study. Bladder cancer tissues were obtained by radical cystectomy or transurethral resection. Genomic DNA was extracted from peripheral blood. mtDNA and p53 genes were amplified by polymerase chain reaction and sequenced directly. A total of 37 polymorphisms were identified, among which, 2 mutations were significant in the patient group, and 1 mutation was significant in the control group. Additionally, 5 different moderate positive correlations between mtDNA mutations and 3 different positive correlations between p53 gene and mtDNA mutations were detected. The high incidence of mtDNA and p53 gene mutations in bladder cancer suggests that these genes could be important in carcinogenesis.